4na1 - Revision history

OCA at 16:50, 20 September 2023

OCA — Wed, 20 Sep 2023 16:50:59 GMT

←Older revision		Revision as of 16:50, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4na1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NA1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4na1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NA1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4na1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4na1 OCA], [https://pdbe.org/4na1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4na1 RCSB], [https://www.ebi.ac.uk/pdbsum/4na1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4na1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4na1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4na1 OCA], [https://pdbe.org/4na1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4na1 RCSB], [https://www.ebi.ac.uk/pdbsum/4na1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4na1 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:16, 11 January 2023

OCA — Wed, 11 Jan 2023 08:16:39 GMT

←Older revision		Revision as of 08:16, 11 January 2023
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	==Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase==		==Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase==
-	<StructureSection load='4na1' size='340' side='right' caption='[[4na1]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='4na1' size='340' side='right'caption='[[4na1]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4na1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacsu Bacsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NA1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4na1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NA1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qo3\|2qo3]], [[2hg4\|2hg4]], [[4na2\|4na2]], [[4na3\|4na3]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4na1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4na1 OCA], [https://pdbe.org/4na1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4na1 RCSB], [https://www.ebi.ac.uk/pdbsum/4na1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4na1 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pksJ, pksK, BSU17180 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4na1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4na1 OCA], [~~http~~://pdbe.org/4na1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4na1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4na1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4na1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PKSJ_BACSU PKSJ_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:16460000</ref> <ref>PMID:17234808</ref>	+	[https://www.uniprot.org/uniprot/PKSJ_BACSU PKSJ_BACSU] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:16460000</ref> <ref>PMID:17234808</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacsu~~]]	+	[[Category: Bacillus subtilis subsp. subtilis str. 168]]
-	[[Category: ~~Gay, D C~~]]	+	[[Category: Large Structures]]
-	[[Category: Gay~~, G R~~]]	+	[[Category: Gay DC]]
-	[[Category: ~~Keatinge-Clay, A T~~]]	+	[[Category: Gay GR]]
-	[[Category: ~~Condensing enzyme fold]]~~	+	[[Category: Keatinge-Clay AT]]
-	~~[[Category: Transferase~~]]	+

OCA at 08:48, 4 August 2016

OCA — Thu, 04 Aug 2016 08:48:36 GMT

←Older revision		Revision as of 08:48, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase==		==Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase==
	<StructureSection load='4na1' size='340' side='right' caption='[[4na1]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4na1' size='340' side='right' caption='[[4na1]], [[Resolution\|resolution]] 1.95Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qo3\|2qo3]], [[2hg4\|2hg4]], [[4na2\|4na2]], [[4na3\|4na3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qo3\|2qo3]], [[2hg4\|2hg4]], [[4na2\|4na2]], [[4na3\|4na3]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pksJ, pksK, BSU17180 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pksJ, pksK, BSU17180 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4na1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4na1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4na1 RCSB], [http://www.ebi.ac.uk/pdbsum/4na1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4na1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4na1 OCA], [http://pdbe.org/4na1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4na1 RCSB], [http://www.ebi.ac.uk/pdbsum/4na1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4na1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4na1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:29, 25 December 2014

OCA — Thu, 25 Dec 2014 07:29:59 GMT

←Older revision		Revision as of 07:29, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4na1\| PDB=4na1 \| SCENE= }}~~	+	==Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase==
-	===Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase===	+	<StructureSection load='4na1' size='340' side='right' caption='[[4na1]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24508341}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4na1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NA1 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qo3\|2qo3]], [[2hg4\|2hg4]], [[4na2\|4na2]], [[4na3\|4na3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pksJ, pksK, BSU17180 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4na1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4na1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4na1 RCSB], [http://www.ebi.ac.uk/pdbsum/4na1 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PKSJ_BACSU PKSJ_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:16460000</ref> <ref>PMID:17234808</ref>		[[http://www.uniprot.org/uniprot/PKSJ_BACSU PKSJ_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:16460000</ref> <ref>PMID:17234808</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The recently discovered trans-acyltransferase modular polyketide synthases catalyze the biosynthesis of a wide range of bioactive natural products in bacteria. Here we report the structure of the second ketosynthase from the bacillaene trans-acyltransferase polyketide synthase. This 1.95 A resolution structure provides the highest resolution view available of a modular polyketide synthase ketosynthase and reveals a flanking subdomain that is homologous to an ordered linker in cis-acyltransferase modular polyketide synthases. The structure of the cysteine-to-serine mutant of the ketosynthase acylated by its natural substrate provides high-resolution details of how a native polyketide intermediate is bound and helps explain the basis of ketosynthase substrate specificity. The substrate range of the ketosynthase was further investigated by mass spectrometry.

-	~~==About this Structure==~~	+	A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase.,Gay DC, Gay G, Axelrod AJ, Jenner M, Kohlhaas C, Kampa A, Oldham NJ, Piel J, Keatinge-Clay AT Structure. 2014 Feb 4. pii: S0969-2126(14)00008-2. doi:, 10.1016/j.str.2013.12.016. PMID:24508341<ref>PMID:24508341</ref>
-	~~[[4na1]] is~~ a 2 ~~chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4NA1 OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024508341</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Gay, D C.]]	+	== References ==
-	[[Category: Gay, G R.]]	+	<references/>
-	[[Category: Keatinge-Clay, A T.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Bacsu]]
		+	[[Category: Gay, D C]]
		+	[[Category: Gay, G R]]
		+	[[Category: Keatinge-Clay, A T]]
	[[Category: Condensing enzyme fold]]		[[Category: Condensing enzyme fold]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 17:19, 19 February 2014

OCA — Wed, 19 Feb 2014 17:19:12 GMT

←Older revision		Revision as of 17:19, 19 February 2014
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4na1\| PDB=4na1 \| SCENE= }}
		+	===Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase===
		+	{{ABSTRACT_PUBMED_24508341}}

-	~~The entry 4na1~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PKSJ_BACSU PKSJ_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:16460000</ref> <ref>PMID:17234808</ref>

-	~~Authors~~: ~~Gay, D~~.C.~~, Gay, G~~.~~R., Keatinge~~-~~Clay, A.T~~.	+	==About this Structure==
		+	[[4na1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA1 OCA].

-	~~Description~~: ~~Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase~~	+	==Reference==
		+	<ref group="xtra">PMID:024508341</ref><references group="xtra"/><references/>
		+	[[Category: Gay, D C.]]
		+	[[Category: Gay, G R.]]
		+	[[Category: Keatinge-Clay, A T.]]
		+	[[Category: Condensing enzyme fold]]
		+	[[Category: Transferase]]

OCA at 06:43, 22 January 2014

OCA — Wed, 22 Jan 2014 06:43:52 GMT

←Older revision		Revision as of 06:43, 22 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4na1 is ON HOLD	+	The entry 4na1 is ON HOLD until Paper Publication

	Authors: Gay, D.C., Gay, G.R., Keatinge-Clay, A.T.		Authors: Gay, D.C., Gay, G.R., Keatinge-Clay, A.T.

	Description: Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase		Description: Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase

OCA: Protected "4na1" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2013 07:05:32 GMT

Protected "4na1" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:05, 6 November 2013

OCA: New page: '''Unreleased structure''' The entry 4na1 is ON HOLD Authors: Gay, D.C., Gay, G.R., Keatinge-Clay, A.T. Description: Crystal Structure of the second ketosynthase from the bacillaene po...

OCA — Wed, 06 Nov 2013 07:05:31 GMT

New page: '''Unreleased structure''' The entry 4na1 is ON HOLD Authors: Gay, D.C., Gay, G.R., Keatinge-Clay, A.T. Description: Crystal Structure of the second ketosynthase from the bacillaene po...

New page

'''Unreleased structure'''

The entry 4na1 is ON HOLD

Authors: Gay, D.C., Gay, G.R., Keatinge-Clay, A.T.

Description: Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase