4lvo - Revision history

OCA at 16:26, 20 September 2023

OCA — Wed, 20 Sep 2023 16:26:57 GMT

←Older revision		Revision as of 16:26, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.26Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [https://pdbe.org/4lvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [https://www.ebi.ac.uk/pdbsum/4lvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [https://pdbe.org/4lvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [https://www.ebi.ac.uk/pdbsum/4lvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvo ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:35, 21 December 2022

OCA — Wed, 21 Dec 2022 10:35:36 GMT

←Older revision		Revision as of 10:35, 21 December 2022
Line 3:		Line 3:
	<StructureSection load='4lvo' size='340' side='right'caption='[[4lvo]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='4lvo' size='340' side='right'caption='[[4lvo]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [~~http~~://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4LVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LVO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sub-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [https://pdbe.org/4lvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [https://www.ebi.ac.uk/pdbsum/4lvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvo ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kexin Kexin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.61 3.4.21.61] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [~~http~~://pdbe.org/4lvo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4lvo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvo ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SUB1_PLAFA SUB1_PLAFA] Serine protease which plays an essential role in merozoite invasion of and egress from host erythrocytes by processing and activating various merozoite surface and parasitophorous vacuole proteins. Mediates the proteolytic maturation of serine proteases SERA4, SERA5 and SERA6 just prior to merozoite egress. Prior to merozoite egress, cleaves merozoite surface proteins MSP1, MSP6 and MSP7, which form the MSP1/6/7 complex, and thereby may prime the parasite cell surface for invasion of fresh erythrocytes. Prior to merozoite egress, cleaves MSRP2 converting it to MSRP2 p25 form, and RAP1 converting it to RAP1 p67 form.[UniProtKB:Q8I0V0]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Kexin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: ~~Plafa~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Blackman~~, M J~~]]	+	[[Category: Blackman MJ]]
-	[[Category: Withers-Martinez, C]]	+	[[Category: Withers-Martinez C]]
-	~~[[Category: Alpha beta]]~~	+
-	~~[[Category: Calcium ion]]~~	+
-	~~[[Category: Enzyme-prodomain complex]]~~	+
-	~~[[Category: Hydrolase-inhibitor-immune system complex]]~~	+
-	~~[[Category: Parasitophorous vacuole]]~~	+
-	~~[[Category: Prodomain]]~~	+
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 08:40, 3 April 2019

OCA — Wed, 03 Apr 2019 08:40:55 GMT

←Older revision		Revision as of 08:40, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex with added CaCl2==		==Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex with added CaCl2==
-	<StructureSection load='4lvo' size='340' side='right' caption='[[4lvo]], [[Resolution\|resolution]] 2.26Å' scene=''>	+	<StructureSection load='4lvo' size='340' side='right'caption='[[4lvo]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LVO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sub-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kexin Kexin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.61 3.4.21.61] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kexin Kexin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.61 3.4.21.61] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [http://pdbe.org/4lvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [http://www.ebi.ac.uk/pdbsum/4lvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [http://pdbe.org/4lvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [http://www.ebi.ac.uk/pdbsum/4lvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvo ProSAT]</span></td></tr>
Line 22:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Kexin]]		[[Category: Kexin]]
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
		+	[[Category: Plafa]]
	[[Category: Blackman, M J]]		[[Category: Blackman, M J]]
	[[Category: Withers-Martinez, C]]		[[Category: Withers-Martinez, C]]

OCA at 13:22, 11 August 2016

OCA — Thu, 11 Aug 2016 13:22:44 GMT

←Older revision		Revision as of 13:22, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex with added CaCl2==		==Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex with added CaCl2==
	<StructureSection load='4lvo' size='340' side='right' caption='[[4lvo]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='4lvo' size='340' side='right' caption='[[4lvo]], [[Resolution\|resolution]] 2.26Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kexin Kexin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.61 3.4.21.61] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kexin Kexin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.61 3.4.21.61] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [http://www.ebi.ac.uk/pdbsum/4lvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [http://pdbe.org/4lvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [http://www.ebi.ac.uk/pdbsum/4lvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lvo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4lvo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:14, 5 January 2015

OCA — Mon, 05 Jan 2015 09:14:05 GMT

←Older revision		Revision as of 09:14, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LVO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kexin Kexin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.61 3.4.21.61] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kexin Kexin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.61 3.4.21.61] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [http://www.ebi.ac.uk/pdbsum/4lvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [http://www.ebi.ac.uk/pdbsum/4lvo PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	[[Category: Kexin]]		[[Category: Kexin]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Blackman, M J.]]	+	[[Category: Blackman, M J]]
-	[[Category: Withers-Martinez, C.]]	+	[[Category: Withers-Martinez, C]]
	[[Category: Alpha beta]]		[[Category: Alpha beta]]
	[[Category: Calcium ion]]		[[Category: Calcium ion]]

OCA at 06:36, 11 June 2014

OCA — Wed, 11 Jun 2014 06:36:50 GMT

←Older revision		Revision as of 06:36, 11 June 2014
Line 2:		Line 2:
	<StructureSection load='4lvo' size='340' side='right' caption='[[4lvo]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='4lvo' size='340' side='right' caption='[[4lvo]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. <br>	+	<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LVO FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.~~2 2~~.7.1.2] </span></td></tr>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kexin Kexin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.61 3.4.21.61] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [http://www.ebi.ac.uk/pdbsum/4lvo PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [http://www.ebi.ac.uk/pdbsum/4lvo PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Malaria is caused by a protozoan parasite that replicates within an intraerythrocytic parasitophorous vacuole. Release (egress) of malaria merozoites from the host erythrocyte is a highly regulated and calcium-dependent event that is critical for disease progression. Minutes before egress, an essential parasite serine protease called SUB1 is discharged into the parasitophorous vacuole, where it proteolytically processes a subset of parasite proteins that play indispensable roles in egress and invasion. Here we report the first crystallographic structure of Plasmodium falciparum SUB1 at 2.25 A, in complex with its cognate prodomain. The structure highlights the basis of the calcium dependence of SUB1, as well as its unusual requirement for interactions with substrate residues on both prime and non-prime sides of the scissile bond. Importantly, the structure also reveals the presence of a solvent-exposed redox-sensitive disulphide bridge, unique among the subtilisin family, that likely acts as a regulator of protease activity in the parasite.
		+
		+	The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.,Withers-Martinez C, Strath M, Hackett F, Haire LF, Howell SA, Walker PA, Evangelos C, Dodson GG, Blackman MJ Nat Commun. 2014 May 2;5:3726. doi: 10.1038/ncomms4726. PMID:24785947<ref>PMID:24785947</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:20, 7 May 2014

OCA — Wed, 07 May 2014 08:20:36 GMT

←Older revision		Revision as of 08:20, 7 May 2014
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-	'''~~Unreleased structure~~'''	+	==Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex with added CaCl2==
-		+	<StructureSection load='4lvo' size='340' side='right' caption='[[4lvo]], [[Resolution\|resolution]] 2.26Å' scene=''>
-	~~The entry~~ 4lvo is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4lvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LVO OCA]. <br>
-	~~Authors~~: ~~Withers~~-~~Martinez~~, C., Blackman, M.J.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	~~Description~~: ~~Crystal structure of PfSUB1~~-prodomain-~~NIMP.M7 Fab~~ complex ~~with added CaCl2~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lvo RCSB], [http://www.ebi.ac.uk/pdbsum/4lvo PDBsum]</span></td></tr>
		+	<table>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kexin]]
		+	[[Category: Mus musculus]]
		+	[[Category: Blackman, M J.]]
		+	[[Category: Withers-Martinez, C.]]
		+	[[Category: Alpha beta]]
		+	[[Category: Calcium ion]]
		+	[[Category: Enzyme-prodomain complex]]
		+	[[Category: Hydrolase-inhibitor-immune system complex]]
		+	[[Category: Parasitophorous vacuole]]
		+	[[Category: Prodomain]]
		+	[[Category: Rossmann fold]]
		+	[[Category: Serine protease]]

OCA: Protected "4lvo" [edit=sysop:move=sysop]

OCA — Wed, 07 Aug 2013 20:16:46 GMT

Protected "4lvo" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:16, 7 August 2013

OCA: New page: '''Unreleased structure''' The entry 4lvo is ON HOLD until Paper Publication Authors: Withers-Martinez, C., Blackman, M.J. Description: Crystal structure of PfSUB1-prodomain-NIMP.M7 Fa...

OCA — Wed, 07 Aug 2013 20:16:45 GMT

New page: '''Unreleased structure''' The entry 4lvo is ON HOLD until Paper Publication Authors: Withers-Martinez, C., Blackman, M.J. Description: Crystal structure of PfSUB1-prodomain-NIMP.M7 Fa...

New page

'''Unreleased structure'''

The entry 4lvo is ON HOLD until Paper Publication

Authors: Withers-Martinez, C., Blackman, M.J.

Description: Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex with added CaCl2