4kxv - Revision history

OCA at 16:06, 20 September 2023

OCA — Wed, 20 Sep 2023 16:06:52 GMT

←Older revision		Revision as of 16:06, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kxv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kxv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KXV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DX5:D-XYLITOL-5-PHOSPHATE'>DX5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.97Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DX5:D-XYLITOL-5-PHOSPHATE'>DX5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxv OCA], [https://pdbe.org/4kxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kxv RCSB], [https://www.ebi.ac.uk/pdbsum/4kxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxv OCA], [https://pdbe.org/4kxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kxv RCSB], [https://www.ebi.ac.uk/pdbsum/4kxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxv ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:22, 10 May 2023

OCA — Wed, 10 May 2023 07:22:35 GMT

←Older revision		Revision as of 07:22, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4kxv' size='340' side='right'caption='[[4kxv]], [[Resolution\|resolution]] 0.97Å' scene=''>		<StructureSection load='4kxv' size='340' side='right'caption='[[4kxv]], [[Resolution\|resolution]] 0.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kxv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kxv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KXV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DX5:D-XYLITOL-5-PHOSPHATE'>DX5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DX5:D-XYLITOL-5-PHOSPHATE'>DX5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TKT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxv OCA], [https://pdbe.org/4kxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kxv RCSB], [https://www.ebi.ac.uk/pdbsum/4kxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxv OCA], [https://pdbe.org/4kxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kxv RCSB], [https://www.ebi.ac.uk/pdbsum/4kxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TKT_HUMAN TKT_HUMAN]] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	+	[https://www.uniprot.org/uniprot/TKT_HUMAN TKT_HUMAN] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Transketolase\|Transketolase]]	+	*[[Transketolase 3D structures\|Transketolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Transketolase]]~~	+	[[Category: Ficner R]]
-	[[Category: Ficner, R]]	+	[[Category: Luedtke S]]
-	[[Category: Luedtke, S]]	+	[[Category: Neumann P]]
-	[[Category: Neumann, P]]	+	[[Category: Tittmann K]]
-	[[Category: Tittmann, K]]	+
-	~~[[Category: Enzyme catalysis]]~~	+
-	~~[[Category: Pentose phosphate pathway]]~~	+
-	~~[[Category: Thiamin diphosphate]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:24, 4 August 2021

OCA — Wed, 04 Aug 2021 10:24:55 GMT

←Older revision		Revision as of 10:24, 4 August 2021
Line 1:		Line 1:

	==Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1==		==Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1==
-	<StructureSection load='4kxv' size='340' side='right' caption='[[4kxv]], [[Resolution\|resolution]] 0.97Å' scene=''>	+	<StructureSection load='4kxv' size='340' side='right'caption='[[4kxv]], [[Resolution\|resolution]] 0.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kxv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kxv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KXV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DX5:D-XYLITOL-5-PHOSPHATE'>DX5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=~~TDP~~:~~THIAMIN~~+DIPHOSPHATE'>~~TDP~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DX5:D-XYLITOL-5-PHOSPHATE'>DX5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TKT ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TKT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxv OCA], [~~http~~://pdbe.org/4kxv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kxv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kxv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxv OCA], [https://pdbe.org/4kxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kxv RCSB], [https://www.ebi.ac.uk/pdbsum/4kxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TKT_HUMAN TKT_HUMAN]] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	+	[[https://www.uniprot.org/uniprot/TKT_HUMAN TKT_HUMAN]] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4kxv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kxv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transketolase\|Transketolase]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Transketolase]]		[[Category: Transketolase]]
	[[Category: Ficner, R]]		[[Category: Ficner, R]]

OCA at 09:28, 15 November 2017

OCA — Wed, 15 Nov 2017 09:28:21 GMT

←Older revision		Revision as of 09:28, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4kxv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kxv" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Transketolase\|Transketolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:52, 11 August 2016

OCA — Thu, 11 Aug 2016 14:52:20 GMT

←Older revision		Revision as of 14:52, 11 August 2016
Line 1:		Line 1:
		+
	==Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1==		==Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1==
	<StructureSection load='4kxv' size='340' side='right' caption='[[4kxv]], [[Resolution\|resolution]] 0.97Å' scene=''>		<StructureSection load='4kxv' size='340' side='right' caption='[[4kxv]], [[Resolution\|resolution]] 0.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kxv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kxv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KXV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DX5:D-XYLITOL-5-PHOSPHATE'>DX5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TDP:THIAMIN+DIPHOSPHATE'>TDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DX5:D-XYLITOL-5-PHOSPHATE'>DX5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TDP:THIAMIN+DIPHOSPHATE'>TDP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TKT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TKT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kxv RCSB], [http://www.ebi.ac.uk/pdbsum/4kxv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxv OCA], [http://pdbe.org/4kxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kxv RCSB], [http://www.ebi.ac.uk/pdbsum/4kxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kxv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TKT_HUMAN TKT_HUMAN]] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kxv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Transketolase]]		[[Category: Transketolase]]
	[[Category: Ficner, R]]		[[Category: Ficner, R]]

OCA at 13:17, 4 January 2015

OCA — Sun, 04 Jan 2015 13:17:58 GMT

←Older revision		Revision as of 13:17, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4kxv\| PDB=4kxv \| SCENE= }}~~	+	==Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1==
-	===Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1===	+	<StructureSection load='4kxv' size='340' side='right' caption='[[4kxv]], [[Resolution\|resolution]] 0.97Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23965678}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kxv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KXV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DX5:D-XYLITOL-5-PHOSPHATE'>DX5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TDP:THIAMIN+DIPHOSPHATE'>TDP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TKT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kxv RCSB], [http://www.ebi.ac.uk/pdbsum/4kxv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	It is recognized widely that enzymes promote reactions by providing a pathway that proceeds through a transition state of lower energy. In principle, further rate enhancements could be achieved if intermediates are prevented from relaxing to their lowest energy state, and thereby reduce the barrier to the subsequent transition state. Here, we report sub-angstrom-resolution crystal structures of genuine covalent reaction intermediates of transketolase. These structures reveal a pronounced out-of-plane distortion of over 20 degrees for the covalent bond that links cofactor and substrate, and a specific elongation of the scissile substrate carbon-carbon bond (d > 1.6 A). To achieve these distortions, the protein's conformation appears to prevent relaxation of a substrate-cofactor intermediate. The results implicate a reduced barrier to the subsequent step that is consistent with an intermediate of raised energy and leads to a more efficient overall process.

-	~~==About this Structure==~~	+	Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.,Ludtke S, Neumann P, Erixon KM, Leeper F, Kluger R, Ficner R, Tittmann K Nat Chem. 2013 Sep;5(9):762-7. doi: 10.1038/nchem.1728. Epub 2013 Aug 18. PMID:23965678<ref>PMID:23965678</ref>
-	~~[[4kxv]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4KXV OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:023965678</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Transketolase\|Transketolase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Transketolase]]		[[Category: Transketolase]]
-	[[Category: Ficner, R.]]	+	[[Category: Ficner, R]]
-	[[Category: Luedtke, S.]]	+	[[Category: Luedtke, S]]
-	[[Category: Neumann, P.]]	+	[[Category: Neumann, P]]
-	[[Category: Tittmann, K.]]	+	[[Category: Tittmann, K]]
	[[Category: Enzyme catalysis]]		[[Category: Enzyme catalysis]]
	[[Category: Pentose phosphate pathway]]		[[Category: Pentose phosphate pathway]]
	[[Category: Thiamin diphosphate]]		[[Category: Thiamin diphosphate]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:03, 4 September 2013

OCA — Wed, 04 Sep 2013 09:03:09 GMT

←Older revision		Revision as of 09:03, 4 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4kxv\| PDB=4kxv \| SCENE= }}		{{STRUCTURE_4kxv\| PDB=4kxv \| SCENE= }}
	===Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1===		===Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1===
		+	{{ABSTRACT_PUBMED_23965678}}

	==About this Structure==		==About this Structure==
	[[4kxv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA].		[[4kxv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023965678</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Transketolase]]		[[Category: Transketolase]]

OCA at 08:36, 21 August 2013

OCA — Wed, 21 Aug 2013 08:36:09 GMT

←Older revision		Revision as of 08:36, 21 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4kxv\| PDB=4kxv \| SCENE= }}
		+	===Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1===

-	~~The entry~~ 4kxv is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4kxv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXV OCA].
-	~~Authors~~: ~~Neumann~~, P., Luedtke, S., ~~Ficner, R~~., Tittmann, K.	+	[[Category: Homo sapiens]]
-		+	[[Category: Transketolase]]
-	~~Description~~: ~~Human transketolase in covalent complex with donor ketose D-xylulose-5-~~phosphate~~, crystal 1~~	+	[[Category: Ficner, R.]]
		+	[[Category: Luedtke, S.]]
		+	[[Category: Neumann, P.]]
		+	[[Category: Tittmann, K.]]
		+	[[Category: Enzyme catalysis]]
		+	[[Category: Pentose phosphate pathway]]
		+	[[Category: Thiamin diphosphate]]
		+	[[Category: Transferase]]

OCA at 20:02, 7 August 2013

OCA — Wed, 07 Aug 2013 20:02:35 GMT

←Older revision		Revision as of 20:02, 7 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kxv is ON HOLD	+	The entry 4kxv is ON HOLD until Paper Publication

	Authors: Neumann, P., Luedtke, S., Ficner, R., Tittmann, K.		Authors: Neumann, P., Luedtke, S., Ficner, R., Tittmann, K.

	Description: Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1		Description: Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1

OCA: Protected "4kxv" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 12:12:29 GMT

Protected "4kxv" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:12, 19 June 2013