4m8y - Revision history

OCA at 16:34, 20 September 2023

OCA — Wed, 20 Sep 2023 16:34:16 GMT

←Older revision		Revision as of 16:34, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M8Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M8Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.22Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [https://pdbe.org/4m8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [https://www.ebi.ac.uk/pdbsum/4m8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m8y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [https://pdbe.org/4m8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [https://www.ebi.ac.uk/pdbsum/4m8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m8y ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:03, 21 December 2022

OCA — Wed, 21 Dec 2022 11:03:30 GMT

←Older revision		Revision as of 11:03, 21 December 2022
Line 3:		Line 3:
	<StructureSection load='4m8y' size='340' side='right'caption='[[4m8y]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='4m8y' size='340' side='right'caption='[[4m8y]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4M8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M8Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rkf\|2rkf]], [[2rkg\|2rkg]], [[4m8x\|4m8x]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [https://pdbe.org/4m8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [https://www.ebi.ac.uk/pdbsum/4m8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m8y ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [~~http~~://pdbe.org/4m8y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4m8y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4m8y ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q90JJ9_9HIV1 Q90JJ9_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~HIV-~~1 ~~retropepsin~~]]	+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brynda, J]]	+	[[Category: Brynda J]]
-	[[Category: ~~Konvalinka, J]]~~	+	[[Category: Grantz saskova K]]
-	~~[[Category: Kozisek, M]]~~	+	[[Category: Konvalinka J]]
-	~~[[Category: Rezacova, P]]~~	+	[[Category: Kozisek M]]
-	~~[[Category: Saskova,~~ K ~~Grantz~~]]	+	[[Category: Rezacova P]]
-	[[Category: ~~Amino acid insertion~~]]	+
-	[[Category: ~~Aspartic protease~~]]	+
-	[[Category: ~~Hiv-1 protease]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 09:48, 3 April 2019

OCA — Wed, 03 Apr 2019 09:48:13 GMT

←Older revision		Revision as of 09:48, 3 April 2019
Line 1:		Line 1:

	==GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions==		==GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions==
-	<StructureSection load='4m8y' size='340' side='right' caption='[[4m8y]], [[Resolution\|resolution]] 2.22Å' scene=''>	+	<StructureSection load='4m8y' size='340' side='right'caption='[[4m8y]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M8Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rkf\|2rkf]], [[2rkg\|2rkg]], [[4m8x\|4m8x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rkf\|2rkf]], [[2rkg\|2rkg]], [[4m8x\|4m8x]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [http://pdbe.org/4m8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [http://www.ebi.ac.uk/pdbsum/4m8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m8y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [http://pdbe.org/4m8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [http://www.ebi.ac.uk/pdbsum/4m8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m8y ProSAT]</span></td></tr>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4m8y" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4m8y" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Immunodeficiency virus protease 3D structures\|Immunodeficiency virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
		+	[[Category: Large Structures]]
	[[Category: Brynda, J]]		[[Category: Brynda, J]]
	[[Category: Konvalinka, J]]		[[Category: Konvalinka, J]]

OCA at 15:52, 11 August 2016

OCA — Thu, 11 Aug 2016 15:52:37 GMT

←Older revision		Revision as of 15:52, 11 August 2016
Line 1:		Line 1:
		+
	==GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions==		==GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions==
	<StructureSection load='4m8y' size='340' side='right' caption='[[4m8y]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='4m8y' size='340' side='right' caption='[[4m8y]], [[Resolution\|resolution]] 2.22Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rkf\|2rkf]], [[2rkg\|2rkg]], [[4m8x\|4m8x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rkf\|2rkf]], [[2rkg\|2rkg]], [[4m8x\|4m8x]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [http://www.ebi.ac.uk/pdbsum/4m8y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [http://pdbe.org/4m8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [http://www.ebi.ac.uk/pdbsum/4m8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m8y ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4m8y" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:51, 5 January 2015

OCA — Mon, 05 Jan 2015 09:51:12 GMT

←Older revision		Revision as of 09:51, 5 January 2015
Line 2:		Line 2:
	<StructureSection load='4m8y' size='340' side='right' caption='[[4m8y]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='4m8y' size='340' side='right' caption='[[4m8y]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. <br>	+	<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M8Y FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rkf\|2rkf]], [[2rkg\|2rkg]], [[4m8x\|4m8x]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rkf\|2rkf]], [[2rkg\|2rkg]], [[4m8x\|4m8x]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.~~2 2~~.7.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [http://www.ebi.ac.uk/pdbsum/4m8y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [http://www.ebi.ac.uk/pdbsum/4m8y PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions.,Grantz Saskova K, Kozisek M, Stray K, de Jong D, Rezaova P, Brynda J, van Maarseveen NM, Nijhuis M, Cihlar T, Konvalinka J J Virol. 2014 Mar;88(6):3586-90. doi: 10.1128/JVI.02688-13. Epub 2013 Dec 26. PMID:24371077<ref>PMID:24371077</ref>		GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions.,Grantz Saskova K, Kozisek M, Stray K, de Jong D, Rezaova P, Brynda J, van Maarseveen NM, Nijhuis M, Cihlar T, Konvalinka J J Virol. 2014 Mar;88(6):3586-90. doi: 10.1128/JVI.02688-13. Epub 2013 Dec 26. PMID:24371077<ref>PMID:24371077</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
-	[[Category: Brynda, J.]]	+	[[Category: Brynda, J]]
-	[[Category: Konvalinka, J.]]	+	[[Category: Konvalinka, J]]
-	[[Category: Kozisek, M.]]	+	[[Category: Kozisek, M]]
-	[[Category: Rezacova, P.]]	+	[[Category: Rezacova, P]]
-	[[Category: Saskova, K Grantz.]]	+	[[Category: Saskova, K Grantz]]
	[[Category: Amino acid insertion]]		[[Category: Amino acid insertion]]
	[[Category: Aspartic protease]]		[[Category: Aspartic protease]]
	[[Category: Hiv-1 protease]]		[[Category: Hiv-1 protease]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 08:15, 7 May 2014

