4nen - Revision history

OCA at 16:55, 20 September 2023

OCA — Wed, 20 Sep 2023 16:55:20 GMT

←Older revision		Revision as of 16:55, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nen]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NEN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nen]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NEN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9012Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nen OCA], [https://pdbe.org/4nen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nen RCSB], [https://www.ebi.ac.uk/pdbsum/4nen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nen ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nen OCA], [https://pdbe.org/4nen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nen RCSB], [https://www.ebi.ac.uk/pdbsum/4nen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nen ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:25, 11 January 2023

OCA — Wed, 11 Jan 2023 08:25:24 GMT

←Older revision		Revision as of 08:25, 11 January 2023
Line 1:		Line 1:

	==An internal ligand-bound, metastable state of a leukocyte integrin, aXb2==		==An internal ligand-bound, metastable state of a leukocyte integrin, aXb2==
-	<StructureSection load='4nen' size='340' side='right' caption='[[4nen]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4nen' size='340' side='right'caption='[[4nen]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nen]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nen]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NEN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:~~MAGNESIUM+ION~~'>MG</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4neh\|4neh]], [[3k6s\|3k6s]], [[3k71\|3k71]], [[3k72\|3k72]], [[2iue\|2iue]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nen OCA], [https://pdbe.org/4nen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nen RCSB], [https://www.ebi.ac.uk/pdbsum/4nen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nen ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITGAX, CD11C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ITGB2, CD18, MFI7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nen OCA], [~~http~~://pdbe.org/4nen PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nen RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nen PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nen ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>	+	[https://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 20:

	==See Also==		==See Also==
-	*[[Integrin\|Integrin]]	+	*[[Integrin 3D structures\|Integrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Sen, M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Springer, T A~~]]	+	[[Category: Sen M]]
-	[[Category: ~~Yuki, K~~]]	+	[[Category: Springer TA]]
-	[[Category: ~~Cell adhesion]]~~	+	[[Category: Yuki K]]
-	~~[[Category: Complement receptor]]~~	+
-	~~[[Category: Denaturated protein]]~~	+
-	~~[[Category: Fibrinogen]]~~	+
-	~~[[Category: Heparin]]~~	+
-	~~[[Category: Ic3b]]~~	+
-	~~[[Category: Icam]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: N-linked glycosylation~~]]	+

OCA at 21:44, 4 August 2016

OCA — Thu, 04 Aug 2016 21:44:15 GMT

←Older revision		Revision as of 21:44, 4 August 2016
Line 1:		Line 1:
		+
	==An internal ligand-bound, metastable state of a leukocyte integrin, aXb2==		==An internal ligand-bound, metastable state of a leukocyte integrin, aXb2==
	<StructureSection load='4nen' size='340' side='right' caption='[[4nen]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4nen' size='340' side='right' caption='[[4nen]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4neh\|4neh]], [[3k6s\|3k6s]], [[3k71\|3k71]], [[3k72\|3k72]], [[2iue\|2iue]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4neh\|4neh]], [[3k6s\|3k6s]], [[3k71\|3k71]], [[3k72\|3k72]], [[2iue\|2iue]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITGAX, CD11C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ITGB2, CD18, MFI7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITGAX, CD11C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ITGB2, CD18, MFI7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nen RCSB], [http://www.ebi.ac.uk/pdbsum/4nen PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nen OCA], [http://pdbe.org/4nen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nen RCSB], [http://www.ebi.ac.uk/pdbsum/4nen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nen ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nen" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:49, 21 December 2014

OCA — Sun, 21 Dec 2014 16:49:39 GMT

←Older revision		Revision as of 16:49, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4nen\| PDB=4nen \| SCENE= }}~~	+	==An internal ligand-bound, metastable state of a leukocyte integrin, aXb2==
-	===An internal ligand-bound, metastable state of a leukocyte integrin, aXb2===	+	<StructureSection load='4nen' size='340' side='right' caption='[[4nen]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24385486}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nen]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NEN FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4neh\|4neh]], [[3k6s\|3k6s]], [[3k71\|3k71]], [[3k72\|3k72]], [[2iue\|2iue]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITGAX, CD11C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ITGB2, CD18, MFI7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nen RCSB], [http://www.ebi.ac.uk/pdbsum/4nen PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>		[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	How is massive conformational change in integrins achieved on a rapid timescale? We report crystal structures of a metastable, putative transition state of integrin alphaXbeta2. The alphaXbeta2 ectodomain is bent; however, a lattice contact stabilizes its ligand-binding alphaI domain in a high affinity, open conformation. Much of the alphaI alpha7 helix unwinds, loses contact with the alphaI domain, and reshapes to form an internal ligand that binds to the interface between the beta propeller and betaI domains. Lift-off of the alphaI domain above this platform enables a range of extensional and rotational motions without precedent in allosteric machines. Movements of secondary structure elements in the beta2 betaI domain occur in an order different than in beta3 integrins, showing that integrin beta subunits can be specialized to assume different intermediate states between closed and open. Mutations demonstrate that the structure trapped here is metastable and can enable rapid equilibration between bent and extended-open integrin conformations and up-regulation of leukocyte adhesiveness.

-	~~==Function==~~	+	An internal ligand-bound, metastable state of a leukocyte integrin, alphaXbeta2.,Sen M, Yuki K, Springer TA J Cell Biol. 2013 Nov 25;203(4):629-42. doi: 10.1083/jcb.201308083. PMID:24385486<ref>PMID:24385486</ref>
-	~~[[http://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha~~-~~X/beta-2 is~~ a ~~receptor for fibrinogen~~. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ~~ICAM2~~, ~~ICAM3 and ICAM4~~. ~~Integrins alpha~~-~~M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen~~. ~~Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain~~. ~~Integrin alpha-M~~/~~beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain~~. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:~~18587400~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4nen]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4NEN OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024385486</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Integrin\|Integrin]]
-	[[Category: Sen, M.]]	+	== References ==
-	[[Category: Springer, T A.]]	+	<references/>
-	[[Category: Yuki, K.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Sen, M]]
		+	[[Category: Springer, T A]]
		+	[[Category: Yuki, K]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Complement receptor]]		[[Category: Complement receptor]]

OCA at 08:13, 15 January 2014

OCA — Wed, 15 Jan 2014 08:13:39 GMT

←Older revision		Revision as of 08:13, 15 January 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4nen\| PDB=4nen \| SCENE= }}
		+	===An internal ligand-bound, metastable state of a leukocyte integrin, aXb2===
		+	{{ABSTRACT_PUBMED_24385486}}

-	~~The~~ entry ~~4nen is ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>

-	~~Authors~~: ~~Sen, M~~.~~, Yuki, K~~., ~~Springer~~, T.A.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>

-	~~Description~~: ~~An internal ligand~~-~~bound~~, ~~metastable state of a leukocyte integrin~~, ~~aXb2~~	+	==About this Structure==
		+	[[4nen]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024385486</ref><references group="xtra"/><references/>
		+	[[Category: Sen, M.]]
		+	[[Category: Springer, T A.]]
		+	[[Category: Yuki, K.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Complement receptor]]
		+	[[Category: Denaturated protein]]
		+	[[Category: Fibrinogen]]
		+	[[Category: Heparin]]
		+	[[Category: Ic3b]]
		+	[[Category: Icam]]
		+	[[Category: Membrane]]
		+	[[Category: N-linked glycosylation]]

OCA at 13:03, 11 December 2013

OCA — Wed, 11 Dec 2013 13:03:28 GMT

←Older revision		Revision as of 13:03, 11 December 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nen is ON HOLD	+	The entry 4nen is ON HOLD until Paper Publication

	Authors: Sen, M., Yuki, K., Springer, T.A.		Authors: Sen, M., Yuki, K., Springer, T.A.

	Description: An internal ligand-bound, metastable state of a leukocyte integrin, aXb2		Description: An internal ligand-bound, metastable state of a leukocyte integrin, aXb2

OCA: Protected "4nen" [edit=sysop:move=sysop]

OCA — Wed, 13 Nov 2013 07:45:41 GMT

Protected "4nen" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:45, 13 November 2013

OCA: New page: '''Unreleased structure''' The entry 4nen is ON HOLD Authors: Sen, M., Yuki, K., Springer, T.A. Description: An internal ligand-bound, metastable state of a leukocyte integrin, aXb2

OCA — Wed, 13 Nov 2013 07:45:40 GMT

New page: '''Unreleased structure''' The entry 4nen is ON HOLD Authors: Sen, M., Yuki, K., Springer, T.A. Description: An internal ligand-bound, metastable state of a leukocyte integrin, aXb2

New page

'''Unreleased structure'''

The entry 4nen is ON HOLD

Authors: Sen, M., Yuki, K., Springer, T.A.

Description: An internal ligand-bound, metastable state of a leukocyte integrin, aXb2