4nat - Revision history

OCA at 12:32, 1 March 2024

OCA — Fri, 01 Mar 2024 12:32:26 GMT

←Older revision		Revision as of 12:32, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nat]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nat]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2W5:(1R,2R)-N-(3,4-DICHLOROBENZYL)-2-(4,6-DIMETHOXYPYRIMIDIN-2-YL)CYCLOHEXANECARBOXAMIDE'>2W5</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.72Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2W5:(1R,2R)-N-(3,4-DICHLOROBENZYL)-2-(4,6-DIMETHOXYPYRIMIDIN-2-YL)CYCLOHEXANECARBOXAMIDE'>2W5</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nat OCA], [https://pdbe.org/4nat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nat RCSB], [https://www.ebi.ac.uk/pdbsum/4nat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nat ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nat OCA], [https://pdbe.org/4nat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nat RCSB], [https://www.ebi.ac.uk/pdbsum/4nat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nat ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).		[https://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-positive species. Mode-of-inhibition studies with Streptococcus pneumoniae and Staphylococcus aureus PPAT demonstrated representatives of this series to be reversible inhibitors competitive with phosphopantetheine and uncompetitive with ATP, binding to the enzyme-ATP complex. The potency of this series was optimized using structure-based design, and inhibition of cell growth of Gram-positive species was achieved. Mode-of-action studies, using generation of resistant mutants with targeted sequencing as well as constructs that overexpress PPAT, demonstrated that growth suppression was due to inhibition of PPAT. An effect on bacterial burden was demonstrated in mouse lung and thigh infection models, but further optimization of dosing requirements and compound properties is needed before these compounds can be considered for progress into clinical development. These studies validated PPAT as a novel target for antibacterial therapy.
-
-	Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.,de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. , Epub 2013 Sep 16. PMID:24041904<ref>PMID:24041904</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4nat" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:18, 11 January 2023

OCA — Wed, 11 Jan 2023 08:18:30 GMT

←Older revision		Revision as of 08:18, 11 January 2023
Line 1:		Line 1:

	==Inhibitors of 4-Phosphopanthetheine Adenylyltransferase==		==Inhibitors of 4-Phosphopanthetheine Adenylyltransferase==
-	<StructureSection load='4nat' size='340' side='right' caption='[[4nat]], [[Resolution\|resolution]] 1.72Å' scene=''>	+	<StructureSection load='4nat' size='340' side='right'caption='[[4nat]], [[Resolution\|resolution]] 1.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nat]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Staaw Staaw~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NAT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nat]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2W5:(1R,2R)-N-(3,4-DICHLOROBENZYL)-2-(4,6-DIMETHOXYPYRIMIDIN-2-YL)CYCLOHEXANECARBOXAMIDE'>2W5</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2W5:(1R,2R)-N-(3,4-DICHLOROBENZYL)-2-(4,6-DIMETHOXYPYRIMIDIN-2-YL)CYCLOHEXANECARBOXAMIDE'>2W5</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nah\|4nah]], [[4nau\|4nau]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nat OCA], [https://pdbe.org/4nat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nat RCSB], [https://www.ebi.ac.uk/pdbsum/4nat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nat ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaD, MW1007 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=196620 STAAW])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantetheine-phosphate_adenylyltransferase Pantetheine-phosphate adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nat OCA], [~~http~~://pdbe.org/4nat PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nat RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nat PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nat ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW]] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).	+	[https://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pantetheine-phosphate adenylyltransferase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Staaw~~]]	+	[[Category: Staphylococcus aureus subsp. aureus MW2]]
-	[[Category: Lahiri~~, S D]]~~	+	[[Category: Lahiri SD]]
-	~~[[Category: Coabc]]~~	+
-	~~[[Category: Coad]]~~	+
-	~~[[Category: Cytosolic]]~~	+
-	~~[[Category: Panthetheine]]~~	+
-	~~[[Category: Phosphopanthetheine adenylyltransferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 16:43, 4 August 2016

OCA — Thu, 04 Aug 2016 16:43:55 GMT

←Older revision		Revision as of 16:43, 4 August 2016
Line 1:		Line 1:
		+
	==Inhibitors of 4-Phosphopanthetheine Adenylyltransferase==		==Inhibitors of 4-Phosphopanthetheine Adenylyltransferase==
	<StructureSection load='4nat' size='340' side='right' caption='[[4nat]], [[Resolution\|resolution]] 1.72Å' scene=''>		<StructureSection load='4nat' size='340' side='right' caption='[[4nat]], [[Resolution\|resolution]] 1.72Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaD, MW1007 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=196620 STAAW])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaD, MW1007 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=196620 STAAW])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantetheine-phosphate_adenylyltransferase Pantetheine-phosphate adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantetheine-phosphate_adenylyltransferase Pantetheine-phosphate adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nat OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nat RCSB], [http://www.ebi.ac.uk/pdbsum/4nat PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nat OCA], [http://pdbe.org/4nat PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nat RCSB], [http://www.ebi.ac.uk/pdbsum/4nat PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nat ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nat" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:05, 25 December 2014

OCA — Thu, 25 Dec 2014 11:05:12 GMT

←Older revision		Revision as of 11:05, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4nat\| PDB~~=4nat \| ~~SCENE~~= }}	+	==Inhibitors of 4-Phosphopanthetheine Adenylyltransferase==
-	===~~Inhibitors of~~ 4-~~Phosphopanthetheine Adenylyltransferase~~===	+	<StructureSection load='4nat' size='340' side='right' caption='[[4nat]], [[Resolution\|resolution]] 1.72Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24041904}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nat]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staaw Staaw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NAT FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2W5:(1R,2R)-N-(3,4-DICHLOROBENZYL)-2-(4,6-DIMETHOXYPYRIMIDIN-2-YL)CYCLOHEXANECARBOXAMIDE'>2W5</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nah\|4nah]], [[4nau\|4nau]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">coaD, MW1007 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=196620 STAAW])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantetheine-phosphate_adenylyltransferase Pantetheine-phosphate adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nat OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nat RCSB], [http://www.ebi.ac.uk/pdbsum/4nat PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW]] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).		[[http://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW]] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-positive species. Mode-of-inhibition studies with Streptococcus pneumoniae and Staphylococcus aureus PPAT demonstrated representatives of this series to be reversible inhibitors competitive with phosphopantetheine and uncompetitive with ATP, binding to the enzyme-ATP complex. The potency of this series was optimized using structure-based design, and inhibition of cell growth of Gram-positive species was achieved. Mode-of-action studies, using generation of resistant mutants with targeted sequencing as well as constructs that overexpress PPAT, demonstrated that growth suppression was due to inhibition of PPAT. An effect on bacterial burden was demonstrated in mouse lung and thigh infection models, but further optimization of dosing requirements and compound properties is needed before these compounds can be considered for progress into clinical development. These studies validated PPAT as a novel target for antibacterial therapy.

-	~~==About this Structure==~~	+	Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.,de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. , Epub 2013 Sep 16. PMID:24041904<ref>PMID:24041904</ref>
-	~~[[4nat]] is~~ a ~~3 chain structure~~. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann.ac~~.il/~~oca~~-~~bin/ocashort?id=4NAT OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024041904</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Pantetheine-phosphate adenylyltransferase]]		[[Category: Pantetheine-phosphate adenylyltransferase]]
-	[[Category: Lahiri, S D.]]	+	[[Category: Staaw]]
		+	[[Category: Lahiri, S D]]
	[[Category: Coabc]]		[[Category: Coabc]]
	[[Category: Coad]]		[[Category: Coad]]

OCA at 13:44, 12 March 2014

OCA — Wed, 12 Mar 2014 13:44:20 GMT

←Older revision		Revision as of 13:44, 12 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4nat\| PDB=4nat \| SCENE= }}
		+	===Inhibitors of 4-Phosphopanthetheine Adenylyltransferase===
		+	{{ABSTRACT_PUBMED_24041904}}

-	~~The entry 4nat is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW]] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).

-	~~Authors~~: ~~Lahiri, S~~.D.	+	==About this Structure==
		+	[[4nat]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA].

-	~~Description~~: ~~Inhibitors of 4~~-Phosphopanthetheine ~~Adenylyltransferase~~	+	==Reference==
		+	<ref group="xtra">PMID:024041904</ref><references group="xtra"/><references/>
		+	[[Category: Pantetheine-phosphate adenylyltransferase]]
		+	[[Category: Lahiri, S D.]]
		+	[[Category: Coabc]]
		+	[[Category: Coad]]
		+	[[Category: Cytosolic]]
		+	[[Category: Panthetheine]]
		+	[[Category: Phosphopanthetheine adenylyltransferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 13:02, 11 December 2013

OCA — Wed, 11 Dec 2013 13:02:48 GMT

←Older revision		Revision as of 13:02, 11 December 2013
Line 3:		Line 3:
	The entry 4nat is ON HOLD		The entry 4nat is ON HOLD

-	Authors: ~~Sushmita,~~ Lahiri	+	Authors: Lahiri, S.D.

-	Description: Inhibitors of 4 -Phosphopanthetheine Adenylyltransferase	+	Description: Inhibitors of 4-Phosphopanthetheine Adenylyltransferase

OCA: Protected "4nat" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2013 07:06:37 GMT

Protected "4nat" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:06, 6 November 2013

OCA: New page: '''Unreleased structure''' The entry 4nat is ON HOLD Authors: Sushmita, Lahiri Description: Inhibitors of 4 -Phosphopanthetheine Adenylyltransferase

OCA — Wed, 06 Nov 2013 07:06:36 GMT

New page: '''Unreleased structure''' The entry 4nat is ON HOLD Authors: Sushmita, Lahiri Description: Inhibitors of 4 -Phosphopanthetheine Adenylyltransferase

New page

'''Unreleased structure'''

The entry 4nat is ON HOLD

Authors: Sushmita, Lahiri

Description: Inhibitors of 4 -Phosphopanthetheine Adenylyltransferase