4n9z - Revision history

OCA at 16:50, 20 September 2023

OCA — Wed, 20 Sep 2023 16:50:51 GMT

←Older revision		Revision as of 16:50, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V3L:2-O-(5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSYL)ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>V3L</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V3L:2-O-(5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSYL)ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>V3L</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9z OCA], [https://pdbe.org/4n9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9z RCSB], [https://www.ebi.ac.uk/pdbsum/4n9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9z OCA], [https://pdbe.org/4n9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9z RCSB], [https://www.ebi.ac.uk/pdbsum/4n9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9z ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:16, 11 January 2023

OCA — Wed, 11 Jan 2023 08:16:34 GMT

←Older revision		Revision as of 08:16, 11 January 2023
Line 1:		Line 1:

	==Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q==		==Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q==
-	<StructureSection load='4n9z' size='340' side='right' caption='[[4n9z]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4n9z' size='340' side='right'caption='[[4n9z]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4n9z]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4N9Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4n9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V3L:2-O-(5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSYL)ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>V3L</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V3L:2-O-(5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSYL)ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>V3L</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fc2\|4fc2]], [[4n9y\|4n9y]], [[4na0\|4na0]], [[4na4\|4na4]], [[4na5\|4na5]], [[4na6\|4na6]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9z OCA], [https://pdbe.org/4n9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9z RCSB], [https://www.ebi.ac.uk/pdbsum/4n9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9z ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Parg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(ADP-ribose)_glycohydrolase Poly(ADP-ribose) glycohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.143 3.2.1.143] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4n9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9z OCA], [~~http~~://pdbe.org/4n9z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4n9z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4n9z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9z ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE]] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).	+	[https://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Poly (ADP-ribose) glycohydrolase\|Poly (ADP-ribose) glycohydrolase]]	+	*[[Poly(ADP-ribose) glycohydrolase 3D structures\|Poly(ADP-ribose) glycohydrolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Cheng, Z~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Wang,~~ Z]]	+	[[Category: Cheng Z]]
-	[[Category: ~~Xu, W~~]]	+	[[Category: Wang Z]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Xu W]]
-	~~[[Category: Parg~~]]	+

OCA at 21:44, 4 August 2016

OCA — Thu, 04 Aug 2016 21:44:45 GMT

←Older revision		Revision as of 21:44, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q==		==Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q==
	<StructureSection load='4n9z' size='340' side='right' caption='[[4n9z]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4n9z' size='340' side='right' caption='[[4n9z]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Parg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Parg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(ADP-ribose)_glycohydrolase Poly(ADP-ribose) glycohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.143 3.2.1.143] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(ADP-ribose)_glycohydrolase Poly(ADP-ribose) glycohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.143 3.2.1.143] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n9z RCSB], [http://www.ebi.ac.uk/pdbsum/4n9z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9z OCA], [http://pdbe.org/4n9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n9z RCSB], [http://www.ebi.ac.uk/pdbsum/4n9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4n9z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:24, 25 December 2014

OCA — Thu, 25 Dec 2014 13:24:16 GMT

←Older revision		Revision as of 13:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4n9z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[4n9z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V3L:2-O-(5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSYL)ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>V3L</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V3L:2-O-(5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSYL)ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>V3L</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fc2\|4fc2]], [[4n9y\|4n9y]], [[4na0\|4na0]], [[4na4\|4na4]], [[4na5\|4na5]], [[4na6\|4na6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fc2\|4fc2]], [[4n9y\|4n9y]], [[4na0\|4na0]], [[4na4\|4na4]], [[4na5\|4na5]], [[4na6\|4na6]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Parg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Parg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(ADP-ribose)_glycohydrolase Poly(ADP-ribose) glycohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.143 3.2.1.143] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(ADP-ribose)_glycohydrolase Poly(ADP-ribose) glycohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.143 3.2.1.143] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n9z RCSB], [http://www.ebi.ac.uk/pdbsum/4n9z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n9z RCSB], [http://www.ebi.ac.uk/pdbsum/4n9z PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE]] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
-	[[Category: Cheng, Z.]]	+	[[Category: Cheng, Z]]
-	[[Category: Wang, Z.]]	+	[[Category: Wang, Z]]
-	[[Category: Xu, W.]]	+	[[Category: Xu, W]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Parg]]		[[Category: Parg]]

OCA at 06:11, 24 September 2014

OCA — Wed, 24 Sep 2014 06:11:53 GMT

←Older revision		Revision as of 06:11, 24 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4n9z\| PDB=4n9z \| SCENE= }}~~	+	==Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q==
-	===Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q===	+	<StructureSection load='4n9z' size='340' side='right' caption='[[4n9z]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4n9z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N9Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V3L:2-O-(5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSYL)ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>V3L</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fc2\|4fc2]], [[4n9y\|4n9y]], [[4na0\|4na0]], [[4na4\|4na4]], [[4na5\|4na5]], [[4na6\|4na6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Parg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(ADP-ribose)_glycohydrolase Poly(ADP-ribose) glycohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.143 3.2.1.143] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n9z RCSB], [http://www.ebi.ac.uk/pdbsum/4n9z PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein poly(ADP-ribosyl)ation (PARylation) regulates a number of important cellular processes. Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for hydrolyzing the poly(ADP-ribose) (PAR) polymer in vivo. Here we report crystal structures of the mouse PARG (mPARG) catalytic domain, its complexes with ADP-ribose (ADPr) and a PARG inhibitor ADP-HPD, as well as four PARG catalytic residues mutants. With these structures and biochemical analysis of 20 mPARG mutants, we provide a structural basis for understanding how the PAR polymer is recognized and hydrolyzed by mPARG. The structures and activity complementation experiment also suggest how the N-terminal flexible peptide preceding the PARG catalytic domain may regulate the enzymatic activity of PARG. This study contributes to our understanding of PARG catalytic and regulatory mechanisms as well as the rational design of PARG inhibitors.

-	~~==Function==~~	+	Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.,Wang Z, Gagne JP, Poirier GG, Xu W PLoS One. 2014 Jan 21;9(1):e86010. doi: 10.1371/journal.pone.0086010. eCollection, 2014. PMID:24465839<ref>PMID:24465839</ref>
-	~~[[http://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE]] Poly(ADP-ribose) synthesized after DNA damage is only present transiently~~ and ~~is rapidly degraded by~~ poly(ADP-ribose) glycohydrolase. ~~PARG acts both as an endo- and exoglycosidase~~, ~~releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation~~, ~~probably by dePARsylating histone demethylase KDM4D~~, ~~allowing chromatin derepression at RAR-dependent gene promoters~~ (~~By similarity~~).	+

-	==~~About this Structure~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[~~4n9z~~]] ~~is a 2 chain structure. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Z OCA~~].	+	</div>
		+
		+	==See Also==
		+	*[[Poly (ADP-ribose) glycohydrolase\|Poly (ADP-ribose) glycohydrolase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Cheng, Z.]]		[[Category: Cheng, Z.]]
	[[Category: Wang, Z.]]		[[Category: Wang, Z.]]

OCA at 07:50, 29 January 2014

OCA — Wed, 29 Jan 2014 07:50:49 GMT

←Older revision		Revision as of 07:50, 29 January 2014
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4n9z\| PDB=4n9z \| SCENE= }}
		+	===Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q===

-	~~The entry 4n9z~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE]] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).

-	~~Authors~~: ~~Wang, Z~~., Cheng, Z., Xu, W.	+	==About this Structure==
-		+	[[4n9z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Z OCA].
-	~~Description~~: ~~Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q~~	+	[[Category: Cheng, Z.]]
		+	[[Category: Wang, Z.]]
		+	[[Category: Xu, W.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Parg]]

OCA at 07:41, 13 November 2013

OCA — Wed, 13 Nov 2013 07:41:51 GMT

←Older revision		Revision as of 07:41, 13 November 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4n9z is ON HOLD	+	The entry 4n9z is ON HOLD until Paper Publication

-	Authors: Wang, Z, Cheng, Z, Xu, W	+	Authors: Wang, Z., Cheng, Z., Xu, W.

	Description: Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q		Description: Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q

OCA: Protected "4n9z" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2013 07:05:26 GMT

Protected "4n9z" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:05, 6 November 2013

OCA: New page: '''Unreleased structure''' The entry 4n9z is ON HOLD Authors: Wang, Z, Cheng, Z, Xu, W Description: Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain m...

OCA — Wed, 06 Nov 2013 07:05:25 GMT

New page: '''Unreleased structure''' The entry 4n9z is ON HOLD Authors: Wang, Z, Cheng, Z, Xu, W Description: Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain m...

New page

'''Unreleased structure'''

The entry 4n9z is ON HOLD

Authors: Wang, Z, Cheng, Z, Xu, W

Description: Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E749Q