4llw - Revision history

OCA at 11:10, 14 December 2022

OCA — Wed, 14 Dec 2022 11:10:04 GMT

←Older revision		Revision as of 11:10, 14 December 2022
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	<StructureSection load='4llw' size='340' side='right'caption='[[4llw]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4llw' size='340' side='right'caption='[[4llw]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4llw]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4llw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LLW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4llu\|4llu]], [[4lld\|4lld]], [[4llm\|4llm]], [[4llq\|4llq]], [[4lly\|4lly]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4llw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llw OCA], [https://pdbe.org/4llw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4llw RCSB], [https://www.ebi.ac.uk/pdbsum/4llw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4llw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4llw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llw OCA], [~~http~~://pdbe.org/4llw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4llw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4llw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4llw ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/S6B291_HUMAN S6B291_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Atwell, S]]	+	[[Category: Atwell S]]
-	[[Category: Chamberlain~~, A K~~]]	+	[[Category: Chamberlain AK]]
-	[[Category: Demarest~~, S J~~]]	+	[[Category: Demarest SJ]]
-	[[Category: Guntas, G]]	+	[[Category: Guntas G]]
-	[[Category: Hansen-Estruch, C]]	+	[[Category: Hansen-Estruch C]]
-	[[Category: Ho, C]]	+	[[Category: Ho C]]
-	[[Category: Huang, F]]	+	[[Category: Huang F]]
-	[[Category: Kuhlman, B]]	+	[[Category: Kuhlman B]]
-	[[Category: Leaver-Fay, A]]	+	[[Category: Leaver-Fay A]]
-	[[Category: Lewis~~, S M~~]]	+	[[Category: Lewis SM]]
-	[[Category: Pustilnik, A]]	+	[[Category: Pustilnik A]]
-	[[Category: Sereno, A]]	+	[[Category: Sereno A]]
-	[[Category: Smith~~, E M~~]]	+	[[Category: Smith EM]]
-	[[Category: Truhlar~~, S M~~]]	+	[[Category: Truhlar SM]]
-	[[Category: Wu, X]]	+	[[Category: Wu X]]
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 07:13, 26 June 2019

OCA — Wed, 26 Jun 2019 07:13:24 GMT

←Older revision		Revision as of 07:13, 26 June 2019
Line 1:		Line 1:

	==Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A==		==Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A==
-	<StructureSection load='4llw' size='340' side='right' caption='[[4llw]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='4llw' size='340' side='right'caption='[[4llw]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4llw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LLW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4llw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LLW FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Atwell, S]]		[[Category: Atwell, S]]
	[[Category: Chamberlain, A K]]		[[Category: Chamberlain, A K]]

OCA at 21:22, 11 August 2016

OCA — Thu, 11 Aug 2016 21:22:27 GMT

←Older revision		Revision as of 21:22, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A==		==Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A==
	<StructureSection load='4llw' size='340' side='right' caption='[[4llw]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4llw' size='340' side='right' caption='[[4llw]], [[Resolution\|resolution]] 1.95Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4llu\|4llu]], [[4lld\|4lld]], [[4llm\|4llm]], [[4llq\|4llq]], [[4lly\|4lly]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4llu\|4llu]], [[4lld\|4lld]], [[4llm\|4llm]], [[4llq\|4llq]], [[4lly\|4lly]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4llw RCSB], [http://www.ebi.ac.uk/pdbsum/4llw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llw OCA], [http://pdbe.org/4llw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4llw RCSB], [http://www.ebi.ac.uk/pdbsum/4llw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4llw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4llw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:49, 5 January 2015

OCA — Mon, 05 Jan 2015 09:49:32 GMT

←Older revision		Revision as of 09:49, 5 January 2015
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-	~~{{STRUCTURE_4llw\| PDB=4llw \| SCENE= }}~~	+	==Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A==
-	===Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A===	+	<StructureSection load='4llw' size='340' side='right' caption='[[4llw]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24463572}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4llw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LLW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4llu\|4llu]], [[4lld\|4lld]], [[4llm\|4llm]], [[4llq\|4llq]], [[4lly\|4lly]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4llw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4llw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4llw RCSB], [http://www.ebi.ac.uk/pdbsum/4llw PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Robust generation of IgG bispecific antibodies has been a long-standing challenge. Existing methods require extensive engineering of each individual antibody, discovery of common light chains, or complex and laborious biochemical processing. Here we combine computational and rational design approaches with experimental structural validation to generate antibody heavy and light chains with orthogonal Fab interfaces. Parental monoclonal antibodies incorporating these interfaces, when simultaneously co-expressed, assemble into bispecific IgG with improved heavy chain-light chain pairing. Bispecific IgGs generated with this approach exhibit pharmacokinetic and other desirable properties of native IgG, but bind target antigens monovalently. As such, these bispecific reagents may be useful in many biotechnological applications.

-	~~==About this Structure==~~	+	Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface.,Lewis SM, Wu X, Pustilnik A, Sereno A, Huang F, Rick HL, Guntas G, Leaver-Fay A, Smith EM, Ho C, Hansen-Estruch C, Chamberlain AK, Truhlar SM, Conner EM, Atwell S, Kuhlman B, Demarest SJ Nat Biotechnol. 2014 Feb;32(2):191-8. doi: 10.1038/nbt.2797. Epub 2014 Jan 26. PMID:24463572<ref>PMID:24463572</ref>
-	~~[[4llw]] is a 4 chain~~ structure. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4LLW OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024463572</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Atwell, S.]]	+	== References ==
-	[[Category: Chamberlain, A K.]]	+	<references/>
-	[[Category: Demarest, S J.]]	+	__TOC__
-	[[Category: Guntas, G.]]	+	</StructureSection>
-	[[Category: Hansen-Estruch, C.]]	+	[[Category: Human]]
-	[[Category: Ho, C.]]	+	[[Category: Atwell, S]]
-	[[Category: Huang, F.]]	+	[[Category: Chamberlain, A K]]
-	[[Category: Kuhlman, B.]]	+	[[Category: Demarest, S J]]
-	[[Category: Leaver-Fay, A.]]	+	[[Category: Guntas, G]]
-	[[Category: Lewis, S M.]]	+	[[Category: Hansen-Estruch, C]]
-	[[Category: Pustilnik, A.]]	+	[[Category: Ho, C]]
-	[[Category: Sereno, A.]]	+	[[Category: Huang, F]]
-	[[Category: Smith, E M.]]	+	[[Category: Kuhlman, B]]
-	[[Category: Truhlar, S M.]]	+	[[Category: Leaver-Fay, A]]
-	[[Category: Wu, X.]]	+	[[Category: Lewis, S M]]
		+	[[Category: Pustilnik, A]]
		+	[[Category: Sereno, A]]
		+	[[Category: Smith, E M]]
		+	[[Category: Truhlar, S M]]
		+	[[Category: Wu, X]]
	[[Category: Fab]]		[[Category: Fab]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 04:33, 13 February 2014

OCA — Thu, 13 Feb 2014 04:33:29 GMT

←Older revision		Revision as of 04:33, 13 February 2014
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	{{STRUCTURE_4llw\| PDB=4llw \| SCENE= }}		{{STRUCTURE_4llw\| PDB=4llw \| SCENE= }}
	===Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A===		===Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A===
		+	{{ABSTRACT_PUBMED_24463572}}

	==About this Structure==		==About this Structure==
	[[4llw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLW OCA].		[[4llw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024463572</ref><references group="xtra"/><references/>
	[[Category: Atwell, S.]]		[[Category: Atwell, S.]]
	[[Category: Chamberlain, A K.]]		[[Category: Chamberlain, A K.]]

OCA at 07:48, 29 January 2014

OCA — Wed, 29 Jan 2014 07:48:57 GMT

←Older revision		Revision as of 07:48, 29 January 2014
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4llw\| PDB=4llw \| SCENE= }}
		+	===Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A===

-	~~The entry~~ 4llw is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4llw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LLW OCA].
-	~~Authors~~: ~~Pustilnik~~, A.~~, Lewis~~, S.M., ~~Wu, X~~., ~~Sereno, A~~., Huang, F., ~~Guntas, G~~., Leaver-Fay, A., ~~Smith, E.~~M., ~~Ho, C~~.~~, Hansen-Estruch, C., Chamberlain~~, A.K., Truhlar, S.M., ~~Kuhlman, B., Demarest, S.J., Atwell, S~~.	+	[[Category: Atwell, S.]]
-		+	[[Category: Chamberlain, A K.]]
-	~~Description~~: ~~Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A~~	+	[[Category: Demarest, S J.]]
		+	[[Category: Guntas, G.]]
		+	[[Category: Hansen-Estruch, C.]]
		+	[[Category: Ho, C.]]
		+	[[Category: Huang, F.]]
		+	[[Category: Kuhlman, B.]]
		+	[[Category: Leaver-Fay, A.]]
		+	[[Category: Lewis, S M.]]
		+	[[Category: Pustilnik, A.]]
		+	[[Category: Sereno, A.]]
		+	[[Category: Smith, E M.]]
		+	[[Category: Truhlar, S M.]]
		+	[[Category: Wu, X.]]
		+	[[Category: Fab]]
		+	[[Category: Immune system]]

OCA at 20:11, 7 August 2013

OCA — Wed, 07 Aug 2013 20:11:33 GMT

←Older revision		Revision as of 20:11, 7 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4llw is ON HOLD	+	The entry 4llw is ON HOLD until Paper Publication

	Authors: Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch, C., Chamberlain, A.K., Truhlar, S.M., Kuhlman, B., Demarest, S.J., Atwell, S.		Authors: Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch, C., Chamberlain, A.K., Truhlar, S.M., Kuhlman, B., Demarest, S.J., Atwell, S.

	Description: Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A		Description: Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A

OCA: Protected "4llw" [edit=sysop:move=sysop]

OCA — Thu, 18 Jul 2013 04:48:04 GMT

Protected "4llw" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:48, 18 July 2013

OCA: New page: '''Unreleased structure''' The entry 4llw is ON HOLD Authors: Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch,...

OCA — Thu, 18 Jul 2013 04:48:03 GMT

New page: '''Unreleased structure''' The entry 4llw is ON HOLD Authors: Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch,...

New page

'''Unreleased structure'''

The entry 4llw is ON HOLD

Authors: Pustilnik, A., Lewis, S.M., Wu, X., Sereno, A., Huang, F., Guntas, G., Leaver-Fay, A., Smith, E.M., Ho, C., Hansen-Estruch, C., Chamberlain, A.K., Truhlar, S.M., Kuhlman, B., Demarest, S.J., Atwell, S.

Description: Crystal structure of Pertuzumab Clambda Fab with variable domain redesign (VRD2) at 1.95A