4mho - Revision history

OCA at 16:37, 20 September 2023

OCA — Wed, 20 Sep 2023 16:37:56 GMT

←Older revision		Revision as of 16:37, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MHO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MHO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=26M:N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE'>26M</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=26M:N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE'>26M</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [https://pdbe.org/4mho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [https://www.ebi.ac.uk/pdbsum/4mho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mho ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [https://pdbe.org/4mho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [https://www.ebi.ac.uk/pdbsum/4mho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mho ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:39, 28 December 2022

OCA — Wed, 28 Dec 2022 09:39:00 GMT

←Older revision		Revision as of 09:39, 28 December 2022
Line 3:		Line 3:
	<StructureSection load='4mho' size='340' side='right'caption='[[4mho]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4mho' size='340' side='right'caption='[[4mho]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MHO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MHO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=26M:N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE'>26M</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=26M:N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE'>26M</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [https://pdbe.org/4mho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [https://www.ebi.ac.uk/pdbsum/4mho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mho ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mhs\|4mhs]], [[4mi3\|4mi3]], [[4mi6\|4mi6]], [[4mi9\|4mi9]], [[4mic\|4mic]]</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [~~http~~://pdbe.org/4mho PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mho PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mho ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	+	[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	~~[[Category: Phosphorylase]]~~	+	[[Category: Chatzileontiadou DSM]]
-	[[Category: Chatzileontiadou~~, D S.M~~]]	+	[[Category: Kantsadi AL]]
-	[[Category: Kantsadi~~, A L~~]]	+	[[Category: Leonidas DD]]
-	[[Category: Leonidas~~, D D]]~~	+
-	~~[[Category: Alpha and beta protein]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 04:58, 13 February 2020

OCA — Thu, 13 Feb 2020 04:58:08 GMT

←Older revision		Revision as of 04:58, 13 February 2020
Line 1:		Line 1:

	==Crystal structure of Gpb in complex with S3, SUGAR (N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE)==		==Crystal structure of Gpb in complex with S3, SUGAR (N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE)==
-	<StructureSection load='4mho' size='340' side='right' caption='[[4mho]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4mho' size='340' side='right'caption='[[4mho]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MHO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MHO FirstGlance]. <br>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4mho" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4mho" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glycogen phosphorylase 3D structures\|Glycogen phosphorylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Phosphorylase]]		[[Category: Phosphorylase]]

OCA at 09:51, 15 November 2017

OCA — Wed, 15 Nov 2017 09:51:19 GMT

←Older revision		Revision as of 09:51, 15 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4mho" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4mho" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glycogen Phosphorylase\|Glycogen Phosphorylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:20, 5 August 2016

OCA — Fri, 05 Aug 2016 05:20:24 GMT

←Older revision		Revision as of 05:20, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Gpb in complex with S3, SUGAR (N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE)==		==Crystal structure of Gpb in complex with S3, SUGAR (N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE)==
	<StructureSection load='4mho' size='340' side='right' caption='[[4mho]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4mho' size='340' side='right' caption='[[4mho]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MHO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MHO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=26M:N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE'>26M</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=26M:N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE'>26M</scene></td></tr>
-	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-~~LYSINE(~~3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-~~YLMETHANE)~~'>LLP</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mhs\|4mhs]], [[4mi3\|4mi3]], [[4mi6\|4mi6]], [[4mi9\|4mi9]], [[4mic\|4mic]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mhs\|4mhs]], [[4mi3\|4mi3]], [[4mi6\|4mi6]], [[4mi9\|4mi9]], [[4mic\|4mic]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [http://www.ebi.ac.uk/pdbsum/4mho PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [http://pdbe.org/4mho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [http://www.ebi.ac.uk/pdbsum/4mho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mho ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4mho" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glycogen Phosphorylase\|Glycogen Phosphorylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:19, 24 December 2014

OCA — Wed, 24 Dec 2014 23:19:52 GMT

←Older revision		Revision as of 23:19, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [http://www.ebi.ac.uk/pdbsum/4mho PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [http://www.ebi.ac.uk/pdbsum/4mho PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:51, 10 December 2014

OCA — Wed, 10 Dec 2014 11:51:05 GMT

←Older revision		Revision as of 11:51, 10 December 2014
Line 23:		Line 23:
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Phosphorylase]]		[[Category: Phosphorylase]]
-	[[Category: Chatzileontiadou, D S.M.]]	+	[[Category: Chatzileontiadou, D S.M]]
	[[Category: Kantsadi, A L]]		[[Category: Kantsadi, A L]]
-	[[Category: Leonidas, D D.]]	+	[[Category: Leonidas, D D]]
	[[Category: Alpha and beta protein]]		[[Category: Alpha and beta protein]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 08:36, 20 October 2014

OCA — Mon, 20 Oct 2014 08:36:29 GMT

←Older revision		Revision as of 08:36, 20 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MHO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MHO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=26M:N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE'>26M</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=26M:N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE'>26M</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mhs\|4mhs]], [[4mi3\|4mi3]], [[4mi6\|4mi6]], [[4mi9\|4mi9]], [[4mic\|4mic]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mhs\|4mhs]], [[4mi3\|4mi3]], [[4mi6\|4mi6]], [[4mi9\|4mi9]], [[4mic\|4mic]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [http://www.ebi.ac.uk/pdbsum/4mho PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [http://www.ebi.ac.uk/pdbsum/4mho PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Phosphorylase]]		[[Category: Phosphorylase]]
-	[[Category: Chatzileontiadou, D S.M]]	+	[[Category: Chatzileontiadou, D S.M.]]
	[[Category: Kantsadi, A L]]		[[Category: Kantsadi, A L]]
-	[[Category: Leonidas, D D]]	+	[[Category: Leonidas, D D.]]
	[[Category: Alpha and beta protein]]		[[Category: Alpha and beta protein]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 07:20, 10 September 2014

OCA — Wed, 10 Sep 2014 07:20:38 GMT

←Older revision		Revision as of 07:20, 10 September 2014
Line 9:		Line 9:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [http://www.ebi.ac.uk/pdbsum/4mho PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [http://www.ebi.ac.uk/pdbsum/4mho PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycogen phosphorylase (GP) is a validated target for the development of new type 2 diabetes treatments. Exploiting the Zinc docking database, we report the in silico screening of 1888 N-acyl-beta-d-glucopyranosylamines putative GP inhibitors differing only in their R groups. CombiGlide and GOLD docking programs with different scoring functions were employed with the best performing methods combined in a 'consensus scoring' approach to ranking of ligand binding affinities for the active site. Six selected candidates from the screening were then synthesized and their inhibitory potency was assessed both in vitro and ex vivo. Their inhibition constants' values, in vitro, ranged from 5 to 377muM while two of them were effective at causing inactivation of GP in rat hepatocytes at low muM concentrations. The crystal structures of GP in complex with the inhibitors were defined and provided the structural basis for their inhibitory potency and data for further structure based design of more potent inhibitors.
		+
		+	Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-beta-d-glucopyranosylamines.,Parmenopoulou V, Kantsadi AL, Tsirkone VG, Chatzileontiadou DS, Manta S, Zographos SE, Molfeta C, Archontis G, Agius L, Hayes JM, Leonidas DD, Komiotis D Bioorg Med Chem. 2014 Sep 1;22(17):4810-25. doi: 10.1016/j.bmc.2014.06.058. Epub , 2014 Jul 16. PMID:25092521<ref>PMID:25092521</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:07, 23 July 2014

OCA — Wed, 23 Jul 2014 08:07:49 GMT

←Older revision		Revision as of 08:07, 23 July 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Gpb in complex with S3, SUGAR (N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE)==
-		+	<StructureSection load='4mho' size='340' side='right' caption='[[4mho]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~The entry~~ 4mho is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4mho]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MHO FirstGlance]. <br>
-	~~Authors~~: ~~Kantsadi~~, A.L, Chatzileontiadou, D.S.M, Leonidas, D.D	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=26M:N-[(BIPHENYL-4-YLOXY)ACETYL]-BETA-D-GLUCOPYRANOSYLAMINE'>26M</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
-	~~Description~~: ~~Crystal structure of Gpb in~~ complex ~~with S3~~	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mhs\|4mhs]], [[4mi3\|4mi3]], [[4mi6\|4mi6]], [[4mi9\|4mi9]], [[4mic\|4mic]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mho OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mho RCSB], [http://www.ebi.ac.uk/pdbsum/4mho PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Phosphorylase]]
		+	[[Category: Chatzileontiadou, D S.M]]
		+	[[Category: Kantsadi, A L]]
		+	[[Category: Leonidas, D D]]
		+	[[Category: Alpha and beta protein]]
		+	[[Category: Transferase-transferase inhibitor complex]]