4n3z - Revision history

OCA at 14:45, 8 November 2023

OCA — Wed, 08 Nov 2023 14:45:23 GMT

←Older revision		Revision as of 14:45, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n3z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N3Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n3z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N3Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [https://pdbe.org/4n3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [https://www.ebi.ac.uk/pdbsum/4n3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [https://pdbe.org/4n3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [https://www.ebi.ac.uk/pdbsum/4n3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3z ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:31, 28 December 2022

OCA — Wed, 28 Dec 2022 10:31:08 GMT

←Older revision		Revision as of 10:31, 28 December 2022
Line 1:		Line 1:

	==Crystal structure of Rabex-5delta and Rabaptin-5C21 complex==		==Crystal structure of Rabex-5delta and Rabaptin-5C21 complex==
-	<StructureSection load='4n3z' size='340' side='right' caption='[[4n3z]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='4n3z' size='340' side='right'caption='[[4n3z]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n3z]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4N3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n3z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N3Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3x\|4n3x]], [[4n3y\|4n3y]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [https://pdbe.org/4n3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [https://www.ebi.ac.uk/pdbsum/4n3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3z ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RABEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RABEP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [~~http~~://pdbe.org/4n3z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4n3z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3z ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RABX5_HUMAN RABX5_HUMAN]] Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).<ref>PMID:9323142</ref> <ref>PMID:11452015</ref> <ref>PMID:15339665</ref> [[http://www.uniprot.org/uniprot/RABE1_HUMAN RABE1_HUMAN]] Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.<ref>PMID:8521472</ref> <ref>PMID:10698684</ref> <ref>PMID:11452015</ref> <ref>PMID:12773381</ref>	+	[https://www.uniprot.org/uniprot/RABX5_HUMAN RABX5_HUMAN] Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).<ref>PMID:9323142</ref> <ref>PMID:11452015</ref> <ref>PMID:15339665</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4n3z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4n3z" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rab5 GDP/GTP exchange factor\|Rab5 GDP/GTP exchange factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Ding, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Zhang, T~~]]	+	[[Category: Ding J]]
-	[[Category: Zhang~~, Z~~]]	+	[[Category: Zhang T]]
-	[[Category: ~~Early endosome]]~~	+	[[Category: Zhang Z]]
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Gef activity]]~~	+
-	~~[[Category: Rab5]]~~	+
-	~~[[Category: Rabaptin-5]]~~	+
-	~~[[Category: Rabex-5~~]]	+

OCA at 10:01, 15 November 2017

OCA — Wed, 15 Nov 2017 10:01:20 GMT

←Older revision		Revision as of 10:01, 15 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of Rabex-5delta and Rabaptin-5C21 complex==		==Crystal structure of Rabex-5delta and Rabaptin-5C21 complex==
	<StructureSection load='4n3z' size='340' side='right' caption='[[4n3z]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='4n3z' size='340' side='right' caption='[[4n3z]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n3z]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n3z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N3Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3x\|4n3x]], [[4n3y\|4n3y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3x\|4n3x]], [[4n3y\|4n3y]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [http://pdbe.org/4n3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [http://www.ebi.ac.uk/pdbsum/4n3z PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RABEX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RABEP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [http://pdbe.org/4n3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [http://www.ebi.ac.uk/pdbsum/4n3z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4n3z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4n3z" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Rab5 GDP/GTP exchange factor\|Rab5 GDP/GTP exchange factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Ding, J]]		[[Category: Ding, J]]
	[[Category: Zhang, T]]		[[Category: Zhang, T]]

OCA at 07:19, 9 December 2015

OCA — Wed, 09 Dec 2015 07:19:07 GMT

←Older revision		Revision as of 07:19, 9 December 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3x\|4n3x]], [[4n3y\|4n3y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3x\|4n3x]], [[4n3y\|4n3y]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [http://www.ebi.ac.uk/pdbsum/4n3z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [http://pdbe.org/4n3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [http://www.ebi.ac.uk/pdbsum/4n3z PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4n3z" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rab5 GDP/GTP exchange factor\|Rab5 GDP/GTP exchange factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:00, 24 December 2014

OCA — Wed, 24 Dec 2014 16:00:27 GMT

←Older revision		Revision as of 16:00, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n3z]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N3Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n3z]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N3Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3x\|4n3x]], [[4n3y\|4n3y]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3x\|4n3x]], [[4n3y\|4n3y]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [http://www.ebi.ac.uk/pdbsum/4n3z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [http://www.ebi.ac.uk/pdbsum/4n3z PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RABX5_HUMAN RABX5_HUMAN]] Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).<ref>PMID:9323142</ref> <ref>PMID:11452015</ref> <ref>PMID:15339665</ref> [[http://www.uniprot.org/uniprot/RABE1_HUMAN RABE1_HUMAN]] Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.<ref>PMID:8521472</ref> <ref>PMID:10698684</ref> <ref>PMID:11452015</ref> <ref>PMID:12773381</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ding, J.]]	+	[[Category: Ding, J]]
-	[[Category: Zhang, T.]]	+	[[Category: Zhang, T]]
-	[[Category: Zhang, Z.]]	+	[[Category: Zhang, Z]]
	[[Category: Early endosome]]		[[Category: Early endosome]]
	[[Category: Endocytosis]]		[[Category: Endocytosis]]

OCA at 07:56, 23 July 2014

OCA — Wed, 23 Jul 2014 07:56:02 GMT

←Older revision		Revision as of 07:56, 23 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Rabex-5delta and Rabaptin-5C21 complex==
		+	<StructureSection load='4n3z' size='340' side='right' caption='[[4n3z]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4n3z]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N3Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n3x\|4n3x]], [[4n3y\|4n3y]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n3z RCSB], [http://www.ebi.ac.uk/pdbsum/4n3z PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rabex-5 and Rabaptin-5 function together to activate Rab5 and further promote early endosomal fusion in endocytosis. The Rabex-5 GEF activity is autoinhibited by the Rabex-5 CC domain (Rabex-5CC) and activated by the Rabaptin-5 C2-1 domain (Rabaptin-5C21) with yet unknown mechanism. We report here the crystal structures of Rabex-5 in complex with the dimeric Rabaptin-5C21 (Rabaptin-5C212) and in complex with Rabaptin-5C212 and Rab5, along with biophysical and biochemical analyses. We show that Rabex-5CC assumes an amphipathic alpha-helix which binds weakly to the substrate-binding site of the GEF domain, leading to weak autoinhibition of the GEF activity. Binding of Rabaptin-5C21 to Rabex-5 displaces Rabex-5CC to yield a largely exposed substrate-binding site, leading to release of the GEF activity. In the ternary complex the substrate-binding site of Rabex-5 is completely exposed to bind and activate Rab5. Our results reveal the molecular mechanism for the regulation of the Rabex-5 GEF activity.

-	~~The entry 4n3z is ON HOLD until Paper Publication~~	+	Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5.,Zhang Z, Zhang T, Wang S, Gong Z, Tang C, Chen J, Ding J Elife (Cambridge). 2014 Jun 23:e02687. doi: 10.7554/eLife.02687. PMID:24957337<ref>PMID:24957337</ref>

-	~~Authors: Zhang~~, Z., Zhang, T., ~~Ding, J~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Rabex-5delta and~~ Rabaptin-~~5C21 complex~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ding, J.]]
		+	[[Category: Zhang, T.]]
		+	[[Category: Zhang, Z.]]
		+	[[Category: Early endosome]]
		+	[[Category: Endocytosis]]
		+	[[Category: Gef activity]]
		+	[[Category: Rab5]]
		+	[[Category: Rabaptin-5]]
		+	[[Category: Rabex-5]]

OCA at 06:14, 23 October 2013

OCA — Wed, 23 Oct 2013 06:14:24 GMT

←Older revision		Revision as of 06:14, 23 October 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4n3z is ON HOLD	+	The entry 4n3z is ON HOLD until Paper Publication

-	Authors: Zhang, Z, Zhang, T, Ding, J	+	Authors: Zhang, Z., Zhang, T., Ding, J.

	Description: Crystal structure of Rabex-5delta and Rabaptin-5C21 complex		Description: Crystal structure of Rabex-5delta and Rabaptin-5C21 complex

OCA: Protected "4n3z" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2013 07:34:12 GMT

Protected "4n3z" [edit=sysop:move=sysop]

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Revision as of 07:34, 16 October 2013

OCA: New page: '''Unreleased structure''' The entry 4n3z is ON HOLD Authors: Zhang, Z, Zhang, T, Ding, J Description: Crystal structure of Rabex-5delta and Rabaptin-5C21 complex

OCA — Wed, 16 Oct 2013 07:34:11 GMT

New page: '''Unreleased structure''' The entry 4n3z is ON HOLD Authors: Zhang, Z, Zhang, T, Ding, J Description: Crystal structure of Rabex-5delta and Rabaptin-5C21 complex

New page

'''Unreleased structure'''

The entry 4n3z is ON HOLD

Authors: Zhang, Z, Zhang, T, Ding, J

Description: Crystal structure of Rabex-5delta and Rabaptin-5C21 complex