4mnd - Revision history

OCA at 16:39, 20 September 2023

OCA — Wed, 20 Sep 2023 16:39:47 GMT

←Older revision		Revision as of 16:39, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MND FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MND FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.66Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [https://pdbe.org/4mnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [https://www.ebi.ac.uk/pdbsum/4mnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [https://pdbe.org/4mnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [https://www.ebi.ac.uk/pdbsum/4mnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnd ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:53, 28 December 2022

OCA — Wed, 28 Dec 2022 09:53:52 GMT

←Older revision		Revision as of 09:53, 28 December 2022
Line 3:		Line 3:
	<StructureSection load='4mnd' size='340' side='right'caption='[[4mnd]], [[Resolution\|resolution]] 2.66Å' scene=''>		<StructureSection load='4mnd' size='340' side='right'caption='[[4mnd]], [[Resolution\|resolution]] 2.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arcfl Arcfl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MND FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MND FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF_0263 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [https://pdbe.org/4mnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [https://www.ebi.ac.uk/pdbsum/4mnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnd ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [~~http~~://pdbe.org/4mnd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mnd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnd ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DIPPS_ARCFU DIPPS_ARCFU]] Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments. Catalyzes the condensation of CTP and L-myo-inositol-1-phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di-myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate. The cytidylyltransferase is absolutely specific for CTP and L-myo-inositol-1-P. The DIPP synthase uses only L-myoinositol-1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myoinositol, are recognized as alcohol donors.<ref>PMID:17028285</ref> <ref>PMID:17526717</ref> <ref>PMID:21378188</ref>	+	[https://www.uniprot.org/uniprot/DIPPS_ARCFU DIPPS_ARCFU] Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments. Catalyzes the condensation of CTP and L-myo-inositol-1-phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di-myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate. The cytidylyltransferase is absolutely specific for CTP and L-myo-inositol-1-P. The DIPP synthase uses only L-myoinositol-1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myoinositol, are recognized as alcohol donors.<ref>PMID:17028285</ref> <ref>PMID:17526717</ref> <ref>PMID:21378188</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arcfl~~]]	+	[[Category: Archaeoglobus fulgidus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Archer, M]]	+	[[Category: Archer M]]
-	[[Category: Borges, N]]	+	[[Category: Borges N]]
-	[[Category: Borshchevskiy, V]]	+	[[Category: Borshchevskiy V]]
-	[[Category: Esteves~~, A M~~]]	+	[[Category: Esteves AM]]
-	[[Category: Gordeliy, V]]	+	[[Category: Gordeliy V]]
-	[[Category: Grudinin, S]]	+	[[Category: Grudinin S]]
-	[[Category: Gushchin, I]]	+	[[Category: Gushchin I]]
-	[[Category: Ishchenko, A]]	+	[[Category: Ishchenko A]]
-	[[Category: Ma, P]]	+	[[Category: Ma P]]
-	[[Category: Moraes, I]]	+	[[Category: Moraes I]]
-	[[Category: Nogly, P]]	+	[[Category: Nogly P]]
-	[[Category: Remeeva, A]]	+	[[Category: Remeeva A]]
-	[[Category: Round, E]]	+	[[Category: Round E]]
-	[[Category: Santos, H]]	+	[[Category: Santos H]]
-	~~[[Category: Cdp-alcohol phosphotransferase]]~~	+
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transmembrane protein~~]]	+

OCA at 08:56, 10 April 2019

OCA — Wed, 10 Apr 2019 08:56:09 GMT

←Older revision		Revision as of 08:56, 10 April 2019
Line 1:		Line 1:

	==Crystal structure of Archaeoglobus fulgidus IPCT-DIPPS bifunctional membrane protein==		==Crystal structure of Archaeoglobus fulgidus IPCT-DIPPS bifunctional membrane protein==
-	<StructureSection load='4mnd' size='340' side='right' caption='[[4mnd]], [[Resolution\|resolution]] 2.66Å' scene=''>	+	<StructureSection load='4mnd' size='340' side='right'caption='[[4mnd]], [[Resolution\|resolution]] 2.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MND FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MND FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AF_0263 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [http://pdbe.org/4mnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [http://www.ebi.ac.uk/pdbsum/4mnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [http://pdbe.org/4mnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [http://www.ebi.ac.uk/pdbsum/4mnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnd ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arcfl]]
		+	[[Category: Large Structures]]
	[[Category: Archer, M]]		[[Category: Archer, M]]
	[[Category: Borges, N]]		[[Category: Borges, N]]

OCA at 20:42, 5 August 2016

OCA — Fri, 05 Aug 2016 20:42:57 GMT

←Older revision		Revision as of 20:42, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Archaeoglobus fulgidus IPCT-DIPPS bifunctional membrane protein==		==Crystal structure of Archaeoglobus fulgidus IPCT-DIPPS bifunctional membrane protein==
	<StructureSection load='4mnd' size='340' side='right' caption='[[4mnd]], [[Resolution\|resolution]] 2.66Å' scene=''>		<StructureSection load='4mnd' size='340' side='right' caption='[[4mnd]], [[Resolution\|resolution]] 2.66Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MND FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MND FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [http://www.ebi.ac.uk/pdbsum/4mnd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [http://pdbe.org/4mnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [http://www.ebi.ac.uk/pdbsum/4mnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4mnd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:43, 25 December 2014

OCA — Thu, 25 Dec 2014 05:43:15 GMT

←Older revision		Revision as of 05:43, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MND FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MND FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [http://www.ebi.ac.uk/pdbsum/4mnd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [http://www.ebi.ac.uk/pdbsum/4mnd PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DIPPS_ARCFU DIPPS_ARCFU]] Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments. Catalyzes the condensation of CTP and L-myo-inositol-1-phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di-myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate. The cytidylyltransferase is absolutely specific for CTP and L-myo-inositol-1-P. The DIPP synthase uses only L-myoinositol-1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-L-myo-inositol and CDP-D-myoinositol, are recognized as alcohol donors.<ref>PMID:17028285</ref> <ref>PMID:17526717</ref> <ref>PMID:21378188</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Archer, M.]]	+	[[Category: Archer, M]]
-	[[Category: Borges, N.]]	+	[[Category: Borges, N]]
-	[[Category: Borshchevskiy, V.]]	+	[[Category: Borshchevskiy, V]]
-	[[Category: Esteves, A M.]]	+	[[Category: Esteves, A M]]
-	[[Category: Gordeliy, V.]]	+	[[Category: Gordeliy, V]]
-	[[Category: Grudinin, S.]]	+	[[Category: Grudinin, S]]
-	[[Category: Gushchin, I.]]	+	[[Category: Gushchin, I]]
-	[[Category: Ishchenko, A.]]	+	[[Category: Ishchenko, A]]
-	[[Category: Ma, P.]]	+	[[Category: Ma, P]]
-	[[Category: Moraes, I.]]	+	[[Category: Moraes, I]]
-	[[Category: Nogly, P.]]	+	[[Category: Nogly, P]]
-	[[Category: Remeeva, A.]]	+	[[Category: Remeeva, A]]
-	[[Category: Round, E.]]	+	[[Category: Round, E]]
-	[[Category: Santos, H.]]	+	[[Category: Santos, H]]
	[[Category: Cdp-alcohol phosphotransferase]]		[[Category: Cdp-alcohol phosphotransferase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transmembrane protein]]		[[Category: Transmembrane protein]]

OCA at 08:24, 2 July 2014

OCA — Wed, 02 Jul 2014 08:24:38 GMT

←Older revision		Revision as of 08:24, 2 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Archaeoglobus fulgidus IPCT-DIPPS bifunctional membrane protein==
		+	<StructureSection load='4mnd' size='340' side='right' caption='[[4mnd]], [[Resolution\|resolution]] 2.66Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4mnd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MND FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mnd RCSB], [http://www.ebi.ac.uk/pdbsum/4mnd PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phospholipids have major roles in the structure and function of all cell membranes. Most integral membrane proteins from the large CDP-alcohol phosphatidyltransferase family are involved in phospholipid biosynthesis across the three domains of life. They share a conserved sequence pattern and catalyse the displacement of CMP from a CDP-alcohol by a second alcohol. Here we report the crystal structure of a bifunctional enzyme comprising a cytoplasmic nucleotidyltransferase domain (IPCT) fused with a membrane CDP-alcohol phosphotransferase domain (DIPPS) at 2.65 A resolution. The bifunctional protein dimerizes through the DIPPS domains, each comprising six transmembrane alpha-helices. The active site cavity is hydrophilic and widely open to the cytoplasm with a magnesium ion surrounded by four highly conserved aspartate residues from helices TM2 and TM3. We show that magnesium is essential for the enzymatic activity and is involved in catalysis. Substrates docking is validated by mutagenesis studies, and a structure-based catalytic mechanism is proposed.

-	~~The entry 4mnd is ON HOLD until Paper Publication~~	+	X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism.,Nogly P, Gushchin I, Remeeva A, Esteves AM, Borges N, Ma P, Ishchenko A, Grudinin S, Round E, Moraes I, Borshchevskiy V, Santos H, Gordeliy V, Archer M Nat Commun. 2014 Jun 19;5:4169. doi: 10.1038/ncomms5169. PMID:24942835<ref>PMID:24942835</ref>

-	~~Authors: Nogly~~, P., ~~Gushchin, I~~., ~~Remeeva, A~~., Esteves, A.M., ~~Ishchenko, A~~.~~, Ma, P.,~~ Grudinin, S., ~~Borges, N~~., ~~Round, E~~., Moraes, I., ~~Borshchevskiy~~, V., Santos, H.~~, Gordeliy, V., Archer, M.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure of a membrane~~ protein	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Archer, M.]]
		+	[[Category: Borges, N.]]
		+	[[Category: Borshchevskiy, V.]]
		+	[[Category: Esteves, A M.]]
		+	[[Category: Gordeliy, V.]]
		+	[[Category: Grudinin, S.]]
		+	[[Category: Gushchin, I.]]
		+	[[Category: Ishchenko, A.]]
		+	[[Category: Ma, P.]]
		+	[[Category: Moraes, I.]]
		+	[[Category: Nogly, P.]]
		+	[[Category: Remeeva, A.]]
		+	[[Category: Round, E.]]
		+	[[Category: Santos, H.]]
		+	[[Category: Cdp-alcohol phosphotransferase]]
		+	[[Category: Rossmann fold]]
		+	[[Category: Transferase]]
		+	[[Category: Transmembrane protein]]

OCA at 07:35, 15 January 2014

OCA — Wed, 15 Jan 2014 07:35:46 GMT

←Older revision		Revision as of 07:35, 15 January 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4mnd is ON HOLD	+	The entry 4mnd is ON HOLD until Paper Publication

	Authors: Nogly, P., Gushchin, I., Remeeva, A., Esteves, A.M., Ishchenko, A., Ma, P., Grudinin, S., Borges, N., Round, E., Moraes, I., Borshchevskiy, V., Santos, H., Gordeliy, V., Archer, M.		Authors: Nogly, P., Gushchin, I., Remeeva, A., Esteves, A.M., Ishchenko, A., Ma, P., Grudinin, S., Borges, N., Round, E., Moraes, I., Borshchevskiy, V., Santos, H., Gordeliy, V., Archer, M.

	Description: Structure of a membrane protein		Description: Structure of a membrane protein

OCA: Protected "4mnd" [edit=sysop:move=sysop]

OCA — Fri, 20 Sep 2013 03:43:18 GMT

Protected "4mnd" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:43, 20 September 2013

OCA: New page: '''Unreleased structure''' The entry 4mnd is ON HOLD Authors: Nogly, P., Gushchin, I., Remeeva, A., Esteves, A.M., Ishchenko, A., Ma, P., Grudinin, S., Borges, N., Round, E., Moraes, I....

OCA — Fri, 20 Sep 2013 03:43:17 GMT

New page: '''Unreleased structure''' The entry 4mnd is ON HOLD Authors: Nogly, P., Gushchin, I., Remeeva, A., Esteves, A.M., Ishchenko, A., Ma, P., Grudinin, S., Borges, N., Round, E., Moraes, I....

New page

'''Unreleased structure'''

The entry 4mnd is ON HOLD

Authors: Nogly, P., Gushchin, I., Remeeva, A., Esteves, A.M., Ishchenko, A., Ma, P., Grudinin, S., Borges, N., Round, E., Moraes, I., Borshchevskiy, V., Santos, H., Gordeliy, V., Archer, M.

Description: Structure of a membrane protein