4n98 - Revision history

OCA at 16:49, 20 September 2023

OCA — Wed, 20 Sep 2023 16:49:54 GMT

←Older revision		Revision as of 16:49, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N98 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N98 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4FC:4-FLUORO-1,1-BIPHENYL-4-CARBOXYLIC+ACID'>4FC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4FC:4-FLUORO-1,1-BIPHENYL-4-CARBOXYLIC+ACID'>4FC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n98 OCA], [https://pdbe.org/4n98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n98 RCSB], [https://www.ebi.ac.uk/pdbsum/4n98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n98 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n98 OCA], [https://pdbe.org/4n98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n98 RCSB], [https://www.ebi.ac.uk/pdbsum/4n98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n98 ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4n98" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4n98" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:15, 11 January 2023

OCA — Wed, 11 Jan 2023 08:15:30 GMT

←Older revision		Revision as of 08:15, 11 January 2023
Line 1:		Line 1:

	==E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid==		==E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid==
-	<StructureSection load='4n98' size='340' side='right' caption='[[4n98]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4n98' size='340' side='right'caption='[[4n98]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n98]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N98 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4N98 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N98 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4FC:4-FLUORO-1,1-BIPHENYL-4-CARBOXYLIC+ACID'>4FC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4FC:4-FLUORO-1,1-BIPHENYL-4-CARBOXYLIC+ACID'>4FC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n94\|4n94]], [[4n95\|4n95]], [[4n96\|4n96]], [[4n97\|4n97]], [[4n99\|4n99]], [[4n9a\|4n9a]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n98 OCA], [https://pdbe.org/4n98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n98 RCSB], [https://www.ebi.ac.uk/pdbsum/4n98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n98 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b3701, dnaN, JW3678 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4n98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n98 OCA], [~~http~~://pdbe.org/4n98 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4n98 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4n98 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4n98 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.	+	[https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4n98" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4n98" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~DNA~~-~~directed DNA polymerase~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: ~~Ecoli~~]]	+	[[Category: Large Structures]]
-	[[Category: Oakley~~, A J~~]]	+	[[Category: Oakley AJ]]
-	[[Category: Yin, Z]]	+	[[Category: Yin Z]]
-	~~[[Category: Dnan]]~~	+
-	~~[[Category: Poliii beta]]~~	+
-	~~[[Category: Sliding clamp]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 13:06, 4 August 2016

OCA — Thu, 04 Aug 2016 13:06:32 GMT

←Older revision		Revision as of 13:06, 4 August 2016
Line 1:		Line 1:
		+
	==E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid==		==E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid==
	<StructureSection load='4n98' size='340' side='right' caption='[[4n98]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4n98' size='340' side='right' caption='[[4n98]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b3701, dnaN, JW3678 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b3701, dnaN, JW3678 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n98 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n98 RCSB], [http://www.ebi.ac.uk/pdbsum/4n98 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n98 OCA], [http://pdbe.org/4n98 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n98 RCSB], [http://www.ebi.ac.uk/pdbsum/4n98 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n98 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4n98" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:51, 24 December 2014

OCA — Wed, 24 Dec 2014 14:51:19 GMT

←Older revision		Revision as of 14:51, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4n98\| PDB=4n98 \| SCENE= }}~~	+	==E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid==
-	===E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid===	+	<StructureSection load='4n98' size='340' side='right' caption='[[4n98]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24592885}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4n98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N98 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N98 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4FC:4-FLUORO-1,1-BIPHENYL-4-CARBOXYLIC+ACID'>4FC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4n94\|4n94]], [[4n95\|4n95]], [[4n96\|4n96]], [[4n97\|4n97]], [[4n99\|4n99]], [[4n9a\|4n9a]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b3701, dnaN, JW3678 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n98 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n98 RCSB], [http://www.ebi.ac.uk/pdbsum/4n98 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.		[[http://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial sliding clamp (SC), also known as the DNA polymerase III beta subunit, is an emerging antibacterial target that plays a central role in DNA replication, serving as a protein-protein interaction hub with a common binding pocket to recognize linear motifs in the partner proteins. Here, fragment-based screening using X-ray crystallography produced four hits bound in the linear-motif-binding pocket of the Escherichia coli SC. Compounds structurally related to the hits were identified that inhibited the E. coli SC and SC-mediated DNA replication in vitro. A tetrahydrocarbazole derivative emerged as a promising lead whose methyl and ethyl ester prodrug forms showed minimum inhibitory concentrations in the range of 21-43 mug/mL against representative Gram-negative and Gram-positive bacteria species. The work demonstrates the utility of a fragment-based approach for identifying bacterial sliding clamp inhibitors as lead compounds with broad-spectrum antibacterial activity.

-	~~==About this Structure==~~	+	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.,Yin Z, Whittell LR, Wang Y, Jergic S, Liu M, Harry EJ, Dixon NE, Beck JL, Kelso MJ, Oakley AJ J Med Chem. 2014 Mar 27;57(6):2799-806. doi: 10.1021/jm500122r. Epub 2014 Mar 18. PMID:24592885<ref>PMID:24592885</ref>
-	~~[[4n98]] is~~ a ~~2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Ecoli Ecoli]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4N98 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[DNA polymerase\|DNA polymerase]]		*[[DNA polymerase\|DNA polymerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024592885</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: DNA-directed DNA polymerase]]		[[Category: DNA-directed DNA polymerase]]
	[[Category: Ecoli]]		[[Category: Ecoli]]
-	[[Category: Oakley, A J.]]	+	[[Category: Oakley, A J]]
-	[[Category: Yin, Z.]]	+	[[Category: Yin, Z]]
	[[Category: Dnan]]		[[Category: Dnan]]
	[[Category: Poliii beta]]		[[Category: Poliii beta]]
	[[Category: Sliding clamp]]		[[Category: Sliding clamp]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 07:20, 2 April 2014

OCA — Wed, 02 Apr 2014 07:20:58 GMT

←Older revision		Revision as of 07:20, 2 April 2014
Line 1:		Line 1:
	{{STRUCTURE_4n98\| PDB=4n98 \| SCENE= }}		{{STRUCTURE_4n98\| PDB=4n98 \| SCENE= }}
	===E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid===		===E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid===
		+	{{ABSTRACT_PUBMED_24592885}}

	==Function==		==Function==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4n98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12 Escherichia coli k-12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N98 OCA].	+	[[4n98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N98 OCA].
		+
		+	==See Also==
		+	*[[DNA polymerase\|DNA polymerase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024592885</ref><references group="xtra"/><references/>
	[[Category: DNA-directed DNA polymerase]]		[[Category: DNA-directed DNA polymerase]]
-	[[Category: ~~Escherichia coli k-12~~]]	+	[[Category: Ecoli]]
	[[Category: Oakley, A J.]]		[[Category: Oakley, A J.]]
	[[Category: Yin, Z.]]		[[Category: Yin, Z.]]

OCA at 07:56, 6 November 2013

OCA — Wed, 06 Nov 2013 07:56:15 GMT

←Older revision		Revision as of 07:56, 6 November 2013
Line 1:		Line 1:
-	'~~''Unreleased structure'''~~	+	{{STRUCTURE_4n98\| PDB=4n98 \| SCENE= }}
		+	===E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid===

-	The ~~entry 4n98~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.

-	~~Authors~~: ~~Yin, Z~~., Oakley, A.J.	+	==About this Structure==
-		+	[[4n98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N98 OCA].
-	~~Description~~: E. ~~coli sliding~~ clamp ~~in complex with 4'~~-~~fluorobiphenyl-4-carboxylic acid~~	+	[[Category: DNA-directed DNA polymerase]]
		+	[[Category: Escherichia coli k-12]]
		+	[[Category: Oakley, A J.]]
		+	[[Category: Yin, Z.]]
		+	[[Category: Dnan]]
		+	[[Category: Poliii beta]]
		+	[[Category: Sliding clamp]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA: Protected "4n98" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2013 07:04:28 GMT

Protected "4n98" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:04, 6 November 2013

OCA: New page: '''Unreleased structure''' The entry 4n98 is ON HOLD Authors: Yin, Z., Oakley, A.J. Description: E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid

OCA — Wed, 06 Nov 2013 07:04:28 GMT

New page: '''Unreleased structure''' The entry 4n98 is ON HOLD Authors: Yin, Z., Oakley, A.J. Description: E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid

New page

'''Unreleased structure'''

The entry 4n98 is ON HOLD

Authors: Yin, Z., Oakley, A.J.

Description: E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid