4kzv - Revision history

OCA at 09:23, 7 December 2022

OCA — Wed, 07 Dec 2022 09:23:09 GMT

←Older revision		Revision as of 09:23, 7 December 2022
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	==Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose==		==Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose==
-	<StructureSection load='4kzv' size='340' side='right' caption='[[4kzv]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='4kzv' size='340' side='right'caption='[[4kzv]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kzv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KZV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:~~SODIUM+ION~~'>NA</scene>, <scene name='pdbligand=~~TRE~~:~~TREHALOSE~~'>~~TRE~~</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PRD_900006:trehalose'>PRD_900006</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4kzw\|4kzw]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzv OCA], [https://pdbe.org/4kzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kzv RCSB], [https://www.ebi.ac.uk/pdbsum/4kzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzv ProSAT]</span></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">CLEC4E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzv OCA], [~~http~~://pdbe.org/4kzv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kzv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kzv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzv ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/E1BHM0_BOVIN E1BHM0_BOVIN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
-	[[Category: Brash~~, M A~~]]	+	[[Category: Large Structures]]
-	[[Category: Drickamer, K]]	+	[[Category: Brash MA]]
-	[[Category: Feinberg, H]]	+	[[Category: Drickamer K]]
-	[[Category: Guan, Y]]	+	[[Category: Feinberg H]]
-	[[Category: Jegouzo~~, S A.F~~]]	+	[[Category: Guan Y]]
-	[[Category: Rowntree~~, T J.W~~]]	+	[[Category: Jegouzo SAF]]
-	[[Category: Taylor~~, M E~~]]	+	[[Category: Rowntree TJW]]
-	[[Category: Weis~~, W I]]~~	+	[[Category: Taylor ME]]
-	~~[[Category: C-type lectin]]~~	+	[[Category: Weis WI]]
-	~~[[Category: Carbohydrate-binding protein]]~~	+
-	~~[[Category: Carbohydrate-recognition domain~~]]	+

OCA at 12:21, 5 August 2016

OCA — Fri, 05 Aug 2016 12:21:42 GMT

←Older revision		Revision as of 12:21, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose==		==Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose==
	<StructureSection load='4kzv' size='340' side='right' caption='[[4kzv]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4kzv' size='340' side='right' caption='[[4kzv]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kzw\|4kzw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kzw\|4kzw]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLEC4E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLEC4E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzv RCSB], [http://www.ebi.ac.uk/pdbsum/4kzv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzv OCA], [http://pdbe.org/4kzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kzv RCSB], [http://www.ebi.ac.uk/pdbsum/4kzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kzv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kzv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Brash, M A]]		[[Category: Brash, M A]]
	[[Category: Drickamer, K]]		[[Category: Drickamer, K]]

OCA at 15:23, 21 December 2014

OCA — Sun, 21 Dec 2014 15:23:07 GMT

←Older revision		Revision as of 15:23, 21 December 2014
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-	~~{{STRUCTURE_4kzv\| PDB=4kzv \| SCENE= }}~~	+	==Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose==
-	===Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose===	+	<StructureSection load='4kzv' size='340' side='right' caption='[[4kzv]], [[Resolution\|resolution]] 1.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23960080}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kzw\|4kzw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLEC4E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzv RCSB], [http://www.ebi.ac.uk/pdbsum/4kzv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Binding of the macrophage lectin mincle to trehalose dimycolate, a key glycolipid virulence factor on the surface of Mycobacterium tuberculosis and Mycobacterium bovis, initiates responses that can lead both to toxicity and to protection of these pathogens from destruction. Crystallographic structural analysis, site-directed mutagenesis, and binding studies with glycolipid mimics have been used to define an extended binding site in the C-type carbohydrate-recognition domain (CRD) of bovine mincle that encompasses both the headgroup and a portion of the attached acyl chains. One glucose residue of the trehalose Glcalpha1-1Glcalpha headgroup is liganded to a Ca2+ in a manner common to many C-type CRDs, while the second glucose residue is accommodated in a novel secondary binding site. The additional contacts in the secondary site lead to a 36-fold higher affinity for trehalose compared to glucose. An adjacent hydrophobic groove, not seen in other C-type CRDs, provides a docking site for one of the acyl chains attached to the trehalose, which can be targeted with small molecule analogues of trehalose dimycolate that bind with 52-fold higher affinity than trehalose. The data demonstrate how mincle bridges between the surfaces of the macrophage and the mycobacterium and suggest the possibility of disrupting this interaction. In addition, the results may provide a basis for design of adjuvants that mimic the ability of mycobacteria to stimulate a response to immunization that can be employed in vaccine development.

-	~~==About this Structure==~~	+	Mechanism for recognition of an unusual mycobacterial glycolipid by the macrophage receptor mincle.,Feinberg H, Jegouzo SA, Rowntree TJ, Guan Y, Brash MA, Taylor ME, Weis WI, Drickamer K J Biol Chem. 2013 Aug 19. PMID:23960080<ref>PMID:23960080</ref>
-	~~[[4kzv]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4KZV OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023960080</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Brash, M A.]]	+	[[Category: Brash, M A]]
-	[[Category: Drickamer, K.]]	+	[[Category: Drickamer, K]]
-	[[Category: Feinberg, H.]]	+	[[Category: Feinberg, H]]
-	[[Category: Guan, Y.]]	+	[[Category: Guan, Y]]
-	[[Category: Jegouzo, S A.F.]]	+	[[Category: Jegouzo, S A.F]]
-	[[Category: Rowntree, T J.W.]]	+	[[Category: Rowntree, T J.W]]
-	[[Category: Taylor, M E.]]	+	[[Category: Taylor, M E]]
-	[[Category: Weis, W I.]]	+	[[Category: Weis, W I]]
	[[Category: C-type lectin]]		[[Category: C-type lectin]]
	[[Category: Carbohydrate-binding protein]]		[[Category: Carbohydrate-binding protein]]
	[[Category: Carbohydrate-recognition domain]]		[[Category: Carbohydrate-recognition domain]]

OCA at 08:40, 4 September 2013

OCA — Wed, 04 Sep 2013 08:40:30 GMT

←Older revision		Revision as of 08:40, 4 September 2013
Line 1:		Line 1:
	{{STRUCTURE_4kzv\| PDB=4kzv \| SCENE= }}		{{STRUCTURE_4kzv\| PDB=4kzv \| SCENE= }}
	===Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose===		===Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose===
		+	{{ABSTRACT_PUBMED_23960080}}

	==About this Structure==		==About this Structure==
	[[4kzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZV OCA].		[[4kzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023960080</ref><references group="xtra"/><references/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Brash, M A.]]		[[Category: Brash, M A.]]

OCA at 07:39, 28 August 2013

OCA — Wed, 28 Aug 2013 07:39:35 GMT

←Older revision		Revision as of 07:39, 28 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4kzv\| PDB=4kzv \| SCENE= }}
		+	===Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose===

-	~~The entry~~ 4kzv is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4kzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZV OCA].
-	~~Authors~~: Feinberg, H., Jegouzo, S.A.F., Rowntree, T.J.W.~~, Guan, Y., Brash, M.A.,~~ Taylor, M.E., Weis, W.I.~~, Drickamer, K.~~	+	[[Category: Bos taurus]]
-		+	[[Category: Brash, M A.]]
-	~~Description~~: ~~Structure of the carbohydrate-recognition domain of the~~ C-type lectin ~~mincle bound to trehalose~~	+	[[Category: Drickamer, K.]]
		+	[[Category: Feinberg, H.]]
		+	[[Category: Guan, Y.]]
		+	[[Category: Jegouzo, S A.F.]]
		+	[[Category: Rowntree, T J.W.]]
		+	[[Category: Taylor, M E.]]
		+	[[Category: Weis, W I.]]
		+	[[Category: C-type lectin]]
		+	[[Category: Carbohydrate-binding protein]]
		+	[[Category: Carbohydrate-recognition domain]]

OCA at 12:23, 24 July 2013

OCA — Wed, 24 Jul 2013 12:23:19 GMT

←Older revision		Revision as of 12:23, 24 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kzv is ON HOLD	+	The entry 4kzv is ON HOLD until Paper Publication

	Authors: Feinberg, H., Jegouzo, S.A.F., Rowntree, T.J.W., Guan, Y., Brash, M.A., Taylor, M.E., Weis, W.I., Drickamer, K.		Authors: Feinberg, H., Jegouzo, S.A.F., Rowntree, T.J.W., Guan, Y., Brash, M.A., Taylor, M.E., Weis, W.I., Drickamer, K.

	Description: Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose		Description: Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose

OCA at 13:17, 3 July 2013

OCA — Wed, 03 Jul 2013 13:17:12 GMT

←Older revision		Revision as of 13:17, 3 July 2013
Line 3:		Line 3:
	The entry 4kzv is ON HOLD		The entry 4kzv is ON HOLD

-	Authors: ~~Hadar~~ Feinberg, ~~Sabine~~ A. F. ~~Jegouzo~~, ~~Thomas~~ J. W. ~~Rowntree~~, ~~Yue~~ Guan, ~~Matthew A~~. Brash, ~~Maureen E~~. Taylor, ~~William I~~. Weis, ~~Kurt~~ Drickamer	+	Authors: Feinberg, H., Jegouzo, S.A.F., Rowntree, T.J.W., Guan, Y., Brash, M.A., Taylor, M.E., Weis, W.I., Drickamer, K.

-	Description: Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose.	+	Description: Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose

OCA: Protected "4kzv" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 12:17:29 GMT

Protected "4kzv" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:17, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4kzv is ON HOLD Authors: Hadar Feinberg, Sabine A. F. Jegouzo, Thomas J. W. Rowntree, Yue Guan, Matthew A. Brash, Maureen E. Taylor, William I. Weis...

OCA — Wed, 19 Jun 2013 12:17:28 GMT

New page: '''Unreleased structure''' The entry 4kzv is ON HOLD Authors: Hadar Feinberg, Sabine A. F. Jegouzo, Thomas J. W. Rowntree, Yue Guan, Matthew A. Brash, Maureen E. Taylor, William I. Weis...

New page

'''Unreleased structure'''

The entry 4kzv is ON HOLD

Authors: Hadar Feinberg, Sabine A. F. Jegouzo, Thomas J. W. Rowntree, Yue Guan, Matthew A. Brash, Maureen E. Taylor, William I. Weis, Kurt Drickamer

Description: Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose.