4m1j - Revision history

OCA at 10:46, 21 December 2022

OCA — Wed, 21 Dec 2022 10:46:56 GMT

←Older revision		Revision as of 10:46, 21 December 2022
Line 1:		Line 1:

	==Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue==		==Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue==
-	<StructureSection load='4m1j' size='340' side='right' caption='[[4m1j]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4m1j' size='340' side='right'caption='[[4m1j]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m1j]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4M1J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M1J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B0S:TRIDECYLBORONIC+ACID'>B0S</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B0S:TRIDECYLBORONIC+ACID'>B0S</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA2385, pvdQ, qsc112 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885]), pvdQ, qsc112, PA2385 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1j OCA], [https://pdbe.org/4m1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m1j RCSB], [https://www.ebi.ac.uk/pdbsum/4m1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m1j ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyl-homoserine-lactone_acylase Acyl-homoserine-lactone acylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.97 3.5.1.97] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4m1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1j OCA], [~~http~~://pdbe.org/4m1j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4m1j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4m1j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4m1j ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref>	+	[https://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acyl-homoserine-lactone acylase~~]]	+	[[Category: Large Structures]]
-	[[Category: Clevenger, K]]	+	[[Category: Pseudomonas aeruginosa]]
-	[[Category: Er, J]]	+	[[Category: Clevenger K]]
-	[[Category: Fast~~, W L~~]]	+	[[Category: Er J]]
-	[[Category: Liu, D]]	+	[[Category: Fast WL]]
-	[[Category: Wu, R]]	+	[[Category: Liu D]]
-	~~[[Category: Acylase]]~~	+	[[Category: Wu R]]
-	~~[[Category: Boronic acid]]~~	+
-	~~[[Category: Heterodimer]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Transition state analogue~~]]	+

OCA at 09:02, 4 August 2016

OCA — Thu, 04 Aug 2016 09:02:05 GMT

←Older revision		Revision as of 09:02, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue==		==Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue==
	<StructureSection load='4m1j' size='340' side='right' caption='[[4m1j]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4m1j' size='340' side='right' caption='[[4m1j]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa Pseudomonas aeruginosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M1J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M1J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B0S:TRIDECYLBORONIC+ACID'>B0S</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B0S:TRIDECYLBORONIC+ACID'>B0S</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA2385, pvdQ, qsc112 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 ~~Pseudomonas aeruginosa~~]), pvdQ, qsc112, PA2385 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 ~~Pseudomonas aeruginosa~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA2385, pvdQ, qsc112 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885]), pvdQ, qsc112, PA2385 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyl-homoserine-lactone_acylase Acyl-homoserine-lactone acylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.97 3.5.1.97] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyl-homoserine-lactone_acylase Acyl-homoserine-lactone acylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.97 3.5.1.97] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m1j RCSB], [http://www.ebi.ac.uk/pdbsum/4m1j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1j OCA], [http://pdbe.org/4m1j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m1j RCSB], [http://www.ebi.ac.uk/pdbsum/4m1j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m1j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4m1j" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Acyl-homoserine-lactone acylase]]		[[Category: Acyl-homoserine-lactone acylase]]
-	[[Category: Pseudomonas aeruginosa]]
	[[Category: Clevenger, K]]		[[Category: Clevenger, K]]
	[[Category: Er, J]]		[[Category: Er, J]]

OCA at 07:37, 25 December 2014

OCA — Thu, 25 Dec 2014 07:37:47 GMT

←Older revision		Revision as of 07:37, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m1j RCSB], [http://www.ebi.ac.uk/pdbsum/4m1j PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m1j RCSB], [http://www.ebi.ac.uk/pdbsum/4m1j PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:22, 21 December 2014

OCA — Sun, 21 Dec 2014 15:22:11 GMT

←Older revision		Revision as of 15:22, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4m1j\| PDB=4m1j \| SCENE= }}~~	+	==Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue==
-	===Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue===	+	<StructureSection load='4m1j' size='340' side='right' caption='[[4m1j]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23883096}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4m1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M1J FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B0S:TRIDECYLBORONIC+ACID'>B0S</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA2385, pvdQ, qsc112 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa]), pvdQ, qsc112, PA2385 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyl-homoserine-lactone_acylase Acyl-homoserine-lactone acylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.97 3.5.1.97] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m1j RCSB], [http://www.ebi.ac.uk/pdbsum/4m1j PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Pseudomonas aeruginosa enzyme PvdQ can process different substrates involved in quorum-sensing or in siderophore biosynthesis. Substrate selectivity was evaluated using steady-state kinetic constants for hydrolysis of N-acyl-homoserine lactones (HSLs) and p-nitrophenyl fatty acid esters. PvdQ prefers substrates with alkyl chains between 12 and 14 carbons long that do not bear a 3-oxo substitution and is revealed here to have a relatively high specificity constant for selected N-acyl-HSLs (kcat/KM = 105 to 106 M-1 s-1). However, endogenous P. aeruginosa N-acyl-HSLs are >/=100-fold disfavored, supporting the conclusion that PvdQ was not primarily evolved to regulate endogenous quorum-sensing. PvdQ plays an essential biosynthetic role for the siderophore pyoverdine, on which P. aeruginosa depends for growth in iron-limited environments. A series of alkylboronate inhibitors was found to be reversible, competitive, and extremely potent (Ki >/= 190 pM). A 1.8 A X-ray structure shows that 1-tridecylboronic acid forms a monocovalent bond with the N-terminal beta-chain Ser residue in the PvdQ heterodimer, mimicking a reaction transition state. This boronic acid inhibits growth of P. aeruginosa in iron-limited media, reproducing the phenotype of a genetic pvdQ disruption, although co-administration of an efflux pump inhibitor is required to maintain growth inhibition. These findings support the strategy of designing boron-based inhibitors of siderophore biosynthetic enzymes to control P. aeruginosa infections.

-	~~==Function==~~	+	Rational Design of a Transition State Analogue with Picomolar Affinity for Pseudomonas aeruginosa PvdQ, a Siderophore Biosynthetic Enzyme.,Clevenger KD, Wu R, Er JA, Liu D, Fast W ACS Chem Biol. 2013 Aug 6. PMID:23883096<ref>PMID:23883096</ref>
-	~~[[http://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation~~ of ~~acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses~~ a ~~specificity~~ for ~~the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.~~aeruginosa, ~~and thereby functions as~~ a ~~quorum quencher, inhibiting the las quorum-sensing system~~. ~~Therefore~~, ~~may enable P~~.~~aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential~~. ~~Also appears to be required for pyoverdin biosynthesis.<ref>~~PMID:~~16495538</ref> <ref>PMID:14532048</ref>~~ <ref>PMID:~~12686626~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4m1j]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4M1J OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023883096</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Acyl-homoserine-lactone acylase]]		[[Category: Acyl-homoserine-lactone acylase]]
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
-	[[Category: Clevenger, K.]]	+	[[Category: Clevenger, K]]
-	[[Category: Er, J.]]	+	[[Category: Er, J]]
-	[[Category: Fast, W L.]]	+	[[Category: Fast, W L]]
-	[[Category: Liu, D.]]	+	[[Category: Liu, D]]
-	[[Category: Wu, R.]]	+	[[Category: Wu, R]]
	[[Category: Acylase]]		[[Category: Acylase]]
	[[Category: Boronic acid]]		[[Category: Boronic acid]]

OCA at 07:33, 28 August 2013

OCA — Wed, 28 Aug 2013 07:33:38 GMT

←Older revision		Revision as of 07:33, 28 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4m1j\| PDB=4m1j \| SCENE= }}
		+	===Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue===
		+	{{ABSTRACT_PUBMED_23883096}}

-	~~The entry 4m1j is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref>

-	~~Authors~~: ~~Wu, R~~.~~, Clevenger, K~~.~~, Er, J~~.~~, Fast, W~~.L.~~, Liu, D~~.	+	==About this Structure==
		+	[[4m1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1J OCA].

-	~~Description~~: ~~Crystal structure of~~ Pseudomonas aeruginosa ~~PvdQ in complex with a transition~~ state analogue	+	==Reference==
		+	<ref group="xtra">PMID:023883096</ref><references group="xtra"/><references/>
		+	[[Category: Acyl-homoserine-lactone acylase]]
		+	[[Category: Pseudomonas aeruginosa]]
		+	[[Category: Clevenger, K.]]
		+	[[Category: Er, J.]]
		+	[[Category: Fast, W L.]]
		+	[[Category: Liu, D.]]
		+	[[Category: Wu, R.]]
		+	[[Category: Acylase]]
		+	[[Category: Boronic acid]]
		+	[[Category: Heterodimer]]
		+	[[Category: Hydrolase]]
		+	[[Category: Secreted]]
		+	[[Category: Transition state analogue]]

OCA at 07:54, 21 August 2013

OCA — Wed, 21 Aug 2013 07:54:17 GMT

←Older revision		Revision as of 07:54, 21 August 2013
Line 3:		Line 3:
	The entry 4m1j is ON HOLD		The entry 4m1j is ON HOLD

-	Authors: ~~Rui~~ Wu, ~~Kenneth~~ Clevenger, ~~Joyce~~ Er, ~~Walter L~~. Fast, ~~Dali~~ Liu	+	Authors: Wu, R., Clevenger, K., Er, J., Fast, W.L., Liu, D.

	Description: Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue		Description: Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue

OCA: Protected "4m1j" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2013 07:22:07 GMT

Protected "4m1j" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:22, 14 August 2013

OCA: New page: '''Unreleased structure''' The entry 4m1j is ON HOLD Authors: Rui Wu, Kenneth Clevenger, Joyce Er, Walter L. Fast, Dali Liu Description: Crystal structure of Pseudomonas aeruginosa Pvd...

OCA — Wed, 14 Aug 2013 07:22:07 GMT

New page: '''Unreleased structure''' The entry 4m1j is ON HOLD Authors: Rui Wu, Kenneth Clevenger, Joyce Er, Walter L. Fast, Dali Liu Description: Crystal structure of Pseudomonas aeruginosa Pvd...

New page

'''Unreleased structure'''

The entry 4m1j is ON HOLD

Authors: Rui Wu, Kenneth Clevenger, Joyce Er, Walter L. Fast, Dali Liu

Description: Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue