4mll - Revision history

OCA at 16:39, 20 September 2023

OCA — Wed, 20 Sep 2023 16:39:13 GMT

←Older revision		Revision as of 16:39, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mll]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MLL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mll]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MLL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1S6:(2R,4S)-5,5-DIMETHYL-2-[(1R)-1-{[(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)CARBONYL]AMINO}-2-OXOETHYL]-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>1S6</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.37Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1S6:(2R,4S)-5,5-DIMETHYL-2-[(1R)-1-{[(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)CARBONYL]AMINO}-2-OXOETHYL]-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>1S6</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mll OCA], [https://pdbe.org/4mll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mll RCSB], [https://www.ebi.ac.uk/pdbsum/4mll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mll ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mll OCA], [https://pdbe.org/4mll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mll RCSB], [https://www.ebi.ac.uk/pdbsum/4mll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mll ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:48, 28 December 2022

OCA — Wed, 28 Dec 2022 09:48:12 GMT

←Older revision		Revision as of 09:48, 28 December 2022
Line 1:		Line 1:

	==The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin==		==The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin==
-	<StructureSection load='4mll' size='340' side='right' caption='[[4mll]], [[Resolution\|resolution]] 1.37Å' scene=''>	+	<StructureSection load='4mll' size='340' side='right'caption='[[4mll]], [[Resolution\|resolution]] 1.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mll]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MLL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mll]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MLL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1S6:(2R,4S)-5,5-DIMETHYL-2-[(1R)-1-{[(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)CARBONYL]AMINO}-2-OXOETHYL]-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>1S6</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1S6:(2R,4S)-5,5-DIMETHYL-2-[(1R)-1-{[(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)CARBONYL]AMINO}-2-OXOETHYL]-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>1S6</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f94\|4f94]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mll OCA], [https://pdbe.org/4mll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mll RCSB], [https://www.ebi.ac.uk/pdbsum/4mll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mll ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla, bla oxa1, oxa1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mll OCA], [~~http~~://pdbe.org/4mll PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mll RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mll PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mll ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BLO1_ECOLX BLO1_ECOLX]] This is an oxacillin-hydrolyzing beta-lactamase.	+	[https://www.uniprot.org/uniprot/BLO1_ECOLX BLO1_ECOLX] This is an oxacillin-hydrolyzing beta-lactamase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
-	[[Category: ~~Beta-lactamase~~]]	+	[[Category: Large Structures]]
-	[[Category: Bonomo~~, R A~~]]	+	[[Category: Bonomo RA]]
-	[[Category: June~~, C M~~]]	+	[[Category: June CM]]
-	[[Category: Leonard~~, D A~~]]	+	[[Category: Leonard DA]]
-	[[Category: Powers~~, R A~~]]	+	[[Category: Powers RA]]
-	[[Category: Vallier~~, B C]]~~	+	[[Category: Vallier BC]]
-	~~[[Category: Antibiotic resistance]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-antibiotic complex]]~~	+
-	~~[[Category: Oxacillinase~~]]	+

OCA at 08:17, 5 August 2016

OCA — Fri, 05 Aug 2016 08:17:56 GMT

←Older revision		Revision as of 08:17, 5 August 2016
Line 1:		Line 1:
		+
	==The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin==		==The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin==
	<StructureSection load='4mll' size='340' side='right' caption='[[4mll]], [[Resolution\|resolution]] 1.37Å' scene=''>		<StructureSection load='4mll' size='340' side='right' caption='[[4mll]], [[Resolution\|resolution]] 1.37Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla, bla oxa1, oxa1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla, bla oxa1, oxa1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mll RCSB], [http://www.ebi.ac.uk/pdbsum/4mll PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mll OCA], [http://pdbe.org/4mll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mll RCSB], [http://www.ebi.ac.uk/pdbsum/4mll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mll ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4mll" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:12, 25 December 2014

OCA — Thu, 25 Dec 2014 17:12:21 GMT

←Older revision		Revision as of 17:12, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4mll\| PDB=4mll \| SCENE= }}~~	+	==The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin==
-	===The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin===	+	<StructureSection load='4mll' size='340' side='right' caption='[[4mll]], [[Resolution\|resolution]] 1.37Å' scene=''>
-	{~~{ABSTRACT_PUBMED_24165180}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4mll]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MLL FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1S6:(2R,4S)-5,5-DIMETHYL-2-[(1R)-1-{[(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)CARBONYL]AMINO}-2-OXOETHYL]-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>1S6</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4f94\|4f94]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bla, bla oxa1, oxa1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mll RCSB], [http://www.ebi.ac.uk/pdbsum/4mll PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/BLO1_ECOLX BLO1_ECOLX]] This is an oxacillin-hydrolyzing beta-lactamase.		[[http://www.uniprot.org/uniprot/BLO1_ECOLX BLO1_ECOLX]] This is an oxacillin-hydrolyzing beta-lactamase.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Since the discovery and use of penicillin, the increase of antibiotic resistance among bacterial pathogens has become a major health concern. The most prevalent resistance mechanism in Gram-negative bacteria is due to beta-lactamase expression. Class D beta-lactamases are of particular importance due to their presence in multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa. The class D enzymes were initially characterized by their ability to efficiently hydrolyze isoxazolyl-type beta-lactams like oxacillin. Due to this substrate preference, these enzymes are traditionally referred to as oxacillinases or OXAs. However, this class is comprised of subfamilies characterized by diverse activities that include oxacillinase, carbapenemase, or cephalosporinase substrate specificity. OXA-1 represents one subtype of class D enzyme that efficiently hydrolyzes oxacillin, and OXA-24/40 represents another with weak oxacillinase, but increased carbapenemase, activity. To examine the structural basis for the substrate selectivity differences between OXA-1 and OXA-24/40, the X-ray crystal structures of deacylation-deficient mutants of these enzymes (Lys70Asp for OXA-1; Lys84Asp for OXA-24) in complexes with oxacillin were determined to 1.4 A and 2.4 A, respectively. In the OXA-24/40/oxacillin structure, the hydrophobic R1 side chain of oxacillin disrupts the bridge between Tyr112 and Met223 present in the apo OXA-24/40 structure, causing the main chain of the Met223-containing loop to adopt a completely different conformation. In contrast, in the OXA-1/oxacillin structure, a hydrophobic pocket consisting of Trp102, Met99, Phe217, Leu161, and Leu255 nicely complements oxacillin's nonpolar R1 side chain. Comparison of the OXA-1/oxacillin and OXA-24/40/oxacillin complexes provides novel insight on how substrate selectivity is achieved among subtypes of class D beta-lactamases. By elucidating important active site interactions, these findings can also inform the design of novel antibiotics and inhibitors.
		+
		+	Structural Origins of Oxacillinase Specificity in Class D beta-Lactamases.,June CM, Vallier BC, Bonomo RA, Leonard DA, Powers RA Antimicrob Agents Chemother. 2014 Jan;58(1):333-41. doi: 10.1128/AAC.01483-13., Epub 2013 Oct 28. PMID:24165180<ref>PMID:24165180</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4mll]] is~~ a ~~4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024165180</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Beta-lactamase\|Beta-lactamase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Bonomo, R A.]]	+	[[Category: Bonomo, R A]]
-	[[Category: June, C M.]]	+	[[Category: June, C M]]
-	[[Category: Leonard, D A.]]	+	[[Category: Leonard, D A]]
-	[[Category: Powers, R A.]]	+	[[Category: Powers, R A]]
-	[[Category: Vallier, B C.]]	+	[[Category: Vallier, B C]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-antibiotic complex]]		[[Category: Hydrolase-antibiotic complex]]
	[[Category: Oxacillinase]]		[[Category: Oxacillinase]]

OCA at 08:16, 8 January 2014

OCA — Wed, 08 Jan 2014 08:16:10 GMT

←Older revision		Revision as of 08:16, 8 January 2014
Line 1:		Line 1:
	{{STRUCTURE_4mll\| PDB=4mll \| SCENE= }}		{{STRUCTURE_4mll\| PDB=4mll \| SCENE= }}
	===The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin===		===The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin===
		+	{{ABSTRACT_PUBMED_24165180}}

	==Function==		==Function==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4mll]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA].	+	[[4mll]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024165180</ref><references group="xtra"/><references/>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Escherichia coli]]
	[[Category: Bonomo, R A.]]		[[Category: Bonomo, R A.]]
	[[Category: June, C M.]]		[[Category: June, C M.]]

OCA at 06:18, 10 October 2013

OCA — Thu, 10 Oct 2013 06:18:59 GMT

←Older revision		Revision as of 06:18, 10 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4mll\| PDB=4mll \| SCENE= }}
		+	===The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin===

-	~~The entry 4mll~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BLO1_ECOLX BLO1_ECOLX]] This is an oxacillin-hydrolyzing beta-lactamase.

-	~~Authors~~: ~~June, C~~.M.~~, Vallier, B~~.C., Bonomo, R.A., Leonard, D.A., Powers, R.A.	+	==About this Structure==
-		+	[[4mll]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4f7y 4f7y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLL OCA].
-	~~Description~~: ~~The 1~~.~~4 A structure of the class D beta~~-~~lactamase OXA-1 K70D complexed with oxacillin~~	+	[[Category: Beta-lactamase]]
		+	[[Category: Escherichia coli]]
		+	[[Category: Bonomo, R A.]]
		+	[[Category: June, C M.]]
		+	[[Category: Leonard, D A.]]
		+	[[Category: Powers, R A.]]
		+	[[Category: Vallier, B C.]]
		+	[[Category: Antibiotic resistance]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-antibiotic complex]]
		+	[[Category: Oxacillinase]]

OCA: Protected "4mll" [edit=sysop:move=sysop]

OCA — Fri, 20 Sep 2013 03:41:01 GMT

Protected "4mll" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:41, 20 September 2013

OCA: New page: '''Unreleased structure''' The entry 4mll is ON HOLD Authors: June, C.M., Vallier, B.C., Bonomo, R.A., Leonard, D.A., Powers, R.A. Description: The 1.4 A structure of the class D beta-...

OCA — Fri, 20 Sep 2013 03:41:00 GMT

New page: '''Unreleased structure''' The entry 4mll is ON HOLD Authors: June, C.M., Vallier, B.C., Bonomo, R.A., Leonard, D.A., Powers, R.A. Description: The 1.4 A structure of the class D beta-...

New page

'''Unreleased structure'''

The entry 4mll is ON HOLD

Authors: June, C.M., Vallier, B.C., Bonomo, R.A., Leonard, D.A., Powers, R.A.

Description: The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin