4m5i - Revision history

OCA at 16:32, 20 September 2023

OCA — Wed, 20 Sep 2023 16:32:13 GMT

←Older revision		Revision as of 16:32, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4m5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M5I FirstGlance]. <br>		<table><tr><td colspan='2'>[[4m5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M5I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YH6:2-AMINO-8-{[2-(4-METHYLPHENYL)-2-OXOETHYL]SULFANYL}-1,7-DIHYDRO-6H-PURIN-6-ONE'>YH6</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.08Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YH6:2-AMINO-8-{[2-(4-METHYLPHENYL)-2-OXOETHYL]SULFANYL}-1,7-DIHYDRO-6H-PURIN-6-ONE'>YH6</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5i OCA], [https://pdbe.org/4m5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m5i RCSB], [https://www.ebi.ac.uk/pdbsum/4m5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m5i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5i OCA], [https://pdbe.org/4m5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m5i RCSB], [https://www.ebi.ac.uk/pdbsum/4m5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m5i ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:57, 21 December 2022

OCA — Wed, 21 Dec 2022 10:57:18 GMT

←Older revision		Revision as of 10:57, 21 December 2022
Line 1:		Line 1:

	==The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase==		==The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase==
-	<StructureSection load='4m5i' size='340' side='right' caption='[[4m5i]], [[Resolution\|resolution]] 1.08Å' scene=''>	+	<StructureSection load='4m5i' size='340' side='right'caption='[[4m5i]], [[Resolution\|resolution]] 1.08Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m5i]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4M5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M5I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YH6:2-AMINO-8-{[2-(4-METHYLPHENYL)-2-OXOETHYL]SULFANYL}-1,7-DIHYDRO-6H-PURIN-6-ONE'>YH6</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YH6:2-AMINO-8-{[2-(4-METHYLPHENYL)-2-OXOETHYL]SULFANYL}-1,7-DIHYDRO-6H-PURIN-6-ONE'>YH6</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q0n\|1q0n]], [[1hka\|1hka]], [[1kbr\|1kbr]], [[4m5g\|4m5g]], [[4m5h\|4m5h]], [[4m5j\|4m5j]], [[4m5k\|4m5k]], [[4m5l\|4m5l]], [[4m5m\|4m5m]], [[4m5n\|4m5n]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5i OCA], [https://pdbe.org/4m5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m5i RCSB], [https://www.ebi.ac.uk/pdbsum/4m5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m5i ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folK, b0142, JW0138 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine_diphosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.3 2.7.6.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4m5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5i OCA], [~~http~~://pdbe.org/4m5i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4m5i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4m5i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4m5i ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HPPK_ECOLI HPPK_ECOLI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[~~6-hydroxymethyl-7%2C8-dihydropterin pyrophosphokinase~~\|~~6-hydroxymethyl-7%2C8-dihydropterin pyrophosphokinase~~]]	+	*[[HPPK 3D structures\|HPPK 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 2-~~amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: ~~Ecoli~~]]	+	[[Category: Large Structures]]
-	[[Category: Hoagland, D]]	+	[[Category: Hoagland D]]
-	[[Category: Kumar, G]]	+	[[Category: Kumar G]]
-	[[Category: Lee~~, R E~~]]	+	[[Category: Lee RE]]
-	[[Category: Rock~~, C O~~]]	+	[[Category: Rock CO]]
-	[[Category: Waddell, B]]	+	[[Category: Waddell B]]
-	[[Category: White~~, S W~~]]	+	[[Category: White SW]]
-	[[Category: Yun, M]]	+	[[Category: Yun M]]
-	~~[[Category: Atp binding]]~~	+
-	~~[[Category: Diphosphotransferase]]~~	+
-	~~[[Category: Folate biosynthesis]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Pterin]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 10:02, 11 August 2016

OCA — Thu, 11 Aug 2016 10:02:54 GMT

←Older revision		Revision as of 10:02, 11 August 2016
Line 1:		Line 1:
		+
	==The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase==		==The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase==
	<StructureSection load='4m5i' size='340' side='right' caption='[[4m5i]], [[Resolution\|resolution]] 1.08Å' scene=''>		<StructureSection load='4m5i' size='340' side='right' caption='[[4m5i]], [[Resolution\|resolution]] 1.08Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folK, b0142, JW0138 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folK, b0142, JW0138 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine_diphosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.3 2.7.6.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine_diphosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.3 2.7.6.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m5i RCSB], [http://www.ebi.ac.uk/pdbsum/4m5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5i OCA], [http://pdbe.org/4m5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m5i RCSB], [http://www.ebi.ac.uk/pdbsum/4m5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m5i ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4m5i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:22, 5 January 2015

OCA — Mon, 05 Jan 2015 09:22:01 GMT

←Older revision		Revision as of 09:22, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4m5i\| PDB=4m5i \| SCENE= }}~~	+	==The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase==
-	===The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase===	+	<StructureSection load='4m5i' size='340' side='right' caption='[[4m5i]], [[Resolution\|resolution]] 1.08Å' scene=''>
-	{~~{ABSTRACT_PUBMED_24613625}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4m5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M5I FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YH6:2-AMINO-8-{[2-(4-METHYLPHENYL)-2-OXOETHYL]SULFANYL}-1,7-DIHYDRO-6H-PURIN-6-ONE'>YH6</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1q0n\|1q0n]], [[1hka\|1hka]], [[1kbr\|1kbr]], [[4m5g\|4m5g]], [[4m5h\|4m5h]], [[4m5j\|4m5j]], [[4m5k\|4m5k]], [[4m5l\|4m5l]], [[4m5m\|4m5m]], [[4m5n\|4m5n]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">folK, b0142, JW0138 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine_diphosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.3 2.7.6.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m5i RCSB], [http://www.ebi.ac.uk/pdbsum/4m5i PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is an essential enzyme in the microbial folate biosynthetic pathway. This pathway has proven to be an excellent target for antimicrobial development, but widespread resistance to common therapeutics including the sulfa drugs has stimulated interest in HPPK as an alternative target in the pathway. A screen of a pterin-biased compound set identified several HPPK inhibitors that contain an aryl substituted 8-thioguanine scaffold, and structural analyses showed that these compounds engage the HPPK pterin-binding pocket and an induced cryptic pocket. A preliminary structure activity relationship profile was developed from biophysical and biochemical characterizations of derivative molecules. Also, a similarity search identified additional scaffolds that bind more tightly within the HPPK pterin pocket. These inhibitory scaffolds have the potential for rapid elaboration into novel lead antimicrobial agents.

-	~~==About this Structure==~~	+	The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.,Yun MK, Hoagland D, Kumar G, Waddell MB, Rock CO, Lee RE, White SW Bioorg Med Chem. 2014 Apr 1;22(7):2157-65. doi: 10.1016/j.bmc.2014.02.022. Epub, 2014 Feb 25. PMID:24613625<ref>PMID:24613625</ref>
-	~~[[4m5i]] is a 1 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ecoli Ecoli]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4M5I OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:024613625</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[6-hydroxymethyl-7%2C8-dihydropterin pyrophosphokinase\|6-hydroxymethyl-7%2C8-dihydropterin pyrophosphokinase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase]]		[[Category: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase]]
	[[Category: Ecoli]]		[[Category: Ecoli]]
-	[[Category: Hoagland, D.]]	+	[[Category: Hoagland, D]]
-	[[Category: Kumar, G.]]	+	[[Category: Kumar, G]]
-	[[Category: Lee, R E.]]	+	[[Category: Lee, R E]]
-	[[Category: Rock, C O.]]	+	[[Category: Rock, C O]]
-	[[Category: Waddell, B.]]	+	[[Category: Waddell, B]]
-	[[Category: White, S W.]]	+	[[Category: White, S W]]
-	[[Category: Yun, M.]]	+	[[Category: Yun, M]]
	[[Category: Atp binding]]		[[Category: Atp binding]]
	[[Category: Diphosphotransferase]]		[[Category: Diphosphotransferase]]

OCA at 08:04, 16 April 2014

OCA — Wed, 16 Apr 2014 08:04:41 GMT

←Older revision		Revision as of 08:04, 16 April 2014
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4m5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5I OCA].	+	[[4m5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5I OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024613625</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024613625</ref><references group="xtra"/><references/>
	[[Category: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase]]		[[Category: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase]]
		+	[[Category: Ecoli]]
	[[Category: Hoagland, D.]]		[[Category: Hoagland, D.]]
	[[Category: Kumar, G.]]		[[Category: Kumar, G.]]

OCA at 09:00, 2 April 2014

OCA — Wed, 02 Apr 2014 09:00:45 GMT

←Older revision		Revision as of 09:00, 2 April 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4m5i\| PDB=4m5i \| SCENE= }}
		+	===The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase===
		+	{{ABSTRACT_PUBMED_24613625}}

-	~~The entry~~ 4m5i is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4m5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5I OCA].

-	~~Authors~~: ~~Yun, M.,~~ Hoagland, D., Kumar, G., ~~Waddell, B~~., Rock, C.O., ~~Lee, R~~.~~E.,~~ White, S.W.	+	==Reference==
-		+	<ref group="xtra">PMID:024613625</ref><references group="xtra"/><references/>
-	~~Description~~: ~~The Identification~~, ~~Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8~~-~~dihydropterin pyrophosphokinase~~	+	[[Category: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase]]
		+	[[Category: Hoagland, D.]]
		+	[[Category: Kumar, G.]]
		+	[[Category: Lee, R E.]]
		+	[[Category: Rock, C O.]]
		+	[[Category: Waddell, B.]]
		+	[[Category: White, S W.]]
		+	[[Category: Yun, M.]]
		+	[[Category: Atp binding]]
		+	[[Category: Diphosphotransferase]]
		+	[[Category: Folate biosynthesis]]
		+	[[Category: Inhibitor]]
		+	[[Category: Pterin]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 05:59, 23 October 2013

OCA — Wed, 23 Oct 2013 05:59:39 GMT

←Older revision		Revision as of 05:59, 23 October 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4m5i is ON HOLD	+	The entry 4m5i is ON HOLD until Paper Publication

	Authors: Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.		Authors: Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.

	Description: The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase		Description: The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

OCA: Protected "4m5i" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2013 07:27:33 GMT

Protected "4m5i" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:27, 14 August 2013

OCA: New page: '''Unreleased structure''' The entry 4m5i is ON HOLD Authors: Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W. Description: The Identification, Analysi...

OCA — Wed, 14 Aug 2013 07:27:32 GMT

New page: '''Unreleased structure''' The entry 4m5i is ON HOLD Authors: Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W. Description: The Identification, Analysi...

New page

'''Unreleased structure'''

The entry 4m5i is ON HOLD

Authors: Yun, M., Hoagland, D., Kumar, G., Waddell, B., Rock, C.O., Lee, R.E., White, S.W.

Description: The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase