4nco - Revision history

OCA at 16:53, 20 September 2023

OCA — Wed, 20 Sep 2023 16:53:22 GMT

←Older revision		Revision as of 16:53, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nco]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. The February 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Broadly Neutralizing Antibodies'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_2 10.2210/rcsb_pdb/mom_2014_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NCO FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nco]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. The February 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Broadly Neutralizing Antibodies'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_2 10.2210/rcsb_pdb/mom_2014_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NCO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900111:2alpha-alpha-mannobiose'>PRD_900111</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900111:2alpha-alpha-mannobiose'>PRD_900111</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nco OCA], [https://pdbe.org/4nco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nco RCSB], [https://www.ebi.ac.uk/pdbsum/4nco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nco ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nco OCA], [https://pdbe.org/4nco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nco RCSB], [https://www.ebi.ac.uk/pdbsum/4nco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nco ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:22, 11 January 2023

OCA — Wed, 11 Jan 2023 08:22:15 GMT

←Older revision		Revision as of 08:22, 11 January 2023
Line 1:		Line 1:

	==Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122==		==Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122==
-	<StructureSection load='4nco' size='340' side='right' caption='[[4nco]], [[Resolution\|resolution]] 4.70Å' scene=''>	+	<StructureSection load='4nco' size='340' side='right'caption='[[4nco]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nco]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~] and [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~]. The February 2014 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Broadly Neutralizing Antibodies'' by David Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2014_2 10.2210/rcsb_pdb/mom_2014_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nco]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. The February 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Broadly Neutralizing Antibodies'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_2 10.2210/rcsb_pdb/mom_2014_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NCO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900111:2alpha-alpha-mannobiose'>PRD_900111</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~UNK~~:~~UNKNOWN~~'>~~UNK~~</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nco OCA], [https://pdbe.org/4nco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nco RCSB], [https://www.ebi.ac.uk/pdbsum/4nco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nco ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jy4\|4jy4]], [[4jy5\|4jy5]], [[4jy6\|4jy6]], [[3j5m\|3j5m]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nco OCA], [~~http~~://pdbe.org/4nco PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nco RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nco PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nco ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]	+	[https://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4nco" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4nco" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gp120 3D structures\|Gp120 3D structures]]
		+	*[[Gp41 3D Structures\|Gp41 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Broadly Neutralizing Antibodies]]		[[Category: Broadly Neutralizing Antibodies]]
-	[[Category: Human]]	+	[[Category: Homo sapiens]]
		+	[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
-	[[Category: Julien, J P]]	+	[[Category: Julien J-P]]
-	[[Category: Lyumkis, D]]	+	[[Category: Lyumkis D]]
-	[[Category: Stanfield~~, R L~~]]	+	[[Category: Stanfield RL]]
-	[[Category: Ward~~, A B~~]]	+	[[Category: Ward AB]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Broadly neutralizing antibody]]~~	+
-	~~[[Category: Ccr5/cxcr4]]~~	+
-	~~[[Category: Cd4]]~~	+
-	~~[[Category: Gp120]]~~	+
-	~~[[Category: Gp41]]~~	+
-	~~[[Category: Hiv-1 envelope]]~~	+
-	~~[[Category: Membrane fusion]]~~	+
-	~~[[Category: Type-1 membrane fusion glycoprotein trimer]]~~	+
-	~~[[Category: Viral entry]]~~	+
-	~~[[Category: Viral protein-immune system complex]]~~	+
-	~~[[Category: Viral surface~~]]	+

OCA at 23:10, 4 August 2016

OCA — Thu, 04 Aug 2016 23:10:56 GMT

←Older revision		Revision as of 23:10, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122==		==Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122==
	<StructureSection load='4nco' size='340' side='right' caption='[[4nco]], [[Resolution\|resolution]] 4.70Å' scene=''>		<StructureSection load='4nco' size='340' side='right' caption='[[4nco]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nco]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NCO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nco]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. The February 2014 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Broadly Neutralizing Antibodies'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2014_2 10.2210/rcsb_pdb/mom_2014_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NCO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jy4\|4jy4]], [[4jy5\|4jy5]], [[4jy6\|4jy6]], [[3j5m\|3j5m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jy4\|4jy4]], [[4jy5\|4jy5]], [[4jy6\|4jy6]], [[3j5m\|3j5m]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nco RCSB], [http://www.ebi.ac.uk/pdbsum/4nco PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nco OCA], [http://pdbe.org/4nco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nco RCSB], [http://www.ebi.ac.uk/pdbsum/4nco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nco ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nco" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Broadly Neutralizing Antibodies]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Julien, J P]]		[[Category: Julien, J P]]
	[[Category: Lyumkis, D]]		[[Category: Lyumkis, D]]

OCA at 20:33, 24 December 2014

OCA — Wed, 24 Dec 2014 20:33:16 GMT

←Older revision		Revision as of 20:33, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4nco\| PDB=4nco \| SCENE= }}~~	+	==Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122==
-	===Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122===	+	<StructureSection load='4nco' size='340' side='right' caption='[[4nco]], [[Resolution\|resolution]] 4.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24179159}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nco]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NCO FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jy4\|4jy4]], [[4jy5\|4jy5]], [[4jy6\|4jy6]], [[3j5m\|3j5m]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nco RCSB], [http://www.ebi.ac.uk/pdbsum/4nco PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]		[[http://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	HIV-1 entry into CD4+ target cells is mediated by cleaved envelope glycoprotein (Env) trimers that have been challenging to characterize structurally. Here, we describe the crystal structure at 4.7 A of an antigenically near-native, cleaved, stabilized, soluble Env trimer (termed BG505 SOSIP.664 gp140) in complex with a potent broadly neutralizing antibody, PGT122. The structure shows a pre-fusion state of gp41, the interaction between the component gp120 and gp41 subunits, and how a close association between the gp120 V1/V2/V3 loops stabilizes the trimer apex around the three-fold axis. The complete epitope of PGT122 on the trimer involves gp120 V1, V3 and several surrounding glycans. This trimer structure advances our understanding of how Env functions and is presented to the immune system, and provides a blueprint for structure-based vaccine design.

-	~~==About this~~ Structure==	+	Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer.,Julien JP, Cupo A, Sok D, Stanfield RL, Lyumkis D, Deller MC, Klasse PJ, Burton DR, Sanders RW, Moore JP, Ward AB, Wilson IA Science. 2013 Oct 31. PMID:24179159<ref>PMID:24179159</ref>
-	~~[[4nco]] is~~ a ~~12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/9hiv1 9hiv1] and [http://en~~.~~wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024179159</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	~~[[Category: 9hiv1]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Julien, J P.]]	+	[[Category: Julien, J P]]
-	[[Category: Lyumkis, D.]]	+	[[Category: Lyumkis, D]]
-	[[Category: Stanfield, R L.]]	+	[[Category: Stanfield, R L]]
-	[[Category: Ward, A B.]]	+	[[Category: Ward, A B]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
	[[Category: Broadly neutralizing antibody]]		[[Category: Broadly neutralizing antibody]]
	[[Category: Ccr5/cxcr4]]		[[Category: Ccr5/cxcr4]]

OCA at 07:12, 15 January 2014

OCA — Wed, 15 Jan 2014 07:12:34 GMT

←Older revision		Revision as of 07:12, 15 January 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4nco]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA].	+	[[4nco]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:024179159</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:024179159</ref><references group="xtra"/><references/>
		+	[[Category: 9hiv1]]
		+	[[Category: Human]]
	[[Category: Julien, J P.]]		[[Category: Julien, J P.]]
	[[Category: Lyumkis, D.]]		[[Category: Lyumkis, D.]]

OCA at 08:19, 13 November 2013

OCA — Wed, 13 Nov 2013 08:19:41 GMT

←Older revision		Revision as of 08:19, 13 November 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4nco\| PDB=4nco \| SCENE= }}
		+	===Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122===
		+	{{ABSTRACT_PUBMED_24179159}}

-	The ~~entry 4nco is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]

-	~~Authors~~: ~~Julien, J~~.-P.~~, Stanfield, R~~.~~L., Lyumkis, D., Ward, A.B., Wilson, I.A~~.	+	==About this Structure==
		+	[[4nco]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCO OCA].

-	~~Description~~: ~~Crystal Structure of the BG505 SOSIP gp140 HIV~~-1 ~~Env~~ trimer ~~in Complex with the Broadly Neutralizing Fab PGT122~~	+	==Reference==
		+	<ref group="xtra">PMID:024179159</ref><references group="xtra"/><references/>
		+	[[Category: Julien, J P.]]
		+	[[Category: Lyumkis, D.]]
		+	[[Category: Stanfield, R L.]]
		+	[[Category: Ward, A B.]]
		+	[[Category: Wilson, I A.]]
		+	[[Category: Broadly neutralizing antibody]]
		+	[[Category: Ccr5/cxcr4]]
		+	[[Category: Cd4]]
		+	[[Category: Gp120]]
		+	[[Category: Gp41]]
		+	[[Category: Hiv-1 envelope]]
		+	[[Category: Membrane fusion]]
		+	[[Category: Type-1 membrane fusion glycoprotein trimer]]
		+	[[Category: Viral entry]]
		+	[[Category: Viral protein-immune system complex]]
		+	[[Category: Viral surface]]

OCA: Protected "4nco" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2013 07:09:00 GMT

Protected "4nco" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:09, 6 November 2013

OCA: New page: '''Unreleased structure''' The entry 4nco is ON HOLD Authors: Julien, J.-P., Stanfield, R.L., Lyumkis, D., Ward, A.B., Wilson, I.A. Description: Crystal Structure of the BG505 SOSIP gp...

OCA — Wed, 06 Nov 2013 07:08:59 GMT

New page: '''Unreleased structure''' The entry 4nco is ON HOLD Authors: Julien, J.-P., Stanfield, R.L., Lyumkis, D., Ward, A.B., Wilson, I.A. Description: Crystal Structure of the BG505 SOSIP gp...

New page

'''Unreleased structure'''

The entry 4nco is ON HOLD

Authors: Julien, J.-P., Stanfield, R.L., Lyumkis, D., Ward, A.B., Wilson, I.A.

Description: Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122