4l7r - Revision history

OCA at 16:14, 20 September 2023

OCA — Wed, 20 Sep 2023 16:14:13 GMT

←Older revision		Revision as of 16:14, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4l7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7R FirstGlance]. <br>		<table><tr><td colspan='2'>[[4l7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M00:N-[(2S)-1-HYDROXYBUTAN-2-YL]-3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PROPANAMIDE'>M00</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M00:N-[(2S)-1-HYDROXYBUTAN-2-YL]-3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PROPANAMIDE'>M00</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7r OCA], [https://pdbe.org/4l7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7r RCSB], [https://www.ebi.ac.uk/pdbsum/4l7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7r OCA], [https://pdbe.org/4l7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7r RCSB], [https://www.ebi.ac.uk/pdbsum/4l7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7r ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:43, 14 December 2022

OCA — Wed, 14 Dec 2022 10:43:21 GMT

←Older revision		Revision as of 10:43, 14 December 2022
Line 1:		Line 1:

	==Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0400==		==Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0400==
-	<StructureSection load='4l7r' size='340' side='right' caption='[[4l7r]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4l7r' size='340' side='right'caption='[[4l7r]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4l7r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4L7R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4l7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M00:N-[(2S)-1-HYDROXYBUTAN-2-YL]-3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PROPANAMIDE'>M00</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M00:N-[(2S)-1-HYDROXYBUTAN-2-YL]-3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PROPANAMIDE'>M00</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l6z\|4l6z]], [[4l70\|4l70]], [[4l7l\|4l7l]], [[4l7n\|4l7n]], [[4l7o\|4l7o]], [[4l7p\|4l7p]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7r OCA], [https://pdbe.org/4l7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7r RCSB], [https://www.ebi.ac.uk/pdbsum/4l7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7r ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADPRT3, ADPRTL3, PARP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7r OCA], [~~http~~://pdbe.org/4l7r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4l7r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4l7r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7r ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>	+	[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]	+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Andersson~~, C D~~]]	+	[[Category: Large Structures]]
-	[[Category: Ekblad, T]]	+	[[Category: Andersson CD]]
-	[[Category: Elofsson, M]]	+	[[Category: Ekblad T]]
-	[[Category: Karlberg, T]]	+	[[Category: Elofsson M]]
-	[[Category: Lindgren~~, A E.G~~]]	+	[[Category: Karlberg T]]
-	[[Category: Linusson, A]]	+	[[Category: Lindgren AEG]]
-	[[Category: Schuler, H]]	+	[[Category: Linusson A]]
-	[[Category: Spjut, S]]	+	[[Category: Schuler H]]
-	[[Category: Thorsell~~, A G~~]]	+	[[Category: Spjut S]]
-	[[Category: Weigelt, J]]	+	[[Category: Thorsell AG]]
-	~~[[Category: Adp-ribosylation]]~~	+	[[Category: Weigelt J]]
-	~~[[Category: Diphtheria toxin like adp-ribose transferase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 18:47, 5 August 2016

OCA — Fri, 05 Aug 2016 18:47:06 GMT

←Older revision		Revision as of 18:47, 5 August 2016
Line 1:		Line 1:
		+
	==Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0400==		==Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0400==
	<StructureSection load='4l7r' size='340' side='right' caption='[[4l7r]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4l7r' size='340' side='right' caption='[[4l7r]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADPRT3, ADPRTL3, PARP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADPRT3, ADPRTL3, PARP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l7r RCSB], [http://www.ebi.ac.uk/pdbsum/4l7r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7r OCA], [http://pdbe.org/4l7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l7r RCSB], [http://www.ebi.ac.uk/pdbsum/4l7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4l7r" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 04:56, 25 December 2014

OCA — Thu, 25 Dec 2014 04:56:22 GMT

←Older revision		Revision as of 04:56, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l7r RCSB], [http://www.ebi.ac.uk/pdbsum/4l7r PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l7r RCSB], [http://www.ebi.ac.uk/pdbsum/4l7r PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:56, 21 December 2014

OCA — Sun, 21 Dec 2014 16:56:17 GMT

←Older revision		Revision as of 16:56, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4l7r\| PDB=4l7r \| SCENE= }}~~	+	==Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0400==
-	===Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0400===	+	<StructureSection load='4l7r' size='340' side='right' caption='[[4l7r]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24188023}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4l7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L7R FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M00:N-[(2S)-1-HYDROXYBUTAN-2-YL]-3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PROPANAMIDE'>M00</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l6z\|4l6z]], [[4l70\|4l70]], [[4l7l\|4l7l]], [[4l7n\|4l7n]], [[4l7o\|4l7o]], [[4l7p\|4l7p]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADPRT3, ADPRTL3, PARP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l7r RCSB], [http://www.ebi.ac.uk/pdbsum/4l7r PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The racemic 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(pyridin-2-yl)ethyl]propanamide, 1, has previously been identified as a potent but unselective inhibitor of diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3). Herein we describe synthesis and evaluation of 55 compounds in this class. It was found that the stereochemistry is of great importance for both selectivity and potency and that substituents on the phenyl ring resulted in poor solubility. Certain variations at the meso position were tolerated and caused a large shift in the binding pose. Changes to the ethylene linker that connects the quinazolinone to the amide were also investigated but proved detrimental to binding. By combination of synthetic organic chemistry and structure-based design, two selective inhibitors of ARTD3 were discovered.

-	~~==Function==~~	+	Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.,Lindgren AE, Karlberg T, Ekblad T, Spjut S, Thorsell AG, Andersson CD, Nhan TT, Hellsten V, Weigelt J, Linusson A, Schuler H, Elofsson M J Med Chem. 2013 Dec 12;56(23):9556-68. doi: 10.1021/jm401394u. Epub 2013 Nov 22. PMID:24188023<ref>PMID:24188023</ref>
-	~~[[http~~:/~~/www~~.~~uniprot~~.~~org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair~~ (~~BER~~) ~~pathway, by catalyzing the poly(ADP~~-~~ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism~~. ~~This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks~~. ~~May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1~~/~~S cell cycle progression without interfering with centrosome duplication~~. ~~Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing~~.<ref>PMID:~~16924674~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4l7r]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4L7R OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024188023</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
-	[[Category: Andersson, C D.]]	+	== References ==
-	[[Category: Ekblad, T.]]	+	<references/>
-	[[Category: Elofsson, M.]]	+	__TOC__
-	[[Category: Karlberg, T.]]	+	</StructureSection>
-	[[Category: Lindgren, A E.G.]]	+	[[Category: Human]]
-	[[Category: Linusson, A.]]	+	[[Category: Andersson, C D]]
-	[[Category: Schuler, H.]]	+	[[Category: Ekblad, T]]
-	[[Category: Spjut, S.]]	+	[[Category: Elofsson, M]]
-	[[Category: Thorsell, A G.]]	+	[[Category: Karlberg, T]]
-	[[Category: Weigelt, J.]]	+	[[Category: Lindgren, A E.G]]
		+	[[Category: Linusson, A]]
		+	[[Category: Schuler, H]]
		+	[[Category: Spjut, S]]
		+	[[Category: Thorsell, A G]]
		+	[[Category: Weigelt, J]]
	[[Category: Adp-ribosylation]]		[[Category: Adp-ribosylation]]
	[[Category: Diphtheria toxin like adp-ribose transferase]]		[[Category: Diphtheria toxin like adp-ribose transferase]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 17:36, 19 February 2014

OCA — Wed, 19 Feb 2014 17:36:17 GMT

←Older revision		Revision as of 17:36, 19 February 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4l7r\| PDB=4l7r \| SCENE= }}
		+	===Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0400===
		+	{{ABSTRACT_PUBMED_24188023}}

-	~~The entry 4l7r is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>

-	~~Authors~~: ~~Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J~~.~~, Linusson, A~~.~~, Elofsson, M~~.~~, Schuler, H~~.	+	==About this Structure==
		+	[[4l7r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7R OCA].

-	~~Description~~: ~~Human artd3 (parp3)~~ -~~catalytic domain in complex with~~ inhibitor ~~ME0400~~	+	==Reference==
		+	<ref group="xtra">PMID:024188023</ref><references group="xtra"/><references/>
		+	[[Category: Andersson, C D.]]
		+	[[Category: Ekblad, T.]]
		+	[[Category: Elofsson, M.]]
		+	[[Category: Karlberg, T.]]
		+	[[Category: Lindgren, A E.G.]]
		+	[[Category: Linusson, A.]]
		+	[[Category: Schuler, H.]]
		+	[[Category: Spjut, S.]]
		+	[[Category: Thorsell, A G.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Adp-ribosylation]]
		+	[[Category: Diphtheria toxin like adp-ribose transferase]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 04:45, 18 July 2013

OCA — Thu, 18 Jul 2013 04:45:31 GMT

←Older revision		Revision as of 04:45, 18 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4l7r is ON HOLD	+	The entry 4l7r is ON HOLD until Paper Publication

	Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson, M., Schuler, H.		Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson, M., Schuler, H.

	Description: Human artd3 (parp3) -catalytic domain in complex with inhibitor ME0400		Description: Human artd3 (parp3) -catalytic domain in complex with inhibitor ME0400

OCA: Protected "4l7r" [edit=sysop:move=sysop]

OCA — Sun, 30 Jun 2013 09:01:58 GMT

Protected "4l7r" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:01, 30 June 2013

OCA: New page: '''Unreleased structure''' The entry 4l7r is ON HOLD Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson...

OCA — Sun, 30 Jun 2013 09:01:57 GMT

New page: '''Unreleased structure''' The entry 4l7r is ON HOLD Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson...

New page

'''Unreleased structure'''

The entry 4l7r is ON HOLD

Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson, M., Schuler, H.

Description: Human artd3 (parp3) -catalytic domain in complex with inhibitor ME0400