4lo6 - Revision history

OCA at 12:20, 1 March 2024

OCA — Fri, 01 Mar 2024 12:20:49 GMT

←Older revision		Revision as of 12:20, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4lo6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LO6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4lo6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LO6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lo6 OCA], [https://pdbe.org/4lo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lo6 RCSB], [https://www.ebi.ac.uk/pdbsum/4lo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lo6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lo6 OCA], [https://pdbe.org/4lo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lo6 RCSB], [https://www.ebi.ac.uk/pdbsum/4lo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lo6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q8KHU9_CLOBO Q8KHU9_CLOBO]		[https://www.uniprot.org/uniprot/Q8KHU9_CLOBO Q8KHU9_CLOBO]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Botulinum neurotoxins (BoNTs) are produced by Clostridium botulinum and cause the fatal disease botulism, a flaccid paralysis of the muscle. BoNTs are released together with several auxiliary proteins as progenitor toxin complexes (PTCs) to become highly potent oral poisons. Here, we report the structure of a approximately 760 kDa 14-subunit large PTC of serotype A (L-PTC/A) and reveal insight into its absorption mechanism. Using a combination of X-ray crystallography, electron microscopy, and functional studies, we found that L-PTC/A consists of two structurally and functionally independent sub-complexes. A hetero-dimeric 290 kDa complex protects BoNT, while a hetero-dodecameric 470 kDa complex facilitates its absorption in the harsh environment of the gastrointestinal tract. BoNT absorption is mediated by nine glycan-binding sites on the dodecameric sub-complex that forms multivalent interactions with carbohydrate receptors on intestinal epithelial cells. We identified monosaccharides that blocked oral BoNT intoxication in mice, which suggests a new strategy for the development of preventive countermeasures for BoNTs based on carbohydrate receptor mimicry.
-
-	Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity.,Lee K, Gu S, Jin L, Le TT, Cheng LW, Strotmeier J, Kruel AM, Yao G, Perry K, Rummel A, Jin R PLoS Pathog. 2013 Oct;9(10):e1003690. doi: 10.1371/journal.ppat.1003690. Epub, 2013 Oct 10. PMID:24130488<ref>PMID:24130488</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4lo6" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:15, 14 December 2022

OCA — Wed, 14 Dec 2022 11:15:08 GMT

←Older revision		Revision as of 11:15, 14 December 2022
Line 1:		Line 1:

	==HA70-alpha2,6-SiaLC==		==HA70-alpha2,6-SiaLC==
-	<StructureSection load='4lo6' size='340' side='right' caption='[[4lo6]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4lo6' size='340' side='right'caption='[[4lo6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lo6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LO6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LO6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lo6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LO6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lo6 OCA], [https://pdbe.org/4lo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lo6 RCSB], [https://www.ebi.ac.uk/pdbsum/4lo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lo6 ProSAT]</span></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lo0\|4lo0]], [[4lo1\|4lo1]], [[4lo2\|4lo2]], [[4lo3\|4lo3]], [[4lo4\|4lo4]], [[4lo5\|4lo5]], [[4lo7\|4lo7]], [[4lo8\|4lo8]]</td></tr>	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ha70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lo6 OCA], [~~http~~://pdbe.org/4lo6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4lo6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4lo6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4lo6 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8KHU9_CLOBO Q8KHU9_CLOBO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus botulinus van ermengem 1896~~]]	+	[[Category: Clostridium botulinum]]
-	[[Category: Cheng~~, L W~~]]	+	[[Category: Large Structures]]
-	[[Category: Gu, S]]	+	[[Category: Cheng LW]]
-	[[Category: Jin, L]]	+	[[Category: Gu S]]
-	[[Category: Jin, R]]	+	[[Category: Jin L]]
-	[[Category: Kruel~~, A M~~]]	+	[[Category: Jin R]]
-	[[Category: Le~~, T T~~]]	+	[[Category: Kruel AM]]
-	[[Category: Lee, K]]	+	[[Category: Le TT]]
-	[[Category: Perry, K]]	+	[[Category: Lee K]]
-	[[Category: Rummel, A]]	+	[[Category: Perry K]]
-	[[Category: Strotmeier, J]]	+	[[Category: Rummel A]]
-	[[Category: Yao, G]]	+	[[Category: Strotmeier J]]
-	~~[[Category: Botulinum neurotoxin]]~~	+	[[Category: Yao G]]
-	~~[[Category: Botulism]]~~	+
-	~~[[Category: Carbohydrate/sugar binding]]~~	+
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Neurotoxin associated protein]]~~	+
-	~~[[Category: Progenitor toxin complex]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Secreted protein~~]]	+

