4mqt - Revision history

OCA at 16:40, 20 September 2023

OCA — Wed, 20 Sep 2023 16:40:45 GMT

←Older revision		Revision as of 16:40, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mqt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MQT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mqt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MQT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CU:3-AMINO-5-CHLORO-N-CYCLOPROPYL-4-METHYL-6-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHOXY]THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE'>2CU</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CU:3-AMINO-5-CHLORO-N-CYCLOPROPYL-4-METHYL-6-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHOXY]THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE'>2CU</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqt OCA], [https://pdbe.org/4mqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mqt RCSB], [https://www.ebi.ac.uk/pdbsum/4mqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqt OCA], [https://pdbe.org/4mqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mqt RCSB], [https://www.ebi.ac.uk/pdbsum/4mqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqt ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:02, 28 December 2022

OCA — Wed, 28 Dec 2022 10:02:13 GMT

←Older revision		Revision as of 10:02, 28 December 2022
Line 3:		Line 3:
	<StructureSection load='4mqt' size='340' side='right'caption='[[4mqt]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='4mqt' size='340' side='right'caption='[[4mqt]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mqt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Camelus_glama Camelus glama~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MQT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mqt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MQT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CU:3-AMINO-5-CHLORO-N-CYCLOPROPYL-4-METHYL-6-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHOXY]THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE'>2CU</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CU:3-AMINO-5-CHLORO-N-CYCLOPROPYL-4-METHYL-6-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHOXY]THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE'>2CU</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3uon\|3uon]], [[4mqs\|4mqs]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqt OCA], [https://pdbe.org/4mqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mqt RCSB], [https://www.ebi.ac.uk/pdbsum/4mqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqt ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHRM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqt OCA], [~~http~~://pdbe.org/4mqt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mqt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mqt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqt ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.	+	[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4mqt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4mqt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Muscarinic acetylcholine receptor\|Muscarinic acetylcholine receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Camelus glama~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Christopoulos, A]]	+	[[Category: Christopoulos A]]
-	[[Category: Eitel, K]]	+	[[Category: Eitel K]]
-	[[Category: Felder~~, C C~~]]	+	[[Category: Felder CC]]
-	[[Category: Garcia~~, K C~~]]	+	[[Category: Garcia KC]]
-	[[Category: Gmeiner, P]]	+	[[Category: Gmeiner P]]
-	[[Category: Hu, J]]	+	[[Category: Hu J]]
-	[[Category: Hu, K]]	+	[[Category: Hu K]]
-	[[Category: Huebner, H]]	+	[[Category: Huebner H]]
-	[[Category: Kobilka~~, B K~~]]	+	[[Category: Kobilka BK]]
-	[[Category: Kruse~~, A C~~]]	+	[[Category: Kruse AC]]
-	[[Category: Manglik, A]]	+	[[Category: Manglik A]]
-	[[Category: Pardon, E]]	+	[[Category: Pardon E]]
-	[[Category: Ring~~, A M~~]]	+	[[Category: Ring AM]]
-	[[Category: Sexton~~, P M~~]]	+	[[Category: Sexton PM]]
-	[[Category: Steyaert, J]]	+	[[Category: Steyaert J]]
-	[[Category: Valant, C]]	+	[[Category: Valant C]]
-	[[Category: Weis~~, W I~~]]	+	[[Category: Weis WI]]
-	[[Category: Wess, J]]	+	[[Category: Wess J]]
-	~~[[Category: Allosteric modulation]]~~	+
-	~~[[Category: G protein-coupled receptor]]~~	+
-	~~[[Category: Muscarinic acetylcholine receptor]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 09:00, 1 May 2019

OCA — Wed, 01 May 2019 09:00:29 GMT

←Older revision		Revision as of 09:00, 1 May 2019
Line 1:		Line 1:

	==Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620==		==Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620==
-	<StructureSection load='4mqt' size='340' side='right' caption='[[4mqt]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<StructureSection load='4mqt' size='340' side='right'caption='[[4mqt]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mqt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mqt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQT FirstGlance]. <br>
Line 28:		Line 28:
	[[Category: Camelus glama]]		[[Category: Camelus glama]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Christopoulos, A]]		[[Category: Christopoulos, A]]
	[[Category: Eitel, K]]		[[Category: Eitel, K]]

OCA at 19:39, 4 August 2016

OCA — Thu, 04 Aug 2016 19:39:28 GMT

←Older revision		Revision as of 19:39, 4 August 2016
Line 1:		Line 1:
-	{{STRUCTURE_4mqt\| PDB=4mqt \| SCENE= }}
-	===Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620===
-	{{ABSTRACT_PUBMED_24256733}}

-	==Disease==	+	==Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620==
		+	<StructureSection load='4mqt' size='340' side='right' caption='[[4mqt]], [[Resolution\|resolution]] 3.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4mqt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CU:3-AMINO-5-CHLORO-N-CYCLOPROPYL-4-METHYL-6-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHOXY]THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE'>2CU</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3uon\|3uon]], [[4mqs\|4mqs]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHRM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqt OCA], [http://pdbe.org/4mqt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mqt RCSB], [http://www.ebi.ac.uk/pdbsum/4mqt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqt ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.		[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Despite recent advances in crystallography and the availability of G-protein-coupled receptor (GPCR) structures, little is known about the mechanism of their activation process, as only the beta2 adrenergic receptor (beta2AR) and rhodopsin have been crystallized in fully active conformations. Here we report the structure of an agonist-bound, active state of the human M2 muscarinic acetylcholine receptor stabilized by a G-protein mimetic camelid antibody fragment isolated by conformational selection using yeast surface display. In addition to the expected changes in the intracellular surface, the structure reveals larger conformational changes in the extracellular region and orthosteric binding site than observed in the active states of the beta2AR and rhodopsin. We also report the structure of the M2 receptor simultaneously bound to the orthosteric agonist iperoxo and the positive allosteric modulator LY2119620. This structure reveals that LY2119620 recognizes a largely pre-formed binding site in the extracellular vestibule of the iperoxo-bound receptor, inducing a slight contraction of this outer binding pocket. These structures offer important insights into the activation mechanism and allosteric modulation of muscarinic receptors.

-	~~==About this Structure==~~	+	Activation and allosteric modulation of a muscarinic acetylcholine receptor.,Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hubner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK Nature. 2013 Nov 20. doi: 10.1038/nature12735. PMID:24256733<ref>PMID:24256733</ref>
-	~~[[4mqt]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Camelus_glama Camelus glama] and [http~~:~~//en.wikipedia~~.~~org~~/~~wiki/Human Human]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA].~~	+

-	~~==Reference==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<~~ref group~~="~~xtra~~"~~>PMID~~:~~024256733~~</~~ref~~><references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	<div class="pdbe-citations 4mqt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Camelus glama]]		[[Category: Camelus glama]]
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Christopoulos, A.]]	+	[[Category: Christopoulos, A]]
-	[[Category: Eitel, K.]]	+	[[Category: Eitel, K]]
-	[[Category: Felder, C C.]]	+	[[Category: Felder, C C]]
-	[[Category: Garcia, K C.]]	+	[[Category: Garcia, K C]]
-	[[Category: Gmeiner, P.]]	+	[[Category: Gmeiner, P]]
-	[[Category: Hu, J.]]	+	[[Category: Hu, J]]
-	[[Category: Hu, K.]]	+	[[Category: Hu, K]]
-	[[Category: Huebner, H.]]	+	[[Category: Huebner, H]]
-	[[Category: Kobilka, B K.]]	+	[[Category: Kobilka, B K]]
-	[[Category: Kruse, A C.]]	+	[[Category: Kruse, A C]]
-	[[Category: Manglik, A.]]	+	[[Category: Manglik, A]]
-	[[Category: Pardon, E.]]	+	[[Category: Pardon, E]]
-	[[Category: Ring, A M.]]	+	[[Category: Ring, A M]]
-	[[Category: Sexton, P M.]]	+	[[Category: Sexton, P M]]
-	[[Category: Steyaert, J.]]	+	[[Category: Steyaert, J]]
-	[[Category: Valant, C.]]	+	[[Category: Valant, C]]
-	[[Category: Weis, W I.]]	+	[[Category: Weis, W I]]
-	[[Category: Wess, J.]]	+	[[Category: Wess, J]]
	[[Category: Allosteric modulation]]		[[Category: Allosteric modulation]]
	[[Category: G protein-coupled receptor]]		[[Category: G protein-coupled receptor]]
	[[Category: Muscarinic acetylcholine receptor]]		[[Category: Muscarinic acetylcholine receptor]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 07:49, 18 December 2013

