4naz - Revision history

OCA at 12:32, 1 March 2024

OCA — Fri, 01 Mar 2024 12:32:29 GMT

←Older revision		Revision as of 12:32, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4naz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4naz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.15Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4naz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4naz OCA], [https://pdbe.org/4naz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4naz RCSB], [https://www.ebi.ac.uk/pdbsum/4naz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4naz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4naz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4naz OCA], [https://pdbe.org/4naz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4naz RCSB], [https://www.ebi.ac.uk/pdbsum/4naz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4naz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/FOSB_STAAN FOSB_STAAN] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).		[https://www.uniprot.org/uniprot/FOSB_STAAN FOSB_STAAN] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The Gram-positive pathogen Staphylococcus aureus is a leading cause of global morbidity and mortality. Like many multi-drug-resistant organisms, S. aureus contains antibiotic-modifying enzymes that facilitate resistance to a multitude of antimicrobial compounds. FosB is a Mn(2+)-dependent fosfomycin-inactivating enzyme found in S. aureus that catalyzes nucleophilic addition of either l-cysteine (l-Cys) or bacillithiol (BSH) to the antibiotic, resulting in a modified compound with no bactericidal properties. The three-dimensional X-ray crystal structure of FosB from S. aureus (FosB(Sa)) has been determined to a resolution of 1.15 A. Cocrystallization of FosB(Sa) with either l-Cys or BSH results in a disulfide bond between the exogenous thiol and the active site Cys9 of the enzyme. An analysis of the structures suggests that a highly conserved loop region of the FosB enzymes must change conformation to bind fosfomycin. While two crystals of FosB(Sa) contain Zn(2+) in the active site, kinetic analyses of FosB(Sa) indicated that the enzyme is inhibited by Zn(2+) for l-Cys transferase activity and only marginally active for BSH transferase activity. Fosfomycin-treated disk diffusion assays involving S. aureus Newman and the USA300 JE2 methicillin-resistant S. aureus demonstrate a marked increase in the sensitivity of the organism to the antibiotic in either the BSH or FosB null strains, indicating that both are required for survival of the organism in the presence of the antibiotic. This work identifies FosB as a primary fosfomycin-modifying pathway of S. aureus and establishes the enzyme as a potential therapeutic target for increased efficacy of fosfomycin against the pathogen.
-
-	Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus.,Thompson MK, Keithly ME, Goodman MC, Hammer ND, Cook PD, Jagessar KL, Harp J, Skaar EP, Armstrong RN Biochemistry. 2014 Feb 4;53(4):755-65. doi: 10.1021/bi4015852. Epub 2014 Jan 21. PMID:24447055<ref>PMID:24447055</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4naz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Metallothiol transferase FosB\|Metallothiol transferase FosB]]		*[[Metallothiol transferase FosB\|Metallothiol transferase FosB]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:18, 11 January 2023

OCA — Wed, 11 Jan 2023 08:18:38 GMT

←Older revision		Revision as of 08:18, 11 January 2023
Line 1:		Line 1:

	==Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution==		==Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution==
-	<StructureSection load='4naz' size='340' side='right' caption='[[4naz]], [[Resolution\|resolution]] 1.15Å' scene=''>	+	<StructureSection load='4naz' size='340' side='right'caption='[[4naz]], [[Resolution\|resolution]] 1.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4naz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Staan Staan~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4naz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nay\|4nay]], [[4nb0\|4nb0]], [[4nb1\|4nb1]], [[4nb2\|4nb2]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4naz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4naz OCA], [https://pdbe.org/4naz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4naz RCSB], [https://www.ebi.ac.uk/pdbsum/4naz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4naz ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fosB, SA2124 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158879 STAAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4naz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4naz OCA], [~~http~~://pdbe.org/4naz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4naz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4naz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4naz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FOSB_STAAN FOSB_STAAN]] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).	+	[https://www.uniprot.org/uniprot/FOSB_STAAN FOSB_STAAN] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Staan~~]]	+	[[Category: Large Structures]]
-	[[Category: Armstrong~~, R N~~]]	+	[[Category: Staphylococcus aureus subsp. aureus N315]]
-	[[Category: Cook~~, P D~~]]	+	[[Category: Armstrong RN]]
-	[[Category: Goodman~~, M C~~]]	+	[[Category: Cook PD]]
-	[[Category: Harp, J]]	+	[[Category: Goodman MC]]
-	[[Category: Jagessar, K]]	+	[[Category: Harp J]]
-	[[Category: Keithly~~, M E~~]]	+	[[Category: Jagessar K]]
-	[[Category: Thompson~~, M K]]~~	+	[[Category: Keithly ME]]
-	~~[[Category: Bacillithiol-s-transferase]]~~	+	[[Category: Thompson MK]]
-	~~[[Category: Transferase~~]]	+

OCA at 13:39, 5 August 2016

OCA — Fri, 05 Aug 2016 13:39:50 GMT

←Older revision		Revision as of 13:39, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution==		==Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution==
	<StructureSection load='4naz' size='340' side='right' caption='[[4naz]], [[Resolution\|resolution]] 1.15Å' scene=''>		<StructureSection load='4naz' size='340' side='right' caption='[[4naz]], [[Resolution\|resolution]] 1.15Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nay\|4nay]], [[4nb0\|4nb0]], [[4nb1\|4nb1]], [[4nb2\|4nb2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nay\|4nay]], [[4nb0\|4nb0]], [[4nb1\|4nb1]], [[4nb2\|4nb2]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fosB, SA2124 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158879 STAAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fosB, SA2124 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158879 STAAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4naz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4naz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4naz RCSB], [http://www.ebi.ac.uk/pdbsum/4naz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4naz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4naz OCA], [http://pdbe.org/4naz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4naz RCSB], [http://www.ebi.ac.uk/pdbsum/4naz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4naz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4naz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Metallothiol transferase FosB\|Metallothiol transferase FosB]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:16, 25 December 2014

OCA — Thu, 25 Dec 2014 19:16:03 GMT

←Older revision		Revision as of 19:16, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4naz\| PDB=4naz \| SCENE= }}~~	+	==Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution==
-	===Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution===	+	<StructureSection load='4naz' size='340' side='right' caption='[[4naz]], [[Resolution\|resolution]] 1.15Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24447055}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4naz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staan Staan]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NAZ FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nay\|4nay]], [[4nb0\|4nb0]], [[4nb1\|4nb1]], [[4nb2\|4nb2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fosB, SA2124 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158879 STAAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4naz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4naz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4naz RCSB], [http://www.ebi.ac.uk/pdbsum/4naz PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/FOSB_STAAN FOSB_STAAN]] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).		[[http://www.uniprot.org/uniprot/FOSB_STAAN FOSB_STAAN]] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Gram-positive pathogen Staphylococcus aureus is a leading cause of global morbidity and mortality. Like many multi-drug-resistant organisms, S. aureus contains antibiotic-modifying enzymes that facilitate resistance to a multitude of antimicrobial compounds. FosB is a Mn(2+)-dependent fosfomycin-inactivating enzyme found in S. aureus that catalyzes nucleophilic addition of either l-cysteine (l-Cys) or bacillithiol (BSH) to the antibiotic, resulting in a modified compound with no bactericidal properties. The three-dimensional X-ray crystal structure of FosB from S. aureus (FosB(Sa)) has been determined to a resolution of 1.15 A. Cocrystallization of FosB(Sa) with either l-Cys or BSH results in a disulfide bond between the exogenous thiol and the active site Cys9 of the enzyme. An analysis of the structures suggests that a highly conserved loop region of the FosB enzymes must change conformation to bind fosfomycin. While two crystals of FosB(Sa) contain Zn(2+) in the active site, kinetic analyses of FosB(Sa) indicated that the enzyme is inhibited by Zn(2+) for l-Cys transferase activity and only marginally active for BSH transferase activity. Fosfomycin-treated disk diffusion assays involving S. aureus Newman and the USA300 JE2 methicillin-resistant S. aureus demonstrate a marked increase in the sensitivity of the organism to the antibiotic in either the BSH or FosB null strains, indicating that both are required for survival of the organism in the presence of the antibiotic. This work identifies FosB as a primary fosfomycin-modifying pathway of S. aureus and establishes the enzyme as a potential therapeutic target for increased efficacy of fosfomycin against the pathogen.

-	~~==About this~~ Structure==	+	Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus.,Thompson MK, Keithly ME, Goodman MC, Hammer ND, Cook PD, Jagessar KL, Harp J, Skaar EP, Armstrong RN Biochemistry. 2014 Feb 4;53(4):755-65. doi: 10.1021/bi4015852. Epub 2014 Jan 21. PMID:24447055<ref>PMID:24447055</ref>
-	~~[[4naz]] is a 1 chain structure with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Staan Staan]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4NAZ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024447055</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Staan]]		[[Category: Staan]]
-	[[Category: Armstrong, R N.]]	+	[[Category: Armstrong, R N]]
-	[[Category: Cook, P D.]]	+	[[Category: Cook, P D]]
-	[[Category: Goodman, M C.]]	+	[[Category: Goodman, M C]]
-	[[Category: Harp, J.]]	+	[[Category: Harp, J]]
-	[[Category: Jagessar, K.]]	+	[[Category: Jagessar, K]]
-	[[Category: Keithly, M E.]]	+	[[Category: Keithly, M E]]
-	[[Category: Thompson, M K.]]	+	[[Category: Thompson, M K]]
	[[Category: Bacillithiol-s-transferase]]		[[Category: Bacillithiol-s-transferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:20, 16 April 2014

OCA — Wed, 16 Apr 2014 07:20:43 GMT

←Older revision		Revision as of 07:20, 16 April 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4naz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAZ OCA].	+	[[4naz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staan Staan]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAZ OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024447055</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024447055</ref><references group="xtra"/><references/>
		+	[[Category: Staan]]
		+	[[Category: Armstrong, R N.]]
	[[Category: Cook, P D.]]		[[Category: Cook, P D.]]
	[[Category: Goodman, M C.]]		[[Category: Goodman, M C.]]
Line 16:		Line 18:
	[[Category: Jagessar, K.]]		[[Category: Jagessar, K.]]
	[[Category: Keithly, M E.]]		[[Category: Keithly, M E.]]
		+	[[Category: Thompson, M K.]]
	[[Category: Bacillithiol-s-transferase]]		[[Category: Bacillithiol-s-transferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 17:55, 3 March 2014

OCA — Mon, 03 Mar 2014 17:55:15 GMT

←Older revision		Revision as of 17:55, 3 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4naz\| PDB=4naz \| SCENE= }}
		+	===Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution===
		+	{{ABSTRACT_PUBMED_24447055}}

-	~~The entry 4naz~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/FOSB_STAAN FOSB_STAAN]] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).

-	~~Authors~~: ~~Goodman, M.C., Jagessar, K., Harp, J., Keithly, M~~.E.~~, Cook, P~~.D.	+	==About this Structure==
		+	[[4naz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAZ OCA].

-	~~Description~~: ~~Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1~~.~~15 Angstrom Resolution~~	+	==Reference==
		+	<ref group="xtra">PMID:024447055</ref><references group="xtra"/><references/>
		+	[[Category: Cook, P D.]]
		+	[[Category: Goodman, M C.]]
		+	[[Category: Harp, J.]]
		+	[[Category: Jagessar, K.]]
		+	[[Category: Keithly, M E.]]
		+	[[Category: Bacillithiol-s-transferase]]
		+	[[Category: Transferase]]

OCA at 09:11, 8 January 2014

OCA — Wed, 08 Jan 2014 09:11:21 GMT

←Older revision		Revision as of 09:11, 8 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4naz is ON HOLD	+	The entry 4naz is ON HOLD until Paper Publication

	Authors: Goodman, M.C., Jagessar, K., Harp, J., Keithly, M.E., Cook, P.D.		Authors: Goodman, M.C., Jagessar, K., Harp, J., Keithly, M.E., Cook, P.D.

	Description: Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution		Description: Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution

OCA at 07:42, 13 November 2013

OCA — Wed, 13 Nov 2013 07:42:18 GMT

←Older revision		Revision as of 07:42, 13 November 2013
Line 3:		Line 3:
	The entry 4naz is ON HOLD		The entry 4naz is ON HOLD

-	Authors: Goodman, ~~Michael~~ C., Jagessar, ~~Kevin~~, Harp, ~~Joel~~, Keithly, ~~Mary~~ E., Cook, ~~Paul~~ D.	+	Authors: Goodman, M.C., Jagessar, K., Harp, J., Keithly, M.E., Cook, P.D.

	Description: Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution		Description: Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution

OCA: Protected "4naz" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2013 07:06:51 GMT

Protected "4naz" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:06, 6 November 2013

OCA: New page: '''Unreleased structure''' The entry 4naz is ON HOLD Authors: Goodman, Michael C., Jagessar, Kevin, Harp, Joel, Keithly, Mary E., Cook, Paul D. Description: Crystal Structure of FosB f...

OCA — Wed, 06 Nov 2013 07:06:50 GMT

New page: '''Unreleased structure''' The entry 4naz is ON HOLD Authors: Goodman, Michael C., Jagessar, Kevin, Harp, Joel, Keithly, Mary E., Cook, Paul D. Description: Crystal Structure of FosB f...

New page

'''Unreleased structure'''

The entry 4naz is ON HOLD

Authors: Goodman, Michael C., Jagessar, Kevin, Harp, Joel, Keithly, Mary E., Cook, Paul D.

Description: Crystal Structure of FosB from Staphylococcus aureus with Zn and Sulfate at 1.15 Angstrom Resolution