4ms6 - Revision history

OCA at 16:41, 20 September 2023

OCA — Wed, 20 Sep 2023 16:41:34 GMT

←Older revision		Revision as of 16:41, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ms6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MS6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ms6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MS6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=28T:1-{4-OXO-4-[(2S)-PYRROLIDIN-2-YL]BUTANOYL}-L-PROLINE'>28T</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.72Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=28T:1-{4-OXO-4-[(2S)-PYRROLIDIN-2-YL]BUTANOYL}-L-PROLINE'>28T</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms6 OCA], [https://pdbe.org/4ms6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ms6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ms6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ms6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms6 OCA], [https://pdbe.org/4ms6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ms6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ms6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ms6 ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4ms6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ms6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Leukotriene A4 Hydrolase\|Leukotriene A4 Hydrolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:05, 28 December 2022

OCA — Wed, 28 Dec 2022 10:05:05 GMT

←Older revision		Revision as of 10:05, 28 December 2022
Line 1:		Line 1:

	==Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue==		==Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue==
-	<StructureSection load='4ms6' size='340' side='right' caption='[[4ms6]], [[Resolution\|resolution]] 1.72Å' scene=''>	+	<StructureSection load='4ms6' size='340' side='right'caption='[[4ms6]], [[Resolution\|resolution]] 1.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ms6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MS6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ms6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MS6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=28T:1-{4-OXO-4-[(2S)-PYRROLIDIN-2-YL]BUTANOYL}-L-PROLINE'>28T</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=28T:1-{4-OXO-4-[(2S)-PYRROLIDIN-2-YL]BUTANOYL}-L-PROLINE'>28T</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mkt\|4mkt]], [[4l2l\|4l2l]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms6 OCA], [https://pdbe.org/4ms6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ms6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ms6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ms6 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4, LTA4H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms6 OCA], [~~http~~://pdbe.org/4ms6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ms6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ms6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ms6 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>	+	[https://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Haeggstrom, J Z~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Rinaldo-Matthis, A~~]]	+	[[Category: Haeggstrom JZ]]
-	[[Category: ~~Stsiapanava,~~ A]]	+	[[Category: Rinaldo-Matthis A]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Stsiapanava A]]
-	~~[[Category: Leukotriene a4 hydrolase]]~~	+
-	~~[[Category: Metalloprotein]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Zinc binding~~]]	+

OCA at 13:12, 4 August 2016

OCA — Thu, 04 Aug 2016 13:12:51 GMT

←Older revision		Revision as of 13:12, 4 August 2016
Line 1:		Line 1:
		+
	==Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue==		==Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue==
	<StructureSection load='4ms6' size='340' side='right' caption='[[4ms6]], [[Resolution\|resolution]] 1.72Å' scene=''>		<StructureSection load='4ms6' size='340' side='right' caption='[[4ms6]], [[Resolution\|resolution]] 1.72Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4, LTA4H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4, LTA4H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ms6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ms6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms6 OCA], [http://pdbe.org/4ms6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ms6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ms6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ms6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ms6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:37, 25 December 2014

OCA — Thu, 25 Dec 2014 09:37:01 GMT

←Older revision		Revision as of 09:37, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ms6\| PDB=4ms6 \| SCENE= }}~~	+	==Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue==
-	===Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue===	+	<StructureSection load='4ms6' size='340' side='right' caption='[[4ms6]], [[Resolution\|resolution]] 1.72Å' scene=''>
-	{~~{ABSTRACT_PUBMED_24591641}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ms6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MS6 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=28T:1-{4-OXO-4-[(2S)-PYRROLIDIN-2-YL]BUTANOYL}-L-PROLINE'>28T</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mkt\|4mkt]], [[4l2l\|4l2l]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTA4, LTA4H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ms6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ms6 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>		[[http://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Leukotriene (LT) A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes the committed step in the formation of the proinflammatory mediator LTB4. Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as an endogenous aminopeptidase substrate for LTA4 hydrolase. Here, we determined the crystal structure of LTA4 hydrolase in complex with a Pro-Gly-Pro analog at 1.72 A. From the structure, which includes the catalytic water, and mass spectrometric analysis of enzymatic hydrolysis products of Pro-Gly-Pro, it could be inferred that LTA4 hydrolase cleaves at the N terminus of the palindromic tripeptide. Furthermore, we designed a small molecule, 4-(4-benzylphenyl)thiazol-2-amine, denoted ARM1, that inhibits LTB4 synthesis in human neutrophils (IC50 of approximately 0.5 muM) and conversion of LTA4 into LTB4 by purified LTA4H with a Ki of 2.3 muM. In contrast, 50- to 100-fold higher concentrations of ARM1 did not significantly affect hydrolysis of Pro-Gly-Pro. A 1.62-A crystal structure of LTA4 hydrolase in a dual complex with ARM1 and the Pro-Gly-Pro analog revealed that ARM1 binds in the hydrophobic pocket that accommodates the omega-end of LTA4, distant from the aminopeptidase active site, thus providing a molecular basis for its inhibitory profile. Hence, ARM1 selectively blocks conversion of LTA4 into LTB4, although sparing the enzyme's anti-inflammatory aminopeptidase activity (i.e., degradation and inactivation of Pro-Gly-Pro). ARM1 represents a new class of LTA4 hydrolase inhibitor that holds promise for improved anti-inflammatory properties.

-	~~==About this Structure==~~	+	Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.,Stsiapanava A, Olsson U, Wan M, Kleinschmidt T, Rutishauser D, Zubarev RA, Samuelsson B, Rinaldo-Matthis A, Haeggstrom JZ Proc Natl Acad Sci U S A. 2014 Mar 3. PMID:24591641<ref>PMID:24591641</ref>
-	~~[[4ms6]] is a 1 chain structure with sequence from [http:~~/~~/en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4MS6 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024591641</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Haeggstrom, J Z.]]	+	[[Category: Haeggstrom, J Z]]
-	[[Category: Rinaldo-Matthis, A.]]	+	[[Category: Rinaldo-Matthis, A]]
-	[[Category: Stsiapanava, A.]]	+	[[Category: Stsiapanava, A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Leukotriene a4 hydrolase]]		[[Category: Leukotriene a4 hydrolase]]

OCA at 06:43, 23 April 2014

OCA — Wed, 23 Apr 2014 06:43:58 GMT

←Older revision		Revision as of 06:43, 23 April 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4ms6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS6 OCA].	+	[[4ms6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS6 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024591641</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024591641</ref><references group="xtra"/><references/>
		+	[[Category: Human]]
	[[Category: Haeggstrom, J Z.]]		[[Category: Haeggstrom, J Z.]]
	[[Category: Rinaldo-Matthis, A.]]		[[Category: Rinaldo-Matthis, A.]]

OCA at 13:46, 12 March 2014

OCA — Wed, 12 Mar 2014 13:46:43 GMT

←Older revision		Revision as of 13:46, 12 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ms6\| PDB=4ms6 \| SCENE= }}
		+	===Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue===
		+	{{ABSTRACT_PUBMED_24591641}}

-	~~The entry 4ms6 is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/LKHA4_HUMAN LKHA4_HUMAN]] Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.<ref>PMID:1897988</ref> <ref>PMID:1975494</ref> <ref>PMID:2244921</ref> <ref>PMID:12207002</ref> <ref>PMID:11917124</ref> <ref>PMID:15078870</ref> <ref>PMID:18804029</ref>

-	~~Authors~~: ~~Stsiapanava, A~~.~~, Rinaldo-Matthis, A~~.~~, Haeggstrom, J~~.Z.	+	==About this Structure==
		+	[[4ms6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS6 OCA].

-	~~Description~~: ~~Human Leukotriene A4 Hydrolase in complex with Pro~~-~~Gly-Pro analogue~~	+	==Reference==
		+	<ref group="xtra">PMID:024591641</ref><references group="xtra"/><references/>
		+	[[Category: Haeggstrom, J Z.]]
		+	[[Category: Rinaldo-Matthis, A.]]
		+	[[Category: Stsiapanava, A.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Leukotriene a4 hydrolase]]
		+	[[Category: Metalloprotein]]
		+	[[Category: Protease]]
		+	[[Category: Zinc binding]]

OCA at 09:40, 27 November 2013

OCA — Wed, 27 Nov 2013 09:40:21 GMT

←Older revision		Revision as of 09:40, 27 November 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ms6 is ON HOLD	+	The entry 4ms6 is ON HOLD until Paper Publication

	Authors: Stsiapanava, A., Rinaldo-Matthis, A., Haeggstrom, J.Z.		Authors: Stsiapanava, A., Rinaldo-Matthis, A., Haeggstrom, J.Z.

	Description: Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue		Description: Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue

OCA: Protected "4ms6" [edit=sysop:move=sysop]

OCA — Sun, 29 Sep 2013 07:43:31 GMT

Protected "4ms6" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:43, 29 September 2013

OCA: New page: '''Unreleased structure''' The entry 4ms6 is ON HOLD Authors: Stsiapanava, A., Rinaldo-Matthis, A., Haeggstrom, J.Z. Description: Human Leukotriene A4 Hydrolase in complex with Pro-Gly...

OCA — Sun, 29 Sep 2013 07:43:30 GMT

New page: '''Unreleased structure''' The entry 4ms6 is ON HOLD Authors: Stsiapanava, A., Rinaldo-Matthis, A., Haeggstrom, J.Z. Description: Human Leukotriene A4 Hydrolase in complex with Pro-Gly...

New page

'''Unreleased structure'''

The entry 4ms6 is ON HOLD

Authors: Stsiapanava, A., Rinaldo-Matthis, A., Haeggstrom, J.Z.

Description: Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue