4lmo - Revision history

OCA at 11:11, 14 December 2022

OCA — Wed, 14 Dec 2022 11:11:34 GMT

←Older revision		Revision as of 11:11, 14 December 2022
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	==Structure of a vertebrate RNA binding domain of telomerase (TRBD)==		==Structure of a vertebrate RNA binding domain of telomerase (TRBD)==
-	<StructureSection load='4lmo' size='340' side='right' caption='[[4lmo]], [[Resolution\|resolution]] 2.37Å' scene=''>	+	<StructureSection load='4lmo' size='340' side='right'caption='[[4lmo]], [[Resolution\|resolution]] 2.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lmo]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fugu_rubripes Fugu~~ rubripes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LMO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lmo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Takifugu_rubripes Takifugu rubripes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LMO FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r4g\|2r4g]], [[3du5\|3du5]], [[3du6\|3du6]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lmo OCA], [https://pdbe.org/4lmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lmo RCSB], [https://www.ebi.ac.uk/pdbsum/4lmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lmo ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31033 Fugu rubripes])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4lmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lmo OCA], [~~http~~://pdbe.org/4lmo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4lmo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4lmo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4lmo ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TERT_TAKRU TERT_TAKRU] Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.<ref>PMID:18039659</ref> <ref>PMID:24055314</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[~~Reverse transcriptase~~\|~~Reverse transcriptase~~]]	+	*[[Telomerase 3D structures\|Telomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Fugu~~ rubripes]]	+	[[Category: Large Structures]]
-	[[Category: Harkisheimer, M]]	+	[[Category: Takifugu rubripes]]
-	[[Category: Mason, M]]	+	[[Category: Harkisheimer M]]
-	[[Category: Shuvaeva, E]]	+	[[Category: Mason M]]
-	[[Category: Skordalakes, E]]	+	[[Category: Shuvaeva E]]
-	~~[[Category: Rna binding domain of the reverse transcriptase telomerase]]~~	+	[[Category: Skordalakes E]]
-	~~[[Category: Rna binding protein~~]]	+

OCA at 06:55, 5 August 2016

OCA — Fri, 05 Aug 2016 06:55:25 GMT

←Older revision		Revision as of 06:55, 5 August 2016
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		+
	==Structure of a vertebrate RNA binding domain of telomerase (TRBD)==		==Structure of a vertebrate RNA binding domain of telomerase (TRBD)==
	<StructureSection load='4lmo' size='340' side='right' caption='[[4lmo]], [[Resolution\|resolution]] 2.37Å' scene=''>		<StructureSection load='4lmo' size='340' side='right' caption='[[4lmo]], [[Resolution\|resolution]] 2.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lmo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Takifugu_rubripes Takifugu~~ rubripes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LMO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lmo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Fugu_rubripes Fugu rubripes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LMO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r4g\|2r4g]], [[3du5\|3du5]], [[3du6\|3du6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r4g\|2r4g]], [[3du5\|3du5]], [[3du6\|3du6]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31033 ~~Takifugu~~ rubripes])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31033 Fugu rubripes])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lmo RCSB], [http://www.ebi.ac.uk/pdbsum/4lmo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lmo OCA], [http://pdbe.org/4lmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lmo RCSB], [http://www.ebi.ac.uk/pdbsum/4lmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lmo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4lmo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Reverse transcriptase\|Reverse transcriptase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Takifugu~~ rubripes]]	+	[[Category: Fugu rubripes]]
	[[Category: Harkisheimer, M]]		[[Category: Harkisheimer, M]]
	[[Category: Mason, M]]		[[Category: Mason, M]]

OCA at 15:13, 21 December 2014

OCA — Sun, 21 Dec 2014 15:13:28 GMT

←Older revision		Revision as of 15:13, 21 December 2014
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-	~~{{STRUCTURE_4lmo\| PDB=4lmo \| SCENE= }}~~	+	==Structure of a vertebrate RNA binding domain of telomerase (TRBD)==
-	===Structure of a vertebrate RNA binding domain of telomerase (TRBD)===	+	<StructureSection load='4lmo' size='340' side='right' caption='[[4lmo]], [[Resolution\|resolution]] 2.37Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24055314}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4lmo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Takifugu_rubripes Takifugu rubripes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LMO FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r4g\|2r4g]], [[3du5\|3du5]], [[3du6\|3du6]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31033 Takifugu rubripes])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lmo RCSB], [http://www.ebi.ac.uk/pdbsum/4lmo PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Telomerase is a ribonucleoprotein reverse transcriptase that replicates the ends of chromosomes, thus maintaining genome stability. Telomerase ribonucleoprotein assembly is primarily mediated by the RNA binding domain (TRBD) of the enzyme. Here we present the high-resolution TRBD structure of the vertebrate, Takifugu rubripes (trTRBD). The structure shows that with the exception of the N-terminal linker, the trTRBD is conserved with the Tribolium castaneum and Tetrahymena thermophila TRBDs, suggesting evolutionary conservation across species. The structure provides a view of the structural organization of the vertebrate-specific VSR motif that binds the activation domain (CR4/5) of the RNA component of telomerase. It also reveals a motif (TFLY) that forms part of the T-CP pocket implicated in template boundary element (TBE) binding. Mutant proteins of conserved residues that consist of part of the T and TFLY motifs disrupt trTRBD-TBE binding and telomerase activity and processivity, supporting an essential role of these motifs in telomerase RNP assembly and function.

-	~~==About this~~ Structure==	+	A Motif in the Vertebrate Telomerase N-Terminal Linker of TERT Contributes to RNA Binding and Telomerase Activity and Processivity.,Harkisheimer M, Mason M, Shuvaeva E, Skordalakes E Structure. 2013 Sep 17. pii: S0969-2126(13)00305-5. doi:, 10.1016/j.str.2013.08.013. PMID:24055314<ref>PMID:24055314</ref>
-	~~[[4lmo]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Takifugu_rubripes Takifugu rubripes]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4LMO OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024055314</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Takifugu rubripes]]		[[Category: Takifugu rubripes]]
-	[[Category: Harkisheimer, M.]]	+	[[Category: Harkisheimer, M]]
-	[[Category: Mason, M.]]	+	[[Category: Mason, M]]
-	[[Category: Shuvaeva, E.]]	+	[[Category: Shuvaeva, E]]
-	[[Category: Skordalakes, E.]]	+	[[Category: Skordalakes, E]]
	[[Category: Rna binding domain of the reverse transcriptase telomerase]]		[[Category: Rna binding domain of the reverse transcriptase telomerase]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 06:31, 10 October 2013

OCA — Thu, 10 Oct 2013 06:31:48 GMT

←Older revision		Revision as of 06:31, 10 October 2013
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4lmo\| PDB=4lmo \| SCENE= }}
		+	===Structure of a vertebrate RNA binding domain of telomerase (TRBD)===
		+	{{ABSTRACT_PUBMED_24055314}}

-	~~The entry~~ 4lmo is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4lmo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Takifugu_rubripes Takifugu rubripes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMO OCA].

-	~~Authors~~: Harkisheimer, M., Mason, M., Shuvaeva, E., Skordalakes, E.	+	==Reference==
-		+	<ref group="xtra">PMID:024055314</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Structure of a vertebrate RNA~~ binding domain of telomerase ~~(TRBD)~~	+	[[Category: Takifugu rubripes]]
		+	[[Category: Harkisheimer, M.]]
		+	[[Category: Mason, M.]]
		+	[[Category: Shuvaeva, E.]]
		+	[[Category: Skordalakes, E.]]
		+	[[Category: Rna binding domain of the reverse transcriptase telomerase]]
		+	[[Category: Rna binding protein]]

OCA at 07:50, 21 August 2013

OCA — Wed, 21 Aug 2013 07:50:49 GMT

←Older revision		Revision as of 07:50, 21 August 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4lmo is ON HOLD	+	The entry 4lmo is ON HOLD until Paper Publication

	Authors: Harkisheimer, M., Mason, M., Shuvaeva, E., Skordalakes, E.		Authors: Harkisheimer, M., Mason, M., Shuvaeva, E., Skordalakes, E.

	Description: Structure of a vertebrate RNA binding domain of telomerase (TRBD)		Description: Structure of a vertebrate RNA binding domain of telomerase (TRBD)

OCA at 04:18, 1 August 2013

OCA — Thu, 01 Aug 2013 04:18:53 GMT

←Older revision		Revision as of 04:18, 1 August 2013
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	The entry 4lmo is ON HOLD		The entry 4lmo is ON HOLD

-	Authors: ~~Michael~~ Harkisheimer, ~~Mark~~ Mason, ~~Elena~~ Shuvaeva, ~~Emmanuel~~ Skordalakes	+	Authors: Harkisheimer, M., Mason, M., Shuvaeva, E., Skordalakes, E.

	Description: Structure of a vertebrate RNA binding domain of telomerase (TRBD)		Description: Structure of a vertebrate RNA binding domain of telomerase (TRBD)

OCA: Protected "4lmo" [edit=sysop:move=sysop]

OCA — Thu, 18 Jul 2013 04:48:28 GMT

Protected "4lmo" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:48, 18 July 2013

OCA: New page: '''Unreleased structure''' The entry 4lmo is ON HOLD Authors: Michael Harkisheimer, Mark Mason, Elena Shuvaeva, Emmanuel Skordalakes Description: Structure of a vertebrate RNA binding ...

OCA — Thu, 18 Jul 2013 04:48:27 GMT

New page: '''Unreleased structure''' The entry 4lmo is ON HOLD Authors: Michael Harkisheimer, Mark Mason, Elena Shuvaeva, Emmanuel Skordalakes Description: Structure of a vertebrate RNA binding ...

New page

'''Unreleased structure'''

The entry 4lmo is ON HOLD

Authors: Michael Harkisheimer, Mark Mason, Elena Shuvaeva, Emmanuel Skordalakes

Description: Structure of a vertebrate RNA binding domain of telomerase (TRBD)