4n36 - Revision history

OCA at 16:47, 20 September 2023

OCA — Wed, 20 Sep 2023 16:47:15 GMT

←Older revision		Revision as of 16:47, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n36]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N36 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n36]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N36 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2F8:METHYL+2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE'>2F8</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2F8:METHYL+2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE'>2F8</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n36 OCA], [https://pdbe.org/4n36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n36 RCSB], [https://www.ebi.ac.uk/pdbsum/4n36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n36 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n36 OCA], [https://pdbe.org/4n36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n36 RCSB], [https://www.ebi.ac.uk/pdbsum/4n36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n36 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:29, 28 December 2022

OCA — Wed, 28 Dec 2022 10:29:45 GMT

←Older revision		Revision as of 10:29, 28 December 2022
Line 1:		Line 1:

	==Structure of langerin CRD I313 D288 complexed with Me-GlcNAc==		==Structure of langerin CRD I313 D288 complexed with Me-GlcNAc==
-	<StructureSection load='4n36' size='340' side='right' caption='[[4n36]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4n36' size='340' side='right'caption='[[4n36]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n36]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N36 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4N36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n36]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N36 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2F8:METHYL+2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE'>2F8</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2F8:METHYL+2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE'>2F8</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n32\|4n32]], [[4n33\|4n33]], [[4n34\|4n34]], [[4n35\|4n35]], [[4n37\|4n37]], [[4n38\|4n38]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n36 OCA], [https://pdbe.org/4n36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n36 RCSB], [https://www.ebi.ac.uk/pdbsum/4n36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n36 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD207, CLEC4K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4n36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n36 OCA], [~~http~~://pdbe.org/4n36 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4n36 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4n36 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4n36 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[~~http~~://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>	+	[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[https://omim.org/entry/613393 613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>	+	[https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Drickamer, K]]	+	[[Category: Large Structures]]
-	[[Category: Feinberg, H]]	+	[[Category: Drickamer K]]
-	[[Category: Rowntree~~, T J.W~~]]	+	[[Category: Feinberg H]]
-	[[Category: Tan~~, S L.W~~]]	+	[[Category: Rowntree TJW]]
-	[[Category: Taylor~~, M E~~]]	+	[[Category: Tan SLW]]
-	[[Category: Weis~~, W I]]~~	+	[[Category: Taylor ME]]
-	~~[[Category: C-type lectin on langerhans cell]]~~	+	[[Category: Weis WI]]
-	~~[[Category: Carbohydrate-recognition domain]]~~	+
-	~~[[Category: Carbohydrate/sugar binding]]~~	+
-	~~[[Category: Crd carbohydrate complex]]~~	+
-	~~[[Category: Receptor on langerhans cell]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 11:00, 4 August 2016

OCA — Thu, 04 Aug 2016 11:00:19 GMT

←Older revision		Revision as of 11:00, 4 August 2016
Line 1:		Line 1:
-	{{STRUCTURE_4n36\| PDB=4n36 \| SCENE= }}
-	===Structure of langerin CRD I313 D288 complexed with Me-GlcNAc===
-	{{ABSTRACT_PUBMED_24217250}}

-	==Disease==	+	==Structure of langerin CRD I313 D288 complexed with Me-GlcNAc==
		+	<StructureSection load='4n36' size='340' side='right' caption='[[4n36]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4n36]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N36 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2F8:METHYL+2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE'>2F8</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n32\|4n32]], [[4n33\|4n33]], [[4n34\|4n34]], [[4n35\|4n35]], [[4n37\|4n37]], [[4n38\|4n38]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD207, CLEC4K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n36 OCA], [http://pdbe.org/4n36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n36 RCSB], [http://www.ebi.ac.uk/pdbsum/4n36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n36 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>		[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>		[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Langerin, a C-type lectin on Langerhans cells, mediates carbohydrate-dependent uptake of pathogens in the first step of antigen presentation to the adaptive immune system. Langerin binds a diverse range of carbohydrates including high mannose structures, fucosylated blood group antigens and glycans with terminal 6-sulfated galactose. Mutagenesis and quantitative binding assays indicate that salt bridges between the sulfate group and two lysine residues compensate for the non-optimal binding of galactose at the primary Ca2+ site. A commonly occurring single nucleotide polymorphism (SNP) in human langerin results in change of one of these lysine residues, Lys313, to isoleucine. Glycan array screening reveals that this amino acid change abolishes binding to oligosaccharides with terminal 6SO4-Gal and enhances binding to oligosaccharides with terminal GlcNAc residues. Structural analysis shows that enhanced binding to GlcNAc may result from Ile313 packing against the N-acetyl group. The Lys313Ile polymorphism is tightly linked to another SNP that results in the change Asn288Asp, which reduces affinity for glycan ligands by destabilizing the Ca2+ binding site. Langerin with Asp288 and Ile313 shows no binding to 6SO4-Gal-terminated glycans and increased binding to GlcNAc-terminated structures, but overall decreased binding to glycans. Altered langerin function in individuals with the linked Asn288Asp and Lys313Ile polymorphisms may affect susceptibility to infection by micro-organisms.