OCA — Wed, 07 May 2014 08:15:03 GMT

←Older revision		Revision as of 08:15, 7 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions==
		+	<StructureSection load='4m8y' size='340' side='right' caption='[[4m8y]], [[Resolution\|resolution]] 2.22Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4m8y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8Y OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rkf\|2rkf]], [[2rkg\|2rkg]], [[4m8x\|4m8x]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m8y RCSB], [http://www.ebi.ac.uk/pdbsum/4m8y PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Insertions in the protease (PR) region of human immunodeficiency virus (HIV) represent an interesting mechanism of antiviral resistance against HIV PR inhibitors (PIs). Here, we demonstrate the improved ability of a phosphonate-containing experimental HIV PI, GS-8374, relative to that of other PIs, to effectively inhibit patient-derived recombinant HIV strains bearing PR insertions and numerous other mutations. We correlate enzyme inhibition with the catalytic activities of corresponding recombinant PRs in vitro and provide a biochemical and structural analysis of the PR-inhibitor complex.

-	~~The entry 4m8y is ON HOLD until Paper Publication~~	+	GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions.,Grantz Saskova K, Kozisek M, Stray K, de Jong D, Rezaova P, Brynda J, van Maarseveen NM, Nijhuis M, Cihlar T, Konvalinka J J Virol. 2014 Mar;88(6):3586-90. doi: 10.1128/JVI.02688-13. Epub 2013 Dec 26. PMID:24371077<ref>PMID:24371077</ref>

-	~~Authors: Grantz saskova~~, K., Brynda, J., ~~Rezacova, P~~., Kozisek, M., ~~Konvalinka~~, J.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV~~-1 ~~Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: HIV-1 retropepsin]]
		+	[[Category: Brynda, J.]]
		+	[[Category: Konvalinka, J.]]
		+	[[Category: Kozisek, M.]]
		+	[[Category: Rezacova, P.]]
		+	[[Category: Saskova, K Grantz.]]
		+	[[Category: Amino acid insertion]]
		+	[[Category: Aspartic protease]]
		+	[[Category: Hiv-1 protease]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 09:03, 8 January 2014

OCA — Wed, 08 Jan 2014 09:03:26 GMT

←Older revision		Revision as of 09:03, 8 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4m8y is ON HOLD	+	The entry 4m8y is ON HOLD until Paper Publication

	Authors: Grantz saskova, K., Brynda, J., Rezacova, P., Kozisek, M., Konvalinka, J.		Authors: Grantz saskova, K., Brynda, J., Rezacova, P., Kozisek, M., Konvalinka, J.

	Description: GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions		Description: GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions

OCA at 09:59, 4 September 2013

OCA — Wed, 04 Sep 2013 09:59:31 GMT

←Older revision		Revision as of 09:59, 4 September 2013
Line 3:		Line 3:
	The entry 4m8y is ON HOLD		The entry 4m8y is ON HOLD

-	Authors: Grantz ~~Saskova~~, K., Brynda, J., Rezacova, P., Kozisek, M., Konvalinka, J.	+	Authors: Grantz saskova, K., Brynda, J., Rezacova, P., Kozisek, M., Konvalinka, J.

	Description: GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions		Description: GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions

OCA: Protected "4m8y" [edit=sysop:move=sysop]

OCA — Wed, 21 Aug 2013 07:59:23 GMT

Protected "4m8y" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:59, 21 August 2013

OCA: New page: '''Unreleased structure''' The entry 4m8y is ON HOLD Authors: Grantz Saskova, K., Brynda, J., Rezacova, P., Kozisek, M., Konvalinka, J. Description: GS-8374, a Novel Phosphonate-Contai...

OCA — Wed, 21 Aug 2013 07:59:22 GMT

New page: '''Unreleased structure''' The entry 4m8y is ON HOLD Authors: Grantz Saskova, K., Brynda, J., Rezacova, P., Kozisek, M., Konvalinka, J. Description: GS-8374, a Novel Phosphonate-Contai...

New page

'''Unreleased structure'''

The entry 4m8y is ON HOLD

Authors: Grantz Saskova, K., Brynda, J., Rezacova, P., Kozisek, M., Konvalinka, J.

Description: GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions