4n1y - Revision history

OCA at 12:30, 1 March 2024

OCA — Fri, 01 Mar 2024 12:30:55 GMT

←Older revision		Revision as of 12:30, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n1y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Crassostrea_gigas Crassostrea gigas]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N1Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n1y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Crassostrea_gigas Crassostrea gigas]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N1Y FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1y OCA], [https://pdbe.org/4n1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n1y RCSB], [https://www.ebi.ac.uk/pdbsum/4n1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n1y ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.605Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1y OCA], [https://pdbe.org/4n1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n1y RCSB], [https://www.ebi.ac.uk/pdbsum/4n1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n1y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/K1QUU5_CRAGI K1QUU5_CRAGI]		[https://www.uniprot.org/uniprot/K1QUU5_CRAGI K1QUU5_CRAGI]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	An important goal in molecular evolution is to understand the genetic and physical mechanisms by which protein functions evolve and, in turn, to characterize how a protein's physical architecture influences its evolution. Here we dissect the mechanisms for an evolutionary shift in function in the mollusk ortholog of the steroid hormone receptors (SRs), a family of biologically essential transcription factors. In vertebrates, the activity of SRs allosterically depends on binding a hormonal ligand; in mollusks, however, the SR ortholog (called ER, because of high sequence similarity to vertebrate estrogen receptors) activates transcription in the absence of ligand and does not respond to steroid hormones. To understand how this shift in regulation evolved, we combined evolutionary, structural, and functional analyses. We first determined the X-ray crystal structure of the ER of the Pacific oyster Crassostrea gigas (CgER), and found that its ligand pocket is filled with bulky residues that prevent ligand occupancy. To understand the genetic basis for the evolution of mollusk ERs' unique functions, we resurrected an ancient SR progenitor and characterized the effect of historical amino acid replacements on its functions. We found that reintroducing just two ancient replacements from the lineage leading to mollusk ERs recapitulates the evolution of full constitutive activity and the loss of ligand activation. These substitutions stabilize interactions among key helices, causing the allosteric switch to become "stuck" in the active conformation and making activation independent of ligand binding. Subsequent changes filled the ligand pocket without further affecting activity; by degrading the allosteric switch, these substitutions vestigialized elements of the protein's architecture required for ligand regulation and made reversal to the ancestral function more complex. These findings show how the physical architecture of allostery enabled a few large-effect mutations to trigger a profound evolutionary change in the protein's function and shaped the genetics of evolutionary reversibility.
-
-	Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.,Bridgham JT, Keay J, Ortlund EA, Thornton JW PLoS Genet. 2014 Jan;10(1):e1004058. doi: 10.1371/journal.pgen.1004058. Epub 2014, Jan 9. PMID:24415950<ref>PMID:24415950</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4n1y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Estrogen receptor 3D structures\|Estrogen receptor 3D structures]]		*[[Estrogen receptor 3D structures\|Estrogen receptor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:27, 28 December 2022

OCA — Wed, 28 Dec 2022 10:27:44 GMT

←Older revision		Revision as of 10:27, 28 December 2022
Line 1:		Line 1:

	==Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain==		==Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain==
-	<StructureSection load='4n1y' size='340' side='right' caption='[[4n1y]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4n1y' size='340' side='right'caption='[[4n1y]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n1y]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cragi Cragi~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4N1Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n1y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Crassostrea_gigas Crassostrea gigas]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N1Y FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CGI_10024100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29159 CRAGI])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1y OCA], [https://pdbe.org/4n1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n1y RCSB], [https://www.ebi.ac.uk/pdbsum/4n1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n1y ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4n1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1y OCA], [~~http~~://pdbe.org/4n1y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4n1y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4n1y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4n1y ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/K1QUU5_CRAGI K1QUU5_CRAGI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4n1y" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4n1y" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Estrogen receptor 3D structures\|Estrogen receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cragi~~]]	+	[[Category: Crassostrea gigas]]
-	[[Category: ~~Ortlund, E O~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Endocrine signaling]]~~	+	[[Category: Ortlund EO]]
-	~~[[Category: Estrogen]]~~	+
-	~~[[Category: Nuclear hormone receptor]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 10:00, 15 November 2017

OCA — Wed, 15 Nov 2017 10:00:34 GMT

←Older revision		Revision as of 10:00, 15 November 2017
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 4n1y" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4n1y" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Estrogen receptor\|Estrogen receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:45, 11 August 2016

OCA — Thu, 11 Aug 2016 19:45:48 GMT

←Older revision		Revision as of 19:45, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain==		==Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain==
	<StructureSection load='4n1y' size='340' side='right' caption='[[4n1y]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4n1y' size='340' side='right' caption='[[4n1y]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4n1y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cragi Cragi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N1Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n1y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cragi Cragi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N1Y FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CGI_10024100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29159 CRAGI])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CGI_10024100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29159 CRAGI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n1y RCSB], [http://www.ebi.ac.uk/pdbsum/4n1y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1y OCA], [http://pdbe.org/4n1y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n1y RCSB], [http://www.ebi.ac.uk/pdbsum/4n1y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n1y ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4n1y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:39, 5 January 2015

OCA — Mon, 05 Jan 2015 08:39:27 GMT

←Older revision		Revision as of 08:39, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4n1y\| PDB=4n1y \| SCENE= }}~~	+	==Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain==
-	===Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain===	+	<StructureSection load='4n1y' size='340' side='right' caption='[[4n1y]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24415950}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4n1y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cragi Cragi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N1Y FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CGI_10024100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29159 CRAGI])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n1y RCSB], [http://www.ebi.ac.uk/pdbsum/4n1y PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An important goal in molecular evolution is to understand the genetic and physical mechanisms by which protein functions evolve and, in turn, to characterize how a protein's physical architecture influences its evolution. Here we dissect the mechanisms for an evolutionary shift in function in the mollusk ortholog of the steroid hormone receptors (SRs), a family of biologically essential transcription factors. In vertebrates, the activity of SRs allosterically depends on binding a hormonal ligand; in mollusks, however, the SR ortholog (called ER, because of high sequence similarity to vertebrate estrogen receptors) activates transcription in the absence of ligand and does not respond to steroid hormones. To understand how this shift in regulation evolved, we combined evolutionary, structural, and functional analyses. We first determined the X-ray crystal structure of the ER of the Pacific oyster Crassostrea gigas (CgER), and found that its ligand pocket is filled with bulky residues that prevent ligand occupancy. To understand the genetic basis for the evolution of mollusk ERs' unique functions, we resurrected an ancient SR progenitor and characterized the effect of historical amino acid replacements on its functions. We found that reintroducing just two ancient replacements from the lineage leading to mollusk ERs recapitulates the evolution of full constitutive activity and the loss of ligand activation. These substitutions stabilize interactions among key helices, causing the allosteric switch to become "stuck" in the active conformation and making activation independent of ligand binding. Subsequent changes filled the ligand pocket without further affecting activity; by degrading the allosteric switch, these substitutions vestigialized elements of the protein's architecture required for ligand regulation and made reversal to the ancestral function more complex. These findings show how the physical architecture of allostery enabled a few large-effect mutations to trigger a profound evolutionary change in the protein's function and shaped the genetics of evolutionary reversibility.

-	~~==About this Structure==~~	+	Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.,Bridgham JT, Keay J, Ortlund EA, Thornton JW PLoS Genet. 2014 Jan;10(1):e1004058. doi: 10.1371/journal.pgen.1004058. Epub 2014, Jan 9. PMID:24415950<ref>PMID:24415950</ref>
-	~~[[4n1y]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Cragi Cragi]~~. ~~This structure supersedes the now removed PDB entry [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4N1Y OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Estrogen receptor\|Estrogen receptor]]		*[[Estrogen receptor\|Estrogen receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024415950</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cragi]]		[[Category: Cragi]]
-	[[Category: Ortlund, E O.]]	+	[[Category: Ortlund, E O]]
	[[Category: Endocrine signaling]]		[[Category: Endocrine signaling]]
	[[Category: Estrogen]]		[[Category: Estrogen]]
	[[Category: Nuclear hormone receptor]]		[[Category: Nuclear hormone receptor]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 08:02, 16 April 2014

OCA — Wed, 16 Apr 2014 08:02:16 GMT

←Older revision		Revision as of 08:02, 16 April 2014
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[4n1y]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1Y OCA].	+	[[4n1y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cragi Cragi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1Y OCA].
		+
		+	==See Also==
		+	*[[Estrogen receptor\|Estrogen receptor]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:024415950</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024415950</ref><references group="xtra"/><references/>
		+	[[Category: Cragi]]
	[[Category: Ortlund, E O.]]		[[Category: Ortlund, E O.]]
	[[Category: Endocrine signaling]]		[[Category: Endocrine signaling]]

OCA at 04:57, 13 February 2014

OCA — Thu, 13 Feb 2014 04:57:47 GMT

←Older revision		Revision as of 04:57, 13 February 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4n1y\| PDB=4n1y \| SCENE= }}
		+	===Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain===
		+	{{ABSTRACT_PUBMED_24415950}}

-	~~The entry~~ 4n1y is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4n1y]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ltx 3ltx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1Y OCA].

-	~~Authors~~: Ortlund, E.O.	+	==Reference==
-		+	<ref group="xtra">PMID:024415950</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal Structure of the Pacific Oyster~~ Estrogen ~~Receptor Ligand Binding Domain~~	+	[[Category: Ortlund, E O.]]
		+	[[Category: Endocrine signaling]]
		+	[[Category: Estrogen]]
		+	[[Category: Nuclear hormone receptor]]
		+	[[Category: Transcription]]

OCA at 09:43, 27 November 2013

OCA — Wed, 27 Nov 2013 09:43:55 GMT

←Older revision		Revision as of 09:43, 27 November 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4n1y is ON HOLD	+	The entry 4n1y is ON HOLD until Paper Publication

	Authors: Ortlund, E.O.		Authors: Ortlund, E.O.

	Description: Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain		Description: Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain

OCA: Protected "4n1y" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2013 07:31:43 GMT

Protected "4n1y" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:31, 16 October 2013

OCA: New page: '''Unreleased structure''' The entry 4n1y is ON HOLD Authors: Ortlund, E.O. Description: Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain

OCA — Wed, 16 Oct 2013 07:31:42 GMT

New page: '''Unreleased structure''' The entry 4n1y is ON HOLD Authors: Ortlund, E.O. Description: Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain

New page

'''Unreleased structure'''

The entry 4n1y is ON HOLD

Authors: Ortlund, E.O.

Description: Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain