4muy - Revision history

OCA at 16:42, 20 September 2023

OCA — Wed, 20 Sep 2023 16:42:59 GMT

←Older revision		Revision as of 16:42, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4muy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MUY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4muy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MUY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2E5:PYRIDIN-4-YLMETHYL+TRIHYDROGEN+DIPHOSPHATE'>2E5</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2E5:PYRIDIN-4-YLMETHYL+TRIHYDROGEN+DIPHOSPHATE'>2E5</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [https://pdbe.org/4muy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [https://www.ebi.ac.uk/pdbsum/4muy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4muy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [https://pdbe.org/4muy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [https://www.ebi.ac.uk/pdbsum/4muy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4muy ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:11, 28 December 2022

OCA — Wed, 28 Dec 2022 10:11:39 GMT

←Older revision		Revision as of 10:11, 28 December 2022
Line 3:		Line 3:
	<StructureSection load='4muy' size='340' side='right'caption='[[4muy]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4muy' size='340' side='right'caption='[[4muy]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4muy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4MUY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4muy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MUY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E5:PYRIDIN-4-YLMETHYL+TRIHYDROGEN+DIPHOSPHATE'>2E5</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2E5:PYRIDIN-4-YLMETHYL+TRIHYDROGEN+DIPHOSPHATE'>2E5</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4mux\|4mux]], [[4mv0\|4mv0]], [[4mv5\|4mv5]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [https://pdbe.org/4muy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [https://www.ebi.ac.uk/pdbsum/4muy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4muy ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECDH1ME8569_0026, ispH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [~~http~~://pdbe.org/4muy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4muy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4muy ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Function ==
-	[[http://www.uniprot.org/uniprot/C9QSC3_ECOD1 C9QSC3_ECOD1]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity).[SAAS:SAAS003451_004_011514][HAMAP-Rule:MF_00191]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 4-~~hydroxy-3-methylbut-2-enyl diphosphate reductase]]~~	+	[[Category: Escherichia coli K-12]]
-	~~[[Category: Ecoli~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bacher, A]]	+	[[Category: Bacher A]]
-	[[Category: Eisenreich, W]]	+	[[Category: Eisenreich W]]
-	[[Category: Groll, M]]	+	[[Category: Groll M]]
-	[[Category: Oldfield, E]]	+	[[Category: Oldfield E]]
-	[[Category: Song, Y]]	+	[[Category: Song Y]]
-	[[Category: Span, I]]	+	[[Category: Span I]]
-	[[Category: Wang, K]]	+	[[Category: Wang K]]
-	~~[[Category: Cytosol]]~~	+
-	~~[[Category: Iron-sulfur protein]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pyridin-4-ylmethyl diphosphate]]~~	+
-	~~[[Category: Reductase~~]]	+

OCA at 08:11, 10 April 2019

OCA — Wed, 10 Apr 2019 08:11:32 GMT

←Older revision		Revision as of 08:11, 10 April 2019
Line 1:		Line 1:

	==IspH in complex with pyridin-4-ylmethyl diphosphate==		==IspH in complex with pyridin-4-ylmethyl diphosphate==
-	<StructureSection load='4muy' size='340' side='right' caption='[[4muy]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4muy' size='340' side='right'caption='[[4muy]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4muy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MUY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4muy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MUY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E5:PYRIDIN-4-YLMETHYL+TRIHYDROGEN+DIPHOSPHATE'>2E5</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E5:PYRIDIN-4-YLMETHYL+TRIHYDROGEN+DIPHOSPHATE'>2E5</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4mux\|4mux]], [[4mv0\|4mv0]], [[4mv5\|4mv5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4mux\|4mux]], [[4mv0\|4mv0]], [[4mv5\|4mv5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ECDH1ME8569_0026, ispH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [http://pdbe.org/4muy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [http://www.ebi.ac.uk/pdbsum/4muy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4muy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [http://pdbe.org/4muy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [http://www.ebi.ac.uk/pdbsum/4muy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4muy ProSAT]</span></td></tr>
Line 22:		Line 23:

	==See Also==		==See Also==
-	*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]	+	*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
		+	[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Bacher, A]]		[[Category: Bacher, A]]
	[[Category: Eisenreich, W]]		[[Category: Eisenreich, W]]

OCA at 14:34, 4 August 2016

OCA — Thu, 04 Aug 2016 14:34:20 GMT

←Older revision		Revision as of 14:34, 4 August 2016
Line 1:		Line 1:
		+
	==IspH in complex with pyridin-4-ylmethyl diphosphate==		==IspH in complex with pyridin-4-ylmethyl diphosphate==
	<StructureSection load='4muy' size='340' side='right' caption='[[4muy]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4muy' size='340' side='right' caption='[[4muy]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4mux\|4mux]], [[4mv0\|4mv0]], [[4mv5\|4mv5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4mux\|4mux]], [[4mv0\|4mv0]], [[4mv5\|4mv5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [http://www.ebi.ac.uk/pdbsum/4muy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [http://pdbe.org/4muy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [http://www.ebi.ac.uk/pdbsum/4muy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4muy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4muy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:50, 24 December 2014

OCA — Wed, 24 Dec 2014 15:50:28 GMT

←Older revision		Revision as of 15:50, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4muy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MUY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4muy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MUY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E5:PYRIDIN-4-YLMETHYL+TRIHYDROGEN+DIPHOSPHATE'>2E5</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E5:PYRIDIN-4-YLMETHYL+TRIHYDROGEN+DIPHOSPHATE'>2E5</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4mux\|4mux]], [[4mv0\|4mv0]], [[4mv5\|4mv5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4mux\|4mux]], [[4mv0\|4mv0]], [[4mv5\|4mv5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [http://www.ebi.ac.uk/pdbsum/4muy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [http://www.ebi.ac.uk/pdbsum/4muy PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C9QSC3_ECOD1 C9QSC3_ECOD1]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity).[SAAS:SAAS003451_004_011514][HAMAP-Rule:MF_00191]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
-	[[Category: Bacher, A.]]	+	[[Category: Bacher, A]]
-	[[Category: Eisenreich, W.]]	+	[[Category: Eisenreich, W]]
-	[[Category: Groll, M.]]	+	[[Category: Groll, M]]
-	[[Category: Oldfield, E.]]	+	[[Category: Oldfield, E]]
-	[[Category: Song, Y.]]	+	[[Category: Song, Y]]
-	[[Category: Span, I.]]	+	[[Category: Span, I]]
-	[[Category: Wang, K.]]	+	[[Category: Wang, K]]
	[[Category: Cytosol]]		[[Category: Cytosol]]
	[[Category: Iron-sulfur protein]]		[[Category: Iron-sulfur protein]]

OCA at 08:45, 11 June 2014

OCA — Wed, 11 Jun 2014 08:45:38 GMT

←Older revision		Revision as of 08:45, 11 June 2014
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-	'''~~Unreleased~~ structure'''	+	==IspH in complex with pyridin-4-ylmethyl diphosphate==
		+	<StructureSection load='4muy' size='340' side='right' caption='[[4muy]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4muy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MUY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E5:PYRIDIN-4-YLMETHYL+TRIHYDROGEN+DIPHOSPHATE'>2E5</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ke8\|3ke8]], [[3dnf\|3dnf]], [[3f7t\|3f7t]], [[4mux\|4mux]], [[4mv0\|4mv0]], [[4mv5\|4mv5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4muy RCSB], [http://www.ebi.ac.uk/pdbsum/4muy PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	(E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate reductase (IspH) is a [Fe4S4] cluster-containing enzyme involved in isoprenoid biosynthesis in many bacteria as well as in malaria parasites and is an important drug target. Several inhibitors including amino and thiol substrate analogues, as well as acetylene and pyridine diphosphates, have been reported. Here, we investigate the mode of binding of four pyridine diphosphates to Escherichia coli IspH by using X-ray crystallography. In three cases, one of the iron atoms in the cluster is absent, but in the structure with (pyridin-3-yl)methyl diphosphate, the most potent pyridine-analogue inhibitor reported previously, the fourth iron of the [Fe4S4] cluster is present and interacts with the pyridine ring of the ligand. Based on the results of quantum chemical calculations together with the crystallographic results we propose a side-on eta2 coordination of the nitrogen and the carbon in the 2-position of the pyridine ring to the unique fourth iron in the cluster, which is in the reduced state. The X-ray structure enables excellent predictions using density functional theory of the 14N hyperfine coupling and quadrupole coupling constants reported previously using HYSCORE spectroscopy, as well as providing a further example of the ability of such [Fe4S4]-containing proteins to form organometallic complexes.

-	~~The entry 4muy is ON HOLD until Paper Publication~~	+	Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme IspH.,Span I, Wang K, Eisenreich W, Bacher A, Zhang Y, Oldfield E, Groll M J Am Chem Soc. 2014 May 22. PMID:24813236<ref>PMID:24813236</ref>

-	~~Authors: Span~~, I.~~, Wang, K~~.~~, Song, Y~~., Eisenreich, W., ~~Bacher, A~~., Oldfield, E., ~~Groll~~, M.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~IspH in complex with pyridin~~-4-ylmethyl diphosphate	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
		+	[[Category: Bacher, A.]]
		+	[[Category: Eisenreich, W.]]
		+	[[Category: Groll, M.]]
		+	[[Category: Oldfield, E.]]
		+	[[Category: Song, Y.]]
		+	[[Category: Span, I.]]
		+	[[Category: Wang, K.]]
		+	[[Category: Cytosol]]
		+	[[Category: Iron-sulfur protein]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Pyridin-4-ylmethyl diphosphate]]
		+	[[Category: Reductase]]

OCA at 06:59, 6 November 2013

OCA — Wed, 06 Nov 2013 06:59:05 GMT

←Older revision		Revision as of 06:59, 6 November 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4muy is ON HOLD	+	The entry 4muy is ON HOLD until Paper Publication

	Authors: Span, I., Wang, K., Song, Y., Eisenreich, W., Bacher, A., Oldfield, E., Groll, M.		Authors: Span, I., Wang, K., Song, Y., Eisenreich, W., Bacher, A., Oldfield, E., Groll, M.

	Description: IspH in complex with pyridin-4-ylmethyl diphosphate		Description: IspH in complex with pyridin-4-ylmethyl diphosphate

OCA: Protected "4muy" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2013 06:55:24 GMT

Protected "4muy" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:55, 2 October 2013

OCA: New page: '''Unreleased structure''' The entry 4muy is ON HOLD Authors: Span, I., Wang, K., Song, Y., Eisenreich, W., Bacher, A., Oldfield, E., Groll, M. Description: IspH in complex with pyridi...

OCA — Wed, 02 Oct 2013 06:55:23 GMT

New page: '''Unreleased structure''' The entry 4muy is ON HOLD Authors: Span, I., Wang, K., Song, Y., Eisenreich, W., Bacher, A., Oldfield, E., Groll, M. Description: IspH in complex with pyridi...

New page

'''Unreleased structure'''

The entry 4muy is ON HOLD

Authors: Span, I., Wang, K., Song, Y., Eisenreich, W., Bacher, A., Oldfield, E., Groll, M.

Description: IspH in complex with pyridin-4-ylmethyl diphosphate