4la7 - Revision history

OCA at 16:15, 20 September 2023

OCA — Wed, 20 Sep 2023 16:15:23 GMT

←Older revision		Revision as of 16:15, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4la7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LA7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4la7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LA7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1O:QUINABACTIN'>A1O</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1O:QUINABACTIN'>A1O</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4la7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la7 OCA], [https://pdbe.org/4la7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4la7 RCSB], [https://www.ebi.ac.uk/pdbsum/4la7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4la7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4la7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la7 OCA], [https://pdbe.org/4la7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4la7 RCSB], [https://www.ebi.ac.uk/pdbsum/4la7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4la7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:47, 14 December 2022

OCA — Wed, 14 Dec 2022 10:47:41 GMT

←Older revision		Revision as of 10:47, 14 December 2022
Line 1:		Line 1:

	==X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary complex==		==X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary complex==
-	<StructureSection load='4la7' size='340' side='right' caption='[[4la7]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='4la7' size='340' side='right'caption='[[4la7]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4la7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LA7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4la7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LA7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A1O:QUINABACTIN'>A1O</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1O:QUINABACTIN'>A1O</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2, RCAR14, T19L18.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), At1g72770, F28P22.4, HAB1, HAB1 (Residues 179-511), P2C-HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4la7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la7 OCA], [https://pdbe.org/4la7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4la7 RCSB], [https://www.ebi.ac.uk/pdbsum/4la7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4la7 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4la7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la7 OCA], [~~http~~://pdbe.org/4la7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4la7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4la7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4la7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>	+	[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[~~PYR/PYL/RCAR family of ABA receptors~~\|~~PYR/PYL/RCAR family of ABA receptors~~]]	+	*[[Abscisic acid receptor 3D structures\|Abscisic acid receptor 3D structures]]
		+	*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
-	[[Category: ~~Phosphoprotein phosphatase~~]]	+	[[Category: Large Structures]]
-	[[Category: Cutler~~, S R~~]]	+	[[Category: Cutler SR]]
-	[[Category: Peterson~~, F C~~]]	+	[[Category: Peterson FC]]
-	[[Category: Volkman~~, B F]]~~	+	[[Category: Volkman BF]]
-	~~[[Category: Hab1]]~~	+
-	~~[[Category: Hydrolase-receptor-inhibitor complex]]~~	+
-	~~[[Category: Pp2c inhibition]]~~	+
-	~~[[Category: Pyl2~~]]	+

OCA at 09:34, 15 November 2017

OCA — Wed, 15 Nov 2017 09:34:54 GMT

←Older revision		Revision as of 09:34, 15 November 2017
Line 23:		Line 23:
	==See Also==		==See Also==
	*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]		*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
-	*[[Protein phosphatase\|Protein phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:27, 4 August 2016

OCA — Thu, 04 Aug 2016 08:27:38 GMT

←Older revision		Revision as of 08:27, 4 August 2016
Line 1:		Line 1:
		+
	==X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary complex==		==X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary complex==
	<StructureSection load='4la7' size='340' side='right' caption='[[4la7]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='4la7' size='340' side='right' caption='[[4la7]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4la7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LA7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4la7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LA7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A1O:QUINABACTIN'>A1O</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A1O:QUINABACTIN'>A1O</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2, RCAR14, T19L18.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~]), At1g72770, F28P22.4, HAB1, HAB1 (Residues 179-511), P2C-HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2, RCAR14, T19L18.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), At1g72770, F28P22.4, HAB1, HAB1 (Residues 179-511), P2C-HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4la7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4la7 RCSB], [http://www.ebi.ac.uk/pdbsum/4la7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4la7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la7 OCA], [http://pdbe.org/4la7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4la7 RCSB], [http://www.ebi.ac.uk/pdbsum/4la7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4la7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4la7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Cutler, S R]]		[[Category: Cutler, S R]]

OCA at 07:20, 25 December 2014

OCA — Thu, 25 Dec 2014 07:20:09 GMT

←Older revision		Revision as of 07:20, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4la7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4la7 RCSB], [http://www.ebi.ac.uk/pdbsum/4la7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4la7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4la7 RCSB], [http://www.ebi.ac.uk/pdbsum/4la7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:05, 21 December 2014

OCA — Sun, 21 Dec 2014 15:05:59 GMT

←Older revision		Revision as of 15:05, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4la7\| PDB=4la7 \| SCENE= }}~~	+	==X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary complex==
-	===X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary complex===	+	<StructureSection load='4la7' size='340' side='right' caption='[[4la7]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23818638}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4la7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LA7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A1O:QUINABACTIN'>A1O</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g26040, PYL2, RCAR14, T19L18.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana]), At1g72770, F28P22.4, HAB1, HAB1 (Residues 179-511), P2C-HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4la7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4la7 RCSB], [http://www.ebi.ac.uk/pdbsum/4la7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Abscisic acid (ABA) is an essential molecule in plant abiotic stress responses. It binds to soluble pyrabactin resistance1/PYR1-like/regulatory component of ABA receptor receptors and stabilizes them in a conformation that inhibits clade A type II C protein phosphatases; this leads to downstream SnRK2 kinase activation and numerous cellular outputs. We previously described the synthetic naphthalene sulfonamide ABA agonist pyrabactin, which activates seed ABA responses but fails to trigger substantial responses in vegetative tissues in Arabidopsis thaliana. Here we describe quinabactin, a sulfonamide ABA agonist that preferentially activates dimeric ABA receptors and possesses ABA-like potency in vivo. In Arabidopsis, the transcriptional responses induced by quinabactin are highly correlated with those induced by ABA treatments. Quinabactin treatments elicit guard cell closure, suppress water loss, and promote drought tolerance in adult Arabidopsis and soybean plants. The effects of quinabactin are sufficiently similar to those of ABA that it is able to rescue multiple phenotypes observed in the ABA-deficient mutant aba2. Genetic analyses show that quinabactin's effects in vegetative tissues are primarily mediated by dimeric ABA receptors. A PYL2-quinabactin-HAB1 X-ray crystal structure solved at 1.98-A resolution shows that quinabactin forms a hydrogen bond with the receptor/PP2C "lock" hydrogen bond network, a structural feature absent in pyrabactin-receptor/PP2C complexes. Our results demonstrate that ABA receptors can be chemically controlled to enable plant protection against water stress and define the dimeric receptors as key targets for chemical modulation of vegetative ABA responses.

-	~~==Function==~~	+	Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance.,Okamoto M, Peterson FC, Defries A, Park SY, Endo A, Nambara E, Volkman BF, Cutler SR Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12132-7. doi:, 10.1073/pnas.1305919110. Epub 2013 Jul 1. PMID:23818638<ref>PMID:23818638</ref>
-	~~[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (~~ABA~~) required for~~ ABA-~~mediated responses such as stomatal closure~~ and ~~germination inhibition~~. ~~Inhibits the activity of group-~~A ~~protein phosphatases type 2C~~ (~~PP2Cs~~) ~~when activated by ABA~~.~~<ref>PMID~~:~~19898420</ref> <ref>PMID:19893533</ref> [[http:/~~/~~www~~.~~uniprot~~.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. ~~Confers enhanced sensitivity to drought.<ref>~~PMID:~~14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref>~~ <ref>PMID:~~19033529~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4la7]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4LA7 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023818638</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[PYR/PYL/RCAR family of ABA receptors\|PYR/PYL/RCAR family of ABA receptors]]
		+	*[[Protein phosphatase\|Protein phosphatase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
-	[[Category: Cutler, S R.]]	+	[[Category: Cutler, S R]]
-	[[Category: Peterson, F C.]]	+	[[Category: Peterson, F C]]
-	[[Category: Volkman, B F.]]	+	[[Category: Volkman, B F]]
	[[Category: Hab1]]		[[Category: Hab1]]
	[[Category: Hydrolase-receptor-inhibitor complex]]		[[Category: Hydrolase-receptor-inhibitor complex]]
	[[Category: Pp2c inhibition]]		[[Category: Pp2c inhibition]]
	[[Category: Pyl2]]		[[Category: Pyl2]]

OCA at 20:49, 7 August 2013

OCA — Wed, 07 Aug 2013 20:49:25 GMT

←Older revision		Revision as of 20:49, 7 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4la7\| PDB=4la7 \| SCENE= }}
		+	===X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary complex===
		+	{{ABSTRACT_PUBMED_23818638}}

-	~~The entry 4la7 is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref> [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref>

-	~~Authors~~: ~~Peterson, F~~.C.~~, Volkman, B~~.F.~~, Cutler, S~~.R.	+	==About this Structure==
		+	[[4la7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA7 OCA].

-	~~Description~~: X-~~ray crystal structure of the PYL2~~-~~quinabactin-Hab1 ternary~~ complex	+	==Reference==
		+	<ref group="xtra">PMID:023818638</ref><references group="xtra"/><references/>
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Phosphoprotein phosphatase]]
		+	[[Category: Cutler, S R.]]
		+	[[Category: Peterson, F C.]]
		+	[[Category: Volkman, B F.]]
		+	[[Category: Hab1]]
		+	[[Category: Hydrolase-receptor-inhibitor complex]]
		+	[[Category: Pp2c inhibition]]
		+	[[Category: Pyl2]]

OCA: Protected "4la7" [edit=sysop:move=sysop]

OCA — Sun, 30 Jun 2013 09:10:24 GMT

Protected "4la7" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:10, 30 June 2013

OCA: New page: '''Unreleased structure''' The entry 4la7 is ON HOLD Authors: Peterson, F.C., Volkman, B.F., Cutler, S.R. Description: X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary comp...

OCA — Sun, 30 Jun 2013 09:10:23 GMT

New page: '''Unreleased structure''' The entry 4la7 is ON HOLD Authors: Peterson, F.C., Volkman, B.F., Cutler, S.R. Description: X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary comp...

New page

'''Unreleased structure'''

The entry 4la7 is ON HOLD

Authors: Peterson, F.C., Volkman, B.F., Cutler, S.R.

Description: X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary complex