OCA — Wed, 18 Dec 2013 07:49:24 GMT

←Older revision		Revision as of 07:49, 18 December 2013
Line 10:		Line 10:

	==About this Structure==		==About this Structure==
-	[[4mqt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA].	+	[[4mqt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024256733</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024256733</ref><references group="xtra"/><references/>
		+	[[Category: Camelus glama]]
		+	[[Category: Human]]
	[[Category: Christopoulos, A.]]		[[Category: Christopoulos, A.]]
	[[Category: Eitel, K.]]		[[Category: Eitel, K.]]

OCA at 06:04, 4 December 2013

OCA — Wed, 04 Dec 2013 06:04:01 GMT

←Older revision		Revision as of 06:04, 4 December 2013
Line 1:		Line 1:
	{{STRUCTURE_4mqt\| PDB=4mqt \| SCENE= }}		{{STRUCTURE_4mqt\| PDB=4mqt \| SCENE= }}
	===Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620===		===Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620===
		+	{{ABSTRACT_PUBMED_24256733}}

	==Disease==		==Disease==
Line 10:		Line 11:
	==About this Structure==		==About this Structure==
	[[4mqt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA].		[[4mqt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024256733</ref><references group="xtra"/><references/>
	[[Category: Christopoulos, A.]]		[[Category: Christopoulos, A.]]
	[[Category: Eitel, K.]]		[[Category: Eitel, K.]]

OCA at 10:35, 27 November 2013

OCA — Wed, 27 Nov 2013 10:35:13 GMT

←Older revision		Revision as of 10:35, 27 November 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4mqt\| PDB=4mqt \| SCENE= }}
		+	===Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620===

-	~~The entry 4mqt~~ is ~~ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.

-	~~Authors~~: ~~Kruse, A~~.~~C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J~~., ~~Kobilka~~, B.K.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

-	~~Description:~~ Structure ~~of active human M2 muscarinic~~ acetylcholine receptor ~~bound to the agonist iperoxo and allosteric modulator LY2119620~~	+	==About this Structure==
		+	[[4mqt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQT OCA].
		+	[[Category: Christopoulos, A.]]
		+	[[Category: Eitel, K.]]
		+	[[Category: Felder, C C.]]
		+	[[Category: Garcia, K C.]]
		+	[[Category: Gmeiner, P.]]
		+	[[Category: Hu, J.]]
		+	[[Category: Hu, K.]]
		+	[[Category: Huebner, H.]]
		+	[[Category: Kobilka, B K.]]
		+	[[Category: Kruse, A C.]]
		+	[[Category: Manglik, A.]]
		+	[[Category: Pardon, E.]]
		+	[[Category: Ring, A M.]]
		+	[[Category: Sexton, P M.]]
		+	[[Category: Steyaert, J.]]
		+	[[Category: Valant, C.]]
		+	[[Category: Weis, W I.]]
		+	[[Category: Wess, J.]]
		+	[[Category: Allosteric modulation]]
		+	[[Category: G protein-coupled receptor]]
		+	[[Category: Muscarinic acetylcholine receptor]]
		+	[[Category: Signaling protein]]

OCA: Protected "4mqt" [edit=sysop:move=sysop]

OCA — Sun, 29 Sep 2013 07:41:41 GMT

Protected "4mqt" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:41, 29 September 2013

OCA: New page: '''Unreleased structure''' The entry 4mqt is ON HOLD Authors: Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christo...

OCA — Sun, 29 Sep 2013 07:41:40 GMT

New page: '''Unreleased structure''' The entry 4mqt is ON HOLD Authors: Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christo...

New page

'''Unreleased structure'''

The entry 4mqt is ON HOLD

Authors: Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K.

Description: Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620