4kzu - Revision history

OCA at 16:08, 20 September 2023

OCA — Wed, 20 Sep 2023 16:08:03 GMT

←Older revision		Revision as of 16:08, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kzu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KZU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kzu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KZU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A73:2-(4-BROMOPHENYL)-4H-CHROMEN-4-ONE'>A73</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A73:2-(4-BROMOPHENYL)-4H-CHROMEN-4-ONE'>A73</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzu OCA], [https://pdbe.org/4kzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kzu RCSB], [https://www.ebi.ac.uk/pdbsum/4kzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzu OCA], [https://pdbe.org/4kzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kzu RCSB], [https://www.ebi.ac.uk/pdbsum/4kzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzu ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:23, 7 December 2022

OCA — Wed, 07 Dec 2022 09:23:07 GMT

←Older revision		Revision as of 09:23, 7 December 2022
Line 1:		Line 1:

	==Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone==		==Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone==
-	<StructureSection load='4kzu' size='340' side='right' caption='[[4kzu]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4kzu' size='340' side='right'caption='[[4kzu]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kzu]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KZU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kzu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KZU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A73:2-(4-BROMOPHENYL)-4H-CHROMEN-4-ONE'>A73</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A73:2-(4-BROMOPHENYL)-4H-CHROMEN-4-ONE'>A73</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hki\|4hki]], [[4kzl\|4kzl]], [[4kzq\|4kzq]], [[4l09\|4l09]], [[4l0b\|4l0b]], [[4l0i\|4l0i]], [[4l0s\|4l0s]], [[4l0t\|4l0t]], [[4l0v\|4l0v]], [[4l10\|4l10]], [[4l2f\|4l2f]], [[4l2g\|4l2g]], [[4l2k\|4l2k]], [[4l31\|4l31]], [[4l32\|4l32]], [[4l33\|4l33]], [[4l34\|4l34]], [[4bs4\|4bs4]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzu OCA], [https://pdbe.org/4kzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kzu RCSB], [https://www.ebi.ac.uk/pdbsum/4kzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzu ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzu OCA], [~~http~~://pdbe.org/4kzu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kzu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kzu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>	+	[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]	+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Haikarainen, T~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lehtio, L~~]]	+	[[Category: Haikarainen T]]
-	[[Category: ~~Narwal, M~~]]	+	[[Category: Lehtio L]]
-	[[Category: ~~Adp-ribosylation]]~~	+	[[Category: Narwal M]]
-	~~[[Category: Diphtheria toxin like fold]]~~	+
-	~~[[Category: Protein-ligand complex]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 19:03, 5 August 2016

OCA — Fri, 05 Aug 2016 19:03:05 GMT

←Older revision		Revision as of 19:03, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone==		==Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone==
	<StructureSection load='4kzu' size='340' side='right' caption='[[4kzu]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4kzu' size='340' side='right' caption='[[4kzu]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzu RCSB], [http://www.ebi.ac.uk/pdbsum/4kzu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzu OCA], [http://pdbe.org/4kzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kzu RCSB], [http://www.ebi.ac.uk/pdbsum/4kzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kzu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 05:02, 25 December 2014

OCA — Thu, 25 Dec 2014 05:02:49 GMT

←Older revision		Revision as of 05:02, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzu RCSB], [http://www.ebi.ac.uk/pdbsum/4kzu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzu RCSB], [http://www.ebi.ac.uk/pdbsum/4kzu PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:11, 21 December 2014

OCA — Sun, 21 Dec 2014 17:11:50 GMT

←Older revision		Revision as of 17:11, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kzu\| PDB=4kzu \| SCENE= }}~~	+	==Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone==
-	===Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone===	+	<StructureSection load='4kzu' size='340' side='right' caption='[[4kzu]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24116873}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kzu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A73:2-(4-BROMOPHENYL)-4H-CHROMEN-4-ONE'>A73</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hki\|4hki]], [[4kzl\|4kzl]], [[4kzq\|4kzq]], [[4l09\|4l09]], [[4l0b\|4l0b]], [[4l0i\|4l0i]], [[4l0s\|4l0s]], [[4l0t\|4l0t]], [[4l0v\|4l0v]], [[4l10\|4l10]], [[4l2f\|4l2f]], [[4l2g\|4l2g]], [[4l2k\|4l2k]], [[4l31\|4l31]], [[4l32\|4l32]], [[4l33\|4l33]], [[4l34\|4l34]], [[4bs4\|4bs4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzu RCSB], [http://www.ebi.ac.uk/pdbsum/4kzu PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tankyrases are ADP-ribosyltransferases that play key roles in various cellular pathways, including the regulation of cell proliferation, and thus, they are promising drug targets for the treatment of cancer. Flavones have been shown to inhibit tankyrases and we report here the discovery of more potent and selective flavone derivatives. Commercially available flavones with single substitutions were used for structure-activity relationship studies, and cocrystal structures of the 18 hit compounds were analyzed to explain their potency and selectivity. The most potent inhibitors were also tested in a cell-based assay, which demonstrated that they effectively antagonize Wnt signaling. To assess selectivity, they were further tested against a panel of homologous human ADP-ribosyltransferases. The most effective compound, 22 (MN-64), showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition. This work forms a basis for rational development of flavones as tankyrase inhibitors and guides the development of other structurally related inhibitors.

