4n3u - Revision history

OCA at 16:47, 20 September 2023

OCA — Wed, 20 Sep 2023 16:47:25 GMT

←Older revision		Revision as of 16:47, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n3u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N3U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n3u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N3U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3u OCA], [https://pdbe.org/4n3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n3u RCSB], [https://www.ebi.ac.uk/pdbsum/4n3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3u OCA], [https://pdbe.org/4n3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n3u RCSB], [https://www.ebi.ac.uk/pdbsum/4n3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3u ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:30, 28 December 2022

OCA — Wed, 28 Dec 2022 10:30:59 GMT

←Older revision		Revision as of 10:30, 28 December 2022
Line 1:		Line 1:

	==Candida albicans Superoxide Dismutase 5 (SOD5), Cu(II)==		==Candida albicans Superoxide Dismutase 5 (SOD5), Cu(II)==
-	<StructureSection load='4n3u' size='340' side='right' caption='[[4n3u]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='4n3u' size='340' side='right'caption='[[4n3u]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n3u]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Canal Canal~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4N3U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n3u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N3U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3t\|4n3t]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3u OCA], [https://pdbe.org/4n3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n3u RCSB], [https://www.ebi.ac.uk/pdbsum/4n3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3u ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.2060, CaO19.9607, SOD31, SOD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3u OCA], [~~http~~://pdbe.org/4n3u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4n3u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4n3u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SOD5_CANAL SOD5_CANAL]] Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.<ref>PMID:14617819</ref> <ref>PMID:19019164</ref> <ref>PMID:21746956</ref>	+	[https://www.uniprot.org/uniprot/SOD5_CANAL SOD5_CANAL] Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.<ref>PMID:14617819</ref> <ref>PMID:19019164</ref> <ref>PMID:21746956</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Superoxide ~~Dismutase~~\|Superoxide ~~Dismutase~~]]	+	*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canal~~]]	+	[[Category: Candida albicans SC5314]]
-	[[Category: Galaleldeen, A]]	+	[[Category: Large Structures]]
-	[[Category: Hart~~, P J~~]]	+	[[Category: Galaleldeen A]]
-	[[Category: Holloway~~, S P~~]]	+	[[Category: Hart PJ]]
-	[[Category: Taylor~~, A B~~]]	+	[[Category: Holloway SP]]
-	[[Category: Waninger-Saroni~~, J J]]~~	+	[[Category: Taylor AB]]
-	~~[[Category: Antioxidant]]~~	+	[[Category: Waninger-Saroni JJ]]
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Extracellular]]~~	+
-	~~[[Category: Oxidative burst]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Zinc loop~~]]	+

OCA at 01:43, 5 August 2016

OCA — Fri, 05 Aug 2016 01:43:42 GMT

←Older revision		Revision as of 01:43, 5 August 2016
Line 1:		Line 1:
		+
	==Candida albicans Superoxide Dismutase 5 (SOD5), Cu(II)==		==Candida albicans Superoxide Dismutase 5 (SOD5), Cu(II)==
	<StructureSection load='4n3u' size='340' side='right' caption='[[4n3u]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4n3u' size='340' side='right' caption='[[4n3u]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3t\|4n3t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3t\|4n3t]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.2060, CaO19.9607, SOD31, SOD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.2060, CaO19.9607, SOD31, SOD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n3u RCSB], [http://www.ebi.ac.uk/pdbsum/4n3u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3u OCA], [http://pdbe.org/4n3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n3u RCSB], [http://www.ebi.ac.uk/pdbsum/4n3u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4n3u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 21:42, 24 December 2014

OCA — Wed, 24 Dec 2014 21:42:13 GMT

←Older revision		Revision as of 21:42, 24 December 2014
Line 2:		Line 2:
	<StructureSection load='4n3u' size='340' side='right' caption='[[4n3u]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4n3u' size='340' side='right' caption='[[4n3u]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n3u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3U OCA]. <br>	+	<table><tr><td colspan='2'>[[4n3u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N3U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3t\|4n3t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3t\|4n3t]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.2060, CaO19.9607, SOD31, SOD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.2060, CaO19.9607, SOD31, SOD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n3u RCSB], [http://www.ebi.ac.uk/pdbsum/4n3u PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n3u RCSB], [http://www.ebi.ac.uk/pdbsum/4n3u PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SOD5_CANAL SOD5_CANAL]] Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.<ref>PMID:14617819</ref> <ref>PMID:19019164</ref> <ref>PMID:21746956</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 16:
	Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense.,Gleason JE, Galaleldeen A, Peterson RL, Taylor AB, Holloway SP, Waninger-Saroni J, Cormack BP, Cabelli DE, Hart PJ, Culotta VC Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5866-71. doi:, 10.1073/pnas.1400137111. Epub 2014 Apr 7. PMID:24711423<ref>PMID:24711423</ref>		Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense.,Gleason JE, Galaleldeen A, Peterson RL, Taylor AB, Holloway SP, Waninger-Saroni J, Cormack BP, Cabelli DE, Hart PJ, Culotta VC Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5866-71. doi:, 10.1073/pnas.1400137111. Epub 2014 Apr 7. PMID:24711423<ref>PMID:24711423</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Superoxide Dismutase\|Superoxide Dismutase]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Canal]]		[[Category: Canal]]
-	[[Category: Galaleldeen, A.]]	+	[[Category: Galaleldeen, A]]
-	[[Category: Hart, P J.]]	+	[[Category: Hart, P J]]
-	[[Category: Holloway, S P.]]	+	[[Category: Holloway, S P]]
-	[[Category: Taylor, A B.]]	+	[[Category: Taylor, A B]]
-	[[Category: Waninger-Saroni, J J.]]	+	[[Category: Waninger-Saroni, J J]]
	[[Category: Antioxidant]]		[[Category: Antioxidant]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]

OCA at 06:52, 14 May 2014

OCA — Wed, 14 May 2014 06:52:15 GMT

←Older revision		Revision as of 06:52, 14 May 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4n3u\| PDB=4n3u \| SCENE= }}~~	+	==Candida albicans Superoxide Dismutase 5 (SOD5), Cu(II)==
-	===Candida albicans Superoxide Dismutase 5 (SOD5), Cu(II)===	+	<StructureSection load='4n3u' size='340' side='right' caption='[[4n3u]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4n3u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3U OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3t\|4n3t]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaO19.2060, CaO19.9607, SOD31, SOD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n3u RCSB], [http://www.ebi.ac.uk/pdbsum/4n3u PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human fungal pathogens Candida albicans and Histoplasma capsulatum have been reported to protect against the oxidative burst of host innate immune cells using a family of extracellular proteins with similarity to Cu/Zn superoxide dismutase 1 (SOD1). We report here that these molecules are widespread throughout fungi and deviate from canonical SOD1 at the primary, tertiary, and quaternary levels. The structure of C. albicans SOD5 reveals that although the beta-barrel of Cu/Zn SODs is largely preserved, SOD5 is a monomeric copper protein that lacks a zinc-binding site and is missing the electrostatic loop element proposed to promote catalysis through superoxide guidance. Without an electrostatic loop, the copper site of SOD5 is not recessed and is readily accessible to bulk solvent. Despite these structural deviations, SOD5 has the capacity to disproportionate superoxide with kinetics that approach diffusion limits, similar to those of canonical SOD1. In cultures of C. albicans, SOD5 is secreted in a disulfide-oxidized form and apo-pools of secreted SOD5 can readily capture extracellular copper for rapid induction of enzyme activity. We suggest that the unusual attributes of SOD5-like fungal proteins, including the absence of zinc and an open active site that readily captures extracellular copper, make these SODs well suited to meet challenges in zinc and copper availability at the host-pathogen interface.

-	~~==Function==~~	+	Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense.,Gleason JE, Galaleldeen A, Peterson RL, Taylor AB, Holloway SP, Waninger-Saroni J, Cormack BP, Cabelli DE, Hart PJ, Culotta VC Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5866-71. doi:, 10.1073/pnas.1400137111. Epub 2014 Apr 7. PMID:24711423<ref>PMID:24711423</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/SOD5_CANAL SOD5_CANAL]] Superoxide dismutases serve to convert damaging superoxide radicals~~, ~~a key form of ROS~~, ~~to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host~~-~~derived reactive oxygen species to escape innate immune surveillance~~. ~~Involved in the occurrence of miconazole~~-~~tolerant persisters in biofilms~~. ~~Persisters are cells that survive high doses of an antimicrobial agent~~.~~<ref>PMID:14617819<~~/~~ref> <ref>~~PMID:~~19019164</ref>~~ <ref>PMID:~~21746956~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4n3u]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4N3U OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
		+	[[Category: Canal]]
	[[Category: Galaleldeen, A.]]		[[Category: Galaleldeen, A.]]
	[[Category: Hart, P J.]]		[[Category: Hart, P J.]]

OCA at 06:44, 9 April 2014

OCA — Wed, 09 Apr 2014 06:44:43 GMT

←Older revision		Revision as of 06:44, 9 April 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4n3u\| PDB=4n3u \| SCENE= }}
		+	===Candida albicans Superoxide Dismutase 5 (SOD5), Cu(II)===

-	~~The entry 4n3u is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SOD5_CANAL SOD5_CANAL]] Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.<ref>PMID:14617819</ref> <ref>PMID:19019164</ref> <ref>PMID:21746956</ref>

-	~~Authors~~: ~~Galaleldeen, A~~.~~, Taylor, A~~.B.~~, Waninger~~-~~Saroni, J.J., Holloway, S.P., Hart, P.J~~.	+	==About this Structure==
		+	[[4n3u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3U OCA].

-	~~Description~~: ~~Candida albicans Superoxide Dismutase 5~~, ~~Cu(II)~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Galaleldeen, A.]]
		+	[[Category: Hart, P J.]]
		+	[[Category: Holloway, S P.]]
		+	[[Category: Taylor, A B.]]
		+	[[Category: Waninger-Saroni, J J.]]
		+	[[Category: Antioxidant]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Extracellular]]
		+	[[Category: Oxidative burst]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Zinc loop]]

OCA at 06:14, 23 October 2013

OCA — Wed, 23 Oct 2013 06:14:18 GMT

←Older revision		Revision as of 06:14, 23 October 2013
Line 3:		Line 3:
	The entry 4n3u is ON HOLD		The entry 4n3u is ON HOLD

-	Authors: Galaleldeen, A. , Taylor, A.B. , Waninger-Saroni, J.J. , Holloway, S.P. , Hart, P.J.	+	Authors: Galaleldeen, A., Taylor, A.B., Waninger-Saroni, J.J., Holloway, S.P., Hart, P.J.

	Description: Candida albicans Superoxide Dismutase 5, Cu(II)		Description: Candida albicans Superoxide Dismutase 5, Cu(II)

OCA: Protected "4n3u" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2013 07:34:00 GMT

Protected "4n3u" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:34, 16 October 2013

OCA: New page: '''Unreleased structure''' The entry 4n3u is ON HOLD Authors: Galaleldeen, A. , Taylor, A.B. , Waninger-Saroni, J.J. , Holloway, S.P. , Hart, P.J. Description: Candida albicans Superox...

OCA — Wed, 16 Oct 2013 07:33:59 GMT

New page: '''Unreleased structure''' The entry 4n3u is ON HOLD Authors: Galaleldeen, A. , Taylor, A.B. , Waninger-Saroni, J.J. , Holloway, S.P. , Hart, P.J. Description: Candida albicans Superox...

New page

'''Unreleased structure'''

The entry 4n3u is ON HOLD

Authors: Galaleldeen, A. , Taylor, A.B. , Waninger-Saroni, J.J. , Holloway, S.P. , Hart, P.J.

Description: Candida albicans Superoxide Dismutase 5, Cu(II)