4kzj - Revision history

OCA at 08:54, 20 March 2024

OCA — Wed, 20 Mar 2024 08:54:57 GMT

←Older revision		Revision as of 08:54, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kzj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KZJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kzj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KZJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.12Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzj OCA], [https://pdbe.org/4kzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kzj RCSB], [https://www.ebi.ac.uk/pdbsum/4kzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzj OCA], [https://pdbe.org/4kzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kzj RCSB], [https://www.ebi.ac.uk/pdbsum/4kzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>		[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Autophagy is linked to cell death, yet the associated mechanisms are largely undercharacterized. We discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan nuclear receptor TR3. A sequence of molecular events leading to cellular demise is launched by a specific chemical compound, 1-(3,4,5-trihydroxyphenyl)nonan-1-one, newly acquired from screening a library of TR3-targeting compounds. The autophagic cascade comprises TR3 translocation to mitochondria through interaction with the mitochondrial outer membrane protein Nix, crossing into the mitochondrial inner membrane through Tom40 and Tom70 channel proteins, dissipation of mitochondrial membrane potential by the permeability transition pore complex ANT1-VDAC1 and induction of autophagy. This process leads to excessive mitochondria clearance and irreversible cell death. It implicates a new approach to melanoma therapy through activation of a mitochondrial signaling pathway that integrates a nuclear receptor with autophagy for cell death.
-
-	Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.,Wang WJ, Wang Y, Chen HZ, Xing YZ, Li FW, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann F, Wu M, Han J, Huang PQ, Lin T, Wu Q Nat Chem Biol. 2014 Feb;10(2):133-40. doi: 10.1038/nchembio.1406. Epub 2013 Dec, 8. PMID:24316735<ref>PMID:24316735</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4kzj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:22, 7 December 2022

OCA — Wed, 07 Dec 2022 09:22:49 GMT

←Older revision		Revision as of 09:22, 7 December 2022
Line 3:		Line 3:
	<StructureSection load='4kzj' size='340' side='right'caption='[[4kzj]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='4kzj' size='340' side='right'caption='[[4kzj]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kzj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KZJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kzj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KZJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kzi\|4kzi]], [[4kzm\|4kzm]], [[4jgv\|4jgv]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzj OCA], [https://pdbe.org/4kzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kzj RCSB], [https://www.ebi.ac.uk/pdbsum/4kzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzj ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFRP1, HMR, NAK1, NR4A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzj OCA], [~~http~~://pdbe.org/4kzj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kzj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kzj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>	+	[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cai, Q]]	+	[[Category: Cai Q]]
-	[[Category: Chen, H]]	+	[[Category: Chen H]]
-	[[Category: Li, A]]	+	[[Category: Li A]]
-	[[Category: Li, F]]	+	[[Category: Li F]]
-	[[Category: Lin, T]]	+	[[Category: Lin T]]
-	[[Category: Tian, X]]	+	[[Category: Tian X]]
-	[[Category: Wang, W]]	+	[[Category: Wang W]]
-	[[Category: Wang, Y]]	+	[[Category: Wang Y]]
-	[[Category: Wu, Q]]	+	[[Category: Wu Q]]
-	[[Category: Xing, Y]]	+	[[Category: Xing Y]]
-	[[Category: Zhang, Q]]	+	[[Category: Zhang Q]]
-	~~[[Category: Orphan nuclear receptor]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 10:04, 25 December 2019

OCA — Wed, 25 Dec 2019 10:04:07 GMT

←Older revision		Revision as of 10:04, 25 December 2019
Line 1:		Line 1:

	==Crystal Structure of TR3 LBD L449W Mutant==		==Crystal Structure of TR3 LBD L449W Mutant==
-	<StructureSection load='4kzj' size='340' side='right' caption='[[4kzj]], [[Resolution\|resolution]] 2.12Å' scene=''>	+	<StructureSection load='4kzj' size='340' side='right'caption='[[4kzj]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kzj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kzj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZJ FirstGlance]. <br>
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>		[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Autophagy is linked to cell death, yet the associated mechanisms are largely undercharacterized. We discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan nuclear receptor TR3. A sequence of molecular events leading to cellular demise is launched by a specific chemical compound, 1-(3,4,5-trihydroxyphenyl)nonan-1-one, newly acquired from screening a library of TR3-targeting compounds. The autophagic cascade comprises TR3 translocation to mitochondria through interaction with the mitochondrial outer membrane protein Nix, crossing into the mitochondrial inner membrane through Tom40 and Tom70 channel proteins, dissipation of mitochondrial membrane potential by the permeability transition pore complex ANT1-VDAC1 and induction of autophagy. This process leads to excessive mitochondria clearance and irreversible cell death. It implicates a new approach to melanoma therapy through activation of a mitochondrial signaling pathway that integrates a nuclear receptor with autophagy for cell death.
		+
		+	Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.,Wang WJ, Wang Y, Chen HZ, Xing YZ, Li FW, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann F, Wu M, Han J, Huang PQ, Lin T, Wu Q Nat Chem Biol. 2014 Feb;10(2):133-40. doi: 10.1038/nchembio.1406. Epub 2013 Dec, 8. PMID:24316735<ref>PMID:24316735</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4kzj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 16:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cai, Q]]		[[Category: Cai, Q]]
	[[Category: Chen, H]]		[[Category: Chen, H]]

OCA at 21:21, 4 August 2016

OCA — Thu, 04 Aug 2016 21:21:51 GMT

←Older revision		Revision as of 21:21, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of TR3 LBD L449W Mutant==		==Crystal Structure of TR3 LBD L449W Mutant==
	<StructureSection load='4kzj' size='340' side='right' caption='[[4kzj]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='4kzj' size='340' side='right' caption='[[4kzj]], [[Resolution\|resolution]] 2.12Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kzi\|4kzi]], [[4kzm\|4kzm]], [[4jgv\|4jgv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kzi\|4kzi]], [[4kzm\|4kzm]], [[4jgv\|4jgv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFRP1, HMR, NAK1, NR4A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFRP1, HMR, NAK1, NR4A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzj RCSB], [http://www.ebi.ac.uk/pdbsum/4kzj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzj OCA], [http://pdbe.org/4kzj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kzj RCSB], [http://www.ebi.ac.uk/pdbsum/4kzj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 13:15, 25 December 2014

OCA — Thu, 25 Dec 2014 13:15:10 GMT

←Older revision		Revision as of 13:15, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzj RCSB], [http://www.ebi.ac.uk/pdbsum/4kzj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzj RCSB], [http://www.ebi.ac.uk/pdbsum/4kzj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:22, 21 December 2014

OCA — Sun, 21 Dec 2014 16:22:42 GMT

←Older revision		Revision as of 16:22, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kzj\| PDB=4kzj \| SCENE= }}~~	+	==Crystal Structure of TR3 LBD L449W Mutant==
-	===Crystal Structure of TR3 LBD L449W Mutant===	+	<StructureSection load='4kzj' size='340' side='right' caption='[[4kzj]], [[Resolution\|resolution]] 2.12Å' scene=''>
-		+	== Structural highlights ==
-	==~~Function~~==	+	<table><tr><td colspan='2'>[[4kzj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZJ FirstGlance]. <br>
-	[[~~http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN~~]] ~~Orphan nuclear receptor~~. ~~May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5~~'~~-AAAAGGTCA-3~~' ~~(By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref~~>~~PMID:15466594</ref>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kzi\|4kzi]], [[4kzm\|4kzm]], [[4jgv\|4jgv]]</td></tr>
-	==~~About this Structure~~==	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GFRP1, HMR, NAK1, NR4A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	[[4kzj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZJ OCA].	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzj RCSB], [http://www.ebi.ac.uk/pdbsum/4kzj PDBsum]</span></td></tr>
-		+	</table>
-	==~~Reference~~==	+	__TOC__
-	<~~references group~~="~~xtra~~"/><~~references~~/>	+	</StructureSection>
-	[[Category: Cai, Q.]]	+	[[Category: Human]]
-	[[Category: Chen, H.]]	+	[[Category: Cai, Q]]
-	[[Category: Li, A.]]	+	[[Category: Chen, H]]
-	[[Category: Li, F.]]	+	[[Category: Li, A]]
-	[[Category: Lin, T.]]	+	[[Category: Li, F]]
-	[[Category: Tian, X.]]	+	[[Category: Lin, T]]
-	[[Category: Wang, W.]]	+	[[Category: Tian, X]]
-	[[Category: Wang, Y.]]	+	[[Category: Wang, W]]
-	[[Category: Wu, Q.]]	+	[[Category: Wang, Y]]
-	[[Category: Xing, Y.]]	+	[[Category: Wu, Q]]
-	[[Category: Zhang, Q.]]	+	[[Category: Xing, Y]]
		+	[[Category: Zhang, Q]]
	[[Category: Orphan nuclear receptor]]		[[Category: Orphan nuclear receptor]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 10:38, 18 December 2013

OCA — Wed, 18 Dec 2013 10:38:28 GMT

←Older revision		Revision as of 10:38, 18 December 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4kzj\| PDB=4kzj \| SCENE= }}
		+	===Crystal Structure of TR3 LBD L449W Mutant===

-	~~The entry 4kzj is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>

-	~~Authors~~: ~~Li, F., Zhang, Q., Li, A., Tian, X., Cai, Q., Wang, W., Wang, Y., Chen, H~~.~~, Xing, Y~~.~~, Wu, Q~~.~~, Lin, T~~.	+	==About this Structure==
		+	[[4kzj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZJ OCA].

-	~~Description~~: ~~Crystal Structure of TR3 LBD L449W Mutant~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Cai, Q.]]
		+	[[Category: Chen, H.]]
		+	[[Category: Li, A.]]
		+	[[Category: Li, F.]]
		+	[[Category: Lin, T.]]
		+	[[Category: Tian, X.]]
		+	[[Category: Wang, W.]]
		+	[[Category: Wang, Y.]]
		+	[[Category: Wu, Q.]]
		+	[[Category: Xing, Y.]]
		+	[[Category: Zhang, Q.]]
		+	[[Category: Orphan nuclear receptor]]
		+	[[Category: Transcription]]

OCA at 06:38, 4 December 2013

OCA — Wed, 04 Dec 2013 06:38:39 GMT

←Older revision		Revision as of 06:38, 4 December 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kzj is ON HOLD	+	The entry 4kzj is ON HOLD until Paper Publication

	Authors: Li, F., Zhang, Q., Li, A., Tian, X., Cai, Q., Wang, W., Wang, Y., Chen, H., Xing, Y., Wu, Q., Lin, T.		Authors: Li, F., Zhang, Q., Li, A., Tian, X., Cai, Q., Wang, W., Wang, Y., Chen, H., Xing, Y., Wu, Q., Lin, T.

	Description: Crystal Structure of TR3 LBD L449W Mutant		Description: Crystal Structure of TR3 LBD L449W Mutant

OCA at 08:56, 30 June 2013

OCA — Sun, 30 Jun 2013 08:56:51 GMT

←Older revision		Revision as of 08:56, 30 June 2013
Line 3:		Line 3:
	The entry 4kzj is ON HOLD		The entry 4kzj is ON HOLD

-	Authors: Li, ~~Fengwei~~, Zhang, ~~Qian~~, Li, ~~Anzhong~~, Tian, ~~Xuyang~~, Cai, ~~Qixu~~, Wang, ~~Weijia~~, Wang, ~~Yuan~~, Chen, ~~Hangzi~~, Xing, ~~Yongzhen~~, Wu, ~~Qiao~~, Lin, ~~Tianwei~~	+	Authors: Li, F., Zhang, Q., Li, A., Tian, X., Cai, Q., Wang, W., Wang, Y., Chen, H., Xing, Y., Wu, Q., Lin, T.

	Description: Crystal Structure of TR3 LBD L449W Mutant		Description: Crystal Structure of TR3 LBD L449W Mutant

OCA: Protected "4kzj" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 12:16:45 GMT

Protected "4kzj" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:16, 19 June 2013