4lkp - Revision history

OCA at 11:07, 14 December 2022

OCA — Wed, 14 Dec 2022 11:07:05 GMT

←Older revision		Revision as of 11:07, 14 December 2022
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	==Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)==		==Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)==
-	<StructureSection load='4lkp' size='340' side='right' caption='[[4lkp]], [[Resolution\|resolution]] 1.67Å' scene=''>	+	<StructureSection load='4lkp' size='340' side='right'caption='[[4lkp]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lkp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LKP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lkp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LKP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lkt\|4lkt]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lkp OCA], [https://pdbe.org/4lkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lkp RCSB], [https://www.ebi.ac.uk/pdbsum/4lkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lkp ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4lkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lkp OCA], [~~http~~://pdbe.org/4lkp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4lkp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4lkp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4lkp ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN]] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.	+	[https://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4lkp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4lkp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Armstrong, E H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ortlund, E A~~]]	+	[[Category: Armstrong EH]]
-	[[Category: ~~Beta barrel]]~~	+	[[Category: Ortlund EA]]
-	~~[[Category: Beta clam]]~~	+
-	~~[[Category: Fatty acid binding protein]]~~	+
-	~~[[Category: Fatty acid]]~~	+
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Nucleus~~]]	+

OCA at 09:39, 15 November 2017

OCA — Wed, 15 Nov 2017 09:39:43 GMT

←Older revision		Revision as of 09:39, 15 November 2017
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lkt\|4lkt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lkt\|4lkt]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lkp OCA], [http://pdbe.org/4lkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lkp RCSB], [http://www.ebi.ac.uk/pdbsum/4lkp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lkp OCA], [http://pdbe.org/4lkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lkp RCSB], [http://www.ebi.ac.uk/pdbsum/4lkp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lkp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 18:49, 10 May 2016

OCA — Tue, 10 May 2016 18:49:19 GMT

←Older revision		Revision as of 18:49, 10 May 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)==		==Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)==
	<StructureSection load='4lkp' size='340' side='right' caption='[[4lkp]], [[Resolution\|resolution]] 1.67Å' scene=''>		<StructureSection load='4lkp' size='340' side='right' caption='[[4lkp]], [[Resolution\|resolution]] 1.67Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lkt\|4lkt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lkt\|4lkt]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lkp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lkp RCSB], [http://www.ebi.ac.uk/pdbsum/4lkp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lkp OCA], [http://pdbe.org/4lkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lkp RCSB], [http://www.ebi.ac.uk/pdbsum/4lkp PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN]] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.		[[http://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN]] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fatty acid-binding proteins (FABPs) are a widely expressed group of calycins that play a well established role in solubilizing cellular fatty acids. Recent studies, however, have recast FABPs as active participants in vital lipid-signaling pathways. FABP5, like its family members, displays a promiscuous ligand binding profile, capable of interacting with numerous long chain fatty acids of varying degrees of saturation. Certain "activating" fatty acids induce the protein's cytoplasmic to nuclear translocation, stimulating PPARbeta/delta transactivation; however, the rules that govern this process remain unknown. Using a range of structural and biochemical techniques, we show that both linoleic and arachidonic acid elicit FABP5's translocation by permitting allosteric communication between the ligand-sensing beta2 loop and a tertiary nuclear localization signal within the alpha-helical cap of the protein. Furthermore, we show that more saturated, nonactivating fatty acids inhibit nuclear localization signal formation by destabilizing this activation loop, thus implicating FABP5 specifically in cis-bonded, polyunsaturated fatty acid signaling.
		+
		+	Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPARbeta/delta) signaling pathway.,Armstrong EH, Goswami D, Griffin PR, Noy N, Ortlund EA J Biol Chem. 2014 May 23;289(21):14941-54. doi: 10.1074/jbc.M113.514646. Epub, 2014 Apr 1. PMID:24692551<ref>PMID:24692551</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4lkp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:53, 25 December 2014

OCA — Thu, 25 Dec 2014 08:53:06 GMT

←Older revision		Revision as of 08:53, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4lkp\| PDB=4lkp \| SCENE= }}~~	+	==Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)==
-	===Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)===	+	<StructureSection load='4lkp' size='340' side='right' caption='[[4lkp]], [[Resolution\|resolution]] 1.67Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[4lkp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LKP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lkt\|4lkt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lkp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lkp RCSB], [http://www.ebi.ac.uk/pdbsum/4lkp PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN]] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.		[[http://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN]] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	[[~~4lkp~~]] ~~is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKP OCA].~~	+	[[Category: Human]]
-	[[Category: Armstrong, E H.]]	+	[[Category: Armstrong, E H]]
-	[[Category: Ortlund, E A.]]	+	[[Category: Ortlund, E A]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Beta clam]]		[[Category: Beta clam]]

OCA at 09:34, 26 March 2014

OCA — Wed, 26 Mar 2014 09:34:11 GMT

←Older revision		Revision as of 09:34, 26 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4lkp\| PDB=4lkp \| SCENE= }}
		+	===Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)===

-	~~The entry 4lkp is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN]] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.

-	~~Authors~~: Armstrong, E.H., Ortlund, E.A.	+	==About this Structure==
-		+	[[4lkp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKP OCA].
-	~~Description~~: ~~Crystal Structure of Apo Human Epidermal~~ Fatty ~~Acid Binding Protein (FABP5)~~	+	[[Category: Armstrong, E H.]]
		+	[[Category: Ortlund, E A.]]
		+	[[Category: Beta barrel]]
		+	[[Category: Beta clam]]
		+	[[Category: Fatty acid binding protein]]
		+	[[Category: Fatty acid]]
		+	[[Category: Lipid binding protein]]
		+	[[Category: Nucleus]]

OCA: Protected "4lkp" [edit=sysop:move=sysop]

OCA — Thu, 18 Jul 2013 04:47:24 GMT

Protected "4lkp" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:47, 18 July 2013

OCA: New page: '''Unreleased structure''' The entry 4lkp is ON HOLD Authors: Armstrong, E.H., Ortlund, E.A. Description: Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)

OCA — Thu, 18 Jul 2013 04:47:24 GMT

New page: '''Unreleased structure''' The entry 4lkp is ON HOLD Authors: Armstrong, E.H., Ortlund, E.A. Description: Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)

New page

'''Unreleased structure'''

The entry 4lkp is ON HOLD

Authors: Armstrong, E.H., Ortlund, E.A.

Description: Crystal Structure of Apo Human Epidermal Fatty Acid Binding Protein (FABP5)