4l0l - Revision history

OCA at 09:24, 7 December 2022

OCA — Wed, 07 Dec 2022 09:24:46 GMT

←Older revision		Revision as of 09:24, 7 December 2022
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	==Crystal structure of P.aeruginosa PBP3 in complex with compound 4==		==Crystal structure of P.aeruginosa PBP3 in complex with compound 4==
-	<StructureSection load='4l0l' size='340' side='right' caption='[[4l0l]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4l0l' size='340' side='right'caption='[[4l0l]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4l0l]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4L0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4l0l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L0L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PFV:(6R,7S,10Z)-10-(2-AMINO-1,3-THIAZOL-4-YL)-1-(1,5-DIHYDROXY-4-OXO-1,4-DIHYDROPYRIDIN-2-YL)-7-FORMYL-13,13-DIMETHYL-3,9-DIOXO-6-(SULFOAMINO)-12-OXA-2,4,8,11-TETRAAZATETRADEC-10-EN-14-OIC+ACID'>PFV</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PFV:(6R,7S,10Z)-10-(2-AMINO-1,3-THIAZOL-4-YL)-1-(1,5-DIHYDROXY-4-OXO-1,4-DIHYDROPYRIDIN-2-YL)-7-FORMYL-13,13-DIMETHYL-3,9-DIOXO-6-(SULFOAMINO)-12-OXA-2,4,8,11-TETRAAZATETRADEC-10-EN-14-OIC+ACID'>PFV</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pbpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0l OCA], [https://pdbe.org/4l0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l0l RCSB], [https://www.ebi.ac.uk/pdbsum/4l0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l0l ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4l0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0l OCA], [~~http~~://pdbe.org/4l0l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4l0l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4l0l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4l0l ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q51504_PSEAI Q51504_PSEAI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 20:

	==See Also==		==See Also==
-	*[[Penicillin-binding protein\|Penicillin-binding protein]]	+	*[[Penicillin-binding protein 3D structures\|Penicillin-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Han, S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Marr, E S~~]]	+	[[Category: Pseudomonas aeruginosa]]
-	[[Category: ~~Penicillin binding protein 3~~]]	+	[[Category: Han S]]
-	[[Category: ~~Penicillin binding protein-antibiotic complex~~]]	+	[[Category: Marr ES]]

OCA at 12:52, 4 August 2016

OCA — Thu, 04 Aug 2016 12:52:39 GMT

←Older revision		Revision as of 12:52, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of P.aeruginosa PBP3 in complex with compound 4==		==Crystal structure of P.aeruginosa PBP3 in complex with compound 4==
	<StructureSection load='4l0l' size='340' side='right' caption='[[4l0l]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4l0l' size='340' side='right' caption='[[4l0l]], [[Resolution\|resolution]] 2.10Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PFV:(6R,7S,10Z)-10-(2-AMINO-1,3-THIAZOL-4-YL)-1-(1,5-DIHYDROXY-4-OXO-1,4-DIHYDROPYRIDIN-2-YL)-7-FORMYL-13,13-DIMETHYL-3,9-DIOXO-6-(SULFOAMINO)-12-OXA-2,4,8,11-TETRAAZATETRADEC-10-EN-14-OIC+ACID'>PFV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PFV:(6R,7S,10Z)-10-(2-AMINO-1,3-THIAZOL-4-YL)-1-(1,5-DIHYDROXY-4-OXO-1,4-DIHYDROPYRIDIN-2-YL)-7-FORMYL-13,13-DIMETHYL-3,9-DIOXO-6-(SULFOAMINO)-12-OXA-2,4,8,11-TETRAAZATETRADEC-10-EN-14-OIC+ACID'>PFV</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pbpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pbpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l0l RCSB], [http://www.ebi.ac.uk/pdbsum/4l0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0l OCA], [http://pdbe.org/4l0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l0l RCSB], [http://www.ebi.ac.uk/pdbsum/4l0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l0l ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4l0l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:15, 21 December 2014

OCA — Sun, 21 Dec 2014 17:15:31 GMT

←Older revision		Revision as of 17:15, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4l0l\| PDB=4l0l \| SCENE= }}~~	+	==Crystal structure of P.aeruginosa PBP3 in complex with compound 4==
-	===Crystal structure of P.aeruginosa PBP3 in complex with compound 4===	+	<StructureSection load='4l0l' size='340' side='right' caption='[[4l0l]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23755848}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4l0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L0L FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PFV:(6R,7S,10Z)-10-(2-AMINO-1,3-THIAZOL-4-YL)-1-(1,5-DIHYDROXY-4-OXO-1,4-DIHYDROPYRIDIN-2-YL)-7-FORMYL-13,13-DIMETHYL-3,9-DIOXO-6-(SULFOAMINO)-12-OXA-2,4,8,11-TETRAAZATETRADEC-10-EN-14-OIC+ACID'>PFV</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pbpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l0l RCSB], [http://www.ebi.ac.uk/pdbsum/4l0l PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa , Klebsiella pneumoniae , and Escherichia coli . Rat pharmacokinetic studies with compound 17 demonstrate low clearance and low plasma protein binding. In addition, evidence is provided for a number of analogues suggesting that the siderophore receptors PiuA and PirA play a role in drug uptake in P. aeruginosa strain PAO1.

-	~~==About this Structure==~~	+	Pyridone-Conjugated Monobactam Antibiotics with Gram-Negative Activity.,Brown MF, Mitton-Fry MJ, Arcari JT, Barham R, Casavant J, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Lall MS, Lemmon MM, Li C, Lin J, McCurdy SP, McElroy E, McPherson C, Marr ES, Mueller JP, Mullins L, Nikitenko AA, Noe MC, Penzien J, Plummer MS, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Tomaras A, Young JA, Zaniewski RP J Med Chem. 2013 Jun 27. PMID:23755848<ref>PMID:23755848</ref>
-	~~[[4l0l]] is a 1 chain structure~~ with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4L0L OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:023755848</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Han, S.]]	+
-	[[Category: Marr, E S.]]	+	==See Also==
		+	*[[Penicillin-binding protein\|Penicillin-binding protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Han, S]]
		+	[[Category: Marr, E S]]
	[[Category: Penicillin binding protein 3]]		[[Category: Penicillin binding protein 3]]
	[[Category: Penicillin binding protein-antibiotic complex]]		[[Category: Penicillin binding protein-antibiotic complex]]

OCA at 05:57, 22 January 2014

OCA — Wed, 22 Jan 2014 05:57:18 GMT

←Older revision		Revision as of 05:57, 22 January 2014
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4l0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa Pseudomonas aeruginosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0L OCA].	+	[[4l0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0L OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:023755848</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023755848</ref><references group="xtra"/><references/>
-	[[Category: Pseudomonas aeruginosa]]
	[[Category: Han, S.]]		[[Category: Han, S.]]
	[[Category: Marr, E S.]]		[[Category: Marr, E S.]]
	[[Category: Penicillin binding protein 3]]		[[Category: Penicillin binding protein 3]]
	[[Category: Penicillin binding protein-antibiotic complex]]		[[Category: Penicillin binding protein-antibiotic complex]]

OCA at 08:25, 21 August 2013

OCA — Wed, 21 Aug 2013 08:25:53 GMT

←Older revision		Revision as of 08:25, 21 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4l0l\| PDB=4l0l \| SCENE= }}
		+	===Crystal structure of P.aeruginosa PBP3 in complex with compound 4===
		+	{{ABSTRACT_PUBMED_23755848}}

-	~~The entry~~ 4l0l is ~~ON HOLD~~	+	==About this Structure==
		+	[[4l0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0L OCA].

-	~~Authors~~: Han, S., Marr, E.S.	+	==Reference==
-		+	<ref group="xtra">PMID:023755848</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of P.aeruginosa PBP3 in~~ complex ~~with compound 4~~	+	[[Category: Pseudomonas aeruginosa]]
		+	[[Category: Han, S.]]
		+	[[Category: Marr, E S.]]
		+	[[Category: Penicillin binding protein 3]]
		+	[[Category: Penicillin binding protein-antibiotic complex]]

OCA: Protected "4l0l" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 12:19:26 GMT

Protected "4l0l" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:19, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4l0l is ON HOLD Authors: Han, S., Marr, E.S. Description: Crystal structure of P.aeruginosa PBP3 in complex with compound 4

OCA — Wed, 19 Jun 2013 12:19:24 GMT

New page: '''Unreleased structure''' The entry 4l0l is ON HOLD Authors: Han, S., Marr, E.S. Description: Crystal structure of P.aeruginosa PBP3 in complex with compound 4

New page

'''Unreleased structure'''

The entry 4l0l is ON HOLD

Authors: Han, S., Marr, E.S.

Description: Crystal structure of P.aeruginosa PBP3 in complex with compound 4