-	~~==Function==~~	+	Discovery of Tankyrase Inhibiting Flavones with Increased Potency and Isoenzyme Selectivity.,Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala OE, Venkannagari H, Joensuu P, Pihlajaniemi T, Lehtio L J Med Chem. 2013 Oct 11. PMID:24116873<ref>PMID:24116873</ref>
-	~~[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length~~ and ~~vesicle trafficking~~. ~~Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2~~, ~~2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146~~, ~~which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3~~, ~~followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1~~, ~~thereby contributing to the regulation of telomere length~~. ~~May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles~~.~~<ref>~~PMID:~~11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref>~~ <ref>PMID:~~21478859~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4kzu]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4KZU OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024116873</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Haikarainen, T.]]	+	[[Category: Haikarainen, T]]
-	[[Category: Lehtio, L.]]	+	[[Category: Lehtio, L]]
-	[[Category: Narwal, M.]]	+	[[Category: Narwal, M]]
	[[Category: Adp-ribosylation]]		[[Category: Adp-ribosylation]]
	[[Category: Diphtheria toxin like fold]]		[[Category: Diphtheria toxin like fold]]

OCA at 06:52, 15 January 2014

OCA — Wed, 15 Jan 2014 06:52:04 GMT

←Older revision		Revision as of 06:52, 15 January 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4kzu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZU OCA].	+	[[4kzu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZU OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024116873</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024116873</ref><references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Haikarainen, T.]]		[[Category: Haikarainen, T.]]
	[[Category: Lehtio, L.]]		[[Category: Lehtio, L.]]

OCA at 09:34, 30 October 2013

OCA — Wed, 30 Oct 2013 09:34:07 GMT

←Older revision		Revision as of 09:34, 30 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure'''	+	{{STRUCTURE_4kzu\| PDB=4kzu \| SCENE= }}
		+	===Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone===
		+	{{ABSTRACT_PUBMED_24116873}}

-	~~The entry 4kzu is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>

-	~~Authors~~: ~~Narwal, M~~.~~, Haikarainen, T~~.~~, Lehtio, L~~.	+	==About this Structure==
		+	[[4kzu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZU OCA].

-	~~Description~~: ~~Crystal structure of human tankyrase 2 in~~ complex ~~with 4'~~ -~~bromo flavone~~	+	==Reference==
		+	<ref group="xtra">PMID:024116873</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Haikarainen, T.]]
		+	[[Category: Lehtio, L.]]
		+	[[Category: Narwal, M.]]
		+	[[Category: Adp-ribosylation]]
		+	[[Category: Diphtheria toxin like fold]]
		+	[[Category: Protein-ligand complex]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 15:04, 10 July 2013

OCA — Wed, 10 Jul 2013 15:04:06 GMT

←Older revision		Revision as of 15:04, 10 July 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kzu is ON HOLD	+	The entry 4kzu is ON HOLD until Paper Publication

	Authors: Narwal, M., Haikarainen, T., Lehtio, L.		Authors: Narwal, M., Haikarainen, T., Lehtio, L.

	Description: Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone		Description: Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone

OCA: Protected "4kzu" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 12:17:25 GMT

Protected "4kzu" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:17, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4kzu is ON HOLD Authors: Narwal, M., Haikarainen, T., Lehtio, L. Description: Crystal structure of human tankyrase 2 in complex with 4' -bromo flav...

OCA — Wed, 19 Jun 2013 12:17:24 GMT

New page: '''Unreleased structure''' The entry 4kzu is ON HOLD Authors: Narwal, M., Haikarainen, T., Lehtio, L. Description: Crystal structure of human tankyrase 2 in complex with 4' -bromo flav...

New page

'''Unreleased structure'''

The entry 4kzu is ON HOLD

Authors: Narwal, M., Haikarainen, T., Lehtio, L.

Description: Crystal structure of human tankyrase 2 in complex with 4' -bromo flavone