4mrp - Revision history

OCA at 10:03, 28 December 2022

OCA — Wed, 28 Dec 2022 10:03:45 GMT

←Older revision		Revision as of 10:03, 28 December 2022
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	<StructureSection load='4mrp' size='340' side='right'caption='[[4mrp]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4mrp' size='340' side='right'caption='[[4mrp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4mrp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Novad Novad~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MRP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4mrp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Novosphingobium_aromaticivorans_DSM_12444 Novosphingobium aromaticivorans DSM 12444]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MRP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=~~PO4~~:~~PHOSPHATE+ION~~'>~~PO4~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrp OCA], [https://pdbe.org/4mrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mrp RCSB], [https://www.ebi.ac.uk/pdbsum/4mrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mrp ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mrn\|4mrn]], [[4mrr\|4mrr]], [[4mrs\|4mrs]], [[4mrv\|4mrv]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATM1, Saro_2631 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=279238 NOVAD])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrp OCA], [~~http~~://pdbe.org/4mrp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4mrp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4mrp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4mrp ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ATM1_NOVAD ATM1_NOVAD] Mediates the ATP-dependent export of glutathione-conjugated substrates, such as heavy metal-glutathione conjugates. ATP hydrolysis is stimulated by glutathione binding. Protects cells against toxic heavy metal ions, such as silver and mercury ions. May also mediate the transport of glutathione-conjugated aromatic hydrocarbons, such as dinitrobenzene.<ref>PMID:24604198</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Novad~~]]	+	[[Category: Novosphingobium aromaticivorans DSM 12444]]
-	[[Category: Lee~~, J Y~~]]	+	[[Category: Lee JY]]
-	[[Category: Lewinson, O]]	+	[[Category: Lewinson O]]
-	[[Category: Rees~~, D C~~]]	+	[[Category: Rees DC]]
-	[[Category: Yang~~, J G~~]]	+	[[Category: Yang JG]]
-	[[Category: Zhitnitsky, D]]	+	[[Category: Zhitnitsky D]]
-	~~[[Category: Heavy metal resistance]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Substrate exporter]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 12:08, 17 July 2019

OCA — Wed, 17 Jul 2019 12:08:58 GMT

←Older revision		Revision as of 12:08, 17 July 2019
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	==Structure of a bacterial Atm1-family ABC transporter==		==Structure of a bacterial Atm1-family ABC transporter==
-	<StructureSection load='4mrp' size='340' side='right' caption='[[4mrp]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4mrp' size='340' side='right'caption='[[4mrp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4mrp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Novad Novad]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MRP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4mrp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Novad Novad]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MRP FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Novad]]		[[Category: Novad]]
	[[Category: Lee, J Y]]		[[Category: Lee, J Y]]

OCA at 10:35, 11 August 2016

OCA — Thu, 11 Aug 2016 10:35:40 GMT

←Older revision		Revision as of 10:35, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of a bacterial Atm1-family ABC transporter==		==Structure of a bacterial Atm1-family ABC transporter==
	<StructureSection load='4mrp' size='340' side='right' caption='[[4mrp]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4mrp' size='340' side='right' caption='[[4mrp]], [[Resolution\|resolution]] 2.50Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mrn\|4mrn]], [[4mrr\|4mrr]], [[4mrs\|4mrs]], [[4mrv\|4mrv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mrn\|4mrn]], [[4mrr\|4mrr]], [[4mrs\|4mrs]], [[4mrv\|4mrv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATM1, Saro_2631 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=279238 NOVAD])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATM1, Saro_2631 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=279238 NOVAD])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mrp RCSB], [http://www.ebi.ac.uk/pdbsum/4mrp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrp OCA], [http://pdbe.org/4mrp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mrp RCSB], [http://www.ebi.ac.uk/pdbsum/4mrp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mrp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4mrp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:48, 5 January 2015

