4lot - Revision history

OCA at 11:16, 14 December 2022

OCA — Wed, 14 Dec 2022 11:16:32 GMT

←Older revision		Revision as of 11:16, 14 December 2022
Line 1:		Line 1:

	==C1s CUB2-CCP1-CCP2==		==C1s CUB2-CCP1-CCP2==
-	<StructureSection load='4lot' size='340' side='right' caption='[[4lot]], [[Resolution\|resolution]] 2.92Å' scene=''>	+	<StructureSection load='4lot' size='340' side='right'caption='[[4lot]], [[Resolution\|resolution]] 2.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lot]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LOT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LOT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lot]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LOT FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lmf\|4lmf]], [[4lor\|4lor]], [[4los\|4los]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lot OCA], [https://pdbe.org/4lot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lot RCSB], [https://www.ebi.ac.uk/pdbsum/4lot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lot ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1s Complement subcomponent C1s], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.42 3.4.21.42] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4lot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lot OCA], [~~http~~://pdbe.org/4lot PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4lot RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4lot PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4lot ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[~~http~~://omim.org/entry/613783 613783]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.	+	[https://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[https://omim.org/entry/613783 613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.	+	[https://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Complement subcomponent C1s~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Girija, U Venkatraman~~]]	+	[[Category: Marshall JE]]
-	[[Category: ~~Marshall, J E~~]]	+	[[Category: Moody PCE]]
-	[[Category: ~~Moody, P C.E~~]]	+	[[Category: Venkatraman Girija U]]
-	[[Category: Wallis, R]]	+	[[Category: Wallis R]]
-	~~[[Category: Ccp domain]]~~	+
-	~~[[Category: Complement c1]]~~	+
-	~~[[Category: Cub domain]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 18:20, 4 August 2016

OCA — Thu, 04 Aug 2016 18:20:10 GMT

←Older revision		Revision as of 18:20, 4 August 2016
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		+
	==C1s CUB2-CCP1-CCP2==		==C1s CUB2-CCP1-CCP2==
	<StructureSection load='4lot' size='340' side='right' caption='[[4lot]], [[Resolution\|resolution]] 2.92Å' scene=''>		<StructureSection load='4lot' size='340' side='right' caption='[[4lot]], [[Resolution\|resolution]] 2.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LOT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LOT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lmf\|4lmf]], [[4lor\|4lor]], [[4los\|4los]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lmf\|4lmf]], [[4lor\|4lor]], [[4los\|4los]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1s Complement subcomponent C1s], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.42 3.4.21.42] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1s Complement subcomponent C1s], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.42 3.4.21.42] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lot RCSB], [http://www.ebi.ac.uk/pdbsum/4lot PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lot OCA], [http://pdbe.org/4lot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lot RCSB], [http://www.ebi.ac.uk/pdbsum/4lot PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lot ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4lot" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Complement subcomponent C1s]]		[[Category: Complement subcomponent C1s]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Girija, U Venkatraman]]		[[Category: Girija, U Venkatraman]]
	[[Category: Marshall, J E]]		[[Category: Marshall, J E]]

OCA at 15:17, 21 December 2014

OCA — Sun, 21 Dec 2014 15:17:59 GMT

←Older revision		Revision as of 15:17, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4lot~~\| ~~PDB~~=4lot \| ~~SCENE~~= }}	+	==C1s CUB2-CCP1-CCP2==
-	===C1s ~~CUB2~~-~~CCP1~~-~~CCP2~~===	+	<StructureSection load='4lot' size='340' side='right' caption='[[4lot]], [[Resolution\|resolution]] 2.92Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23922389}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4lot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LOT FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4lmf\|4lmf]], [[4lor\|4lor]], [[4los\|4los]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1s Complement subcomponent C1s], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.42 3.4.21.42] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lot RCSB], [http://www.ebi.ac.uk/pdbsum/4lot PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[http://omim.org/entry/613783 613783]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.		[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[http://omim.org/entry/613783 613783]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.		[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Complement component C1, the complex that initiates the classical pathway of complement activation, is a 790-kDa assembly formed from the target-recognition subcomponent C1q and the modular proteases C1r and C1s. The proteases are elongated tetramers that become more compact when they bind to the collagen-like domains of C1q. Here, we describe a series of structures that reveal how the subcomponents associate to form C1. A complex between C1s and a collagen-like peptide containing the C1r/C1s-binding motif of C1q shows that the collagen binds to a shallow groove via a critical lysine side chain that contacts Ca(2+)-coordinating residues. The data explain the Ca(2+)-dependent binding mechanism, which is conserved in C1r and also in mannan-binding lectin-associated serine proteases, the serine proteases of the lectin pathway activation complexes. In an accompanying structure, C1s forms a compact ring-shaped tetramer featuring a unique head-to-tail interaction at its center that replicates the likely arrangement of C1r/C1s polypeptides in the C1 complex. Additional structures reveal how C1s polypeptides are positioned to enable activation by C1r and interaction with the substrate C4 inside the cage-like assembly formed by the collagenous stems of C1q. Together with previously determined structures of C1r fragments, the results reported here provide a structural basis for understanding the early steps of complement activation via the classical pathway.

