4n28 - Revision history

OCA at 16:46, 20 September 2023

OCA — Wed, 20 Sep 2023 16:46:22 GMT

←Older revision		Revision as of 16:46, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n28]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N28 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n28]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N28 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.879Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n28 OCA], [https://pdbe.org/4n28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n28 RCSB], [https://www.ebi.ac.uk/pdbsum/4n28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n28 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n28 OCA], [https://pdbe.org/4n28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n28 RCSB], [https://www.ebi.ac.uk/pdbsum/4n28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n28 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:28, 28 December 2022

OCA — Wed, 28 Dec 2022 10:28:07 GMT

←Older revision		Revision as of 10:28, 28 December 2022
Line 3:		Line 3:
	<StructureSection load='4n28' size='340' side='right'caption='[[4n28]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='4n28' size='340' side='right'caption='[[4n28]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n28]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N28 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4N28 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n28]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N28 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n20\|4n20]], [[4n22\|4n22]], [[4n24\|4n24]], [[4n25\|4n25]], [[4n26\|4n26]], [[4n2a\|4n2a]], [[4n2b\|4n2b]], [[4n2c\|4n2c]], [[4n2d\|4n2d]], [[4n2e\|4n2e]], [[4n2f\|4n2f]], [[4n2g\|4n2g]], [[4n2h\|4n2h]], [[4n2i\|4n2i]], [[4n2k\|4n2k]], [[4n2l\|4n2l]], [[4n2m\|4n2m]], [[4n2n\|4n2n]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n28 OCA], [https://pdbe.org/4n28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n28 RCSB], [https://www.ebi.ac.uk/pdbsum/4n28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n28 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PADI2, KIAA0994, PDI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-arginine_deiminase Protein-arginine deiminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.15 3.5.3.15] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4n28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n28 OCA], [~~http~~://pdbe.org/4n28 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4n28 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4n28 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4n28 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PADI2_HUMAN PADI2_HUMAN]] Catalyzes the deimination of arginine residues of proteins.	+	[https://www.uniprot.org/uniprot/PADI2_HUMAN PADI2_HUMAN] Catalyzes the deimination of arginine residues of proteins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-arginine deiminase]]~~	+	[[Category: Coonrod SA]]
-	[[Category: Coonrod~~, S A~~]]	+	[[Category: Dreyton CJ]]
-	[[Category: Dreyton~~, C J~~]]	+	[[Category: Fang P]]
-	[[Category: Fang, P]]	+	[[Category: Gross ML]]
-	[[Category: Gross~~, M L~~]]	+	[[Category: Guo M]]
-	[[Category: Guo, M]]	+	[[Category: Slade DJ]]
-	[[Category: Slade~~, D J~~]]	+	[[Category: Thompson PR]]
-	[[Category: Thompson~~, P R~~]]	+	[[Category: Zhang X]]
-	[[Category: Zhang, X]]	+	[[Category: Zhang Y]]
-	[[Category: Zhang, Y]]	+
-	~~[[Category: Deiminase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 08:12, 10 April 2019

OCA — Wed, 10 Apr 2019 08:12:15 GMT

←Older revision		Revision as of 08:12, 10 April 2019
Line 1:		Line 1:

	==Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)==		==Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)==
-	<StructureSection load='4n28' size='340' side='right' caption='[[4n28]], [[Resolution\|resolution]] 1.88Å' scene=''>	+	<StructureSection load='4n28' size='340' side='right'caption='[[4n28]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n28]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N28 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n28]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N28 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n20\|4n20]], [[4n22\|4n22]], [[4n24\|4n24]], [[4n25\|4n25]], [[4n26\|4n26]], [[4n2a\|4n2a]], [[4n2b\|4n2b]], [[4n2c\|4n2c]], [[4n2d\|4n2d]], [[4n2e\|4n2e]], [[4n2f\|4n2f]], [[4n2g\|4n2g]], [[4n2h\|4n2h]], [[4n2i\|4n2i]], [[4n2k\|4n2k]], [[4n2l\|4n2l]], [[4n2m\|4n2m]], [[4n2n\|4n2n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n20\|4n20]], [[4n22\|4n22]], [[4n24\|4n24]], [[4n25\|4n25]], [[4n26\|4n26]], [[4n2a\|4n2a]], [[4n2b\|4n2b]], [[4n2c\|4n2c]], [[4n2d\|4n2d]], [[4n2e\|4n2e]], [[4n2f\|4n2f]], [[4n2g\|4n2g]], [[4n2h\|4n2h]], [[4n2i\|4n2i]], [[4n2k\|4n2k]], [[4n2l\|4n2l]], [[4n2m\|4n2m]], [[4n2n\|4n2n]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PADI2, KIAA0994, PDI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-arginine_deiminase Protein-arginine deiminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.15 3.5.3.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-arginine_deiminase Protein-arginine deiminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.15 3.5.3.15] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n28 OCA], [http://pdbe.org/4n28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n28 RCSB], [http://www.ebi.ac.uk/pdbsum/4n28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n28 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n28 OCA], [http://pdbe.org/4n28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n28 RCSB], [http://www.ebi.ac.uk/pdbsum/4n28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n28 ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Protein-arginine deiminase]]		[[Category: Protein-arginine deiminase]]
	[[Category: Coonrod, S A]]		[[Category: Coonrod, S A]]

OCA at 17:21, 9 March 2017

OCA — Thu, 09 Mar 2017 17:21:32 GMT

←Older revision		Revision as of 17:21, 9 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)==		==Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)==
	<StructureSection load='4n28' size='340' side='right' caption='[[4n28]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='4n28' size='340' side='right' caption='[[4n28]], [[Resolution\|resolution]] 1.88Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n20\|4n20]], [[4n22\|4n22]], [[4n24\|4n24]], [[4n25\|4n25]], [[4n26\|4n26]], [[4n2a\|4n2a]], [[4n2b\|4n2b]], [[4n2c\|4n2c]], [[4n2d\|4n2d]], [[4n2e\|4n2e]], [[4n2f\|4n2f]], [[4n2g\|4n2g]], [[4n2h\|4n2h]], [[4n2i\|4n2i]], [[4n2k\|4n2k]], [[4n2l\|4n2l]], [[4n2m\|4n2m]], [[4n2n\|4n2n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n20\|4n20]], [[4n22\|4n22]], [[4n24\|4n24]], [[4n25\|4n25]], [[4n26\|4n26]], [[4n2a\|4n2a]], [[4n2b\|4n2b]], [[4n2c\|4n2c]], [[4n2d\|4n2d]], [[4n2e\|4n2e]], [[4n2f\|4n2f]], [[4n2g\|4n2g]], [[4n2h\|4n2h]], [[4n2i\|4n2i]], [[4n2k\|4n2k]], [[4n2l\|4n2l]], [[4n2m\|4n2m]], [[4n2n\|4n2n]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-arginine_deiminase Protein-arginine deiminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.15 3.5.3.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-arginine_deiminase Protein-arginine deiminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.15 3.5.3.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n28 RCSB], [http://www.ebi.ac.uk/pdbsum/4n28 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n28 OCA], [http://pdbe.org/4n28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n28 RCSB], [http://www.ebi.ac.uk/pdbsum/4n28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n28 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4n28" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:45, 7 February 2015

OCA — Sat, 07 Feb 2015 15:45:02 GMT

←Older revision		Revision as of 15:45, 7 February 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)==
		+	<StructureSection load='4n28' size='340' side='right' caption='[[4n28]], [[Resolution\|resolution]] 1.88Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4n28]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N28 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n20\|4n20]], [[4n22\|4n22]], [[4n24\|4n24]], [[4n25\|4n25]], [[4n26\|4n26]], [[4n2a\|4n2a]], [[4n2b\|4n2b]], [[4n2c\|4n2c]], [[4n2d\|4n2d]], [[4n2e\|4n2e]], [[4n2f\|4n2f]], [[4n2g\|4n2g]], [[4n2h\|4n2h]], [[4n2i\|4n2i]], [[4n2k\|4n2k]], [[4n2l\|4n2l]], [[4n2m\|4n2m]], [[4n2n\|4n2n]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-arginine_deiminase Protein-arginine deiminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.15 3.5.3.15] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n28 RCSB], [http://www.ebi.ac.uk/pdbsum/4n28 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PADI2_HUMAN PADI2_HUMAN]] Catalyzes the deimination of arginine residues of proteins.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein arginine deiminases (PADs) are calcium-dependent histone-modifying enzymes whose activity is dysregulated in inflammatory diseases and cancer. PAD2 functions as an Estrogen Receptor (ER) coactivator in breast cancer cells via the citrullination of histone tail arginine residues at ER binding sites. Although an attractive therapeutic target, the mechanisms that regulate PAD2 activity are largely unknown, especially the detailed role of how calcium facilitates enzyme activation. To gain insights into these regulatory processes, we determined the first structures of PAD2 (27 in total), and through calcium-titrations by X-ray crystallography, determined the order of binding and affinity for the six calcium ions that bind and activate this enzyme. These structures also identified several PAD2 regulatory elements, including a calcium switch that controls proper positioning of the catalytic cysteine residue, and a novel active site shielding mechanism. Additional biochemical and mass-spectrometry-based hydrogen/deuterium exchange studies support these structural findings. The identification of multiple intermediate calcium-bound structures along the PAD2 activation pathway provides critical insights that will aid the development of allosteric inhibitors targeting the PADs.

-	~~The entry 4n28 is ON HOLD until Apr 08 2016~~	+	Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design.,Slade DJ, Fang P, Dreyton CJ, Zhang Y, Fuhrmann J, Rempel D, Bax BD, Coonrod SA, Lewis HD, Guo M, Gross ML, Thompson PR ACS Chem Biol. 2015 Jan 26. PMID:25621824<ref>PMID:25621824</ref>

-	~~Authors: Slade~~, D.J.~~, Zhang, X~~.~~, Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M.,~~ Coonrod, S.A~~., Thompson, P.R.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Coonrod~~, ~~S.A~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Protein-arginine deiminase]]
		+	[[Category: Coonrod, S A]]
		+	[[Category: Dreyton, C J]]
		+	[[Category: Fang, P]]
		+	[[Category: Gross, M L]]
	[[Category: Guo, M]]		[[Category: Guo, M]]
-	[[Category: ~~Fang~~, P]]	+	[[Category: Slade, D J]]
-	[[Category: Thompson, P.R]]	+	[[Category: Thompson, P R]]
-	~~[[Category: Gross, M.L~~]]	+
	[[Category: Zhang, X]]		[[Category: Zhang, X]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]
-	[[Category: ~~Slade, D.J~~]]	+	[[Category: Deiminase]]
-	[[Category: ~~Dreyton, C.J~~]]	+	[[Category: Hydrolase]]

OCA at 14:10, 24 December 2014

OCA — Wed, 24 Dec 2014 14:10:08 GMT

←Older revision		Revision as of 14:10, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)		Description: Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)
		+	[[Category: Unreleased Structures]]
		+	[[Category: Coonrod, S.A]]
		+	[[Category: Guo, M]]
		+	[[Category: Fang, P]]
		+	[[Category: Thompson, P.R]]
		+	[[Category: Gross, M.L]]
		+	[[Category: Zhang, X]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Slade, D.J]]
		+	[[Category: Dreyton, C.J]]

OCA at 06:23, 27 August 2014

OCA — Wed, 27 Aug 2014 06:23:39 GMT

←Older revision		Revision as of 06:23, 27 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4n28 is ON HOLD until ~~Paper Publication~~	+	The entry 4n28 is ON HOLD until Apr 08 2016

	Authors: Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.		Authors: Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.

	Description: Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)		Description: Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)

OCA at 10:14, 5 February 2014

OCA — Wed, 05 Feb 2014 10:14:04 GMT

←Older revision		Revision as of 10:14, 5 February 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4n28 is ON HOLD	+	The entry 4n28 is ON HOLD until Paper Publication

	Authors: Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.		Authors: Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.

	Description: Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)		Description: Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)

OCA: Protected "4n28" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2013 07:32:06 GMT

Protected "4n28" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:32, 16 October 2013

OCA: New page: '''Unreleased structure''' The entry 4n28 is ON HOLD Authors: Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R. Descriptio...

OCA — Wed, 16 Oct 2013 07:32:05 GMT

New page: '''Unreleased structure''' The entry 4n28 is ON HOLD Authors: Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R. Descriptio...

New page

'''Unreleased structure'''

The entry 4n28 is ON HOLD

Authors: Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.

Description: Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+)