OCA — Mon, 05 Jan 2015 09:48:35 GMT

←Older revision		Revision as of 09:48, 5 January 2015
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-	~~{{STRUCTURE_4mrp\| PDB=4mrp \| SCENE= }}~~	+	==Structure of a bacterial Atm1-family ABC transporter==
-	===Structure of a bacterial Atm1-family ABC transporter===	+	<StructureSection load='4mrp' size='340' side='right' caption='[[4mrp]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24604198}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4mrp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Novad Novad]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MRP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mrn\|4mrn]], [[4mrr\|4mrr]], [[4mrs\|4mrs]], [[4mrv\|4mrv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATM1, Saro_2631 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=279238 NOVAD])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mrp RCSB], [http://www.ebi.ac.uk/pdbsum/4mrp PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although substantial progress has been achieved in the structural analysis of exporters from the superfamily of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, much less is known about how they selectively recognize substrates and how substrate binding is coupled to ATP hydrolysis. We have addressed these questions through crystallographic analysis of the Atm1/ABCB7/HMT1/ABCB6 ortholog from Novosphingobium aromaticivorans DSM 12444, NaAtm1, at 2.4 angstrom resolution. Consistent with a physiological role in cellular detoxification processes, functional studies showed that glutathione derivatives can serve as substrates for NaAtm1 and that its overexpression in Escherichia coli confers protection against silver and mercury toxicity. The glutathione binding site highlights the articulated design of ABC exporters, with ligands and nucleotides spanning structurally conserved elements to create adaptable interfaces accommodating conformational rearrangements during the transport cycle.

-	~~==About this Structure==~~	+	Structural basis for heavy metal detoxification by an Atm1-type ABC exporter.,Lee JY, Yang JG, Zhitnitsky D, Lewinson O, Rees DC Science. 2014 Mar 7;343(6175):1133-6. doi: 10.1126/science.1246489. PMID:24604198<ref>PMID:24604198</ref>
-	~~[[4mrp]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4MRP OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024604198</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Lee, J Y.]]	+	== References ==
-	[[Category: Lewinson, O.]]	+	<references/>
-	[[Category: Rees, D C.]]	+	__TOC__
-	[[Category: Yang, J G.]]	+	</StructureSection>
-	[[Category: Zhitnitsky, D.]]	+	[[Category: Novad]]
		+	[[Category: Lee, J Y]]
		+	[[Category: Lewinson, O]]
		+	[[Category: Rees, D C]]
		+	[[Category: Yang, J G]]
		+	[[Category: Zhitnitsky, D]]
	[[Category: Heavy metal resistance]]		[[Category: Heavy metal resistance]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 09:06, 19 March 2014

OCA — Wed, 19 Mar 2014 09:06:35 GMT

←Older revision		Revision as of 09:06, 19 March 2014
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4mrp\| PDB=4mrp \| SCENE= }}
		+	===Structure of a bacterial Atm1-family ABC transporter===
		+	{{ABSTRACT_PUBMED_24604198}}

-	~~The entry~~ 4mrp is ~~ON HOLD~~	+	==About this Structure==
		+	[[4mrp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRP OCA].

-	~~Authors~~: Lee, J.Y., Yang, J.G., Zhitnitsky, D.~~, Lewinson, O., Rees, D.C.~~	+	==Reference==
-		+	<ref group="xtra">PMID:024604198</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Structure of a bacterial Atm1-family ABC transporter~~	+	[[Category: Lee, J Y.]]
		+	[[Category: Lewinson, O.]]
		+	[[Category: Rees, D C.]]
		+	[[Category: Yang, J G.]]
		+	[[Category: Zhitnitsky, D.]]
		+	[[Category: Heavy metal resistance]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Substrate exporter]]
		+	[[Category: Transport protein]]

OCA: Protected "4mrp" [edit=sysop:move=sysop]

OCA — Sun, 29 Sep 2013 07:42:57 GMT

Protected "4mrp" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:42, 29 September 2013

OCA: New page: '''Unreleased structure''' The entry 4mrp is ON HOLD Authors: Lee, J.Y., Yang, J.G., Zhitnitsky, D., Lewinson, O., Rees, D.C. Description: Structure of a bacterial Atm1-family ABC tran...

OCA — Sun, 29 Sep 2013 07:42:56 GMT

New page: '''Unreleased structure''' The entry 4mrp is ON HOLD Authors: Lee, J.Y., Yang, J.G., Zhitnitsky, D., Lewinson, O., Rees, D.C. Description: Structure of a bacterial Atm1-family ABC tran...

New page

'''Unreleased structure'''

The entry 4mrp is ON HOLD

Authors: Lee, J.Y., Yang, J.G., Zhitnitsky, D., Lewinson, O., Rees, D.C.

Description: Structure of a bacterial Atm1-family ABC transporter