4nk3 - Revision history

OCA at 08:31, 11 January 2023

OCA — Wed, 11 Jan 2023 08:31:46 GMT

←Older revision		Revision as of 08:31, 11 January 2023
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	==Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655==		==Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655==
-	<StructureSection load='4nk3' size='340' side='right' caption='[[4nk3]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4nk3' size='340' side='right'caption='[[4nk3]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nk3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NK3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NK3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nk3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NK3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK7:(2S,5R)-1-FORMYL-N-(PIPERIDIN-4-YL)-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>MK7</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MK7:(2S,5R)-1-FORMYL-N-(PIPERIDIN-4-YL)-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>MK7</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ampC, PA4110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nk3 OCA], [https://pdbe.org/4nk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nk3 RCSB], [https://www.ebi.ac.uk/pdbsum/4nk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nk3 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nk3 OCA], [~~http~~://pdbe.org/4nk3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nk3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nk3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nk3 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AMPC_PSEAE AMPC_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beta-lactamase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Fitzgerald~~, P M.D~~]]	+	[[Category: Fitzgerald PMD]]
-	[[Category: Lu, J]]	+	[[Category: Lu J]]
-	[[Category: Scapin, G]]	+	[[Category: Scapin G]]
-	[[Category: Sharma, N]]	+	[[Category: Sharma N]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 21:12, 5 August 2016

OCA — Fri, 05 Aug 2016 21:12:52 GMT

←Older revision		Revision as of 21:12, 5 August 2016
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		+
	==Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655==		==Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655==
	<StructureSection load='4nk3' size='340' side='right' caption='[[4nk3]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4nk3' size='340' side='right' caption='[[4nk3]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ampC, PA4110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ampC, PA4110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nk3 RCSB], [http://www.ebi.ac.uk/pdbsum/4nk3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nk3 OCA], [http://pdbe.org/4nk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nk3 RCSB], [http://www.ebi.ac.uk/pdbsum/4nk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nk3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nk3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:28, 21 December 2014

OCA — Sun, 21 Dec 2014 16:28:44 GMT

←Older revision		Revision as of 16:28, 21 December 2014
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-	~~{{STRUCTURE_4nk3\| PDB=4nk3 \| SCENE= }}~~	+	==Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655==
-	===Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655===	+	<StructureSection load='4nk3' size='340' side='right' caption='[[4nk3]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24433862}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4nk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NK3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK7:(2S,5R)-1-FORMYL-N-(PIPERIDIN-4-YL)-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>MK7</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ampC, PA4110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nk3 RCSB], [http://www.ebi.ac.uk/pdbsum/4nk3 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	beta-Lactamase inhibitors with a bicyclic urea core and a variety of heterocyclic side chains were prepared and evaluated as potential partners for combination with imipenem to overcome class A and C beta-lactamase mediated antibiotic resistance. The piperidine analog 3 (MK-7655) inhibited both class A and C beta-lactamases in vitro. It effectively restored imipenem's activity against imipenem-resistant Pseudomonas and Klebsiella strains at clinically achievable concentrations. A combination of MK-7655 and Primaxin(R) is currently in phase II clinical trials for the treatment of Gram-negative bacterial infections.

-	~~==About this Structure==~~	+	Discovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin((R)).,Blizzard TA, Chen H, Kim S, Wu J, Bodner R, Gude C, Imbriglio J, Young K, Park YW, Ogawa A, Raghoobar S, Hairston N, Painter RE, Wisniewski D, Scapin G, Fitzgerald P, Sharma N, Lu J, Ha S, Hermes J, Hammond ML Bioorg Med Chem Lett. 2014 Feb 1;24(3):780-5. doi: 10.1016/j.bmcl.2013.12.101., Epub 2014 Jan 3. PMID:24433862<ref>PMID:24433862</ref>
-	~~[[4nk3]] is~~ a 1 ~~chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4NK3 OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024433862</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Fitzgerald, P M.D.]]	+	[[Category: Pseae]]
-	[[Category: Lu, J.]]	+	[[Category: Fitzgerald, P M.D]]
-	[[Category: Scapin, G.]]	+	[[Category: Lu, J]]
-	[[Category: Sharma, N.]]	+	[[Category: Scapin, G]]
		+	[[Category: Sharma, N]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 17:33, 19 February 2014

OCA — Wed, 19 Feb 2014 17:33:28 GMT

←Older revision		Revision as of 17:33, 19 February 2014
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4nk3\| PDB=4nk3 \| SCENE= }}
		+	===Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655===
		+	{{ABSTRACT_PUBMED_24433862}}

-	~~The entry~~ 4nk3 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4nk3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NK3 OCA].

-	~~Authors~~: ~~Scapin, G., Lu, J.,~~ Fitzgerald, P.M.D., Sharma, N.	+	==Reference==
-		+	<ref group="xtra">PMID:024433862</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Amp~~-~~c beta-lactamase (pseudomonas aeruginosa) in~~ complex ~~with mk-7655~~	+	[[Category: Beta-lactamase]]
		+	[[Category: Fitzgerald, P M.D.]]
		+	[[Category: Lu, J.]]
		+	[[Category: Scapin, G.]]
		+	[[Category: Sharma, N.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 13:04, 11 December 2013

OCA — Wed, 11 Dec 2013 13:04:26 GMT

←Older revision		Revision as of 13:04, 11 December 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nk3 is ON HOLD	+	The entry 4nk3 is ON HOLD until Paper Publication

	Authors: Scapin, G., Lu, J., Fitzgerald, P.M.D., Sharma, N.		Authors: Scapin, G., Lu, J., Fitzgerald, P.M.D., Sharma, N.

	Description: Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655		Description: Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655

OCA at 06:49, 4 December 2013

OCA — Wed, 04 Dec 2013 06:49:44 GMT

←Older revision		Revision as of 06:49, 4 December 2013
Line 5:		Line 5:
	Authors: Scapin, G., Lu, J., Fitzgerald, P.M.D., Sharma, N.		Authors: Scapin, G., Lu, J., Fitzgerald, P.M.D., Sharma, N.

-	Description: ~~AMP~~-~~C BETA~~-~~LACTAMASE~~ (~~PSEUDOMONAS AERUGINOSA~~) ~~IN COMPLEX WITH MK~~-7655	+	Description: Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655

OCA: Protected "4nk3" [edit=sysop:move=sysop]

OCA — Wed, 20 Nov 2013 13:00:16 GMT

Protected "4nk3" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:00, 20 November 2013

OCA: New page: '''Unreleased structure''' The entry 4nk3 is ON HOLD Authors: Scapin, G., Lu, J., Fitzgerald, P.M.D., Sharma, N. Description: AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) IN COMPLEX W...

OCA — Wed, 20 Nov 2013 13:00:15 GMT

New page: '''Unreleased structure''' The entry 4nk3 is ON HOLD Authors: Scapin, G., Lu, J., Fitzgerald, P.M.D., Sharma, N. Description: AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) IN COMPLEX W...

New page

'''Unreleased structure'''

The entry 4nk3 is ON HOLD

Authors: Scapin, G., Lu, J., Fitzgerald, P.M.D., Sharma, N.

Description: AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) IN COMPLEX WITH MK-7655