4mfu - Revision history

OCA at 08:56, 20 March 2024

OCA — Wed, 20 Mar 2024 08:56:12 GMT

←Older revision		Revision as of 08:56, 20 March 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MFU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MFU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mfu OCA], [https://pdbe.org/4mfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mfu RCSB], [https://www.ebi.ac.uk/pdbsum/4mfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mfu ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.744Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mfu OCA], [https://pdbe.org/4mfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mfu RCSB], [https://www.ebi.ac.uk/pdbsum/4mfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mfu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>		[https://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The hPrp19-CDC5L complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome. In order to elucidate the molecular architecture of the hPrp19-CDC5L complex, the crystal structure of CTNNBL1, one of the major components of this complex, was determined. Unlike canonical ARM-repeat proteins such as beta-catenin and importin-alpha, CTNNBL1 was found to contain a twisted and extended ARM-repeat structure at the C-terminal domain and, more importantly, the protein formed a stable dimer. A highly negatively charged patch formed in the N-terminal ARM-repeat domain of CTNNBL1 provides a binding site for CDC5L, a binding partner of the protein in the hPrp19-CDC5L complex, and these two proteins form a complex with a stoichiometry of 2:2. These findings not only present the crystal structure of a novel ARM-repeat protein, CTNNBL1, but also provide insights into the detailed molecular architecture of the hPrp19-CDC5L complex.
-
-	Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex.,Ahn JW, Kim S, Kim EJ, Kim YJ, Kim KJ Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):780-8. doi:, 10.1107/S139900471303318X. Epub 2014 Feb 22. PMID:24598747<ref>PMID:24598747</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4mfu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:14, 21 December 2022

OCA — Wed, 21 Dec 2022 11:14:19 GMT

←Older revision		Revision as of 11:14, 21 December 2022
Line 1:		Line 1:

	==Crystal structure of human CTNNBL1(residues 77~563)==		==Crystal structure of human CTNNBL1(residues 77~563)==
-	<StructureSection load='4mfu' size='340' side='right' caption='[[4mfu]], [[Resolution\|resolution]] 2.74Å' scene=''>	+	<StructureSection load='4mfu' size='340' side='right'caption='[[4mfu]], [[Resolution\|resolution]] 2.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mfu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MFU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MFU FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mfv\|4mfv]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mfu OCA], [https://pdbe.org/4mfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mfu RCSB], [https://www.ebi.ac.uk/pdbsum/4mfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mfu ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTNNBL1, C20orf33, PP8304 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mfu OCA], [~~http~~://pdbe.org/4mfu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mfu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mfu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mfu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>	+	[https://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Ahn, J W~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Kim, K J~~]]	+	[[Category: Ahn JW]]
-	[[Category: Kim~~, S~~]]	+	[[Category: Kim KJ]]
-	[[Category: ~~Arm repeat]]~~	+	[[Category: Kim S]]
-	~~[[Category: Gene regulation~~]]	+

OCA at 16:32, 4 August 2016

OCA — Thu, 04 Aug 2016 16:32:34 GMT

←Older revision		Revision as of 16:32, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human CTNNBL1(residues 77~563)==		==Crystal structure of human CTNNBL1(residues 77~563)==
	<StructureSection load='4mfu' size='340' side='right' caption='[[4mfu]], [[Resolution\|resolution]] 2.74Å' scene=''>		<StructureSection load='4mfu' size='340' side='right' caption='[[4mfu]], [[Resolution\|resolution]] 2.74Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mfv\|4mfv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mfv\|4mfv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTNNBL1, C20orf33, PP8304 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTNNBL1, C20orf33, PP8304 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mfu RCSB], [http://www.ebi.ac.uk/pdbsum/4mfu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mfu OCA], [http://pdbe.org/4mfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mfu RCSB], [http://www.ebi.ac.uk/pdbsum/4mfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mfu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4mfu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:03, 24 December 2014

OCA — Wed, 24 Dec 2014 17:03:32 GMT

←Older revision		Revision as of 17:03, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4mfu\| PDB=4mfu \| SCENE= }}~~	+	==Crystal structure of human CTNNBL1(residues 77~563)==
-	===Crystal structure of human CTNNBL1(residues 77~563)===	+	<StructureSection load='4mfu' size='340' side='right' caption='[[4mfu]], [[Resolution\|resolution]] 2.74Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24598747}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4mfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MFU FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mfv\|4mfv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTNNBL1, C20orf33, PP8304 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mfu RCSB], [http://www.ebi.ac.uk/pdbsum/4mfu PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>		[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The hPrp19-CDC5L complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome. In order to elucidate the molecular architecture of the hPrp19-CDC5L complex, the crystal structure of CTNNBL1, one of the major components of this complex, was determined. Unlike canonical ARM-repeat proteins such as beta-catenin and importin-alpha, CTNNBL1 was found to contain a twisted and extended ARM-repeat structure at the C-terminal domain and, more importantly, the protein formed a stable dimer. A highly negatively charged patch formed in the N-terminal ARM-repeat domain of CTNNBL1 provides a binding site for CDC5L, a binding partner of the protein in the hPrp19-CDC5L complex, and these two proteins form a complex with a stoichiometry of 2:2. These findings not only present the crystal structure of a novel ARM-repeat protein, CTNNBL1, but also provide insights into the detailed molecular architecture of the hPrp19-CDC5L complex.

-	~~==About this Structure==~~	+	Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex.,Ahn JW, Kim S, Kim EJ, Kim YJ, Kim KJ Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):780-8. doi:, 10.1107/S139900471303318X. Epub 2014 Feb 22. PMID:24598747<ref>PMID:24598747</ref>
-	~~[[4mfu]] is a 1 chain structure~~ with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4MFU OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024598747</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Ahn, J W.]]	+	[[Category: Ahn, J W]]
-	[[Category: Kim, K J.]]	+	[[Category: Kim, K J]]
-	[[Category: Kim, S.]]	+	[[Category: Kim, S]]
	[[Category: Arm repeat]]		[[Category: Arm repeat]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]

OCA at 06:02, 23 April 2014

OCA — Wed, 23 Apr 2014 06:02:00 GMT

←Older revision		Revision as of 06:02, 23 April 2014
Line 1:		Line 1:
	{{STRUCTURE_4mfu\| PDB=4mfu \| SCENE= }}		{{STRUCTURE_4mfu\| PDB=4mfu \| SCENE= }}
	===Crystal structure of human CTNNBL1(residues 77~563)===		===Crystal structure of human CTNNBL1(residues 77~563)===
		+	{{ABSTRACT_PUBMED_24598747}}

	==Function==		==Function==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4mfu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFU OCA].	+	[[4mfu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFU OCA].

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024598747</ref><references group="xtra"/><references/>
		+	[[Category: Human]]
	[[Category: Ahn, J W.]]		[[Category: Ahn, J W.]]
	[[Category: Kim, K J.]]		[[Category: Kim, K J.]]

OCA at 14:00, 12 March 2014

OCA — Wed, 12 Mar 2014 14:00:22 GMT

←Older revision		Revision as of 14:00, 12 March 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4mfu\| PDB=4mfu \| SCENE= }}
		+	===Crystal structure of human CTNNBL1(residues 77~563)===

-	~~The entry 4mfu~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>

-	~~Authors: Ahn, J~~.W.~~, Kim, S~~.~~, Kim, K~~.J.	+	==About this Structure==
		+	[[4mfu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFU OCA].

-	~~Description~~: ~~Crystal structure of human CTNNBL1(residues 77~563)~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Ahn, J W.]]
		+	[[Category: Kim, K J.]]
		+	[[Category: Kim, S.]]
		+	[[Category: Arm repeat]]
		+	[[Category: Gene regulation]]

OCA at 04:50, 12 September 2013

OCA — Thu, 12 Sep 2013 04:50:12 GMT

←Older revision		Revision as of 04:50, 12 September 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4mfu is ON HOLD	+	The entry 4mfu is ON HOLD until Paper Publication

	Authors: Ahn, J.W., Kim, S., Kim, K.J.		Authors: Ahn, J.W., Kim, S., Kim, K.J.

	Description: Crystal structure of human CTNNBL1(residues 77~563)		Description: Crystal structure of human CTNNBL1(residues 77~563)

OCA: Protected "4mfu" [edit=sysop:move=sysop]

OCA — Wed, 04 Sep 2013 10:05:38 GMT

Protected "4mfu" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:05, 4 September 2013

OCA: New page: '''Unreleased structure''' The entry 4mfu is ON HOLD Authors: Ahn, J.W., Kim, S., Kim, K.J. Description: Crystal structure of human CTNNBL1(residues 77~563)

OCA — Wed, 04 Sep 2013 10:05:36 GMT

New page: '''Unreleased structure''' The entry 4mfu is ON HOLD Authors: Ahn, J.W., Kim, S., Kim, K.J. Description: Crystal structure of human CTNNBL1(residues 77~563)

New page

'''Unreleased structure'''

The entry 4mfu is ON HOLD

Authors: Ahn, J.W., Kim, S., Kim, K.J.

Description: Crystal structure of human CTNNBL1(residues 77~563)