4lq6 - Revision history

OCA at 11:19, 14 December 2022

OCA — Wed, 14 Dec 2022 11:19:01 GMT

←Older revision		Revision as of 11:19, 14 December 2022
Line 1:		Line 1:

	==Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis==		==Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis==
-	<StructureSection load='4lq6' size='340' side='right' caption='[[4lq6]], [[Resolution\|resolution]] 1.68Å' scene=''>	+	<StructureSection load='4lq6' size='340' side='right'caption='[[4lq6]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lq6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQ6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LQ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lq6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LQ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hjn\|4hjn]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lq6 OCA], [https://pdbe.org/4lq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lq6 RCSB], [https://www.ebi.ac.uk/pdbsum/4lq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lq6 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT3820, Rv3717 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4lq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lq6 OCA], [~~http~~://pdbe.org/4lq6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4lq6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4lq6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4lq6 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O69684_MYCTO O69684_MYCTO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dewangan, R P~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Kumar, A~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: ~~Kumar, D~~]]	+	[[Category: Dewangan RP]]
-	[[Category: Kumar~~, S~~]]	+	[[Category: Kumar A]]
-	[[Category: ~~Mishra, A~~]]	+	[[Category: Kumar D]]
-	[[Category: ~~Ramachandran,~~ S]]	+	[[Category: Kumar S]]
-	[[Category: ~~Shrivastava, P~~]]	+	[[Category: Mishra A]]
-	[[Category: ~~Taneja, B~~]]	+	[[Category: Ramachandran S]]
-	[[Category: ~~Amidase~~]]	+	[[Category: Shrivastava P]]
-	[[Category: ~~Cell wall hydrolase]]~~	+	[[Category: Taneja B]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 15:18, 11 August 2016

OCA — Thu, 11 Aug 2016 15:18:42 GMT

←Older revision		Revision as of 15:18, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis==		==Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis==
	<StructureSection load='4lq6' size='340' side='right' caption='[[4lq6]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='4lq6' size='340' side='right' caption='[[4lq6]], [[Resolution\|resolution]] 1.68Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hjn\|4hjn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hjn\|4hjn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT3820, Rv3717 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT3820, Rv3717 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lq6 RCSB], [http://www.ebi.ac.uk/pdbsum/4lq6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lq6 OCA], [http://pdbe.org/4lq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lq6 RCSB], [http://www.ebi.ac.uk/pdbsum/4lq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lq6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4lq6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:25, 5 January 2015

OCA — Mon, 05 Jan 2015 09:25:15 GMT

←Older revision		Revision as of 09:25, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4lq6\| PDB=4lq6 \| SCENE= }}~~	+	==Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis==
-	===Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis===	+	<StructureSection load='4lq6' size='340' side='right' caption='[[4lq6]], [[Resolution\|resolution]] 1.68Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24311595}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4lq6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LQ6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hjn\|4hjn]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT3820, Rv3717 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lq6 RCSB], [http://www.ebi.ac.uk/pdbsum/4lq6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial N-acetylmuramoyl-L-alanine amidases are cell-wall hydrolases that hydrolyze the bond between N-acetylmuramic acid and L-alanine in cell-wall glycopeptides. Rv3717 of Mycobacterium tuberculosis has been identified as a unique autolysin that lacks a cell-wall-binding domain (CBD) and its structure has been determined to 1.7 A resolution by the Pt-SAD phasing method. Rv3717 possesses an alpha/beta-fold and is a zinc-dependent hydrolase. The structure reveals a short flexible hairpin turn that partially occludes the active site and may be involved in autoregulation. This type of autoregulation of activity of PG hydrolases has been observed in Bartonella henselae amidase (AmiB) and may be a general mechanism used by some of the redundant amidases to regulate cell-wall hydrolase activity in bacteria. Rv3717 utilizes its net positive charge for substrate binding and exhibits activity towards a broad spectrum of substrate cell walls. The enzymatic activity of Rv3717 was confirmed by isolation and identification of its enzymatic products by LC/MS. These studies indicate that Rv3717, an N-acetylmuramoyl-L-alanine amidase from M. tuberculosis, represents a new family of lytic amidases that do not have a separate CBD and are regulated conformationally.

-	~~==About this Structure==~~	+	The structure of Rv3717 reveals a novel amidase from Mycobacterium tuberculosis.,Kumar A, Kumar S, Kumar D, Mishra A, Dewangan RP, Shrivastava P, Ramachandran S, Taneja B Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2543-54. doi:, 10.1107/S0907444913026371. Epub 2013 Nov 19. PMID:24311595<ref>PMID:24311595</ref>
-	~~[[4lq6]] is a 1 chain~~ structure ~~with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/"bacillus_tuberculosis"_~~(~~zopf_1883~~)~~_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4LQ6 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024311595</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Dewangan, R P.]]	+	== References ==
-	[[Category: Kumar, A.]]	+	<references/>
-	[[Category: Kumar, D.]]	+	__TOC__
-	[[Category: Kumar, S.]]	+	</StructureSection>
-	[[Category: Mishra, A.]]	+	[[Category: Dewangan, R P]]
-	[[Category: Ramachandran, S.]]	+	[[Category: Kumar, A]]
-	[[Category: Shrivastava, P.]]	+	[[Category: Kumar, D]]
-	[[Category: Taneja, B.]]	+	[[Category: Kumar, S]]
		+	[[Category: Mishra, A]]
		+	[[Category: Ramachandran, S]]
		+	[[Category: Shrivastava, P]]
		+	[[Category: Taneja, B]]
	[[Category: Amidase]]		[[Category: Amidase]]
	[[Category: Cell wall hydrolase]]		[[Category: Cell wall hydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 07:07, 15 January 2014

OCA — Wed, 15 Jan 2014 07:07:50 GMT

←Older revision		Revision as of 07:07, 15 January 2014
Line 1:		Line 1:
	{{STRUCTURE_4lq6\| PDB=4lq6 \| SCENE= }}		{{STRUCTURE_4lq6\| PDB=4lq6 \| SCENE= }}
	===Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis===		===Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis===
		+	{{ABSTRACT_PUBMED_24311595}}

	==About this Structure==		==About this Structure==
-	[[4lq6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQ6 OCA].	+	[[4lq6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQ6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024311595</ref><references group="xtra"/><references/>
	[[Category: Dewangan, R P.]]		[[Category: Dewangan, R P.]]
	[[Category: Kumar, A.]]		[[Category: Kumar, A.]]

OCA at 07:32, 4 December 2013

OCA — Wed, 04 Dec 2013 07:32:18 GMT

←Older revision		Revision as of 07:32, 4 December 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4lq6\| PDB=4lq6 \| SCENE= }}
		+	===Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis===

-	~~The entry~~ 4lq6 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4lq6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQ6 OCA].
-	~~Authors~~: Kumar, A., Kumar, S., Kumar, D., Mishra, A., ~~Dewangan, R~~.~~P.,~~ Shrivastava, P.~~, Ramachandran, S.,~~ Taneja, B.	+	[[Category: Dewangan, R P.]]
-		+	[[Category: Kumar, A.]]
-	~~Description~~: ~~Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis~~	+	[[Category: Kumar, D.]]
		+	[[Category: Kumar, S.]]
		+	[[Category: Mishra, A.]]
		+	[[Category: Ramachandran, S.]]
		+	[[Category: Shrivastava, P.]]
		+	[[Category: Taneja, B.]]
		+	[[Category: Amidase]]
		+	[[Category: Cell wall hydrolase]]
		+	[[Category: Hydrolase]]

OCA at 09:52, 4 September 2013

OCA — Wed, 04 Sep 2013 09:52:21 GMT

←Older revision		Revision as of 09:52, 4 September 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4lq6 is ON HOLD	+	The entry 4lq6 is ON HOLD until Paper Publication

	Authors: Kumar, A., Kumar, S., Kumar, D., Mishra, A., Dewangan, R.P., Shrivastava, P., Ramachandran, S., Taneja, B.		Authors: Kumar, A., Kumar, S., Kumar, D., Mishra, A., Dewangan, R.P., Shrivastava, P., Ramachandran, S., Taneja, B.

	Description: Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis		Description: Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis

OCA: Protected "4lq6" [edit=sysop:move=sysop]

OCA — Wed, 24 Jul 2013 12:32:01 GMT

Protected "4lq6" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:32, 24 July 2013

OCA: New page: '''Unreleased structure''' The entry 4lq6 is ON HOLD Authors: Kumar, A., Kumar, S., Kumar, D., Mishra, A., Dewangan, R.P., Shrivastava, P., Ramachandran, S., Taneja, B. Description: Cr...

OCA — Wed, 24 Jul 2013 12:31:59 GMT

New page: '''Unreleased structure''' The entry 4lq6 is ON HOLD Authors: Kumar, A., Kumar, S., Kumar, D., Mishra, A., Dewangan, R.P., Shrivastava, P., Ramachandran, S., Taneja, B. Description: Cr...

New page

'''Unreleased structure'''

The entry 4lq6 is ON HOLD

Authors: Kumar, A., Kumar, S., Kumar, D., Mishra, A., Dewangan, R.P., Shrivastava, P., Ramachandran, S., Taneja, B.

Description: Crystal structure of Rv3717 reveals a novel amidase from M. tuberculosis