-	~~==About this Structure==~~	+	Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.,Venkatraman Girija U, Gingras AR, Marshall JE, Panchal R, Sheikh MA, Gal P, Schwaeble WJ, Mitchell DA, Moody PC, Wallis R Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13916-20. doi:, 10.1073/pnas.1311113110. Epub 2013 Aug 6. PMID:23922389<ref>PMID:23922389</ref>
-	~~[[4lot]] is a 1 chain structure with sequence from [http:/~~/en.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4LOT OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023922389</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Complement subcomponent C1s]]		[[Category: Complement subcomponent C1s]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Girija, U Venkatraman.]]	+	[[Category: Girija, U Venkatraman]]
-	[[Category: Marshall, J E.]]	+	[[Category: Marshall, J E]]
-	[[Category: Moody, P C.E.]]	+	[[Category: Moody, P C.E]]
-	[[Category: Wallis, R.]]	+	[[Category: Wallis, R]]
	[[Category: Ccp domain]]		[[Category: Ccp domain]]
	[[Category: Complement c1]]		[[Category: Complement c1]]
	[[Category: Cub domain]]		[[Category: Cub domain]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 05:50, 28 August 2013

OCA — Wed, 28 Aug 2013 05:50:05 GMT

←Older revision		Revision as of 05:50, 28 August 2013
Line 1:		Line 1:
	{{STRUCTURE_4lot\| PDB=4lot \| SCENE= }}		{{STRUCTURE_4lot\| PDB=4lot \| SCENE= }}
	===C1s CUB2-CCP1-CCP2===		===C1s CUB2-CCP1-CCP2===
		+	{{ABSTRACT_PUBMED_23922389}}

	==Disease==		==Disease==
Line 10:		Line 11:
	==About this Structure==		==About this Structure==
	[[4lot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LOT OCA].		[[4lot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LOT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023922389</ref><references group="xtra"/><references/>
	[[Category: Complement subcomponent C1s]]		[[Category: Complement subcomponent C1s]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 21:20, 7 August 2013

OCA — Wed, 07 Aug 2013 21:20:25 GMT

←Older revision		Revision as of 21:20, 7 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4lot\| PDB=4lot \| SCENE= }}
		+	===C1s CUB2-CCP1-CCP2===

-	~~The~~ entry ~~4lot is ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[http://omim.org/entry/613783 613783]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

-	~~Authors~~: ~~Wallis, R~~.~~, Venkatraman Girija, U~~., ~~Moody, P.C~~.E, ~~Marshall~~, J.E	+	==Function==
		+	[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.

-	~~Description~~: ~~C1s CUB2~~-~~CCP1-CCP2~~	+	==About this Structure==
		+	[[4lot]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LOT OCA].
		+	[[Category: Complement subcomponent C1s]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Girija, U Venkatraman.]]
		+	[[Category: Marshall, J E.]]
		+	[[Category: Moody, P C.E.]]
		+	[[Category: Wallis, R.]]
		+	[[Category: Ccp domain]]
		+	[[Category: Complement c1]]
		+	[[Category: Cub domain]]
		+	[[Category: Hydrolase]]

OCA: Protected "4lot" [edit=sysop:move=sysop]

OCA — Wed, 24 Jul 2013 12:30:13 GMT

Protected "4lot" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:30, 24 July 2013

OCA: New page: '''Unreleased structure''' The entry 4lot is ON HOLD Authors: Wallis, R., Venkatraman Girija, U., Moody, P.C.E, Marshall, J.E Description: C1s CUB2-CCP1-CCP2

OCA — Wed, 24 Jul 2013 12:30:12 GMT

New page: '''Unreleased structure''' The entry 4lot is ON HOLD Authors: Wallis, R., Venkatraman Girija, U., Moody, P.C.E, Marshall, J.E Description: C1s CUB2-CCP1-CCP2

New page

'''Unreleased structure'''

The entry 4lot is ON HOLD

Authors: Wallis, R., Venkatraman Girija, U., Moody, P.C.E, Marshall, J.E

Description: C1s CUB2-CCP1-CCP2