4nfz - Revision history

OCA at 14:47, 8 November 2023

OCA — Wed, 08 Nov 2023 14:47:52 GMT

←Older revision		Revision as of 14:47, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nfz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/little_yellow-shouldered_bat/Guatemala/060/2010(H17N10)) Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NFZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nfz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/little_yellow-shouldered_bat/Guatemala/060/2010(H17N10)) Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NFZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfz OCA], [https://pdbe.org/4nfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nfz RCSB], [https://www.ebi.ac.uk/pdbsum/4nfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nfz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfz OCA], [https://pdbe.org/4nfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nfz RCSB], [https://www.ebi.ac.uk/pdbsum/4nfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nfz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:27, 11 January 2023

OCA — Wed, 11 Jan 2023 08:27:04 GMT

←Older revision		Revision as of 08:27, 11 January 2023
Line 1:		Line 1:

	==Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10==		==Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10==
-	<StructureSection load='4nfz' size='340' side='right' caption='[[4nfz]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4nfz' size='340' side='right'caption='[[4nfz]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nfz]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/little_yellow-shouldered_bat/~~guatemala~~/060/2010(~~h17n10~~)) Influenza a virus (a/little yellow-shouldered bat/~~guatemala~~/060/2010(~~h17n10~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NFZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nfz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/little_yellow-shouldered_bat/Guatemala/060/2010(H17N10)) Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NFZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1129347 Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfz OCA], [https://pdbe.org/4nfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nfz RCSB], [https://www.ebi.ac.uk/pdbsum/4nfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nfz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfz OCA], [~~http~~://pdbe.org/4nfz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nfz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nfz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nfz ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/H6QM92_9INFA H6QM92_9INFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4nfz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4nfz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Deng, T]]	+	[[Category: Large Structures]]
-	[[Category: Gao~~, G F~~]]	+	[[Category: Deng T]]
-	[[Category: Haywood, J]]	+	[[Category: Gao GF]]
-	[[Category: Lu, G]]	+	[[Category: Haywood J]]
-	[[Category: Qi, J]]	+	[[Category: Lu G]]
-	[[Category: Tefsen, B]]	+	[[Category: Qi J]]
-	[[Category: Zhao, L]]	+	[[Category: Tefsen B]]
-	[[Category: Zhu, Y]]	+	[[Category: Zhao L]]
-	~~[[Category: Manganese binding]]~~	+	[[Category: Zhu Y]]
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rna endonuclease~~]]	+

OCA at 20:29, 11 August 2016

OCA — Thu, 11 Aug 2016 20:29:33 GMT

←Older revision		Revision as of 20:29, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10==		==Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10==
	<StructureSection load='4nfz' size='340' side='right' caption='[[4nfz]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4nfz' size='340' side='right' caption='[[4nfz]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1129347 Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1129347 Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nfz RCSB], [http://www.ebi.ac.uk/pdbsum/4nfz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfz OCA], [http://pdbe.org/4nfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nfz RCSB], [http://www.ebi.ac.uk/pdbsum/4nfz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nfz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nfz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:22, 5 January 2015

OCA — Mon, 05 Jan 2015 12:22:42 GMT

←Older revision		Revision as of 12:22, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4nfz\| PDB=4nfz \| SCENE= }}~~	+	==Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10==
-	===Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10===	+	<StructureSection load='4nfz' size='340' side='right' caption='[[4nfz]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24284327}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4nfz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/little_yellow-shouldered_bat/guatemala/060/2010(h17n10)) Influenza a virus (a/little yellow-shouldered bat/guatemala/060/2010(h17n10))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NFZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1129347 Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nfz RCSB], [http://www.ebi.ac.uk/pdbsum/4nfz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Influenza imposes a great burden on society, not only in its seasonal appearance that affects both humans and domesticated animals, but also through the constant threat of potential pandemics. Migratory birds are considered to be the reservoir hosts for influenza viruses, but other animals must also be considered. The recently identified influenza-like virus genome, H17N10, in bats, was shown to be markedly different from other known influenza viruses, as both its surface glycoproteins hemagglutinin (HA) and neuraminidase (NA) do not have canonical functions. However no studies on other individual proteins from this particular virus have been reported until now. Here, we describe the structure of the N-terminal domain of PA from H17N10 influenza-like virus at 2.7 A resolution and show that it has a similar fold as homologous PA domains present in more familiar influenza A strains. Moreover, we demonstrate that it possesses endonuclease activity and that the histidine residue in the active site is essential for this activity. Although this particular influenza subtype is probably not infectious for humans (even its virus state has not been confirmed in bat as only the genome has been sequenced), reassortment of canonical influenza viruses with certain segments from H17N10 cannot be ruled out at this stage. Therefore further studies are urgently called for the sake of influenza prevention and control.

-	~~==About this Structure==~~	+	The N-terminal domain of PA from bat-derived influenza-like virus H17N10 has endonuclease activity.,Tefsen B, Lu G, Zhu Y, Haywood J, Zhao L, Deng T, Qi J, Gao GF J Virol. 2013 Nov 27. PMID:24284327<ref>PMID:24284327</ref>
-	~~[[4nfz]] is a 3 chain structure. Full crystallographic information is available~~ from ~~[http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4NFZ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024284327</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Deng, T.]]	+	== References ==
-	[[Category: Gao, G F.]]	+	<references/>
-	[[Category: Haywood, J.]]	+	__TOC__
-	[[Category: Lu, G.]]	+	</StructureSection>
-	[[Category: Qi, J.]]	+	[[Category: Deng, T]]
-	[[Category: Tefsen, B.]]	+	[[Category: Gao, G F]]
-	[[Category: Zhao, L.]]	+	[[Category: Haywood, J]]
-	[[Category: Zhu, Y.]]	+	[[Category: Lu, G]]
		+	[[Category: Qi, J]]
		+	[[Category: Tefsen, B]]
		+	[[Category: Zhao, L]]
		+	[[Category: Zhu, Y]]
	[[Category: Manganese binding]]		[[Category: Manganese binding]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Rna endonuclease]]		[[Category: Rna endonuclease]]

OCA at 10:19, 18 December 2013

OCA — Wed, 18 Dec 2013 10:19:28 GMT

←Older revision		Revision as of 10:19, 18 December 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4nfz\| PDB=4nfz \| SCENE= }}
		+	===Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10===
		+	{{ABSTRACT_PUBMED_24284327}}

-	~~The entry~~ 4nfz is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4nfz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFZ OCA].

-	~~Authors~~: ~~Tefsen~~, B.~~, Lu~~, G.~~, Zhu, Y.,~~ Haywood, J., ~~Zhao, L~~.~~, Deng, T.,~~ Qi, J., ~~Gao~~, G.F.	+	==Reference==
-		+	<ref group="xtra">PMID:024284327</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of polymerase subunit PA N-terminal~~ endonuclease ~~domain from bat-derived influenza virus H17N10~~	+	[[Category: Deng, T.]]
		+	[[Category: Gao, G F.]]
		+	[[Category: Haywood, J.]]
		+	[[Category: Lu, G.]]
		+	[[Category: Qi, J.]]
		+	[[Category: Tefsen, B.]]
		+	[[Category: Zhao, L.]]
		+	[[Category: Zhu, Y.]]
		+	[[Category: Manganese binding]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rna endonuclease]]

OCA at 12:57, 20 November 2013

OCA — Wed, 20 Nov 2013 12:57:52 GMT

←Older revision		Revision as of 12:57, 20 November 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nfz is ON HOLD	+	The entry 4nfz is ON HOLD until Paper Publication

	Authors: Tefsen, B., Lu, G., Zhu, Y., Haywood, J., Zhao, L., Deng, T., Qi, J., Gao, G.F.		Authors: Tefsen, B., Lu, G., Zhu, Y., Haywood, J., Zhao, L., Deng, T., Qi, J., Gao, G.F.

	Description: Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10		Description: Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10

OCA: Protected "4nfz" [edit=sysop:move=sysop]

OCA — Wed, 13 Nov 2013 07:47:26 GMT

Protected "4nfz" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:47, 13 November 2013

OCA: New page: '''Unreleased structure''' The entry 4nfz is ON HOLD Authors: Tefsen, B., Lu, G., Zhu, Y., Haywood, J., Zhao, L., Deng, T., Qi, J., Gao, G.F. Description: Crystal structure of polymera...

OCA — Wed, 13 Nov 2013 07:47:25 GMT

New page: '''Unreleased structure''' The entry 4nfz is ON HOLD Authors: Tefsen, B., Lu, G., Zhu, Y., Haywood, J., Zhao, L., Deng, T., Qi, J., Gao, G.F. Description: Crystal structure of polymera...

New page

'''Unreleased structure'''

The entry 4nfz is ON HOLD

Authors: Tefsen, B., Lu, G., Zhu, Y., Haywood, J., Zhao, L., Deng, T., Qi, J., Gao, G.F.

Description: Crystal structure of polymerase subunit PA N-terminal endonuclease domain from bat-derived influenza virus H17N10