-	~~==About this Structure==~~	+	Common polymorphisms in human langerin change specificity for glycan ligands.,Feinberg H, Rowntree TJ, Tan SL, Drickamer K, Weis WI, Taylor ME J Biol Chem. 2013 Nov 11. PMID:24217250<ref>PMID:24217250</ref>
-	~~[[4n36]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4N36 OCA].~~	+

-	~~==Reference==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<~~ref group~~="~~xtra~~"~~>PMID~~:~~024217250~~</~~ref~~><references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	<div class="pdbe-citations 4n36" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Drickamer, K.]]	+	[[Category: Drickamer, K]]
-	[[Category: Feinberg, H.]]	+	[[Category: Feinberg, H]]
-	[[Category: Rowntree, T J.W.]]	+	[[Category: Rowntree, T J.W]]
-	[[Category: Tan, S L.W.]]	+	[[Category: Tan, S L.W]]
-	[[Category: Taylor, M E.]]	+	[[Category: Taylor, M E]]
-	[[Category: Weis, W I.]]	+	[[Category: Weis, W I]]
	[[Category: C-type lectin on langerhans cell]]		[[Category: C-type lectin on langerhans cell]]
	[[Category: Carbohydrate-recognition domain]]		[[Category: Carbohydrate-recognition domain]]

OCA at 06:01, 4 December 2013

OCA — Wed, 04 Dec 2013 06:01:16 GMT

←Older revision		Revision as of 06:01, 4 December 2013
Line 1:		Line 1:
	{{STRUCTURE_4n36\| PDB=4n36 \| SCENE= }}		{{STRUCTURE_4n36\| PDB=4n36 \| SCENE= }}
	===Structure of langerin CRD I313 D288 complexed with Me-GlcNAc===		===Structure of langerin CRD I313 D288 complexed with Me-GlcNAc===
		+	{{ABSTRACT_PUBMED_24217250}}

	==Disease==		==Disease==
Line 9:		Line 10:

	==About this Structure==		==About this Structure==
-	[[4n36]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N36 OCA].	+	[[4n36]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N36 OCA].

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024217250</ref><references group="xtra"/><references/>
		+	[[Category: Human]]
	[[Category: Drickamer, K.]]		[[Category: Drickamer, K.]]
	[[Category: Feinberg, H.]]		[[Category: Feinberg, H.]]

OCA at 13:47, 20 November 2013

OCA — Wed, 20 Nov 2013 13:47:19 GMT

←Older revision		Revision as of 13:47, 20 November 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4n36\| PDB=4n36 \| SCENE= }}
		+	===Structure of langerin CRD I313 D288 complexed with Me-GlcNAc===

-	~~The~~ entry ~~4n36~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref>

-	~~Authors~~: ~~Feinberg, H~~.~~, Rowntree, T~~.J.W., ~~Tan, S~~.~~L.W~~., ~~Drickamer~~, K.~~, Weis, W~~.~~I., Taylor, M.E~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref>

-	~~Description:~~ Structure ~~of langerin CRD I313 D288 complexed with Me~~-~~GlcNAc~~	+	==About this Structure==
		+	[[4n36]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N36 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Drickamer, K.]]
		+	[[Category: Feinberg, H.]]
		+	[[Category: Rowntree, T J.W.]]
		+	[[Category: Tan, S L.W.]]
		+	[[Category: Taylor, M E.]]
		+	[[Category: Weis, W I.]]
		+	[[Category: C-type lectin on langerhans cell]]
		+	[[Category: Carbohydrate-recognition domain]]
		+	[[Category: Carbohydrate/sugar binding]]
		+	[[Category: Crd carbohydrate complex]]
		+	[[Category: Receptor on langerhans cell]]
		+	[[Category: Sugar binding protein]]

OCA: Protected "4n36" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2013 07:33:11 GMT

Protected "4n36" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:33, 16 October 2013

OCA: New page: '''Unreleased structure''' The entry 4n36 is ON HOLD until Paper Publication Authors: Feinberg, H., Rowntree, T.J.W., Tan, S.L.W., Drickamer, K., Weis, W.I., Taylor, M.E. Description: ...

OCA — Wed, 16 Oct 2013 07:33:11 GMT

New page: '''Unreleased structure''' The entry 4n36 is ON HOLD until Paper Publication Authors: Feinberg, H., Rowntree, T.J.W., Tan, S.L.W., Drickamer, K., Weis, W.I., Taylor, M.E. Description: ...

New page

'''Unreleased structure'''

The entry 4n36 is ON HOLD until Paper Publication

Authors: Feinberg, H., Rowntree, T.J.W., Tan, S.L.W., Drickamer, K., Weis, W.I., Taylor, M.E.

Description: Structure of langerin CRD I313 D288 complexed with Me-GlcNAc