4lrq - Revision history

OCA at 08:55, 20 March 2024

OCA — Wed, 20 Mar 2024 08:55:36 GMT

←Older revision		Revision as of 08:55, 20 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4lrq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O395 Vibrio cholerae O395]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4lrq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O395 Vibrio cholerae O395]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [https://pdbe.org/4lrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [https://www.ebi.ac.uk/pdbsum/4lrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [https://pdbe.org/4lrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [https://www.ebi.ac.uk/pdbsum/4lrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/A0A0H3ALA8_VIBC3 A0A0H3ALA8_VIBC3]		[https://www.uniprot.org/uniprot/A0A0H3ALA8_VIBC3 A0A0H3ALA8_VIBC3]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Low molecular weight protein tyrosine phosphatase (LMWPTP) is a group of phosphotyrosine phosphatase ubiquitously found in a wide range of organisms ranging from bacteria to mammals. Dimerization in the LMWPTP family has been reported earlier which follows a common mechanism involving active site residues leading to an enzymatically inactive species. Here we report a novel form of dimerization in a LMWPTP from Vibrio cholera 0395 (VcLMWPTP-1). Studies in solution reveal the existence of the dimer in solution while kinetic study depicts the active form of the enzyme. This indicates that the mode of dimerization in VcLMWPTP-1 is different from others where active site residues are not involved in the process. A high resolution (1.45A) crystal structure of VcLMWPTP-1 confirms a different mode of dimerization where the active site is catalytically accessible as evident by a tightly bound substrate mimicking ligand, MOPS at the active site pocket. Although being a member of a prokaryotic protein family, VcLMWPTP-1 structure resembles very closely to LMWPTP from a eukaryote, Entamoeba histolytica. It also delineates the diverse surface properties around the active site of the enzyme.
-
-	Atomic resolution crystal structure of VcLMWPTP-1 from Vibrio cholerae O395: Insights into a novel mode of dimerization in the low molecular weight protein tyrosine phosphatase family.,Nath S, Banerjee R, Sen U Biochem Biophys Res Commun. 2014 Jun 6. pii: S0006-291X(14)01018-3. doi:, 10.1016/j.bbrc.2014.05.129. PMID:24909685<ref>PMID:24909685</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4lrq" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:23, 14 December 2022

OCA — Wed, 14 Dec 2022 11:23:12 GMT

←Older revision		Revision as of 11:23, 14 December 2022
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	<StructureSection load='4lrq' size='340' side='right'caption='[[4lrq]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4lrq' size='340' side='right'caption='[[4lrq]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lrq]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Vibc3 Vibc3~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LRQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lrq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O395 Vibrio cholerae O395]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VC0395_A0559, VC395_1055 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=345073 VIBC3])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [https://pdbe.org/4lrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [https://www.ebi.ac.uk/pdbsum/4lrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrq ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [~~http~~://pdbe.org/4lrq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4lrq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3ALA8_VIBC3 A0A0H3ALA8_VIBC3]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Protein-tyrosine-phosphatase]]~~	+	[[Category: Vibrio cholerae O395]]
-	~~[[Category: Vibc3~~]]	+	[[Category: Banerjee R]]
-	[[Category: Banerjee, R]]	+	[[Category: Nath S]]
-	[[Category: Nath, S]]	+	[[Category: Sen U]]
-	[[Category: Sen, U]]	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 08:45, 3 April 2019

OCA — Wed, 03 Apr 2019 08:45:43 GMT

←Older revision		Revision as of 08:45, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from Vibrio choleraeO395==		==Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from Vibrio choleraeO395==
-	<StructureSection load='4lrq' size='340' side='right' caption='[[4lrq]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='4lrq' size='340' side='right'caption='[[4lrq]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lrq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LRQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lrq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibc3 Vibc3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LRQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VC0395_A0559, VC395_1055 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=345073 VIBC3])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [http://pdbe.org/4lrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [http://www.ebi.ac.uk/pdbsum/4lrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [http://pdbe.org/4lrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [http://www.ebi.ac.uk/pdbsum/4lrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrq ProSAT]</span></td></tr>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
		+	[[Category: Vibc3]]
	[[Category: Banerjee, R]]		[[Category: Banerjee, R]]
	[[Category: Nath, S]]		[[Category: Nath, S]]
	[[Category: Sen, U]]		[[Category: Sen, U]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 17:07, 22 March 2017

OCA — Wed, 22 Mar 2017 17:07:35 GMT

←Older revision		Revision as of 17:07, 22 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from Vibrio choleraeO395==		==Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from Vibrio choleraeO395==
	<StructureSection load='4lrq' size='340' side='right' caption='[[4lrq]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='4lrq' size='340' side='right' caption='[[4lrq]], [[Resolution\|resolution]] 1.45Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [http://www.ebi.ac.uk/pdbsum/4lrq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [http://pdbe.org/4lrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [http://www.ebi.ac.uk/pdbsum/4lrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4lrq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:17, 5 January 2015

OCA — Mon, 05 Jan 2015 09:17:22 GMT

←Older revision		Revision as of 09:17, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4lrq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LRQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4lrq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LRQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [http://www.ebi.ac.uk/pdbsum/4lrq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [http://www.ebi.ac.uk/pdbsum/4lrq PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
-	[[Category: Banerjee, R.]]	+	[[Category: Banerjee, R]]
-	[[Category: Nath, S.]]	+	[[Category: Nath, S]]
-	[[Category: Sen, U.]]	+	[[Category: Sen, U]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 08:34, 2 July 2014

OCA — Wed, 02 Jul 2014 08:34:16 GMT

←Older revision		Revision as of 08:34, 2 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from Vibrio choleraeO395==
		+	<StructureSection load='4lrq' size='340' side='right' caption='[[4lrq]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4lrq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LRQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lrq RCSB], [http://www.ebi.ac.uk/pdbsum/4lrq PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Low molecular weight protein tyrosine phosphatase (LMWPTP) is a group of phosphotyrosine phosphatase ubiquitously found in a wide range of organisms ranging from bacteria to mammals. Dimerization in the LMWPTP family has been reported earlier which follows a common mechanism involving active site residues leading to an enzymatically inactive species. Here we report a novel form of dimerization in a LMWPTP from Vibrio cholera 0395 (VcLMWPTP-1). Studies in solution reveal the existence of the dimer in solution while kinetic study depicts the active form of the enzyme. This indicates that the mode of dimerization in VcLMWPTP-1 is different from others where active site residues are not involved in the process. A high resolution (1.45A) crystal structure of VcLMWPTP-1 confirms a different mode of dimerization where the active site is catalytically accessible as evident by a tightly bound substrate mimicking ligand, MOPS at the active site pocket. Although being a member of a prokaryotic protein family, VcLMWPTP-1 structure resembles very closely to LMWPTP from a eukaryote, Entamoeba histolytica. It also delineates the diverse surface properties around the active site of the enzyme.

-	~~The entry 4lrq is ON HOLD until Paper Publication~~	+	Atomic resolution crystal structure of VcLMWPTP-1 from Vibrio cholerae O395: Insights into a novel mode of dimerization in the low molecular weight protein tyrosine phosphatase family.,Nath S, Banerjee R, Sen U Biochem Biophys Res Commun. 2014 Jun 6. pii: S0006-291X(14)01018-3. doi:, 10.1016/j.bbrc.2014.05.129. PMID:24909685<ref>PMID:24909685</ref>

-	~~Authors: Nath~~, S., Banerjee, R., Sen, U.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from Vibrio choleraeO395~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Protein-tyrosine-phosphatase]]
		+	[[Category: Banerjee, R.]]
		+	[[Category: Nath, S.]]
		+	[[Category: Sen, U.]]
		+	[[Category: Hydrolase]]

OCA at 07:52, 21 August 2013

OCA — Wed, 21 Aug 2013 07:52:02 GMT

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-	The entry 4lrq is ON HOLD	+	The entry 4lrq is ON HOLD until Paper Publication

	Authors: Nath, S., Banerjee, R., Sen, U.		Authors: Nath, S., Banerjee, R., Sen, U.

	Description: Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from Vibrio choleraeO395		Description: Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from Vibrio choleraeO395

OCA: Protected "4lrq" [edit=sysop:move=sysop]

OCA — Thu, 01 Aug 2013 04:20:59 GMT

Protected "4lrq" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:20, 1 August 2013

OCA: New page: '''Unreleased structure''' The entry 4lrq is ON HOLD Authors: Nath, S., Banerjee, R., Sen, U. Description: Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from ...

OCA — Thu, 01 Aug 2013 04:20:59 GMT

New page: '''Unreleased structure''' The entry 4lrq is ON HOLD Authors: Nath, S., Banerjee, R., Sen, U. Description: Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from ...

New page

'''Unreleased structure'''

The entry 4lrq is ON HOLD

Authors: Nath, S., Banerjee, R., Sen, U.

Description: Crystal structure of a Low Molecular Weight Phosphotyrosine phosphatase from Vibrio choleraeO395