OCA at 13:39, 11 August 2016

OCA — Thu, 11 Aug 2016 13:39:06 GMT

←Older revision		Revision as of 13:39, 11 August 2016
Line 1:		Line 1:
		+
	==HA70-alpha2,6-SiaLC==		==HA70-alpha2,6-SiaLC==
	<StructureSection load='4lo6' size='340' side='right' caption='[[4lo6]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4lo6' size='340' side='right' caption='[[4lo6]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lo6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Clostridium_botulinum Clostridium botulinum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LO6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lo6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LO6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lo0\|4lo0]], [[4lo1\|4lo1]], [[4lo2\|4lo2]], [[4lo3\|4lo3]], [[4lo4\|4lo4]], [[4lo5\|4lo5]], [[4lo7\|4lo7]], [[4lo8\|4lo8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lo0\|4lo0]], [[4lo1\|4lo1]], [[4lo2\|4lo2]], [[4lo3\|4lo3]], [[4lo4\|4lo4]], [[4lo5\|4lo5]], [[4lo7\|4lo7]], [[4lo8\|4lo8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ha70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 ~~Clostridium botulinum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ha70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lo6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/4lo6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lo6 OCA], [http://pdbe.org/4lo6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/4lo6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lo6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4lo6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clostridium botulinum~~]]	+	[[Category: Bacillus botulinus van ermengem 1896]]
	[[Category: Cheng, L W]]		[[Category: Cheng, L W]]
	[[Category: Gu, S]]		[[Category: Gu, S]]

OCA at 09:29, 5 January 2015

OCA — Mon, 05 Jan 2015 09:29:24 GMT

←Older revision		Revision as of 09:29, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4lo6~~\| ~~PDB~~=4lo6 \| ~~SCENE~~= }}	+	==HA70-alpha2,6-SiaLC==
-	===~~HA70~~-~~alpha2~~,6-~~SiaLC~~===	+	<StructureSection load='4lo6' size='340' side='right' caption='[[4lo6]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24130488}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4lo6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LO6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lo0\|4lo0]], [[4lo1\|4lo1]], [[4lo2\|4lo2]], [[4lo3\|4lo3]], [[4lo4\|4lo4]], [[4lo5\|4lo5]], [[4lo7\|4lo7]], [[4lo8\|4lo8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ha70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 Clostridium botulinum])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lo6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/4lo6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Botulinum neurotoxins (BoNTs) are produced by Clostridium botulinum and cause the fatal disease botulism, a flaccid paralysis of the muscle. BoNTs are released together with several auxiliary proteins as progenitor toxin complexes (PTCs) to become highly potent oral poisons. Here, we report the structure of a approximately 760 kDa 14-subunit large PTC of serotype A (L-PTC/A) and reveal insight into its absorption mechanism. Using a combination of X-ray crystallography, electron microscopy, and functional studies, we found that L-PTC/A consists of two structurally and functionally independent sub-complexes. A hetero-dimeric 290 kDa complex protects BoNT, while a hetero-dodecameric 470 kDa complex facilitates its absorption in the harsh environment of the gastrointestinal tract. BoNT absorption is mediated by nine glycan-binding sites on the dodecameric sub-complex that forms multivalent interactions with carbohydrate receptors on intestinal epithelial cells. We identified monosaccharides that blocked oral BoNT intoxication in mice, which suggests a new strategy for the development of preventive countermeasures for BoNTs based on carbohydrate receptor mimicry.

-	~~==About this~~ Structure==	+	Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity.,Lee K, Gu S, Jin L, Le TT, Cheng LW, Strotmeier J, Kruel AM, Yao G, Perry K, Rummel A, Jin R PLoS Pathog. 2013 Oct;9(10):e1003690. doi: 10.1371/journal.ppat.1003690. Epub, 2013 Oct 10. PMID:24130488<ref>PMID:24130488</ref>
-	~~[[4lo6]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Clostridium_botulinum Clostridium botulinum]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4LO6 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024130488</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Clostridium botulinum]]		[[Category: Clostridium botulinum]]
-	[[Category: Cheng, L W.]]	+	[[Category: Cheng, L W]]
-	[[Category: Gu, S.]]	+	[[Category: Gu, S]]
-	[[Category: Jin, L.]]	+	[[Category: Jin, L]]
-	[[Category: Jin, R.]]	+	[[Category: Jin, R]]
-	[[Category: Kruel, A M.]]	+	[[Category: Kruel, A M]]
-	[[Category: Le, T T.]]	+	[[Category: Le, T T]]
-	[[Category: Lee, K.]]	+	[[Category: Lee, K]]
-	[[Category: Perry, K.]]	+	[[Category: Perry, K]]
-	[[Category: Rummel, A.]]	+	[[Category: Rummel, A]]
-	[[Category: Strotmeier, J.]]	+	[[Category: Strotmeier, J]]
-	[[Category: Yao, G.]]	+	[[Category: Yao, G]]
	[[Category: Botulinum neurotoxin]]		[[Category: Botulinum neurotoxin]]
	[[Category: Botulism]]		[[Category: Botulism]]

OCA at 09:42, 30 October 2013

OCA — Wed, 30 Oct 2013 09:42:46 GMT

←Older revision		Revision as of 09:42, 30 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4lo6\| PDB=4lo6 \| SCENE= }}
		+	===HA70-alpha2,6-SiaLC===
		+	{{ABSTRACT_PUBMED_24130488}}

-	~~The entry~~ 4lo6 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4lo6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LO6 OCA].

-	~~Authors~~: ~~Lee~~, K., Gu, S., Jin, L., ~~Le, T~~.~~T., Cheng, L.W., Strotmeier, J.,~~ Kruel, A.M., ~~Yao, G~~., Perry, K., Rummel, A., ~~Jin~~, R.	+	==Reference==
-		+	<ref group="xtra">PMID:024130488</ref><references group="xtra"/><references/>
-	~~Description~~: ~~HA70-alpha2,6-SiaLC~~	+	[[Category: Clostridium botulinum]]
		+	[[Category: Cheng, L W.]]
		+	[[Category: Gu, S.]]
		+	[[Category: Jin, L.]]
		+	[[Category: Jin, R.]]
		+	[[Category: Kruel, A M.]]
		+	[[Category: Le, T T.]]
		+	[[Category: Lee, K.]]
		+	[[Category: Perry, K.]]
		+	[[Category: Rummel, A.]]
		+	[[Category: Strotmeier, J.]]
		+	[[Category: Yao, G.]]
		+	[[Category: Botulinum neurotoxin]]
		+	[[Category: Botulism]]
		+	[[Category: Carbohydrate/sugar binding]]
		+	[[Category: Hemagglutinin]]
		+	[[Category: Neurotoxin associated protein]]
		+	[[Category: Progenitor toxin complex]]
		+	[[Category: Protein transport]]
		+	[[Category: Secreted protein]]

OCA at 07:51, 21 August 2013

OCA — Wed, 21 Aug 2013 07:51:19 GMT

←Older revision		Revision as of 07:51, 21 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4lo6 is ON HOLD	+	The entry 4lo6 is ON HOLD until Paper Publication

	Authors: Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.		Authors: Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.

	Description: HA70-alpha2,6-SiaLC		Description: HA70-alpha2,6-SiaLC

OCA at 20:12, 7 August 2013

OCA — Wed, 07 Aug 2013 20:12:50 GMT

←Older revision		Revision as of 20:12, 7 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4lo6 is ON HOLD ~~until sometime in the future~~	+	The entry 4lo6 is ON HOLD

-	Authors: Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A, Jin, R.	+	Authors: Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.

	Description: HA70-alpha2,6-SiaLC		Description: HA70-alpha2,6-SiaLC

OCA at 04:19, 1 August 2013

OCA — Thu, 01 Aug 2013 04:19:27 GMT

←Older revision		Revision as of 04:19, 1 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4lo6 is ON HOLD	+	The entry 4lo6 is ON HOLD until sometime in the future

	Authors: Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A, Jin, R.		Authors: Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A, Jin, R.

	Description: HA70-alpha2,6-SiaLC		Description: HA70-alpha2,6-SiaLC

OCA: Protected "4lo6" [edit=sysop:move=sysop]

OCA — Wed, 24 Jul 2013 12:29:24 GMT

Protected "4lo6" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:29, 24 July 2013

OCA: New page: '''Unreleased structure''' The entry 4lo6 is ON HOLD Authors: Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A, Jin, R. Descr...

OCA — Wed, 24 Jul 2013 12:29:23 GMT

New page: '''Unreleased structure''' The entry 4lo6 is ON HOLD Authors: Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A, Jin, R. Descr...

New page

'''Unreleased structure'''

The entry 4lo6 is ON HOLD

Authors: Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A, Jin, R.

Description: HA70-alpha2,6-SiaLC