4n8c - Revision history

OCA at 14:46, 8 November 2023

OCA — Wed, 08 Nov 2023 14:46:40 GMT

←Older revision		Revision as of 14:46, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1)) Influenza A virus (A/Puerto Rico/8/1934(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N8C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1)) Influenza A virus (A/Puerto Rico/8/1934(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N8C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8c OCA], [https://pdbe.org/4n8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n8c RCSB], [https://www.ebi.ac.uk/pdbsum/4n8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n8c ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8c OCA], [https://pdbe.org/4n8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n8c RCSB], [https://www.ebi.ac.uk/pdbsum/4n8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n8c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:14, 11 January 2023

OCA — Wed, 11 Jan 2023 08:14:14 GMT

←Older revision		Revision as of 08:14, 11 January 2023
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	<StructureSection load='4n8c' size='340' side='right'caption='[[4n8c]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='4n8c' size='340' side='right'caption='[[4n8c]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4N8C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1)) Influenza A virus (A/Puerto Rico/8/1934(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N8C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8c OCA], [~~http~~://pdbe.org/4n8c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4n8c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4n8c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4n8c ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8c OCA], [https://pdbe.org/4n8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n8c RCSB], [https://www.ebi.ac.uk/pdbsum/4n8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n8c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Cho~~, K J~~]]	+	[[Category: Cho KJ]]
-	[[Category: Fiers, W]]	+	[[Category: Fiers W]]
-	[[Category: Kim~~, K H~~]]	+	[[Category: Kim KH]]
-	[[Category: Kim, S]]	+	[[Category: Kim S]]
-	[[Category: Roose, K]]	+	[[Category: Roose K]]
-	[[Category: Saelens, X]]	+	[[Category: Saelens X]]
-	[[Category: Schepens, B]]	+	[[Category: Schepens B]]
-	[[Category: Seok~~, J H]]~~	+	[[Category: Seok JH]]
-	~~[[Category: Antibody-peptide complex]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Influenza a virus protein~~]]	+

OCA at 05:21, 13 February 2020

OCA — Thu, 13 Feb 2020 05:21:43 GMT

←Older revision		Revision as of 05:21, 13 February 2020
Line 1:		Line 1:

	==Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus==		==Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus==
-	<StructureSection load='4n8c' size='340' side='right' caption='[[4n8c]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='4n8c' size='340' side='right'caption='[[4n8c]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N8C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N8C FirstGlance]. <br>
Line 17:		Line 17:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Cho, K J]]		[[Category: Cho, K J]]

OCA at 10:02, 15 November 2017

OCA — Wed, 15 Nov 2017 10:02:59 GMT

←Older revision		Revision as of 10:02, 15 November 2017
Line 1:		Line 1:
		+
	==Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus==		==Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus==
	<StructureSection load='4n8c' size='340' side='right' caption='[[4n8c]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='4n8c' size='340' side='right' caption='[[4n8c]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N8C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N8C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8c OCA], [http://pdbe.org/4n8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n8c RCSB], [http://www.ebi.ac.uk/pdbsum/4n8c PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8c OCA], [http://pdbe.org/4n8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n8c RCSB], [http://www.ebi.ac.uk/pdbsum/4n8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n8c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	</div>		</div>
	<div class="pdbe-citations 4n8c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4n8c" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:36, 30 September 2015

OCA — Wed, 30 Sep 2015 07:36:26 GMT

←Older revision		Revision as of 07:36, 30 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N8C FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N8C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n8c RCSB], [http://www.ebi.ac.uk/pdbsum/4n8c PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8c OCA], [http://pdbe.org/4n8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n8c RCSB], [http://www.ebi.ac.uk/pdbsum/4n8c PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The extracellular domain of influenza A virus matrix protein 2 (M2e) is conserved and is being evaluated as a quasiuniversal influenza A vaccine candidate. We describe the crystal structure at 1.6 A resolution of M2e in complex with the Fab fragment of an M2e-specific monoclonal antibody that protects against influenza A virus challenge. This antibody binds M2 expressed on the surfaces of cells infected with influenza A virus. Five out of six complementary determining regions interact with M2e, and three highly conserved M2e residues are critical for this interaction. In this complex, M2e adopts a compact U-shaped conformation stabilized in the center by the highly conserved tryptophan residue in M2e. This is the first description of the three-dimensional structure of M2e. IMPORTANCE: M2e of influenza A is under investigation as a universal influenza A vaccine, but its three-dimensional structure is unknown. We describe the structure of M2e stabilized with an M2e-specific monoclonal antibody that recognizes natural M2. We found that the conserved tryptophan is positioned in the center of the U-shaped structure of M2e and stabilizes its conformation. The structure also explains why previously reported in vivo escape viruses, selected with a similar monoclonal antibody, carried proline residue substitutions at position 10 in M2.
		+
		+	Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody.,Cho KJ, Schepens B, Seok JH, Kim S, Roose K, Lee JH, Gallardo R, Van Hamme E, Schymkowitz J, Rousseau F, Fiers W, Saelens X, Kim KH J Virol. 2015 Apr;89(7):3700-11. doi: 10.1128/JVI.02576-14. Epub 2015 Jan 21. PMID:25609808<ref>PMID:25609808</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4n8c" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:04, 25 January 2015

OCA — Sun, 25 Jan 2015 08:04:11 GMT

←Older revision		Revision as of 08:04, 25 January 2015
Line 8:		Line 8:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Cho, K J.]]	+	[[Category: Cho, K J]]
-	[[Category: Fiers, W.]]	+	[[Category: Fiers, W]]
-	[[Category: Kim, K H.]]	+	[[Category: Kim, K H]]
-	[[Category: Kim, S.]]	+	[[Category: Kim, S]]
-	[[Category: Roose, K.]]	+	[[Category: Roose, K]]
-	[[Category: Saelens, X.]]	+	[[Category: Saelens, X]]
-	[[Category: Schepens, B.]]	+	[[Category: Schepens, B]]
-	[[Category: Seok, J H.]]	+	[[Category: Seok, J H]]
	[[Category: Antibody-peptide complex]]		[[Category: Antibody-peptide complex]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Influenza a virus protein]]		[[Category: Influenza a virus protein]]

OCA at 11:37, 22 October 2014

OCA — Wed, 22 Oct 2014 11:37:52 GMT

←Older revision		Revision as of 11:37, 22 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus==
-		+	<StructureSection load='4n8c' size='340' side='right' caption='[[4n8c]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~The entry~~ 4n8c is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4n8c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N8C FirstGlance]. <br>
-	~~Authors~~: Cho, K.J., ~~Seok, J~~.H., Kim, S., Roose, K.~~, Schepens, B., Fiers, W.,~~ Saelens, X., ~~Kim, K~~.H.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n8c RCSB], [http://www.ebi.ac.uk/pdbsum/4n8c PDBsum]</span></td></tr>
-		+	</table>
-	~~Description~~: ~~Three~~-~~dimensional structure of the extracellular domain of Matrix~~ protein ~~2 of influenza A virus~~	+	__TOC__
		+	</StructureSection>
		+	[[Category: Mus musculus]]
		+	[[Category: Cho, K J.]]
		+	[[Category: Fiers, W.]]
		+	[[Category: Kim, K H.]]
		+	[[Category: Kim, S.]]
		+	[[Category: Roose, K.]]
		+	[[Category: Saelens, X.]]
		+	[[Category: Schepens, B.]]
		+	[[Category: Seok, J H.]]
		+	[[Category: Antibody-peptide complex]]
		+	[[Category: Immune system]]
		+	[[Category: Influenza a virus protein]]

OCA at 07:41, 13 November 2013

OCA — Wed, 13 Nov 2013 07:41:17 GMT

←Older revision		Revision as of 07:41, 13 November 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4n8c is ON HOLD	+	The entry 4n8c is ON HOLD until Paper Publication

	Authors: Cho, K.J., Seok, J.H., Kim, S., Roose, K., Schepens, B., Fiers, W., Saelens, X., Kim, K.H.		Authors: Cho, K.J., Seok, J.H., Kim, S., Roose, K., Schepens, B., Fiers, W., Saelens, X., Kim, K.H.

	Description: Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus		Description: Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus

OCA: Protected "4n8c" [edit=sysop:move=sysop]

OCA — Wed, 23 Oct 2013 06:18:18 GMT

Protected "4n8c" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:18, 23 October 2013

OCA: New page: '''Unreleased structure''' The entry 4n8c is ON HOLD Authors: Cho, K.J., Seok, J.H., Kim, S., Roose, K., Schepens, B., Fiers, W., Saelens, X., Kim, K.H. Description: Three-dimensional ...

OCA — Wed, 23 Oct 2013 06:18:18 GMT

New page: '''Unreleased structure''' The entry 4n8c is ON HOLD Authors: Cho, K.J., Seok, J.H., Kim, S., Roose, K., Schepens, B., Fiers, W., Saelens, X., Kim, K.H. Description: Three-dimensional ...

New page

'''Unreleased structure'''

The entry 4n8c is ON HOLD

Authors: Cho, K.J., Seok, J.H., Kim, S., Roose, K., Schepens, B., Fiers, W., Saelens, X., Kim, K.H.

Description: Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza A virus