4l7c - Revision history

OCA at 16:13, 20 September 2023

OCA — Wed, 20 Sep 2023 16:13:48 GMT

←Older revision		Revision as of 16:13, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4l7c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4l7c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VW:2-{[(1S)-2-{[(1R,2S)-2-(1H-TETRAZOL-5-YL)CYCLOHEXYL]CARBONYL}-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL]METHYL}-1H-ISOINDOLE-1,3(2H)-DIONE'>1VW</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VW:2-{[(1S)-2-{[(1R,2S)-2-(1H-TETRAZOL-5-YL)CYCLOHEXYL]CARBONYL}-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL]METHYL}-1H-ISOINDOLE-1,3(2H)-DIONE'>1VW</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7c OCA], [https://pdbe.org/4l7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7c RCSB], [https://www.ebi.ac.uk/pdbsum/4l7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7c OCA], [https://pdbe.org/4l7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7c RCSB], [https://www.ebi.ac.uk/pdbsum/4l7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7c ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:36, 7 December 2022

OCA — Wed, 07 Dec 2022 09:36:00 GMT

←Older revision		Revision as of 09:36, 7 December 2022
Line 1:		Line 1:

	==Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione==		==Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione==
-	<StructureSection load='4l7c' size='340' side='right' caption='[[4l7c]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4l7c' size='340' side='right'caption='[[4l7c]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4l7c]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4L7C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4l7c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VW:2-{[(1S)-2-{[(1R,2S)-2-(1H-TETRAZOL-5-YL)CYCLOHEXYL]CARBONYL}-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL]METHYL}-1H-ISOINDOLE-1,3(2H)-DIONE'>1VW</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VW:2-{[(1S)-2-{[(1R,2S)-2-(1H-TETRAZOL-5-YL)CYCLOHEXYL]CARBONYL}-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL]METHYL}-1H-ISOINDOLE-1,3(2H)-DIONE'>1VW</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l7d\|4l7d]], [[4n1b\|4n1b]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7c OCA], [https://pdbe.org/4l7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7c RCSB], [https://www.ebi.ac.uk/pdbsum/4l7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7c ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KEAP1, INRF2, KIAA0132, KLHL19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4l7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7c OCA], [~~http~~://pdbe.org/4l7c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4l7c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4l7c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7c ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Kelch-like protein\|Kelch-like protein]]	+	*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Albrecht, C]]	+	[[Category: Large Structures]]
-	[[Category: Barker~~, J J~~]]	+	[[Category: Albrecht C]]
-	[[Category: Barker, O]]	+	[[Category: Barker JJ]]
-	[[Category: Beaumont, E]]	+	[[Category: Barker O]]
-	[[Category: Bromidge, S]]	+	[[Category: Beaumont E]]
-	[[Category: Brookfield, F]]	+	[[Category: Bromidge S]]
-	[[Category: Brooks, M]]	+	[[Category: Brookfield F]]
-	[[Category: Ceska, T]]	+	[[Category: Brooks M]]
-	[[Category: Courade~~, J P~~]]	+	[[Category: Ceska T]]
-	[[Category: Crabbe, T]]	+	[[Category: Courade JP]]
-	[[Category: Duclos, S]]	+	[[Category: Crabbe T]]
-	[[Category: Fryatt, T]]	+	[[Category: Duclos S]]
-	[[Category: Jigorel, E]]	+	[[Category: Fryatt T]]
-	[[Category: Jnoff, E]]	+	[[Category: Jigorel E]]
-	[[Category: Kwong, J]]	+	[[Category: Jnoff E]]
-	[[Category: Sands, Z]]	+	[[Category: Kwong J]]
-	[[Category: Smith~~, M A]]~~	+	[[Category: Sands Z]]
-	~~[[Category: Beta-propeller]]~~	+	[[Category: Smith MA]]
-	~~[[Category: Kelch domain]]~~	+
-	~~[[Category: Kelch repeat motif]]~~	+
-	~~[[Category: Nrf2]]~~	+
-	~~[[Category: Protein-small molecule complex]]~~	+
-	~~[[Category: Stress sensor]]~~	+
-	~~[[Category: Transcription-inhibitor complex~~]]	+

OCA at 13:27, 19 April 2017

OCA — Wed, 19 Apr 2017 13:27:19 GMT

←Older revision		Revision as of 13:27, 19 April 2017
Line 1:		Line 1:
		+
	==Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione==		==Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione==
	<StructureSection load='4l7c' size='340' side='right' caption='[[4l7c]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4l7c' size='340' side='right' caption='[[4l7c]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l7d\|4l7d]], [[4n1b\|4n1b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l7d\|4l7d]], [[4n1b\|4n1b]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KEAP1, INRF2, KIAA0132, KLHL19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KEAP1, INRF2, KIAA0132, KLHL19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l7c RCSB], [http://www.ebi.ac.uk/pdbsum/4l7c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7c OCA], [http://pdbe.org/4l7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l7c RCSB], [http://www.ebi.ac.uk/pdbsum/4l7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4l7c" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Kelch-like ~~ECH-associated~~ protein 1\|Kelch-like ~~ECH-associated~~ protein 1]]	+	*[[Kelch-like protein\|Kelch-like protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:30, 15 February 2015

OCA — Sun, 15 Feb 2015 09:30:15 GMT

←Older revision		Revision as of 09:30, 15 February 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4l7c\| PDB=4l7c \| SCENE= }}~~	+	==Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione==
-	===Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione===	+	<StructureSection load='4l7c' size='340' side='right' caption='[[4l7c]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	{{~~ABSTRACT_PUBMED_24504667~~}}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4l7c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L7C FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VW:2-{[(1S)-2-{[(1R,2S)-2-(1H-TETRAZOL-5-YL)CYCLOHEXYL]CARBONYL}-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL]METHYL}-1H-ISOINDOLE-1,3(2H)-DIONE'>1VW</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l7d\|4l7d]], [[4n1b\|4n1b]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KEAP1, INRF2, KIAA0132, KLHL19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l7c RCSB], [http://www.ebi.ac.uk/pdbsum/4l7c PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An X-ray crystal structure of Kelch-like ECH-associated protein (Keap1) co-crystallised with (1S,2R)-2-[(1S)-1-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-1,2,3,4-tetrah ydroisoquinolin-2-carbonyl]cyclohexane-1-carboxylic acid (compound (S,R,S)-1 a) was obtained. This X-ray crystal structure provides breakthrough experimental evidence for the true binding mode of the hit compound (S,R,S)-1 a, as the ligand orientation was found to differ from that of the initial docking model, which was available at the start of the project. Crystallographic elucidation of this binding mode helped to focus and drive the drug design process more effectively and efficiently.

-	~~==About this~~ Structure==	+	Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.,Jnoff E, Albrecht C, Barker JJ, Barker O, Beaumont E, Bromidge S, Brookfield F, Brooks M, Bubert C, Ceska T, Corden V, Dawson G, Duclos S, Fryatt T, Genicot C, Jigorel E, Kwong J, Maghames R, Mushi I, Pike R, Sands ZA, Smith MA, Stimson CC, Courade JP ChemMedChem. 2014 Feb 6. doi: 10.1002/cmdc.201300525. PMID:24504667<ref>PMID:24504667</ref>
-	~~[[4l7c]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4L7C OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:024504667</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Kelch-like ECH-associated protein 1\|Kelch-like ECH-associated protein 1]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Albrecht, C.]]	+	[[Category: Albrecht, C]]
-	[[Category: Barker, J J.]]	+	[[Category: Barker, J J]]
-	[[Category: Barker, O.]]	+	[[Category: Barker, O]]
-	[[Category: Beaumont, E.]]	+	[[Category: Beaumont, E]]
-	[[Category: Bromidge, S.]]	+	[[Category: Bromidge, S]]
-	[[Category: Brookfield, F.]]	+	[[Category: Brookfield, F]]
-	[[Category: Brooks, M.]]	+	[[Category: Brooks, M]]
-	[[Category: Ceska, T.]]	+	[[Category: Ceska, T]]
-	[[Category: Courade, J P.]]	+	[[Category: Courade, J P]]
-	[[Category: Crabbe, T.]]	+	[[Category: Crabbe, T]]
-	[[Category: Duclos, S.]]	+	[[Category: Duclos, S]]
-	[[Category: Fryatt, T.]]	+	[[Category: Fryatt, T]]
-	[[Category: Jigorel, E.]]	+	[[Category: Jigorel, E]]
-	[[Category: Jnoff, E.]]	+	[[Category: Jnoff, E]]
-	[[Category: Kwong, J.]]	+	[[Category: Kwong, J]]
-	[[Category: Sands, Z.]]	+	[[Category: Sands, Z]]
-	[[Category: Smith, M A.]]	+	[[Category: Smith, M A]]
	[[Category: Beta-propeller]]		[[Category: Beta-propeller]]
	[[Category: Kelch domain]]		[[Category: Kelch domain]]

OCA at 06:08, 23 April 2014

OCA — Wed, 23 Apr 2014 06:08:23 GMT

←Older revision		Revision as of 06:08, 23 April 2014
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4l7c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7C OCA].	+	[[4l7c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7C OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024504667</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024504667</ref><references group="xtra"/><references/>
		+	[[Category: Human]]
	[[Category: Albrecht, C.]]		[[Category: Albrecht, C.]]
	[[Category: Barker, J J.]]		[[Category: Barker, J J.]]

OCA at 17:16, 19 February 2014

OCA — Wed, 19 Feb 2014 17:16:27 GMT

←Older revision		Revision as of 17:16, 19 February 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4l7c\| PDB=4l7c \| SCENE= }}
		+	===Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione===
		+	{{ABSTRACT_PUBMED_24504667}}

-	~~The entry~~ 4l7c is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4l7c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7C OCA].

-	~~Authors~~: ~~Jnoff, E., Brookfield, F.,~~ Albrecht, C., Barker, J.J., Barker, O., Beaumont, E., Bromidge, S., Brooks, M., Ceska, T., Courade, J.P., Crabbe, T., Duclos, S., Fryatt, T., Jigorel, E., Kwong, J., Sands, Z., Smith, M.A.	+	==Reference==
-		+	<ref group="xtra">PMID:024504667</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Structure of keap1 kelch~~ domain ~~with 2-{~~[~~(1S)-2-{~~[~~(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl~~]~~carbonyl}~~-~~1,2,3,4-tetrahydroisoquinolin-1-yl~~]~~methyl}-1H~~-~~isoindole-1,3(2H)-dione~~	+	[[Category: Albrecht, C.]]
		+	[[Category: Barker, J J.]]
		+	[[Category: Barker, O.]]
		+	[[Category: Beaumont, E.]]
		+	[[Category: Bromidge, S.]]
		+	[[Category: Brookfield, F.]]
		+	[[Category: Brooks, M.]]
		+	[[Category: Ceska, T.]]
		+	[[Category: Courade, J P.]]
		+	[[Category: Crabbe, T.]]
		+	[[Category: Duclos, S.]]
		+	[[Category: Fryatt, T.]]
		+	[[Category: Jigorel, E.]]
		+	[[Category: Jnoff, E.]]
		+	[[Category: Kwong, J.]]
		+	[[Category: Sands, Z.]]
		+	[[Category: Smith, M A.]]
		+	[[Category: Beta-propeller]]
		+	[[Category: Kelch domain]]
		+	[[Category: Kelch repeat motif]]
		+	[[Category: Nrf2]]
		+	[[Category: Protein-small molecule complex]]
		+	[[Category: Stress sensor]]
		+	[[Category: Transcription-inhibitor complex]]

OCA at 20:05, 7 August 2013

OCA — Wed, 07 Aug 2013 20:05:32 GMT

←Older revision		Revision as of 20:05, 7 August 2013
Line 3:		Line 3:
	The entry 4l7c is ON HOLD until Paper Publication		The entry 4l7c is ON HOLD until Paper Publication

-	Authors: ~~Smith~~, M.A., Duclos, S., ~~Beaumont~~, E., Kwong, J., ~~Brooks~~, M., ~~Barker~~, J.	+	Authors: Jnoff, E., Brookfield, F., Albrecht, C., Barker, J.J., Barker, O., Beaumont, E., Bromidge, S., Brooks, M., Ceska, T., Courade, J.P., Crabbe, T., Duclos, S., Fryatt, T., Jigorel, E., Kwong, J., Sands, Z., Smith, M.A.

	Description: Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione		Description: Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione

OCA at 04:14, 1 August 2013

OCA — Thu, 01 Aug 2013 04:14:52 GMT

←Older revision		Revision as of 04:14, 1 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4l7c is ON HOLD	+	The entry 4l7c is ON HOLD until Paper Publication

	Authors: Smith, M.A., Duclos, S., Beaumont, E., Kwong, J., Brooks, M., Barker, J.		Authors: Smith, M.A., Duclos, S., Beaumont, E., Kwong, J., Brooks, M., Barker, J.

	Description: Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione		Description: Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione

OCA at 13:20, 3 July 2013

OCA — Wed, 03 Jul 2013 13:20:44 GMT

←Older revision		Revision as of 13:20, 3 July 2013
Line 3:		Line 3:
	The entry 4l7c is ON HOLD		The entry 4l7c is ON HOLD

-	Authors: Smith, M.A., Duclos, S, Beaumont, E, Kwong, J, Brooks, M, Barker, J	+	Authors: Smith, M.A., Duclos, S., Beaumont, E., Kwong, J., Brooks, M., Barker, J.

-	Description: Structure of keap1 kelch domain with ~~compound~~ 2	+	Description: Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione

OCA: Protected "4l7c" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 12:38:36 GMT

Protected "4l7c" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:38, 19 June 2013