4lvh - Revision history

OCA at 14:38, 8 November 2023

OCA — Wed, 08 Nov 2023 14:38:17 GMT

←Older revision		Revision as of 14:38, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4lvh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Korea/01/2009(H1N1)) Influenza A virus (A/Korea/01/2009(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4lvh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Korea/01/2009(H1N1)) Influenza A virus (A/Korea/01/2009(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvh OCA], [https://pdbe.org/4lvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvh RCSB], [https://www.ebi.ac.uk/pdbsum/4lvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvh OCA], [https://pdbe.org/4lvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvh RCSB], [https://www.ebi.ac.uk/pdbsum/4lvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvh ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:34, 21 December 2022

OCA — Wed, 21 Dec 2022 10:34:59 GMT

←Older revision		Revision as of 10:34, 21 December 2022
Line 3:		Line 3:
	<StructureSection load='4lvh' size='340' side='right'caption='[[4lvh]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4lvh' size='340' side='right'caption='[[4lvh]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lvh]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~korea~~/01/2009(~~h1n1~~)) Influenza a virus (a/~~korea~~/01/2009(~~h1n1~~))] and [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LVH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lvh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Korea/01/2009(H1N1)) Influenza A virus (A/Korea/01/2009(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eda\|4eda]], [[4f15\|4f15]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvh OCA], [https://pdbe.org/4lvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvh RCSB], [https://www.ebi.ac.uk/pdbsum/4lvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvh ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644289 Influenza A virus (A/Korea/01/2009(H1N1))])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4lvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvh OCA], [~~http~~://pdbe.org/4lvh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4lvh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4lvh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/C5MQE6_9INFA C5MQE6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]	+	[https://www.uniprot.org/uniprot/C5MQE6_9INFA C5MQE6_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 28:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Cho~~, K J~~]]	+	[[Category: Cho KJ]]
-	[[Category: Kim~~, K H~~]]	+	[[Category: Kim KH]]
-	[[Category: Kim, S]]	+	[[Category: Kim S]]
-	[[Category: Lee, J H]]	+	[[Category: Lee J-H]]
-	[[Category: Seok~~, J H]]~~	+	[[Category: Seok JH]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Influenza virus~~]]	+

OCA at 07:02, 4 March 2020

OCA — Wed, 04 Mar 2020 07:02:38 GMT

←Older revision		Revision as of 07:02, 4 March 2020
Line 1:		Line 1:

	==Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin==		==Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin==
-	<StructureSection load='4lvh' size='340' side='right' caption='[[4lvh]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4lvh' size='340' side='right'caption='[[4lvh]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4lvh]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/korea/01/2009(h1n1)) Influenza a virus (a/korea/01/2009(h1n1))] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LVH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4lvh]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/korea/01/2009(h1n1)) Influenza a virus (a/korea/01/2009(h1n1))] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LVH FirstGlance]. <br>
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Cho, K J]]		[[Category: Cho, K J]]

OCA at 09:44, 15 November 2017

OCA — Wed, 15 Nov 2017 09:44:04 GMT

←Older revision		Revision as of 09:44, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4lvh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4lvh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin\|Hemagglutinin]]
		+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:49, 4 August 2016

OCA — Thu, 04 Aug 2016 18:49:55 GMT

←Older revision		Revision as of 18:49, 4 August 2016
Line 1:		Line 1:
		+
	==Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin==		==Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin==
	<StructureSection load='4lvh' size='340' side='right' caption='[[4lvh]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4lvh' size='340' side='right' caption='[[4lvh]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eda\|4eda]], [[4f15\|4f15]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eda\|4eda]], [[4f15\|4f15]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644289 Influenza A virus (A/Korea/01/2009(H1N1))])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644289 Influenza A virus (A/Korea/01/2009(H1N1))])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lvh RCSB], [http://www.ebi.ac.uk/pdbsum/4lvh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvh OCA], [http://pdbe.org/4lvh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lvh RCSB], [http://www.ebi.ac.uk/pdbsum/4lvh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4lvh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:07, 25 December 2014

OCA — Thu, 25 Dec 2014 12:07:06 GMT

←Older revision		Revision as of 12:07, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4lvh\| PDB=4lvh \| SCENE= }}~~	+	==Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin==
-	===Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin===	+	<StructureSection load='4lvh' size='340' side='right' caption='[[4lvh]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24587046}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4lvh]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/korea/01/2009(h1n1)) Influenza a virus (a/korea/01/2009(h1n1))] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LVH FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4eda\|4eda]], [[4f15\|4f15]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644289 Influenza A virus (A/Korea/01/2009(H1N1))])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lvh RCSB], [http://www.ebi.ac.uk/pdbsum/4lvh PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/C5MQE6_9INFA C5MQE6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]		[[http://www.uniprot.org/uniprot/C5MQE6_9INFA C5MQE6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Influenza viruses continuously undergo antigenic changes with gradual accumulation of mutations in hemagglutinin (HA) that is a major determinant in subtype specificity. The identification of conserved epitopes within specific HA subtypes gives an important clue for developing new vaccines and diagnostics. We produced and characterized nine monoclonal antibodies that showed significant neutralizing activities against H1 subtype influenza viruses, and determined the complex structure of HA derived from a 2009 pandemic virus A/Korea/01/2009 (KR01) and the Fab fragment from H1-specific monoclonal antibody GC0587. The overall structure of the complex was essentially identical to the previously determined KR01 HA-Fab0757 complex structure. Both Fab0587 and Fab0757 recognize readily accessible head regions of HA, revealing broadly shared and conserved antigenic determinants among H1 subtypes. The beta-strands constituted by Ser110-Glu115 and Lys169-Lys170 form H1 epitopes with distinct conformations from those of H1 and H3 HA sites. In particular, Glu112, Glu115, Lys169, and Lys171 that are highly conserved among H1 subtype HAs have close contacts with HCDR3 and LCDR3. The differences between Fab0587 and Fab0757 complexes reside mainly in HCDR3 and LCDR3, providing distinct antigenic determinants specific for 1918 pdm influenza strain. Our results demonstrate a potential key neutralizing epitope important for H1 subtype specificity in influenza virus.

-	~~==About this Structure==~~	+	Insight into highly conserved h1 subtype-specific epitopes in influenza virus hemagglutinin.,Cho KJ, Hong KW, Kim SH, Seok JH, Kim S, Lee JH, Saelens X, Kim KH PLoS One. 2014 Feb 26;9(2):e89803. doi: 10.1371/journal.pone.0089803. eCollection, 2014. PMID:24587046<ref>PMID:24587046</ref>
-	~~[[4lvh]] is a 12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/ ] and [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4LVH OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024587046</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Cho, K J.]]	+	[[Category: Cho, K J]]
-	[[Category: Kim, K H.]]	+	[[Category: Kim, K H]]
-	[[Category: Kim, S.]]	+	[[Category: Kim, S]]
-	[[Category: Lee, J H.]]	+	[[Category: Lee, J H]]
-	[[Category: Seok, J H.]]	+	[[Category: Seok, J H]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Hemagglutinin]]		[[Category: Hemagglutinin]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Influenza virus]]		[[Category: Influenza virus]]

OCA at 06:26, 9 April 2014

OCA — Wed, 09 Apr 2014 06:26:39 GMT

←Older revision		Revision as of 06:26, 9 April 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4lvh\| PDB=4lvh \| SCENE= }}
		+	===Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin===
		+	{{ABSTRACT_PUBMED_24587046}}

-	~~The entry 4lvh is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/C5MQE6_9INFA C5MQE6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

-	~~Authors~~: ~~Kim, K~~.H.~~, Cho, K~~.J.~~, Kim, S~~.~~, Seok, J~~.H.~~, Lee, J~~.-H.	+	==About this Structure==
		+	[[4lvh]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVH OCA].

-	~~Description~~: ~~Insight into highly conserved H1 subtype-specific epitopes in influenza~~ virus ~~hemagglutinin~~	+	==Reference==
		+	<ref group="xtra">PMID:024587046</ref><references group="xtra"/><references/>
		+	[[Category: Mus musculus]]
		+	[[Category: Cho, K J.]]
		+	[[Category: Kim, K H.]]
		+	[[Category: Kim, S.]]
		+	[[Category: Lee, J H.]]
		+	[[Category: Seok, J H.]]
		+	[[Category: Antibody]]
		+	[[Category: Hemagglutinin]]
		+	[[Category: Immune system]]
		+	[[Category: Influenza virus]]

OCA at 07:52, 21 August 2013

OCA — Wed, 21 Aug 2013 07:52:59 GMT

←Older revision		Revision as of 07:52, 21 August 2013
Line 3:		Line 3:
	The entry 4lvh is ON HOLD		The entry 4lvh is ON HOLD

-	Authors: Kim, K.H., Cho, K.J., Kim, S., Seok, J.H., Lee, J-H	+	Authors: Kim, K.H., Cho, K.J., Kim, S., Seok, J.H., Lee, J.-H.

	Description: Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin		Description: Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin

OCA: Protected "4lvh" [edit=sysop:move=sysop]

OCA — Wed, 07 Aug 2013 20:16:25 GMT

Protected "4lvh" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:16, 7 August 2013

OCA: New page: '''Unreleased structure''' The entry 4lvh is ON HOLD Authors: Kim, K.H., Cho, K.J., Kim, S., Seok, J.H., Lee, J-H Description: Insight into highly conserved H1 subtype-specific epitope...

OCA — Wed, 07 Aug 2013 20:16:24 GMT

New page: '''Unreleased structure''' The entry 4lvh is ON HOLD Authors: Kim, K.H., Cho, K.J., Kim, S., Seok, J.H., Lee, J-H Description: Insight into highly conserved H1 subtype-specific epitope...

New page

'''Unreleased structure'''

The entry 4lvh is ON HOLD

Authors: Kim, K.H., Cho, K.J., Kim, S., Seok, J.H., Lee, J-H

Description: Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin