4ldq - Revision history

OCA at 12:19, 1 March 2024

OCA — Fri, 01 Mar 2024 12:19:05 GMT

←Older revision		Revision as of 12:19, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ldq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ldq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldq OCA], [https://pdbe.org/4ldq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldq RCSB], [https://www.ebi.ac.uk/pdbsum/4ldq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.496Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldq OCA], [https://pdbe.org/4ldq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldq RCSB], [https://www.ebi.ac.uk/pdbsum/4ldq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>		[https://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Metastatic melanoma is among the most intractable cancers to treat, where patients show resistance to therapy and limited survival time. A critical step in the development of metastatic melanoma is the acquisition of invasion and transition from thin to thick tumors on the skin, followed by invasion to lymph nodes. Prior studies have shown that metastatic melanoma is associated with dysregulation of RhoA and enhanced expression of a protein named "mediator of RhoA-dependent invasion (MRDI)". Importantly, MRDI is a "moonlighting" enzyme, with two distinct functions in melanoma cells. First, MRDI acts as a methylthioribose-1-phosphate (MTR-1-P) isomerase, catalyzing a critical step in methionine salvage. Second, MRDI promotes and is necessary for melanoma cell invasion, independent of its catalytic activity. Here, we demonstrate that MtnA, a bacterial MTR-1-P isomerase, rescues the methionine salvage function of MRDI, but is unable to rescue its role in invasion. We then solve the crystal structure of MRDI to a resolution of 2.5 A, in order to identify structural elements important for its invasion activity. We present this structure and its comparison with other MTR-1-P isomerases, and identify mutations within a region separate from the MTR-1-P binding site which interfere with invasion. Thus, structural elements in MRDI distal from the MTR-1-P catalytic site are responsible for the invasion phenotype.
-
-	Structure of MRDI Explains its Dual Function as a Metabolic Enzyme and a Mediator of Cell Invasion.,Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC Biochemistry. 2013 Jul 16. PMID:23859498<ref>PMID:23859498</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4ldq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:53, 14 December 2022

OCA — Wed, 14 Dec 2022 10:53:44 GMT

←Older revision		Revision as of 10:53, 14 December 2022
Line 1:		Line 1:

	==Crystal Structure of the Mediator of Rho Dependent Invasion==		==Crystal Structure of the Mediator of Rho Dependent Invasion==
-	<StructureSection load='4ldq' size='340' side='right' caption='[[4ldq]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4ldq' size='340' side='right'caption='[[4ldq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ldq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LDQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ldq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDQ FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ldr\|4ldr]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldq OCA], [https://pdbe.org/4ldq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldq RCSB], [https://www.ebi.ac.uk/pdbsum/4ldq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldq ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRI1, MRDI, UNQ6390/PRO21135 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5-thioribose-1-phosphate_isomerase S-methyl-5-thioribose-1-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.23 5.3.1.23] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldq OCA], [~~http~~://pdbe.org/4ldq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ldq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ldq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN]] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>	+	[https://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~S-methyl-5-thioribose-1-phosphate isomerase~~]]	+	[[Category: Large Structures]]
-	[[Category: Metzner~~, S I~~]]	+	[[Category: Metzner SI]]
-	[[Category: Sousa~~, M C~~]]	+	[[Category: Sousa MC]]
-	[[Category: Templeton~~, P D]]~~	+	[[Category: Templeton PD]]
-	~~[[Category: Cell invasion]]~~	+
-	~~[[Category: Helix bundle]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Rossmann-like fold~~]]	+

OCA at 11:13, 4 August 2016

OCA — Thu, 04 Aug 2016 11:13:09 GMT

←Older revision		Revision as of 11:13, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Mediator of Rho Dependent Invasion==		==Crystal Structure of the Mediator of Rho Dependent Invasion==
	<StructureSection load='4ldq' size='340' side='right' caption='[[4ldq]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4ldq' size='340' side='right' caption='[[4ldq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ldq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LDQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ldq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LDQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ldr\|4ldr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ldr\|4ldr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRI1, MRDI, UNQ6390/PRO21135 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRI1, MRDI, UNQ6390/PRO21135 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5-thioribose-1-phosphate_isomerase S-methyl-5-thioribose-1-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.23 5.3.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5-thioribose-1-phosphate_isomerase S-methyl-5-thioribose-1-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.23 5.3.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ldq RCSB], [http://www.ebi.ac.uk/pdbsum/4ldq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldq OCA], [http://pdbe.org/4ldq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ldq RCSB], [http://www.ebi.ac.uk/pdbsum/4ldq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ldq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: S-methyl-5-thioribose-1-phosphate isomerase]]		[[Category: S-methyl-5-thioribose-1-phosphate isomerase]]
	[[Category: Metzner, S I]]		[[Category: Metzner, S I]]

OCA at 08:44, 25 December 2014

OCA — Thu, 25 Dec 2014 08:44:01 GMT

←Older revision		Revision as of 08:44, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ldq RCSB], [http://www.ebi.ac.uk/pdbsum/4ldq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ldq RCSB], [http://www.ebi.ac.uk/pdbsum/4ldq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN]] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:15, 21 December 2014

OCA — Sun, 21 Dec 2014 15:15:40 GMT

←Older revision		Revision as of 15:15, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ldq\| PDB=4ldq \| SCENE= }}~~	+	==Crystal Structure of the Mediator of Rho Dependent Invasion==
-	===Crystal Structure of the Mediator of Rho Dependent Invasion===	+	<StructureSection load='4ldq' size='340' side='right' caption='[[4ldq]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23859498}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ldq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LDQ FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ldr\|4ldr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MRI1, MRDI, UNQ6390/PRO21135 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5-thioribose-1-phosphate_isomerase S-methyl-5-thioribose-1-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.23 5.3.1.23] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ldq RCSB], [http://www.ebi.ac.uk/pdbsum/4ldq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Metastatic melanoma is among the most intractable cancers to treat, where patients show resistance to therapy and limited survival time. A critical step in the development of metastatic melanoma is the acquisition of invasion and transition from thin to thick tumors on the skin, followed by invasion to lymph nodes. Prior studies have shown that metastatic melanoma is associated with dysregulation of RhoA and enhanced expression of a protein named "mediator of RhoA-dependent invasion (MRDI)". Importantly, MRDI is a "moonlighting" enzyme, with two distinct functions in melanoma cells. First, MRDI acts as a methylthioribose-1-phosphate (MTR-1-P) isomerase, catalyzing a critical step in methionine salvage. Second, MRDI promotes and is necessary for melanoma cell invasion, independent of its catalytic activity. Here, we demonstrate that MtnA, a bacterial MTR-1-P isomerase, rescues the methionine salvage function of MRDI, but is unable to rescue its role in invasion. We then solve the crystal structure of MRDI to a resolution of 2.5 A, in order to identify structural elements important for its invasion activity. We present this structure and its comparison with other MTR-1-P isomerases, and identify mutations within a region separate from the MTR-1-P binding site which interfere with invasion. Thus, structural elements in MRDI distal from the MTR-1-P catalytic site are responsible for the invasion phenotype.

-	==Function==	+	Structure of MRDI Explains its Dual Function as a Metabolic Enzyme and a Mediator of Cell Invasion.,Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC Biochemistry. 2013 Jul 16. PMID:23859498<ref>PMID:23859498</ref>
-	~~[[http://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN]] Catalyzes the interconversion~~ of ~~methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)~~. ~~Independently from catalytic activity~~, ~~promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover~~.<ref>PMID:~~19620624~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4ldq]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023859498</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: S-methyl-5-thioribose-1-phosphate isomerase]]		[[Category: S-methyl-5-thioribose-1-phosphate isomerase]]
-	[[Category: Metzner, S I.]]	+	[[Category: Metzner, S I]]
-	[[Category: Sousa, M C.]]	+	[[Category: Sousa, M C]]
-	[[Category: Templeton, P D.]]	+	[[Category: Templeton, P D]]
	[[Category: Cell invasion]]		[[Category: Cell invasion]]
	[[Category: Helix bundle]]		[[Category: Helix bundle]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Rossmann-like fold]]		[[Category: Rossmann-like fold]]

OCA at 05:26, 1 August 2013

OCA — Thu, 01 Aug 2013 05:26:32 GMT

←Older revision		Revision as of 05:26, 1 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ldq\| PDB=4ldq \| SCENE= }}
		+	===Crystal Structure of the Mediator of Rho Dependent Invasion===
		+	{{ABSTRACT_PUBMED_23859498}}

-	~~The entry 4ldq is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN]] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>

-	~~Authors~~: ~~Sousa, M~~.C.~~, Templeton, P~~.D.~~, Metzner, S~~.I.	+	==About this Structure==
		+	[[4ldq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDQ OCA].

-	~~Description~~: ~~Crystal Structure of the Mediator of Rho Dependent Invasion~~	+	==Reference==
		+	<ref group="xtra">PMID:023859498</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: S-methyl-5-thioribose-1-phosphate isomerase]]
		+	[[Category: Metzner, S I.]]
		+	[[Category: Sousa, M C.]]
		+	[[Category: Templeton, P D.]]
		+	[[Category: Cell invasion]]
		+	[[Category: Helix bundle]]
		+	[[Category: Isomerase]]
		+	[[Category: Rossmann-like fold]]

OCA: Protected "4ldq" [edit=sysop:move=sysop]

OCA — Wed, 03 Jul 2013 13:25:42 GMT

Protected "4ldq" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:25, 3 July 2013

OCA: New page: '''Unreleased structure''' The entry 4ldq is ON HOLD Authors: Sousa, M.C., Templeton, P.D., Metzner, S.I. Description: Crystal Structure of the Mediator of Rho Dependent Invasion

OCA — Wed, 03 Jul 2013 13:25:41 GMT

New page: '''Unreleased structure''' The entry 4ldq is ON HOLD Authors: Sousa, M.C., Templeton, P.D., Metzner, S.I. Description: Crystal Structure of the Mediator of Rho Dependent Invasion

New page

'''Unreleased structure'''

The entry 4ldq is ON HOLD

Authors: Sousa, M.C., Templeton, P.D., Metzner, S.I.

Description: Crystal Structure of the Mediator of Rho Dependent Invasion