4m97 - Revision history

OCA at 12:24, 1 March 2024

OCA — Fri, 01 Mar 2024 12:24:52 GMT

←Older revision		Revision as of 12:24, 1 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4m97]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neospora_caninum_Liverpool Neospora caninum Liverpool]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M97 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4m97]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neospora_caninum_Liverpool Neospora caninum Liverpool]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M97 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m97 OCA], [https://pdbe.org/4m97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m97 RCSB], [https://www.ebi.ac.uk/pdbsum/4m97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m97 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m97 OCA], [https://pdbe.org/4m97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m97 RCSB], [https://www.ebi.ac.uk/pdbsum/4m97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m97 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/F0V9W9_NEOCL F0V9W9_NEOCL]		[https://www.uniprot.org/uniprot/F0V9W9_NEOCL F0V9W9_NEOCL]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Despite the enormous economic importance of Neospora caninum related veterinary diseases, the number of effective therapeutic agents is relatively small. Development of new therapeutic strategies to combat the economic impact of neosporosis remains an important scientific endeavor. This study demonstrates molecular, structural and phenotypic evidence that N. caninum calcium-dependent protein kinase 1 (NcCDPK1) is a promising molecular target for neosporosis drug development. Recombinant NcCDPK1 was expressed, purified and screened against a select group of bumped kinase inhibitors (BKIs) previously shown to have low IC50s against Toxoplasma gondii CDPK1 and T. gondii tachyzoites. NcCDPK1 was inhibited by low concentrations of BKIs. The three-dimensional structure of NcCDPK1 in complex with BKIs was studied crystallographically. The BKI-NcCDPK1 structures demonstrated the structural basis for potency and selectivity. Calcium-dependent conformational changes in solution as characterized by small-angle X-ray scattering are consistent with previous structures in low Calcium-state but different in the Calcium-bound active state than predicted by X-ray crystallography. BKIs effectively inhibited N. caninum tachyzoite proliferation in vitro. Electron microscopic analysis of N. caninum cells revealed ultra-structural changes in the presence of BKI compound 1294. BKI compound 1294 interfered with an early step in Neospora tachyzoite host cell invasion and egress. Prolonged incubation in the presence of 1294 interfered produced observable interference with viability and replication. Oral dosing of BKI compound 1294 at 50 mg/kg for 5 days in established murine neosporosis resulted in a 10-fold reduced cerebral parasite burden compared to untreated control. Further experiments are needed to determine the PK, optimal dosage, and duration for effective treatment in cattle and dogs, but these data demonstrate proof-of-concept for BKIs, and 1294 specifically, for therapy of bovine and canine neosporosis.
-
-	Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.,Ojo KK, Reid MC, Kallur Siddaramaiah L, Muller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A PLoS One. 2014 Mar 28;9(3):e92929. doi: 10.1371/journal.pone.0092929. eCollection, 2014. PMID:24681759<ref>PMID:24681759</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4m97" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:03, 21 December 2022

OCA — Wed, 21 Dec 2022 11:03:55 GMT

←Older revision		Revision as of 11:03, 21 December 2022
Line 1:		Line 1:

	==Calcium-Dependent Protein Kinase 1 from Neospora caninum==		==Calcium-Dependent Protein Kinase 1 from Neospora caninum==
-	<StructureSection load='4m97' size='340' side='right' caption='[[4m97]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4m97' size='340' side='right'caption='[[4m97]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m97]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Neocl Neocl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M97 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4M97 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4m97]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neospora_caninum_Liverpool Neospora caninum Liverpool]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M97 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDPK1, NCLIV_011980, XP_003880764 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=572307 NEOCL])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m97 OCA], [https://pdbe.org/4m97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m97 RCSB], [https://www.ebi.ac.uk/pdbsum/4m97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m97 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m97 OCA], [~~http~~://pdbe.org/4m97 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4m97 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4m97 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4m97 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F0V9W9_NEOCL F0V9W9_NEOCL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Calcium/calmodulin-dependent protein kinase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Neocl~~]]	+	[[Category: Neospora caninum Liverpool]]
-	[[Category: Merritt~~, E A]]~~	+	[[Category: Merritt EA]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Calcium-binding]]~~	+
-	~~[[Category: Serine/threonine protein kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 14:29, 11 August 2016

OCA — Thu, 11 Aug 2016 14:29:36 GMT

←Older revision		Revision as of 14:29, 11 August 2016
Line 1:		Line 1:
		+
	==Calcium-Dependent Protein Kinase 1 from Neospora caninum==		==Calcium-Dependent Protein Kinase 1 from Neospora caninum==
	<StructureSection load='4m97' size='340' side='right' caption='[[4m97]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4m97' size='340' side='right' caption='[[4m97]], [[Resolution\|resolution]] 2.05Å' scene=''>
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	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDPK1, NCLIV_011980, XP_003880764 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=572307 NEOCL])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDPK1, NCLIV_011980, XP_003880764 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=572307 NEOCL])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m97 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m97 RCSB], [http://www.ebi.ac.uk/pdbsum/4m97 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m97 OCA], [http://pdbe.org/4m97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m97 RCSB], [http://www.ebi.ac.uk/pdbsum/4m97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m97 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4m97" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:45, 5 January 2015

OCA — Mon, 05 Jan 2015 08:45:40 GMT

←Older revision		Revision as of 08:45, 5 January 2015
Line 2:		Line 2:
	<StructureSection load='4m97' size='340' side='right' caption='[[4m97]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4m97' size='340' side='right' caption='[[4m97]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4m97]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neocl Neocl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M97 OCA]. <br>	+	<table><tr><td colspan='2'>[[4m97]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neocl Neocl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M97 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDPK1, NCLIV_011980, XP_003880764 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=572307 NEOCL])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDPK1, NCLIV_011980, XP_003880764 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=572307 NEOCL])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m97 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m97 RCSB], [http://www.ebi.ac.uk/pdbsum/4m97 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m97 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m97 RCSB], [http://www.ebi.ac.uk/pdbsum/4m97 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.,Ojo KK, Reid MC, Kallur Siddaramaiah L, Muller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A PLoS One. 2014 Mar 28;9(3):e92929. doi: 10.1371/journal.pone.0092929. eCollection, 2014. PMID:24681759<ref>PMID:24681759</ref>		Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.,Ojo KK, Reid MC, Kallur Siddaramaiah L, Muller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A PLoS One. 2014 Mar 28;9(3):e92929. doi: 10.1371/journal.pone.0092929. eCollection, 2014. PMID:24681759<ref>PMID:24681759</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 21:
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
	[[Category: Neocl]]		[[Category: Neocl]]
-	[[Category: Merritt, E A.]]	+	[[Category: Merritt, E A]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Calcium-binding]]		[[Category: Calcium-binding]]
	[[Category: Serine/threonine protein kinase]]		[[Category: Serine/threonine protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 06:57, 7 May 2014

OCA — Wed, 07 May 2014 06:57:47 GMT

←Older revision		Revision as of 06:57, 7 May 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4m97\| PDB=4m97 \| SCENE= }}~~	+	==Calcium-Dependent Protein Kinase 1 from Neospora caninum==
-	===Calcium-Dependent Protein Kinase 1 from Neospora caninum===	+	<StructureSection load='4m97' size='340' side='right' caption='[[4m97]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20436472}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4m97]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neocl Neocl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M97 OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDPK1, NCLIV_011980, XP_003880764 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=572307 NEOCL])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m97 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m97 RCSB], [http://www.ebi.ac.uk/pdbsum/4m97 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Despite the enormous economic importance of Neospora caninum related veterinary diseases, the number of effective therapeutic agents is relatively small. Development of new therapeutic strategies to combat the economic impact of neosporosis remains an important scientific endeavor. This study demonstrates molecular, structural and phenotypic evidence that N. caninum calcium-dependent protein kinase 1 (NcCDPK1) is a promising molecular target for neosporosis drug development. Recombinant NcCDPK1 was expressed, purified and screened against a select group of bumped kinase inhibitors (BKIs) previously shown to have low IC50s against Toxoplasma gondii CDPK1 and T. gondii tachyzoites. NcCDPK1 was inhibited by low concentrations of BKIs. The three-dimensional structure of NcCDPK1 in complex with BKIs was studied crystallographically. The BKI-NcCDPK1 structures demonstrated the structural basis for potency and selectivity. Calcium-dependent conformational changes in solution as characterized by small-angle X-ray scattering are consistent with previous structures in low Calcium-state but different in the Calcium-bound active state than predicted by X-ray crystallography. BKIs effectively inhibited N. caninum tachyzoite proliferation in vitro. Electron microscopic analysis of N. caninum cells revealed ultra-structural changes in the presence of BKI compound 1294. BKI compound 1294 interfered with an early step in Neospora tachyzoite host cell invasion and egress. Prolonged incubation in the presence of 1294 interfered produced observable interference with viability and replication. Oral dosing of BKI compound 1294 at 50 mg/kg for 5 days in established murine neosporosis resulted in a 10-fold reduced cerebral parasite burden compared to untreated control. Further experiments are needed to determine the PK, optimal dosage, and duration for effective treatment in cattle and dogs, but these data demonstrate proof-of-concept for BKIs, and 1294 specifically, for therapy of bovine and canine neosporosis.

-	~~==About this Structure==~~	+	Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.,Ojo KK, Reid MC, Kallur Siddaramaiah L, Muller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A PLoS One. 2014 Mar 28;9(3):e92929. doi: 10.1371/journal.pone.0092929. eCollection, 2014. PMID:24681759<ref>PMID:24681759</ref>
-	~~[[4m97]] is a~~ 1 ~~chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Neospora_caninum_liverpool Neospora caninum liverpool]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4M97 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020436472</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
-	[[Category: ~~Neospora caninum liverpool~~]]	+	[[Category: Neocl]]
	[[Category: Merritt, E A.]]		[[Category: Merritt, E A.]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 07:25, 2 October 2013

OCA — Wed, 02 Oct 2013 07:25:37 GMT

←Older revision		Revision as of 07:25, 2 October 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4m97\| PDB=4m97 \| SCENE= }}
		+	===Calcium-Dependent Protein Kinase 1 from Neospora caninum===
		+	{{ABSTRACT_PUBMED_20436472}}

-	~~The entry~~ 4m97 is ~~ON HOLD~~	+	==About this Structure==
		+	[[4m97]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neospora_caninum_liverpool Neospora caninum liverpool]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M97 OCA].

-	~~Authors~~: Merritt, E.A.	+	==Reference==
-		+	<ref group="xtra">PMID:020436472</ref><references group="xtra"/><references/>
-	~~Description~~: Calcium-~~Dependent Protein Kinase 1 from Neospora caninum~~	+	[[Category: Calcium/calmodulin-dependent protein kinase]]
		+	[[Category: Neospora caninum liverpool]]
		+	[[Category: Merritt, E A.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Calcium-binding]]
		+	[[Category: Serine/threonine protein kinase]]
		+	[[Category: Transferase]]

OCA: Protected "4m97" [edit=sysop:move=sysop]

OCA — Wed, 21 Aug 2013 07:59:41 GMT

Protected "4m97" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:59, 21 August 2013

OCA: New page: '''Unreleased structure''' The entry 4m97 is ON HOLD Authors: Merritt, E.A. Description: Calcium-Dependent Protein Kinase 1 from Neospora caninum

OCA — Wed, 21 Aug 2013 07:59:40 GMT

New page: '''Unreleased structure''' The entry 4m97 is ON HOLD Authors: Merritt, E.A. Description: Calcium-Dependent Protein Kinase 1 from Neospora caninum

New page

'''Unreleased structure'''

The entry 4m97 is ON HOLD

Authors: Merritt, E.A.

Description: Calcium-Dependent Protein Kinase 1 from Neospora caninum