4m44 - Revision history

OCA at 10:53, 21 December 2022

OCA — Wed, 21 Dec 2022 10:53:33 GMT

←Older revision		Revision as of 10:53, 21 December 2022
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	==Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa==		==Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa==
-	<StructureSection load='4m44' size='340' side='right' caption='[[4m44]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4m44' size='340' side='right'caption='[[4m44]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m44]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Influenza_b_virus_~~(b/~~yamanashi~~/166/1998) Influenza b virus (b/~~yamanashi~~/166/1998)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M44 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4M44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m44]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Yamanashi/166/1998) Influenza B virus (B/Yamanashi/166/1998)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M44 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m44 OCA], [https://pdbe.org/4m44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m44 RCSB], [https://www.ebi.ac.uk/pdbsum/4m44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m44 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4m40\|4m40]]</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=416659 Influenza B virus (B/Yamanashi/166/1998)])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4m44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m44 OCA], [~~http~~://pdbe.org/4m44 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4m44 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4m44 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4m44 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/A3DQM7_9INFB A3DQM7_9INFB]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324]	+	[https://www.uniprot.org/uniprot/A3DQM7_9INFB A3DQM7_9INFB] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Kondrashkina, E~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ni, F~~]]	+	[[Category: Kondrashkina E]]
-	[[Category: ~~Wang, Q~~]]	+	[[Category: Ni F]]
-	[[Category: ~~Fusion]]~~	+	[[Category: Wang Q]]
-	~~[[Category: Receptor binding]]~~	+
-	~~[[Category: Sialic acid]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 01:36, 5 August 2016

OCA — Fri, 05 Aug 2016 01:36:20 GMT

←Older revision		Revision as of 01:36, 5 August 2016
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		+
	==Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa==		==Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa==
	<StructureSection load='4m44' size='340' side='right' caption='[[4m44]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4m44' size='340' side='right' caption='[[4m44]], [[Resolution\|resolution]] 2.50Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4m40\|4m40]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4m40\|4m40]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=416659 Influenza B virus (B/Yamanashi/166/1998)])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=416659 Influenza B virus (B/Yamanashi/166/1998)])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m44 RCSB], [http://www.ebi.ac.uk/pdbsum/4m44 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m44 OCA], [http://pdbe.org/4m44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m44 RCSB], [http://www.ebi.ac.uk/pdbsum/4m44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m44 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A3DQM7_9INFB A3DQM7_9INFB]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4m44" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:14, 21 December 2014

OCA — Sun, 21 Dec 2014 15:14:56 GMT

←Older revision		Revision as of 15:14, 21 December 2014
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-	~~{{STRUCTURE_4m44\| PDB=4m44 \| SCENE= }}~~	+	==Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa==
-	===Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa===	+	<StructureSection load='4m44' size='340' side='right' caption='[[4m44]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24074573}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4m44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/yamanashi/166/1998) Influenza b virus (b/yamanashi/166/1998)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M44 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4m40\|4m40]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=416659 Influenza B virus (B/Yamanashi/166/1998)])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m44 RCSB], [http://www.ebi.ac.uk/pdbsum/4m44 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Influenza A and B viruses are responsible for the severe morbidity and mortality worldwide in annual influenza epidemics. Currently circulating influenza B virus belongs to the B/Victoria or B/Yamagata lineage that was diverged from each other about 30-40 years ago. However, a mechanistic understanding of their divergent evolution is still lacking. Here we report the crystal structures of influenza B/Yamanashi/166/1998 hemagglutinin (HA) belonging to B/Yamagata lineage and its complex with the avian-like receptor analogue. Comparison of these structures with those of undiverged and diverged influenza B virus HAs, in conjunction with sequence analysis, reveals the molecular basis for the divergent evolution of influenza B virus HAs. Furthermore, HAs of diverged influenza B virus strains display much stronger molecular interactions with terminal sialic acid of bound receptors, which may allow for a different tissue tropism for current influenza B viruses, for which further investigation is required.

-	~~==About this Structure==~~	+	Structural basis for the divergent evolution of influenza B virus hemagglutinin.,Ni F, Kondrashkina E, Wang Q Virology. 2013 Nov;446(1-2):112-22. doi: 10.1016/j.virol.2013.07.035. Epub 2013, Aug 27. PMID:24074573<ref>PMID:24074573</ref>
-	~~[[4m44]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Influenza_b_virus_~~(~~b/yamanashi/166/1998~~) ~~Influenza b virus (b/yamanashi/166/1998)]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4M44 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:024074573</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Kondrashkina, E.]]	+
-	[[Category: Ni, F.]]	+	==See Also==
-	[[Category: Wang, Q.]]	+	*[[Hemagglutinin\|Hemagglutinin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kondrashkina, E]]
		+	[[Category: Ni, F]]
		+	[[Category: Wang, Q]]
	[[Category: Fusion]]		[[Category: Fusion]]
	[[Category: Receptor binding]]		[[Category: Receptor binding]]
	[[Category: Sialic acid]]		[[Category: Sialic acid]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 04:52, 10 October 2013

OCA — Thu, 10 Oct 2013 04:52:31 GMT

←Older revision		Revision as of 04:52, 10 October 2013
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	{{STRUCTURE_4m44\| PDB=4m44 \| SCENE= }}		{{STRUCTURE_4m44\| PDB=4m44 \| SCENE= }}
	===Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa===		===Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa===
		+	{{ABSTRACT_PUBMED_24074573}}

	==About this Structure==		==About this Structure==
	[[4m44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/yamanashi/166/1998) Influenza b virus (b/yamanashi/166/1998)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M44 OCA].		[[4m44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/yamanashi/166/1998) Influenza b virus (b/yamanashi/166/1998)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M44 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024074573</ref><references group="xtra"/><references/>
	[[Category: Kondrashkina, E.]]		[[Category: Kondrashkina, E.]]
	[[Category: Ni, F.]]		[[Category: Ni, F.]]

OCA at 08:20, 29 September 2013

OCA — Sun, 29 Sep 2013 08:20:52 GMT

←Older revision		Revision as of 08:20, 29 September 2013
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4m44\| PDB=4m44 \| SCENE= }}
		+	===Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa===

-	~~The entry~~ 4m44 is ~~ON HOLD~~	+	==About this Structure==
-		+	[[4m44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/yamanashi/166/1998) Influenza b virus (b/yamanashi/166/1998)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M44 OCA].
-	~~Authors~~: ~~Ni, F~~., Kondrashkina, E., Wang, Q.	+	[[Category: Kondrashkina, E.]]
-		+	[[Category: Ni, F.]]
-	~~Description~~: ~~Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa~~	+	[[Category: Wang, Q.]]
		+	[[Category: Fusion]]
		+	[[Category: Receptor binding]]
		+	[[Category: Sialic acid]]
		+	[[Category: Viral protein]]

OCA at 07:55, 21 August 2013

OCA — Wed, 21 Aug 2013 07:55:18 GMT

←Older revision		Revision as of 07:55, 21 August 2013
Line 3:		Line 3:
	The entry 4m44 is ON HOLD		The entry 4m44 is ON HOLD

-	Authors: ~~Fengyun~~ Ni, ~~Elena~~ Kondrashkina, ~~Qinghua~~ Wang	+	Authors: Ni, F., Kondrashkina, E., Wang, Q.

	Description: Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa		Description: Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa

OCA: Protected "4m44" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2013 07:25:37 GMT

Protected "4m44" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:25, 14 August 2013

OCA: New page: '''Unreleased structure''' The entry 4m44 is ON HOLD Authors: Fengyun Ni, Elena Kondrashkina, Qinghua Wang Description: Crystal structure of hemagglutinin of influenza virus B/Yamanash...

OCA — Wed, 14 Aug 2013 07:25:36 GMT

New page: '''Unreleased structure''' The entry 4m44 is ON HOLD Authors: Fengyun Ni, Elena Kondrashkina, Qinghua Wang Description: Crystal structure of hemagglutinin of influenza virus B/Yamanash...

New page

'''Unreleased structure'''

The entry 4m44 is ON HOLD

Authors: Fengyun Ni, Elena Kondrashkina, Qinghua Wang

Description: Crystal structure of hemagglutinin of influenza virus B/Yamanashi/166/1998 in complex with avian-like receptor LSTa