4m49 - Revision history

OCA at 16:31, 20 September 2023

OCA — Wed, 20 Sep 2023 16:31:33 GMT

←Older revision		Revision as of 16:31, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4m49]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M49 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4m49]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M49 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22Y:3-(5-AMINO-6-{[(1R)-1-PHENYLETHYL]AMINO}PYRAZIN-2-YL)-4-CHLOROBENZOIC+ACID'>22Y</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.052Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22Y:3-(5-AMINO-6-{[(1R)-1-PHENYLETHYL]AMINO}PYRAZIN-2-YL)-4-CHLOROBENZOIC+ACID'>22Y</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m49 OCA], [https://pdbe.org/4m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m49 RCSB], [https://www.ebi.ac.uk/pdbsum/4m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m49 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m49 OCA], [https://pdbe.org/4m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m49 RCSB], [https://www.ebi.ac.uk/pdbsum/4m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m49 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:54, 21 December 2022

OCA — Wed, 21 Dec 2022 10:54:08 GMT

←Older revision		Revision as of 10:54, 21 December 2022
Line 1:		Line 1:

	==Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18==		==Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18==
-	<StructureSection load='4m49' size='340' side='right' caption='[[4m49]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4m49' size='340' side='right'caption='[[4m49]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m49]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4M49 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m49]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M49 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=22Y:3-(5-AMINO-6-{[(1R)-1-PHENYLETHYL]AMINO}PYRAZIN-2-YL)-4-CHLOROBENZOIC+ACID'>22Y</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22Y:3-(5-AMINO-6-{[(1R)-1-PHENYLETHYL]AMINO}PYRAZIN-2-YL)-4-CHLOROBENZOIC+ACID'>22Y</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jnk\|4jnk]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m49 OCA], [https://pdbe.org/4m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m49 RCSB], [https://www.ebi.ac.uk/pdbsum/4m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m49 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m49 OCA], [~~http~~://pdbe.org/4m49 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4m49 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4m49 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4m49 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[~~http~~://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>	+	[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[https://omim.org/entry/612933 612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:

	==See Also==		==See Also==
-	*[[Lactate ~~Dehydrogenase~~\|Lactate ~~Dehydrogenase~~]]	+	*[[Lactate dehydrogenase 3D structures\|Lactate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~L-lactate dehydrogenase~~]]	+	[[Category: Large Structures]]
-	[[Category: Eigenbrot, C]]	+	[[Category: Eigenbrot C]]
-	[[Category: Ultsch, M]]	+	[[Category: Ultsch M]]
-	~~[[Category: Dehydrogenase/reductase]]~~	+
-	~~[[Category: Nicotinamide adenine dinucleotide nadh]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 22:00, 5 August 2016

OCA — Fri, 05 Aug 2016 22:00:25 GMT

←Older revision		Revision as of 22:00, 5 August 2016
Line 1:		Line 1:
		+
	==Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18==		==Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18==
	<StructureSection load='4m49' size='340' side='right' caption='[[4m49]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4m49' size='340' side='right' caption='[[4m49]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m49]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M49 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m49]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M49 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=22Y:3-(5-AMINO-6-{[(1R)-1-PHENYLETHYL]AMINO}PYRAZIN-2-YL)-4-CHLOROBENZOIC+ACID'>22Y</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=22Y:3-(5-AMINO-6-{[(1R)-1-PHENYLETHYL]AMINO}PYRAZIN-2-YL)-4-CHLOROBENZOIC+ACID'>22Y</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jnk\|4jnk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jnk\|4jnk]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m49 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m49 RCSB], [http://www.ebi.ac.uk/pdbsum/4m49 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m49 OCA], [http://pdbe.org/4m49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m49 RCSB], [http://www.ebi.ac.uk/pdbsum/4m49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m49 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4m49" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Eigenbrot, C]]		[[Category: Eigenbrot, C]]

OCA at 06:11, 25 December 2014

OCA — Thu, 25 Dec 2014 06:11:56 GMT

←Older revision		Revision as of 06:11, 25 December 2014
Line 11:		Line 11:
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>		[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
-	== Function ==
-
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:59, 21 December 2014

OCA — Sun, 21 Dec 2014 14:59:07 GMT

←Older revision		Revision as of 14:59, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4m49\| PDB=4m49 \| SCENE= }}~~	+	==Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18==
-	===Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18===	+	<StructureSection load='4m49' size='340' side='right' caption='[[4m49]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	{~~{ABSTRACT_PUBMED_24012183}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4m49]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M49 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=22Y:3-(5-AMINO-6-{[(1R)-1-PHENYLETHYL]AMINO}PYRAZIN-2-YL)-4-CHLOROBENZOIC+ACID'>22Y</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jnk\|4jnk]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m49 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m49 RCSB], [http://www.ebi.ac.uk/pdbsum/4m49 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>		[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
		+	== Function ==
		+
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A 2-amino-5-aryl-pyrazine was identified as an inhibitor of human lactate dehydrogenase A (LDHA) via a biochemical screening campaign. Biochemical and biophysical experiments demonstrated that the compound specifically interacted with human LDHA. Structural variation of the screening hit resulted in improvements in LDHA biochemical inhibition and pharmacokinetic properties. A crystal structure of an improved compound bound to human LDHA was also obtained and it explained many of the observed structure-activity relationships.
		+
		+	Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.,Fauber BP, Dragovich PS, Chen J, Corson LB, Ding CZ, Eigenbrot C, Giannetti AM, Hunsaker T, Labadie S, Liu Y, Liu Y, Malek S, Peterson D, Pitts K, Sideris S, Ultsch M, Vanderporten E, Wang J, Wei B, Yen I, Yue Q Bioorg Med Chem Lett. 2013 Oct 15;23(20):5533-9. doi: 10.1016/j.bmcl.2013.08.060., Epub 2013 Aug 22. PMID:24012183<ref>PMID:24012183</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4m49]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024012183</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Lactate Dehydrogenase\|Lactate Dehydrogenase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
-	[[Category: Eigenbrot, C.]]	+	[[Category: Eigenbrot, C]]
-	[[Category: Ultsch, M.]]	+	[[Category: Ultsch, M]]
	[[Category: Dehydrogenase/reductase]]		[[Category: Dehydrogenase/reductase]]
	[[Category: Nicotinamide adenine dinucleotide nadh]]		[[Category: Nicotinamide adenine dinucleotide nadh]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 05:59, 2 October 2013

OCA — Wed, 02 Oct 2013 05:59:01 GMT

←Older revision		Revision as of 05:59, 2 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4m49\| PDB=4m49 \| SCENE= }}		{{STRUCTURE_4m49\| PDB=4m49 \| SCENE= }}
	===Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18===		===Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18===
		+	{{ABSTRACT_PUBMED_24012183}}

	==Disease==		==Disease==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024012183</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]

OCA at 11:02, 4 September 2013

OCA — Wed, 04 Sep 2013 11:02:08 GMT

←Older revision		Revision as of 11:02, 4 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4m49\| PDB=4m49 \| SCENE= }}
		+	===Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18===

-	~~The~~ entry ~~4m49 is ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>

-	~~Authors~~: ~~Eigenbrot, C~~.~~, Ultsch, M~~.	+	==About this Structure==
		+	[[4m49]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA].

-	~~Description~~: ~~Lactate~~ Dehydrogenase ~~A in complex with a substituted pyrazine~~ inhibitor ~~compound 18~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: L-lactate dehydrogenase]]
		+	[[Category: Eigenbrot, C.]]
		+	[[Category: Ultsch, M.]]
		+	[[Category: Dehydrogenase/reductase]]
		+	[[Category: Nicotinamide adenine dinucleotide nadh]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA: Protected "4m49" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2013 07:25:49 GMT

Protected "4m49" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:25, 14 August 2013

OCA: New page: '''Unreleased structure''' The entry 4m49 is ON HOLD Authors: Eigenbrot, C., Ultsch, M. Description: Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 1...

OCA — Wed, 14 Aug 2013 07:25:48 GMT

New page: '''Unreleased structure''' The entry 4m49 is ON HOLD Authors: Eigenbrot, C., Ultsch, M. Description: Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 1...

New page

'''Unreleased structure'''

The entry 4m49 is ON HOLD

Authors: Eigenbrot, C., Ultsch, M.

Description: Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18