4l1h - Revision history

OCA at 09:26, 7 December 2022

OCA — Wed, 07 Dec 2022 09:26:44 GMT

←Older revision		Revision as of 09:26, 7 December 2022
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	<StructureSection load='4l1h' size='340' side='right'caption='[[4l1h]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='4l1h' size='340' side='right'caption='[[4l1h]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4l1h]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4L1H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4l1h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L1H FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bww\|1bww]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1h OCA], [https://pdbe.org/4l1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l1h RCSB], [https://www.ebi.ac.uk/pdbsum/4l1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l1h ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4l1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1h OCA], [~~http~~://pdbe.org/4l1h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4l1h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4l1h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4l1h ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KVD33_HUMAN KVD33_HUMAN] V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Uson, I]]	+	[[Category: Uson I]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin kappa-chain]]~~	+
-	~~[[Category: Recombinant~~]]	+

OCA at 18:15, 14 August 2019

OCA — Wed, 14 Aug 2019 18:15:06 GMT

←Older revision		Revision as of 18:15, 14 August 2019
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	==Bence-Jones immunoglobulin REI variable portion with seven point mutations==		==Bence-Jones immunoglobulin REI variable portion with seven point mutations==
-	<StructureSection load='4l1h' size='340' side='right' caption='[[4l1h]], [[Resolution\|resolution]] 1.68Å' scene=''>	+	<StructureSection load='4l1h' size='340' side='right'caption='[[4l1h]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4l1h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4l1h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1H FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Uson, I]]		[[Category: Uson, I]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin kappa-chain]]		[[Category: Immunoglobulin kappa-chain]]
	[[Category: Recombinant]]		[[Category: Recombinant]]

OCA at 11:53, 6 November 2017

OCA — Mon, 06 Nov 2017 11:53:40 GMT

←Older revision		Revision as of 11:53, 6 November 2017
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	<StructureSection load='4l1h' size='340' side='right' caption='[[4l1h]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='4l1h' size='340' side='right' caption='[[4l1h]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4l1h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4l1h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1H FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bww\|1bww]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bww\|1bww]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1h OCA], [http://pdbe.org/4l1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l1h RCSB], [http://www.ebi.ac.uk/pdbsum/4l1h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l1h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1h OCA], [http://pdbe.org/4l1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l1h RCSB], [http://www.ebi.ac.uk/pdbsum/4l1h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l1h ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Uson, I]]		[[Category: Uson, I]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin kappa-chain]]		[[Category: Immunoglobulin kappa-chain]]
	[[Category: Recombinant]]		[[Category: Recombinant]]

OCA at 20:21, 11 August 2016

OCA — Thu, 11 Aug 2016 20:21:21 GMT

←Older revision		Revision as of 20:21, 11 August 2016
Line 1:		Line 1:
		+
	==Bence-Jones immunoglobulin REI variable portion with seven point mutations==		==Bence-Jones immunoglobulin REI variable portion with seven point mutations==
	<StructureSection load='4l1h' size='340' side='right' caption='[[4l1h]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='4l1h' size='340' side='right' caption='[[4l1h]], [[Resolution\|resolution]] 1.68Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4l1h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1H FirstGlance]. <br>		<table><tr><td colspan='2'>[[4l1h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1H FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bww\|1bww]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bww\|1bww]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l1h RCSB], [http://www.ebi.ac.uk/pdbsum/4l1h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1h OCA], [http://pdbe.org/4l1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l1h RCSB], [http://www.ebi.ac.uk/pdbsum/4l1h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l1h ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 09:05, 5 January 2015

OCA — Mon, 05 Jan 2015 09:05:05 GMT

←Older revision

Revision as of 09:05, 5 January 2015

OCA at 05:12, 4 June 2014

OCA — Wed, 04 Jun 2014 05:12:02 GMT

←Older revision		Revision as of 05:12, 4 June 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Bence-Jones immunoglobulin REI variable portion with seven point mutations==
-		+	<StructureSection load='4l1h' size='340' side='right' caption='[[4l1h]], [[Resolution\|resolution]] 1.68Å' scene=''>
-	~~The entry~~ 4l1h is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4l1h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1H FirstGlance]. <br>
-	~~Authors~~: Uson, I.	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bww\|1bww]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l1h RCSB], [http://www.ebi.ac.uk/pdbsum/4l1h PDBsum]</span></td></tr>
-	~~Description~~: ~~Bence~~-~~Jones immunoglobulin REI variable portion with seven point mutations~~	+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Uson, I.]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin kappa-chain]]
		+	[[Category: Recombinant]]

OCA: Protected "4l1h" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 12:22:01 GMT

Protected "4l1h" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:22, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4l1h is ON HOLD Authors: Uson, I. Description: Bence-Jones immunoglobulin REI variable portion with seven point mutations

OCA — Wed, 19 Jun 2013 12:22:00 GMT

New page: '''Unreleased structure''' The entry 4l1h is ON HOLD Authors: Uson, I. Description: Bence-Jones immunoglobulin REI variable portion with seven point mutations

New page

'''Unreleased structure'''

The entry 4l1h is ON HOLD

Authors: Uson, I.

Description: Bence-Jones immunoglobulin REI variable portion with seven point mutations