4l8q - Revision history

OCA at 16:14, 20 September 2023

OCA — Wed, 20 Sep 2023 16:14:47 GMT

←Older revision		Revision as of 16:14, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4l8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_grandiflora Canavalia grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L8Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4l8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_grandiflora Canavalia grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L8Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8q OCA], [https://pdbe.org/4l8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l8q RCSB], [https://www.ebi.ac.uk/pdbsum/4l8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l8q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8q OCA], [https://pdbe.org/4l8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l8q RCSB], [https://www.ebi.ac.uk/pdbsum/4l8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l8q ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:44, 14 December 2022

OCA — Wed, 14 Dec 2022 10:44:40 GMT

←Older revision		Revision as of 10:44, 14 December 2022
Line 3:		Line 3:
	<StructureSection load='4l8q' size='340' side='right'caption='[[4l8q]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4l8q' size='340' side='right'caption='[[4l8q]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4l8q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Canavalia_grandiflora Canavalia grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4L8Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4l8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_grandiflora Canavalia grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L8Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2d7f\|2d7f]], [[3ju9\|3ju9]], [[3a0k\|3a0k]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8q OCA], [https://pdbe.org/4l8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l8q RCSB], [https://www.ebi.ac.uk/pdbsum/4l8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l8q ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8q OCA], [~~http~~://pdbe.org/4l8q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4l8q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4l8q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4l8q ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LECA_CANGR LECA_CANGR] Lectin (PubMed:24361256). Induces paw edema in mice (PubMed:22368061). Has a weak vasorelaxant effect on rat aorta (PubMed:24361256). Has anti-inflammatory and anti-nociceptive effects (PubMed:19153712).<ref>PMID:19153712</ref> <ref>PMID:22368061</ref> <ref>PMID:24361256</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	[[Category: Canavalia grandiflora]]		[[Category: Canavalia grandiflora]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barroso-Neto~~, I L~~]]	+	[[Category: Barroso-Neto IL]]
-	[[Category: Bezerra~~, M J.B~~]]	+	[[Category: Bezerra MJB]]
-	[[Category: Cavada~~, B S~~]]	+	[[Category: Cavada BS]]
-	[[Category: Delatorre, P]]	+	[[Category: Delatorre P]]
-	[[Category: Nagano~~, C S~~]]	+	[[Category: Nagano CS]]
-	[[Category: Nascimento~~, K S~~]]	+	[[Category: Nascimento KS]]
-	[[Category: Osterne~~, V J.S~~]]	+	[[Category: Osterne VJS]]
-	[[Category: Pereira-Junior~~, F N~~]]	+	[[Category: Pereira-Junior FN]]
-	[[Category: Rocha~~, B A.M~~]]	+	[[Category: Rocha BAM]]
-	[[Category: Sampaio~~, A H~~]]	+	[[Category: Sampaio AH]]
-	[[Category: Simoes~~, R C]]~~	+	[[Category: Simoes RC]]
-	~~[[Category: Carbohydrate/sugar binding]]~~	+
-	~~[[Category: Jelly roll domain]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Plant protein]]~~	+
-	~~[[Category: Protein body]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 05:18, 13 February 2020

OCA — Thu, 13 Feb 2020 05:18:58 GMT

←Older revision		Revision as of 05:18, 13 February 2020
Line 1:		Line 1:

	==Crystal structure of Canavalia grandiflora seed lectin complexed with X-Man.==		==Crystal structure of Canavalia grandiflora seed lectin complexed with X-Man.==
-	<StructureSection load='4l8q' size='340' side='right' caption='[[4l8q]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4l8q' size='340' side='right'caption='[[4l8q]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4l8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_grandiflora Canavalia grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4l8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_grandiflora Canavalia grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8Q FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Canavalia grandiflora]]		[[Category: Canavalia grandiflora]]
		+	[[Category: Large Structures]]
	[[Category: Barroso-Neto, I L]]		[[Category: Barroso-Neto, I L]]
	[[Category: Bezerra, M J.B]]		[[Category: Bezerra, M J.B]]

OCA at 11:11, 11 August 2016

OCA — Thu, 11 Aug 2016 11:11:00 GMT

←Older revision		Revision as of 11:11, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Canavalia grandiflora seed lectin complexed with X-Man.==		==Crystal structure of Canavalia grandiflora seed lectin complexed with X-Man.==
	<StructureSection load='4l8q' size='340' side='right' caption='[[4l8q]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4l8q' size='340' side='right' caption='[[4l8q]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2d7f\|2d7f]], [[3ju9\|3ju9]], [[3a0k\|3a0k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2d7f\|2d7f]], [[3ju9\|3ju9]], [[3a0k\|3a0k]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8q RCSB], [http://www.ebi.ac.uk/pdbsum/4l8q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8q OCA], [http://pdbe.org/4l8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l8q RCSB], [http://www.ebi.ac.uk/pdbsum/4l8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l8q ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4l8q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:54, 5 January 2015

OCA — Mon, 05 Jan 2015 08:54:41 GMT

←Older revision		Revision as of 08:54, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4l8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_grandiflora Canavalia grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4l8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_grandiflora Canavalia grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2d7f\|2d7f]], [[3ju9\|3ju9]], [[3a0k\|3a0k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2d7f\|2d7f]], [[3ju9\|3ju9]], [[3a0k\|3a0k]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8q RCSB], [http://www.ebi.ac.uk/pdbsum/4l8q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8q RCSB], [http://www.ebi.ac.uk/pdbsum/4l8q PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	Vasorelaxant activity of Canavalia grandiflora seed lectin: A structural analysis.,Barroso-Neto IL, Simoes RC, Rocha BA, Bezerra MJ, Pereira-Junior FN, Silva Osterne VJ, Nascimento KS, Nagano CS, Delatorre P, Pereira MG, Freitas Pires A, Sampaio AH, Assreuy AM, Cavada BS Arch Biochem Biophys. 2014 Feb 1;543:31-9. doi: 10.1016/j.abb.2013.12.006. Epub, 2013 Dec 17. PMID:24361256<ref>PMID:24361256</ref>		Vasorelaxant activity of Canavalia grandiflora seed lectin: A structural analysis.,Barroso-Neto IL, Simoes RC, Rocha BA, Bezerra MJ, Pereira-Junior FN, Silva Osterne VJ, Nascimento KS, Nagano CS, Delatorre P, Pereira MG, Freitas Pires A, Sampaio AH, Assreuy AM, Cavada BS Arch Biochem Biophys. 2014 Feb 1;543:31-9. doi: 10.1016/j.abb.2013.12.006. Epub, 2013 Dec 17. PMID:24361256<ref>PMID:24361256</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Canavalia grandiflora]]		[[Category: Canavalia grandiflora]]
-	[[Category: Barroso-Neto, I L.]]	+	[[Category: Barroso-Neto, I L]]
-	[[Category: Bezerra, M J.B.]]	+	[[Category: Bezerra, M J.B]]
-	[[Category: Cavada, B S.]]	+	[[Category: Cavada, B S]]
-	[[Category: Delatorre, P.]]	+	[[Category: Delatorre, P]]
-	[[Category: Nagano, C S.]]	+	[[Category: Nagano, C S]]
-	[[Category: Nascimento, K S.]]	+	[[Category: Nascimento, K S]]
-	[[Category: Osterne, V J.S.]]	+	[[Category: Osterne, V J.S]]
-	[[Category: Pereira-Junior, F N.]]	+	[[Category: Pereira-Junior, F N]]
-	[[Category: Rocha, B A.M.]]	+	[[Category: Rocha, B A.M]]
-	[[Category: Sampaio, A H.]]	+	[[Category: Sampaio, A H]]
-	[[Category: Simoes, R C.]]	+	[[Category: Simoes, R C]]
	[[Category: Carbohydrate/sugar binding]]		[[Category: Carbohydrate/sugar binding]]
	[[Category: Jelly roll domain]]		[[Category: Jelly roll domain]]

OCA at 09:02, 21 May 2014

OCA — Wed, 21 May 2014 09:02:11 GMT

←Older revision		Revision as of 09:02, 21 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Canavalia grandiflora seed lectin complexed with X-Man.==
		+	<StructureSection load='4l8q' size='340' side='right' caption='[[4l8q]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4l8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_grandiflora Canavalia grandiflora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L8Q FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2d7f\|2d7f]], [[3ju9\|3ju9]], [[3a0k\|3a0k]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l8q RCSB], [http://www.ebi.ac.uk/pdbsum/4l8q PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lectins are comprised of a large family of proteins capable of the specific and reversible recognition of carbohydrates. Legume lectins, the most studied plant lectins, show high structural similarity, but with modifications that imply a variation in the intensity of some biological activities. In this work, the primary and tertiary structures of Canavalia grandiflora (ConGF) were determined. ConGF, a lectin isolated from C. grandiflora seeds, is able to induce relaxant activity in rat aortic rings. The complete sequence of ConGF comprises 237 amino acids. This particular protein has primary sequence variations commonly found in lectins from Dioclea and Canavalia genera. The protein structure was solved at 2.3 A resolution by X-ray crystallography. An X-Man molecule was modeled into the carbohydrate recognition domain. Still, ConGF (30 and 100 mug mL(-1)) elicited 25% of vasorelaxation (IC50=34.48 +/- 5.07 mug mL(-1)) in endothelialized aortic rings. A nonselective inhibitor of nitric oxide blocked ConGF relaxant effect, showing mediation by nitric oxide. Key distances between ConGF carbohydrate recognition domain residues were determined in order to explain this effect, in turn revealing some structural aspects that could differentiate lectins from the Canavalia genera with respect to different efficacy in vasorelaxant effect.

-	~~The entry 4l8q is ON HOLD until Paper Publication~~	+	Vasorelaxant activity of Canavalia grandiflora seed lectin: A structural analysis.,Barroso-Neto IL, Simoes RC, Rocha BA, Bezerra MJ, Pereira-Junior FN, Silva Osterne VJ, Nascimento KS, Nagano CS, Delatorre P, Pereira MG, Freitas Pires A, Sampaio AH, Assreuy AM, Cavada BS Arch Biochem Biophys. 2014 Feb 1;543:31-9. doi: 10.1016/j.abb.2013.12.006. Epub, 2013 Dec 17. PMID:24361256<ref>PMID:24361256</ref>

-	~~Authors~~: Barroso-Neto, I.L.~~, Rocha, B.A.M., Simoes, R.C.,~~ Bezerra, M.J.B., ~~Pereira-Junior, F.N~~., ~~Osterne, V.J~~.S., Nascimento, K.S., ~~Nagano, C~~.S., ~~Delatorre, P~~., Sampaio, A.H., ~~Cavada, B.S~~.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Canavalia grandiflora seed lectin complexed with X-Man.~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Canavalia grandiflora]]
		+	[[Category: Barroso-Neto, I L.]]
		+	[[Category: Bezerra, M J.B.]]
		+	[[Category: Cavada, B S.]]
		+	[[Category: Delatorre, P.]]
		+	[[Category: Nagano, C S.]]
		+	[[Category: Nascimento, K S.]]
		+	[[Category: Osterne, V J.S.]]
		+	[[Category: Pereira-Junior, F N.]]
		+	[[Category: Rocha, B A.M.]]
		+	[[Category: Sampaio, A H.]]
		+	[[Category: Simoes, R C.]]
		+	[[Category: Carbohydrate/sugar binding]]
		+	[[Category: Jelly roll domain]]
		+	[[Category: Lectin]]
		+	[[Category: Plant protein]]
		+	[[Category: Protein body]]
		+	[[Category: Sugar binding protein]]

OCA at 04:15, 1 August 2013

OCA — Thu, 01 Aug 2013 04:15:05 GMT

←Older revision		Revision as of 04:15, 1 August 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4l8q is ON HOLD	+	The entry 4l8q is ON HOLD until Paper Publication

	Authors: Barroso-Neto, I.L., Rocha, B.A.M., Simoes, R.C., Bezerra, M.J.B., Pereira-Junior, F.N., Osterne, V.J.S., Nascimento, K.S., Nagano, C.S., Delatorre, P., Sampaio, A.H., Cavada, B.S.		Authors: Barroso-Neto, I.L., Rocha, B.A.M., Simoes, R.C., Bezerra, M.J.B., Pereira-Junior, F.N., Osterne, V.J.S., Nascimento, K.S., Nagano, C.S., Delatorre, P., Sampaio, A.H., Cavada, B.S.

	Description: Crystal structure of Canavalia grandiflora seed lectin complexed with X-Man.		Description: Crystal structure of Canavalia grandiflora seed lectin complexed with X-Man.

OCA: Protected "4l8q" [edit=sysop:move=sysop]

OCA — Sun, 30 Jun 2013 09:03:28 GMT

Protected "4l8q" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:03, 30 June 2013

OCA: New page: '''Unreleased structure''' The entry 4l8q is ON HOLD Authors: Barroso-Neto, I.L., Rocha, B.A.M., Simoes, R.C., Bezerra, M.J.B., Pereira-Junior, F.N., Osterne, V.J.S., Nascimento, K.S., ...

OCA — Sun, 30 Jun 2013 09:03:27 GMT

New page: '''Unreleased structure''' The entry 4l8q is ON HOLD Authors: Barroso-Neto, I.L., Rocha, B.A.M., Simoes, R.C., Bezerra, M.J.B., Pereira-Junior, F.N., Osterne, V.J.S., Nascimento, K.S., ...

New page

'''Unreleased structure'''

The entry 4l8q is ON HOLD

Authors: Barroso-Neto, I.L., Rocha, B.A.M., Simoes, R.C., Bezerra, M.J.B., Pereira-Junior, F.N., Osterne, V.J.S., Nascimento, K.S., Nagano, C.S., Delatorre, P., Sampaio, A.H., Cavada, B.S.

Description: Crystal structure of Canavalia grandiflora seed lectin complexed with X-Man.