4m4z - Revision history

OCA at 16:32, 20 September 2023

OCA — Wed, 20 Sep 2023 16:32:04 GMT

←Older revision		Revision as of 16:32, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4m4z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[4m4z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4z OCA], [https://pdbe.org/4m4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4z RCSB], [https://www.ebi.ac.uk/pdbsum/4m4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4z ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4z OCA], [https://pdbe.org/4m4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4z RCSB], [https://www.ebi.ac.uk/pdbsum/4m4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:56, 21 December 2022

OCA — Wed, 21 Dec 2022 10:56:09 GMT

←Older revision		Revision as of 10:56, 21 December 2022
Line 1:		Line 1:

	==SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)==		==SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)==
-	<StructureSection load='4m4z' size='340' side='right' caption='[[4m4z]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4m4z' size='340' side='right'caption='[[4m4z]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m4z]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4M4Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m4z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4Z FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf156, SLA2, SLAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4z OCA], [https://pdbe.org/4m4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4z RCSB], [https://www.ebi.ac.uk/pdbsum/4m4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4z ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4m4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4z OCA], [~~http~~://pdbe.org/4m4z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4m4z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4m4z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4z ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SLAP2_HUMAN SLAP2_HUMAN]] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.	+	[https://www.uniprot.org/uniprot/SLAP2_HUMAN SLAP2_HUMAN] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~McGlade, C J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Wybenga-Groot, L E~~]]	+	[[Category: McGlade CJ]]
-	[[Category: ~~Adaptor]]~~	+	[[Category: Wybenga-Groot LE]]
-	~~[[Category: Sh3 and sh2 domain]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 08:09, 4 August 2016

OCA — Thu, 04 Aug 2016 08:09:58 GMT

←Older revision		Revision as of 08:09, 4 August 2016
Line 1:		Line 1:
		+
	==SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)==		==SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)==
	<StructureSection load='4m4z' size='340' side='right' caption='[[4m4z]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4m4z' size='340' side='right' caption='[[4m4z]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M4Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M4Z FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf156, SLA2, SLAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf156, SLA2, SLAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m4z RCSB], [http://www.ebi.ac.uk/pdbsum/4m4z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4z OCA], [http://pdbe.org/4m4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m4z RCSB], [http://www.ebi.ac.uk/pdbsum/4m4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4m4z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: McGlade, C J]]		[[Category: McGlade, C J]]
	[[Category: Wybenga-Groot, L E]]		[[Category: Wybenga-Groot, L E]]

OCA at 07:13, 25 December 2014

OCA — Thu, 25 Dec 2014 07:13:26 GMT

←Older revision		Revision as of 07:13, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m4z RCSB], [http://www.ebi.ac.uk/pdbsum/4m4z PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m4z RCSB], [http://www.ebi.ac.uk/pdbsum/4m4z PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SLAP2_HUMAN SLAP2_HUMAN]] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:57, 21 December 2014

OCA — Sun, 21 Dec 2014 14:57:42 GMT

←Older revision		Revision as of 14:57, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4m4z\| PDB=4m4z \| SCENE= }}~~	+	==SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)==
-	===SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)===	+	<StructureSection load='4m4z' size='340' side='right' caption='[[4m4z]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24018043}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4m4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M4Z FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C20orf156, SLA2, SLAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m4z RCSB], [http://www.ebi.ac.uk/pdbsum/4m4z PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Src-like adaptor proteins (SLAP/SLAP2) are key components of Cbl-dependent downregulation of antigen receptor, cytokine receptor, and receptor tyrosine kinase signaling in hematopoietic cells. SLAP and SLAP2 consist of adjacent SH3 and SH2 domains that are most similar in sequence to Src family kinases (SFKs). Notably, the SH3-SH2 connector sequence is significantly shorter in SLAP/SLAP2 than in SFKs. To understand the structural implication of a short SH3-SH2 connector sequence, we solved the crystal structure of a protein encompassing the SH3 domain, SH3-SH2 connector, and SH2 domain of SLAP2 (SLAP2-32). While both domains adopt typical folds, the short SH3-SH2 connector places them in close association. Strand betae of the SH3 domain interacts with strand betaA of the SH2 domain, resulting in the formation of a continuous beta sheet that spans the length of the protein. Disruption of the SH3/SH2 interface through mutagenesis decreases SLAP-32 stability in vitro, consistent with inter-domain binding being an important component of SLAP2 structure and function. The canonical peptide binding pockets of the SH3 and SH2 domains are fully accessible, in contrast to other protein structures that display direct interaction between SH3 and SH2 domains, in which either peptide binding surface is obstructed by the interaction. Our results reveal potential sites of novel interaction for SH3 and SH2 domains, and illustrate the adaptability of SH2 and SH3 domains in mediating interactions. As well, our results suggest that the SH3 and SH2 domains of SLAP2 function interdependently, with implications on their mode of substrate binding.

-	~~==Function==~~	+	Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through beta-sheet formation.,Wybenga-Groot LE, McGlade CJ Cell Signal. 2013 Dec;25(12):2702-8. doi: 10.1016/j.cellsig.2013.08.040. Epub, 2013 Sep 7. PMID:24018043<ref>PMID:24018043</ref>
-	~~[[http://www.uniprot.org/uniprot/SLAP2_HUMAN SLAP2_HUMAN]] Adapter~~ protein, ~~which negatively regulates T~~-~~cell receptor~~ (~~TCR~~) ~~signaling. Inhibits T~~-~~cell antigen-receptor induced activation of nuclear factor of activated T-cells~~. ~~May act by linking signaling proteins such as ZAP70 with CBL~~, ~~leading to a CBL dependent degradation of signaling proteins~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4m4z]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024018043</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: McGlade, C J.]]	+	[[Category: McGlade, C J]]
-	[[Category: Wybenga-Groot, L E.]]	+	[[Category: Wybenga-Groot, L E]]
	[[Category: Adaptor]]		[[Category: Adaptor]]
	[[Category: Sh3 and sh2 domain]]		[[Category: Sh3 and sh2 domain]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 07:52, 6 November 2013

OCA — Wed, 06 Nov 2013 07:52:22 GMT

←Older revision		Revision as of 07:52, 6 November 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4m4z\| PDB=4m4z \| SCENE= }}
		+	===SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)===
		+	{{ABSTRACT_PUBMED_24018043}}

-	~~The entry 4m4z is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SLAP2_HUMAN SLAP2_HUMAN]] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

-	~~Authors~~: ~~Wybenga-Groot, L~~.E.~~, McGlade, C~~.J.	+	==About this Structure==
		+	[[4m4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4Z OCA].

-	~~Description~~: ~~SH3 and SH2 domains of human Src~~-~~like adaptor~~ protein ~~2 (SLAP2)~~	+	==Reference==
		+	<ref group="xtra">PMID:024018043</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: McGlade, C J.]]
		+	[[Category: Wybenga-Groot, L E.]]
		+	[[Category: Adaptor]]
		+	[[Category: Sh3 and sh2 domain]]
		+	[[Category: Signaling protein]]

OCA at 05:59, 23 October 2013

OCA — Wed, 23 Oct 2013 05:59:21 GMT

←Older revision		Revision as of 05:59, 23 October 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4m4z is ON HOLD	+	The entry 4m4z is ON HOLD until Paper Publication

	Authors: Wybenga-Groot, L.E., McGlade, C.J.		Authors: Wybenga-Groot, L.E., McGlade, C.J.

	Description: SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)		Description: SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)

OCA: Protected "4m4z" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2013 07:26:48 GMT

Protected "4m4z" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 14 August 2013

OCA: New page: '''Unreleased structure''' The entry 4m4z is ON HOLD Authors: Wybenga-Groot, L.E., McGlade, C.J. Description: SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)

OCA — Wed, 14 Aug 2013 07:26:47 GMT

New page: '''Unreleased structure''' The entry 4m4z is ON HOLD Authors: Wybenga-Groot, L.E., McGlade, C.J. Description: SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)

New page

'''Unreleased structure'''

The entry 4m4z is ON HOLD

Authors: Wybenga-Groot, L.E., McGlade, C.J.

Description: SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)